Marc A Dall'Era

..We hypothesize that prostate tumors expressing high levels of CD10 have a more aggressive biology with an early propensity towards lymph node metastasis...

..The psychosocial impact of active surveillance on patients is discussed as well as contemporary methods for disease monitoring...

..The best candidates for active surveillance are being defined, as are predictors of active treatment. The psychosocial ramifications of surveillance for prostate cancer can be profound and future needs and unmet goals will be discussed...

..In this study, we compared CD10 mRNA and protein expression between benign and malignant prostate cells and employed proteomic analysis to identify proteins that interact with CD10 in C4-2 prostate cancer cells...

..In this article, the authors report their experience in a contemporary cohort of men with prostate cancer who were managed with active surveillance...

..We describe the frequency of urethrectomy by bladder cancer stage and identify clinical characteristics that predict urethrectomy. We also investigated whether urethrectomy offers any additional independent survival benefit...

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..The purpose of this review is to analyze the economics of active surveillance in comparison with other therapies...

..Prostate cancer (PCa) remains an increasingly common malignancy worldwide. The optimal management of clinically localized, early-stage disease remains unknown, and profound quality of life issues surround PCa interventions...

..To determine if significant differences exist in the prevalence of latent prostate cancer between periods before and after the advent of screening for prostate cancer, we compared 2 groups of men undergoing autopsy during the 2 periods...

..To determine whether the interval between prostate biopsy and radical prostatectomy (RP) affects the immediate postoperative outcome...

..We determined the frequency and predictors of complications of partial and total nephrectomy in a population based sample...

..Finally, we support well-designed prospective clinical trials that evaluate active surveillance compared with immediate definitive treatment...

..Because there are no currently established guidelines for screening and management of prostate cancer in elderly men (older than 75 years), a multidisciplinary panel was convened to develop consensus recommendations...

..The authors hypothesized that differences in hospital volume where patients undergo radical cystectomy may be responsible for race-based differences in outcomes after the procedure...

..We sought to compare complication and mortality rates following urologic procedures derived from population-based data to those of published single-institutional case series...

..We sought to determine whether a high volume of unrelated complex procedures or procedures in the same specialty area (urology) could translate into better outcomes after major urologic cancer surgery...

..The authors report the likelihood of treatment failure and the outcomes after salvage therapy among men with prostate cancer who initially either received external-beam radiation therapy (EBRT) or underwent radical prostatectomy (RP)...

..Complications after radical cystectomy have been reported from large single-institution series but population-based representative data are lacking...

..We quantified the economic impact of caring for patients with bladder and upper tract urothelial cancer, and determined the primary drivers for such costs in the population in the United States...

..However, there are no large-scale studies of actual PSA screening practices in elderly men, according to life expectancy...

..To determine the practice preferences for prostate cancer screening and treatment in men 75 years of age or older among healthcare providers in Iowa...

..We examined patterns of primary treatment for prostate cancer in men 75 years or older...

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..We also surveyed healthcare providers and men >75 years old to determine whether provider attitudes toward continued PCa screening in older men had changed...

..We determined if prostate volume determined by preoperative transrectal ultrasound could predict recovery of urinary function and continence following radical prostatectomy...

..We have developed an in vivo method to quantify antibody uptake using (111)In-capromab pendetide SPECT combined with CT (SPECT/CT). Our goal was to evaluate this method for potential grading of prostate tumors...

..In this study, we investigated the ability of UroVysion to assess response to intravesical therapy in patients with high risk superficial bladder tumors...

..Ongoing clinical trials with watchful waiting and active surveillance for prostate cancer will ultimately provide improved evidence for managing early, localized disease...

..We determined various sociodemographic predictors of prostate cancer risk category at presentation as assessed by serum prostate specific antigen, cancer grade and tumor stage...

..We investigated the effect of caps on the use of and outcomes following aggressive surgical treatment (radical cystectomy) in patients with bladder cancer...

..African-American men presented with a higher stage of disease and statistically significant decreased survival, whereas previously or currently married men presented at an earlier stage of disease and sought more aggressive treatment...

..We studied whether patient personality influences treatment choice and overall treatment satisfaction...

..PET/CT may also be helpful in the detection of disease outside the bladder at nodal or more distant sites and in the assessment of recurrent disease...

..We evaluated a large disease registry to determine the incidence of bladder cancer in patients with prostate cancer and investigate whether the type of treatment for prostate cancer increased the risk of bladder cancer...

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..Personalized chemotherapy is currently being actively pursued to target the underlying molecular changes and tailor to individual needs...

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..We examined data from the Surveillance, Epidemiology, and End Results (SEER) cancer survival database to see if married patients with bladder cancer had a survival advantage vs. nonmarried patients...

..However, the majority of tumors are still detected among men over 65-years-old. The appropriate management of localized disease among these older men is controversial...

..The establishment of firm guideline recommendations regarding PSA testing and further evaluation for prostate cancer in elderly men, perhaps based on individualized geriatric assessment, may be helpful...

..Additional reductions in hospital charges could offset the greater physician charges in the NBL patients and allow full realization of the benefit from the shorter operative time with the two-surgeon team...

..We determined the influence of hospital and surgeon volume on various outcome parameters after radical cystectomy for bladder cancer...

..Positive surgical margin rates are low. This approach yielded good local control of disease, however impact on tumor recurrence and survival is not known...

..However, 81% of surveyed urologists were still reluctant to refer patients with high-grade Ta-T1 disease with failure after intravesical immunotherapy twice for more aggressive therapy such as cystectomy or radiotherapy...

..We quantified the impact of specific post-cystectomy complications and combinations thereof in terms of mortality, charges and length of stay...

..We also examined the correlation between these factors and disease specific survival such aggressive therapy...

..This approach allows one to limit prostate cancer treatment and any risk of related morbidity to the men who will benefit the most from active intervention...

..We hypothesized that the hospital volume of radical cystectomy is an important predictor of complications of other urological procedures...

..The economic and clinical effects of infectious complications after radical cystectomy have not been analyzed...

..We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease...

..We tested the validity of POSSUM and Portsmouth POSSUM in patients undergoing radical cystectomy with continent diversion...

..The net effect of these pressures may be the regionalization of care. We quantified trends in the regionalization of inpatient care for urological oncology in a national administrative database...

..These agents need to be studied in large randomized trials to prove that using these agents can facilitate early diagnosis and improved prognosis in patients with bladder cancer...

..This technique could be used to determine the tissue levels of calcitriol more accurately and to conduct additional studies to better elucidate the effects of castration on the intraprostatic pharmacokinetics of calcitriol...

..Long-term QOL declines even in those with intact bladders, particularly in those with comorbidities...

..It appears to be a transcription factor that may play a role in the regulation of the gene expression in bladder cancer. BLCA-4 is a marker with significant clinical utility that may have an active role in the disease...

..This presents an interesting dilemma as to whether this was recurrence of the original tumor or a new, primary tumor. The patient's outcome and surveillance protocol for these tumors are presented...

..Lymph node counts are often a proxy for the extensiveness of a dissection. In the current study, the impact of an institutional policy requiring a minimum number of lymph nodes was assessed...

..However, the rate of occult kidney cancer per 100 autopsies did not change significantly between the two periods, suggesting a true increase in the frequency of clinically detected kidney cancer...

..Manual compression of the kidney appears to be at least as effective as clamping of the renal vessels in obtaining vascular control during the procedure and is more expeditious...

..The patient continues to be without evidence of disease 2 years postoperatively. This case shows that neoadjuvant chemotherapy with nonstandard regimens can yield responses in patients with bone metastases...

..These data support the hypothesis that populations of African descent share genetic and/or lifestyle factors that contribute to their elevated risk for prostate cancer...

..CONCLUSIONS: Performing more extensive pelvic lymphadenectomy in patients undergoing radical prostatectomy could improve the accuracy of staging and reduce the risk of prostate cancer-specific death in the long term...

..The screening was highly efficacious, with a positive predictive value of 56% for an elevated PSA level and 40% for an elevated PSA level and/or abnormal DRE findings...

..The objectives of this study were to describe the characteristics of patients who were hospitalized for head and neck cancer (HNC) during the years 2000 through 2003 and to identify predictors of in-hospital mortality...

..An alternative would be to attempt to improve outcomes at low volume hospitals by identifying drivers of high quality care at high volume hospitals and transferring some of these characteristics...

..An increased number of positive nodes, as well as an increasing nodal burden, although associated with a lower likelihood of survival, were not independent predictors of RCC-specific mortality...

..There is now considerable evidence suggesting a role for vitamin D in prostate cancer. In this article, we have reviewed the current evidence supporting the use of vitamin D in the prevention and treatment of prostate cancer...

..To determine the effect of axillary lymphadenectomy on breast carcinoma survival, and to determine racial and age differences in the extent of axillary lymphadenectomy...

..Further studies involving larger numbers of patients are required to determine their accuracy and widespread applicability in guiding treatment of bladder cancer...

..Wnt inhibitory factor-1 (Wif-1) was identified as one of the secreted antagonists that can bind Wnt protein. We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis...

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..We investigated the relationship between provider volume and charges for transurethral bladder tumor resection (TURBT) and radical cystectomy in patients with bladder cancer...