David D'Alessio

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques
    D A D'Alessio
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 86:1253-9. 2001
  2. doi request reprint Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV
    David D'Alessio
    Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    JPEN J Parenter Enteral Nutr 32:567-8. 2008
  3. pmc The intestinal lymph fistula model--a novel approach to study ghrelin secretion
    Jenny Tong
    Departments of Medicine, University of Cincinnati, Ohio, 45267 0547, USA
    Am J Physiol Gastrointest Liver Physiol 298:G474-80. 2010
  4. doi request reprint Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose
    Wendell J Lu
    Department of Molecular and Cellular Physiology, Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1130-8. 2008
  5. pmc Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 97:3366-74. 2012
  6. pmc Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 98:2536-43. 2013
  7. pmc Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP
    Wendell J Lu
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45267, USA
    Lipids 47:571-80. 2012
  8. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
  9. pmc Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice
    Chun Min Lo
    Cincinnati Obesity Research Center, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 60:2000-7. 2011
  10. pmc Cooperation between brain and islet in glucose homeostasis and diabetes
    Michael W Schwartz
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 503:59-66. 2013

Research Grants

  1. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 1999
  2. The role of GLP-1 in normal and abnormal glucose tolerance
    DAVID D ALESSIO; Fiscal Year: 2009
  3. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2007
  4. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2006
  5. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2005
  6. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2004
  7. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2003
  8. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2001
  9. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2000
  10. The role of GLP-1 in normal and abnormal glucose tolerance
    DAVID A D apos ALESSIO; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques
    D A D'Alessio
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 86:1253-9. 2001
    ..These results indicate that activation of the PNS during the absorptive phase of meals contributes significantly to the postprandial insulin secretory response...
  2. doi request reprint Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV
    David D'Alessio
    Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    JPEN J Parenter Enteral Nutr 32:567-8. 2008
    ..The effects of cholecystokinin, glucagon-like peptide I, peptide YY, and apolipoprotein A-IV are described...
  3. pmc The intestinal lymph fistula model--a novel approach to study ghrelin secretion
    Jenny Tong
    Departments of Medicine, University of Cincinnati, Ohio, 45267 0547, USA
    Am J Physiol Gastrointest Liver Physiol 298:G474-80. 2010
    ..The postprandial dynamics of ghrelin are slower in lymph than plasma, but the magnitude of change is greater. Assessing ghrelin levels in the lymph may be advantageous for studying its secretion and concentrations in the gastric mucosa...
  4. doi request reprint Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose
    Wendell J Lu
    Department of Molecular and Cellular Physiology, Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1130-8. 2008
    ..We conclude from these studies that the lymph fistula rat is a novel approach to study in vivo GIP secretion in response to nutrient feeding in conscious rats...
  5. pmc Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 97:3366-74. 2012
    ..The 20-kDa hGH promotes growth similarly to 22-kDa or total hGH, the predominant form in circulation, but the relative effects of these isoforms on glucose metabolism have been debated...
  6. pmc Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 98:2536-43. 2013
    ..Infusion of ghrelin to supraphysiologic levels inhibits glucose-stimulated insulin secretion, reduces insulin sensitivity, and worsens glucose tolerance in humans...
  7. pmc Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP
    Wendell J Lu
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45267, USA
    Lipids 47:571-80. 2012
    ..The relative difference in the effect of L-81 on the two incretins provides further support that nutrient-stimulation of GIP and GLP-1 is via distinct mechanisms...
  8. ncbi request reprint Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake
    Koro Gotoh
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Am J Physiol Regul Integr Comp Physiol 290:R202-7. 2006
    ..In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate...
  9. pmc Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice
    Chun Min Lo
    Cincinnati Obesity Research Center, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 60:2000-7. 2011
    ..Cholecystokinin (CCK) is released in response to lipid intake and stimulates insulin secretion. We hypothesized that CCK deficiency would alter the regulation of insulin secretion and glucose homeostasis...
  10. pmc Cooperation between brain and islet in glucose homeostasis and diabetes
    Michael W Schwartz
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 503:59-66. 2013
    ..Consequently, therapies that target the BCGS in addition to conventional approaches based on enhancing insulin effects may have the potential to induce diabetes remission, whereas targeting just one typically does not. ..
  11. ncbi request reprint Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism
    Torsten Vahl
    Division of Endocrinology, University of Cincinnati, Ohio 45267, USA
    Curr Opin Clin Nutr Metab Care 6:461-8. 2003
    ..New findings indicate that the enteroinsular system mediated by the incretins is relevant to both the pathophysiology and treatment of diabetes...
  12. pmc Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, OH
    Diabetes 63:2309-19. 2014
    ..In contrast to previous reports, acute administration of UAG does not have independent effects on glucose tolerance or β-cell function and neither augments nor antagonizes the effects of AG. ..
  13. pmc The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45219 0547, USA
    Eur J Endocrinol 168:821-8. 2013
    ..However, there is only limited data on the pharmacokinetics of AG and DAG...
  14. pmc High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice
    Maarit Lehti
    Diabetes Research Department IDO and IDR, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, München Neuherberg, Germany M L, M K, T O, C S, S C, P T P, S M H Metabolic Diseases Institute, Division of Endocrinology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH M L, E D, W A, O A M, K M H, J W, C R, J M, S S, C T, R K, S M G, R A G D S, D D, W S D, S M H LIKES Research Center for Sport and Health Sciences, Jyvaskyla, Finland M L Energy Metabolism Laboratory ETH Zurich Swiss Federal Institute of Technology, Zurich, UNICAMP
    Circulation 128:2364-71. 2013
    ..We used genetic mouse models with increased HDL levels (apolipoprotein A-I transgenic [apoA-I tg]) and reduced HDL levels (apoA-I-deficient [apoA-I ko]) to investigate whether HDL modulates mitochondrial bioenergetics in skeletal muscle...
  15. doi request reprint Eating disorders and gastrointestinal peptides
    Jenny Tong
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Curr Opin Endocrinol Diabetes Obes 18:42-9. 2011
    ....
  16. pmc Role of carbohydrate modification in weight management among obese children: a randomized clinical trial
    Shelley Kirk
    Center for Better Health and Nutrition, The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr 161:320-7.e1. 2012
    ..To compare the effectiveness and safety of carbohydrate (CHO)-modified diets with a standard portion-controlled (PC) diet in obese children...
  17. ncbi request reprint Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system
    David D'Alessio
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2163-9. 2007
    ..In addition, these data raise the possibility that intestinal lymph may serve as a specialized signaling conduit for regulatory peptides secreted by gastrointestinal endocrine cells...
  18. pmc The role of the transcription factor ETV5 in insulin exocytosis
    Ruth Gutierrez-Aguilar
    Department of Internal Medicine, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH, 45237, USA
    Diabetologia 57:383-91. 2014
    ..Genome-wide association studies have revealed an association of the transcription factor ETS variant gene 5 (ETV5) with human obesity. However, its role in glucose homeostasis and energy balance is unknown...
  19. ncbi request reprint Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis
    Syed A Ahmad
    Pancreatic Disease Center, Department of Surgery, University of Cincinnati, Cincinnati, OH 45219, USA
    J Am Coll Surg 201:680-7. 2005
    ..Factors that determine success after this operation have not been clearly defined...
  20. ncbi request reprint Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
    Sung Hee Um
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, Ohio 45237, USA
    Cell Metab 3:393-402. 2006
    ..Thus, S6K1 may mediate deleterious effects, like insulin resistance, and potentially type 2 diabetes in the face of nutrient excess...
  21. pmc Fibroblast growth factor 21 mediates specific glucagon actions
    Kirk M Habegger
    Metabolic Disease Institute, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 62:1453-63. 2013
    ..Taken together, these data reveal for the first time that glucagon controls glucose, energy, and lipid metabolism at least in part via FGF21-dependent pathways...
  22. pmc Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans
    Jenny Tong
    Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Neurosci 31:5841-6. 2011
    ..This novel role is consistent with ghrelin's overall function as a signal amplifier at the molecular interface between environmental and nutritional cues and neuroendocrine circuits controlling energy homeostasis...
  23. pmc Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    Jenny Tong
    1Department of Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 59:2145-51. 2010
    ..The goal of this study was to test the hypothesis that circulating ghrelin suppresses glucose-stimulated insulin secretion in healthy subjects...
  24. ncbi request reprint Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents
    Lawrence M Dolan
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 146:751-8. 2005
    ..To document the frequency of glucose intolerance in adolescents in a population-based study of primarily African-American/Non-Hispanic whites in an urban-suburban school district...
  25. ncbi request reprint Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII
    Deborah J Clegg
    Department of Psychiatry, University of Cincinnati Medical Center, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Endocrinology 144:2941-6. 2003
    ..These results indicate that consumption of a HF diet decreases signaling through the melanocortin system, an abnormality that could contribute to diet-induced obesity...

Research Grants10

  1. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 1999
    ..The results of these studies will expand the understanding of glucose homeostasis, and promote the development of new strategies to treat type 2 diabetes. ..
  2. The role of GLP-1 in normal and abnormal glucose tolerance
    DAVID D ALESSIO; Fiscal Year: 2009
    ..The goal of this project is to understand the different mechanisms by which GLP-1 acts to allow new and more refined applications of this system to the treatment of diabetes. ..
  3. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2007
    ..The results of these studies will add to the understanding of the regulation of glucose metabolism by GLP-1 and the incretin axis, and contribute to the development of new strategies to treat type 2 diabetes. ..
  4. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2006
    ..The results of these studies will add to the understanding of the regulation of glucose metabolism by GLP-1 and the incretin axis, and contribute to the development of new strategies to treat type 2 diabetes. ..
  5. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2005
    ..The results of these studies will add to the understanding of the regulation of glucose metabolism by GLP-1 and the incretin axis, and contribute to the development of new strategies to treat type 2 diabetes. ..
  6. Role of GLP-1 in Normal and Abnormal Glucose Tolerance
    DAVID D ALESSIO; Fiscal Year: 2004
    ..The results of these studies will add to the understanding of the regulation of glucose metabolism by GLP-1 and the incretin axis, and contribute to the development of new strategies to treat type 2 diabetes. ..
  7. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2003
    ..The results of these studies will expand the understanding of glucose homeostasis, and promote the development of new strategies to treat type 2 diabetes. ..
  8. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2001
    ..The results of these studies will expand the understanding of glucose homeostasis, and promote the development of new strategies to treat type 2 diabetes. ..
  9. GLP-1 IN NORMAL AND ABNORMAL GLUCOSE TOLERANCE
    DAVID D ALESSIO; Fiscal Year: 2000
    ..The results of these studies will expand the understanding of glucose homeostasis, and promote the development of new strategies to treat type 2 diabetes. ..
  10. The role of GLP-1 in normal and abnormal glucose tolerance
    DAVID A D apos ALESSIO; Fiscal Year: 2010
    ..The goal of this project is to understand the different mechanisms by which GLP-1 acts to allow new and more refined applications of this system to the treatment of diabetes. ..