Mary Dallman

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Glucocorticoids, the etiology of obesity and the metabolic syndrome
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143 0444, USA
    Curr Alzheimer Res 4:199-204. 2007
  2. ncbi request reprint Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
  3. ncbi request reprint Fast glucocorticoid actions on brain: back to the future
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Front Neuroendocrinol 26:103-8. 2005
  4. pmc Glucocorticoids and insulin both modulate caloric intake through actions on the brain
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    J Physiol 583:431-6. 2007
  5. pmc Disengaging insulin from corticosterone: roles of each on energy intake and disposition
    James P Warne
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1366-75. 2009
  6. ncbi request reprint Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose
    Kevin D Laugero
    Department of Physiology and Program in Neuroscience, University of California, San Francisco, California 94143 0444, USA
    Endocrinology 143:4552-62. 2002
  7. ncbi request reprint Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to insulin-dependent diabetes and voluntary lard ingestion
    Susanne E la Fleur
    Department of Physiology and Program in Neurosciences, UCSF, San Francisco, CA 94143 0444, USA
    Eur J Neurosci 21:2733-42. 2005
  8. pmc Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint
    Michelle T Foster
    Department of Physiology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0444, USA
    Endocrinology 150:2325-33. 2009
  9. ncbi request reprint Marked regulatory shifts in gonadal, adrenal, and metabolic system responses to repeated restraint stress occur within a 3-week period in pubertal male rats
    Francisca Gomez
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Endocrinology 143:2852-62. 2002
  10. ncbi request reprint Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint
    Susanne E la Fleur
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 146:2193-9. 2005

Research Grants

  1. Chronic stress intensifies incentive relativity
    Mary Dallman; Fiscal Year: 2006
  2. BRAIN PITUITARY ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2002
  3. BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2007

Detail Information

Publications50

  1. ncbi request reprint Glucocorticoids, the etiology of obesity and the metabolic syndrome
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143 0444, USA
    Curr Alzheimer Res 4:199-204. 2007
    ..Correlative results from a clinical study support the powerful role of small changes in glucocorticoids in type 2 diabetes...
  2. ncbi request reprint Glucocorticoids, chronic stress, and obesity
    Mary F Dallman
    University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Prog Brain Res 153:75-105. 2006
    ..Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society...
  3. ncbi request reprint Fast glucocorticoid actions on brain: back to the future
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Front Neuroendocrinol 26:103-8. 2005
    ....
  4. pmc Glucocorticoids and insulin both modulate caloric intake through actions on the brain
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    J Physiol 583:431-6. 2007
    ..Both conditions of reduced food allowance and chronic stress excite glucocorticoid-augmented central neural networks that may lead toward ultimate abdominal obesity...
  5. pmc Disengaging insulin from corticosterone: roles of each on energy intake and disposition
    James P Warne
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1366-75. 2009
    ..Collectively, these data show that corticosterone and insulin determine the intake, form, and compartmentalization of energy both independently and interactively...
  6. ncbi request reprint Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose
    Kevin D Laugero
    Department of Physiology and Program in Neuroscience, University of California, San Francisco, California 94143 0444, USA
    Endocrinology 143:4552-62. 2002
    ..By contrast, tonic GR occupancy in brain initiates metabolic and ACTH responses characteristic of stress...
  7. ncbi request reprint Hepatic vagotomy alters limbic and hypothalamic neuropeptide responses to insulin-dependent diabetes and voluntary lard ingestion
    Susanne E la Fleur
    Department of Physiology and Program in Neurosciences, UCSF, San Francisco, CA 94143 0444, USA
    Eur J Neurosci 21:2733-42. 2005
    ....
  8. pmc Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint
    Michelle T Foster
    Department of Physiology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0444, USA
    Endocrinology 150:2325-33. 2009
    ..The results suggest strongly that ingestion of highly palatable foods reduces activity in the central stress response network, perhaps reducing the feeling of stressors...
  9. ncbi request reprint Marked regulatory shifts in gonadal, adrenal, and metabolic system responses to repeated restraint stress occur within a 3-week period in pubertal male rats
    Francisca Gomez
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Endocrinology 143:2852-62. 2002
    ..In early puberty, priority is placed on maintaining normal ponderal growth, whereas in late puberty, priority is placed on maintaining reproductive capability...
  10. ncbi request reprint Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint
    Susanne E la Fleur
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 146:2193-9. 2005
    ....
  11. ncbi request reprint Repeated stress in young and old 5-HT(2C) receptor knockout mice
    Jennifer M Chou-Green
    Department of Physiology, University of California, San Francisco, 513 Parnassus Avenue, Box 0444, San Francisco, CA 94143, USA
    Physiol Behav 79:217-26. 2003
    ..Together, these findings indicate that 5-HT(2C) receptor KO mice are hyperresponsive to repeated stress and this effect is influenced by stressor intensity and initial metabolic state of the mouse...
  12. ncbi request reprint Filling the interstices: ghrelin neurons plug several holes in regulation of energy balance
    Mary F Dallman
    Department of Physiology, Program in Neuroscience, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 37:550-3. 2003
    ....
  13. ncbi request reprint Androgen-sensitive changes in regulation of restraint-induced adrenocorticotropin secretion between early and late puberty in male rats
    Francisca Gomez
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 145:59-70. 2004
    ..We conclude that during puberty testosterone induces marked changes in regulation of neuropeptides in pathways known to determine autonomic, neuroendocrine, and behavioral responses to chronic stress...
  14. pmc Modulation of stress responses: how we cope with excess glucocorticoids
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143, USA
    Exp Neurol 206:179-82. 2007
  15. doi request reprint Rapid alteration of stress-induced hypothalamic-pituitary-adrenal hormone secretion in the rat: a comparison of glucocorticoids and cannabinoids
    Abigail B Ginsberg
    Department of Physiology, University of California San Francisco, San Francisco, California, USA
    Stress 13:248-57. 2010
    ....
  16. ncbi request reprint Chronic stress and comfort foods: self-medication and abdominal obesity
    Mary F Dallman
    Department of Physiology and Program in Neurosciences, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Brain Behav Immun 19:275-80. 2005
    ..A signal associated with this fat depot appears, as with eating "comfort foods," to reduce the influence of the chronic stress network on behaviors, autonomic, and neuroendocrine outflow...
  17. ncbi request reprint Diverse basal and stress-related phenotypes of Sprague Dawley rats from three vendors
    Norman Pecoraro
    Department of Physiology, School of Medicine, University of California San Francisco, 94143 0444, United States
    Physiol Behav 89:598-610. 2006
    ..Substantial phenotypic differences exist between Sprague Dawley rats from different vendors with respect to metabolism and HPA function. The metabolic feedback hypothesis was supported in two of the three vendors' rats...
  18. ncbi request reprint From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants
    Norman Pecoraro
    Department of Physiology, University of California, San Francisco, CA 94143 0444, United States
    Prog Neurobiol 79:247-340. 2006
    ..Adverse side effects of this yoking under conditions of glucocorticoid excess are discussed...
  19. ncbi request reprint Hepatic branch vagotomy, like insulin replacement, promotes voluntary lard intake in streptozotocin-diabetic rats
    James P Warne
    Department of Physiology, Box 0444, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Endocrinology 148:3288-98. 2007
    ..These actions may be modulated by insulin acting both centrally and peripherally...
  20. pmc Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats
    James P Warne
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    J Physiol 583:455-67. 2007
    ..Collectively, these data suggest that afferent signalling through the common hepatic branch of the vagus inhibits lard, but not chow, intake, directs fat deposition and regulates plasma metabolite levels...
  21. ncbi request reprint Temperature and activity responses to sucrose concentration reductions occur on the 1st but not the 2nd day of concentration shifts, and are blocked by low, constant glucocorticoids
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, San Francisco, CA 94113, USA
    Behav Neurosci 121:764-78. 2007
    ....
  22. doi request reprint An unexpected reduction in sucrose concentration activates the HPA axis on successive post shift days without attenuation by discriminative contextual stimuli
    Norman Pecoraro
    University of California, San Francisco, Department of Physiology, School of Medicine, 415 Parnassus Ave, Box 0444, San Francisco, CA 94143 0444, United States
    Physiol Behav 96:651-61. 2009
    ..The data indicate that thwarting sucrose expectancies is stressful, and that this stress response habituates across days...
  23. doi request reprint Metabolic and neuroendocrine consequences of a duodenal-jejunal bypass in rats on a choice diet
    James P Warne
    Departments of Physiology, University of California San Francisco, 94143, USA
    Ann Surg 249:269-76. 2009
    ..We sought to examine insulin-sensitive food intake behavior and neuroendocrine and metabolic variables of rats that had undergone a duodenal-jejunal bypass (DJB)...
  24. pmc Stress-induced obesity and the emotional nervous system
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Endocrinol Metab 21:159-65. 2010
    ..These effects of stressors emphasize the importance of teaching mental reappraisal techniques to restore responses from habitual to thoughtful, thus battling stress-induced obesity...
  25. ncbi request reprint Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic rat
    Francisca Gomez
    Department of Obstetrics, 513 Parnassus Avenue, HSW1475, Box 0556, University of California, San Francisco, California 94143, USA
    Endocrinology 146:3800-8. 2005
    ..Overeating did not correlate with changes in estradiol or androstenedione levels. We conclude that decreased GnRH neuronal activity is closely associated with decreased reproductive function and dysregulation of food intake...
  26. ncbi request reprint Glucocorticoids dose-dependently remodel energy stores and amplify incentive relativity effects
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, 94143 0444, USA
    Psychoneuroendocrinology 30:815-25. 2005
    ....
  27. ncbi request reprint c-Fos after incentive shifts: expectancy, incredulity, and recovery
    Norman Pecoraro
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Behav Neurosci 119:366-87. 2005
    ..Robust FLI on Shift 1 was absent on Shift 2, consistent with evidence for rapid (1-trial) changes in all major motor outputs mediated by expectancy...
  28. ncbi request reprint Interaction between corticosterone and insulin in obesity: regulation of lard intake and fat stores
    Susanne E la Fleur
    Department of Physiology, University of California, San Francisco, 513 Parnassus Avenue, Box 0444, San Francisco, California 94143 0444, USA
    Endocrinology 145:2174-85. 2004
    ..These results suggest that some human obesities may result from elevated glucocorticoids and insulin increasing the proportional intake of high density calories...
  29. ncbi request reprint Fast glucocorticoid feedback favors 'the munchies'
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Trends Endocrinol Metab 14:394-6. 2003
    ..Similar findings in other hypothalamic neurons suggest that this action of GCs might be common in the brain, and could, in part, explain rapid GC effects on food intake...
  30. ncbi request reprint The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia
    Susanne E la Fleur
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, California 94143 0444, USA
    Diabetes 52:2321-30. 2003
    ..Furthermore, common branch hepatic vagotomy without diabetes induced indexes of obesity. Abnormal function of the hepatic vagus, as occurs in diabetic neuropathy, may contribute to diabetic obesity...
  31. ncbi request reprint Intermittent morphine administration induces dependence and is a chronic stressor in rats
    Hani Houshyar
    Department of Physiology and Neuroscience Program, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Neuropsychopharmacology 28:1960-72. 2003
    ..Drug addicts treat themselves intermittently, and stress causes relapse after withdrawal. Thus, intermittent morphine, itself, may promote relapse...
  32. ncbi request reprint A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress
    Mary F Dallman
    Department of Physiology, University of California San Francisco, Box 0444, San Francisco, CA 94143 0444, USA
    Physiol Behav 79:3-12. 2003
    ..We speculate that the interaction between peripheral and central GC-sensitive signaling systems may be coupled through the inhibitory actions of endogenous opiatergic inputs on corticotropin-releasing factor (CRF) neurons...
  33. ncbi request reprint The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats
    James P Warne
    Dept of Physiology, Box 0444, Univ of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Am J Physiol Endocrinol Metab 294:E190-200. 2008
    ..These data suggest that the gastroduodenal branch of the vagus inhibits lard intake and regulates WAT deposition and plasma metabolite levels in STZ-diabetic rats...
  34. ncbi request reprint Repeated, non-habituating stress suppresses inflammatory plasma extravasation by a novel, sympathoadrenal dependent mechanism
    Holly J Strausbaugh
    Department of Anatomy, University of California, 521 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Eur J Neurosci 17:805-12. 2003
    ..The effect of nonhabituating stress on inflammation was dependent on the sympathoadrenal axis with no detectable contribution by the hypothalamic-pituitary-adrenal axis...
  35. ncbi request reprint Brief access to sucrose engages food-entrainable rhythms in food-deprived rats
    Norman Pecoraro
    Department of Physiology, University of California, San Francisco 94113 0444, USA
    Behav Neurosci 116:757-76. 2002
    ..After a shift to 4% sucrose for 8 days, the 10-min group showed signs of damping of these rhythms, whereas the 5-min group did not. Data indicated that brief access to sucrose engages food-entrainable rhythms in food-deprived rats...
  36. ncbi request reprint Minireview: glucocorticoids--food intake, abdominal obesity, and wealthy nations in 2004
    Mary F Dallman
    Department of Physiology, University of California San Francisco, San Francisco, California 94143 0444, USA
    Endocrinology 145:2633-8. 2004
    ..Finally, we discuss the evolutionary utility of these actions of the stress hormones, and how dysregulatory effects of chronically elevated glucocorticoids may occur in our modern, rich societies...
  37. ncbi request reprint Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0444
    Endocrinology 145:3754-62. 2004
    ..The results of this experiment tend to support our model of chronic effects of stress and GCs, showing a stressor-induced preference for comfort food, and a comfort-food reduction in activity of the HPA axis...
  38. ncbi request reprint Single, but not multiple pairings of sucrose and corticosterone enhance memory for sucrose drinking and amplify remote reward relativity effects
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143 0444, USA
    Neurobiol Learn Mem 83:188-95. 2005
    ..Through effects on memory, stress hormones may modulate reward and reward relativity...
  39. ncbi request reprint Ode to B-flat: questing with quintessential colleagues
    Mary F Dallman
    Department of Physiology, UCSF, San Francisco, CA 94143 0444, USA
    Ann N Y Acad Sci 1032:299-300. 2004
    ..A brief summary of the trajectory of the lab. It includes where the work of the lab has been, where it is now, and, perhaps, where we are going in the next decade...
  40. ncbi request reprint Time-dependent alterations in mRNA expression of brain neuropeptides regulating energy balance and hypothalamo-pituitary-adrenal activity after withdrawal from intermittent morphine treatment
    Hani Houshyar
    Department of Physiology and Neuroscience Program, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 24:9414-24. 2004
    ..Repeated partial withdrawal associated with intermittent morphine treatment, compounded by complete withdrawal associated with termination of the treatment, is likely required for these metabolic and HPA derangements...
  41. pmc Chronic stress and obesity: a new view of "comfort food"
    Mary F Dallman
    Department of Physiology and Neuroscience Program, University of California, San Francisco, CA 94143 0444, USA
    Proc Natl Acad Sci U S A 100:11696-701. 2003
    ..These mechanisms, determined in rats, may explain some of the epidemic of obesity occurring in our society...
  42. ncbi request reprint Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight, and fat stores
    James P Warne
    Department of Physiology, Box 0444, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Endocrinology 147:5443-51. 2006
    ....
  43. ncbi request reprint Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides
    Aditi Bhargava
    Department of Surgery, University of California, San Francisco, CA 94143, USA
    Brain Res Brain Res Protoc 13:115-25. 2004
    ..Thus, using long dsRNA, we were able to ascertain site-specific roles of CRF and AVP in adult rats without any developmental compensation and in a wild-type background...
  44. ncbi request reprint Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage
    Phu V Tran
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 498:637-48. 2006
    ..Collectively, we propose that a reduction in the sf-1 gene dosage directly affects BDNF levels in the VMH and disrupts normal hypothalamic function...
  45. ncbi request reprint Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1
    Aditi Bhargava
    Department of Medicine, Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Mol Endocrinol 16:1629-37. 2002
    ..Prolonged exposure to GCs, resulting in concomitant accumulation of [Ca(2+)](i), is likely to compromise neuronal function and viability...
  46. ncbi request reprint Compulsive behavior in the 5-HT2C receptor knockout mouse
    Jennifer M Chou-Green
    Department of Physiology, University of California San Francisco, 513 Parnassus Avenue, Box 0444, San Francisco, CA 94143, USA
    Physiol Behav 78:641-9. 2003
    ..We conclude that the 5-HT(2C) receptor null mutant mouse provides a promising model of compulsive behavior and a means to further explore the role of 5-HT in OCD...
  47. ncbi request reprint Stress by any other name .....?
    Mary F Dallman
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Horm Behav 43:18-20; discussion 28-30. 2003
  48. ncbi request reprint Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, Box 1109, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 81:545-55. 2004
    ..Together, these data suggest that the 5-HT-3A receptor does not have a unitary role in the regulation of anxiety- and fear-related behaviors but has a potentially substantial role in the regulation of HPA activity...
  49. ncbi request reprint Stress, diet and abdominal obesity: Y?
    James P Warne
    Nat Med 13:781-3. 2007
  50. ncbi request reprint Adrenocortical function, feedback, and alphabet soup
    Mary F Dallman
    Am J Physiol Endocrinol Metab 289:E361-2. 2005

Research Grants17

  1. Chronic stress intensifies incentive relativity
    Mary Dallman; Fiscal Year: 2006
    ..abstract_text> ..
  2. BRAIN PITUITARY ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2002
    ..If the underlying hypotheses are correct, these experiments will provide evidence that the basis neural circuit that mediates facilitated stress responses in chronically stressed rats is part of the "conditioned fear response" circuit. ..
  3. BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2007
    ..The information should be useful for therapeutic advice for overweight, stressed people, and possibly provide insights into mechanisms underlying different types of depressive and anxiety disorders ..