D D'ALESSIO

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4
    Lene Jessen
    Division of Endocrinology, University of Cincinnati, Cincinnati, OH 45237, USA
    Endocrinology 153:5735-45. 2012
  2. ncbi request reprint Effects of glucagon-like peptide 1 on the hepatic glucose metabolism
    D D'ALESSIO
    Division of Endocrinology, University of Cincinnati, OH 45267 0547, USA
    Horm Metab Res 36:837-41. 2004
  3. ncbi request reprint Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system
    David D'Alessio
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2163-9. 2007
  4. ncbi request reprint Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes
    DAVID A D'ALESSIO
    University of Cincinnati, Division of Endocrinology, ML 0547, Cincinnati, OH 45267, USA
    Am J Physiol Endocrinol Metab 286:E882-90. 2004
  5. ncbi request reprint Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches
    DAVID A D'ALESSIO
    University of Cincinnati, Division of Endocrinology Metabolism, ML 0547, Vontz Center, 3125 Eden Avenue, Cincinnati, OH 45220 0547, USA
    Curr Diab Rep 5:346-52. 2005
  6. pmc Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes
    DAVID A D'ALESSIO
    University of Cincinnati, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, ML 0547, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 94:81-8. 2009
  7. doi request reprint The role of dysregulated glucagon secretion in type 2 diabetes
    D D'ALESSIO
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Cincinnati and Cincinnati VA Medical Center, Cincinnati, OH 45267 0547, USA
    Diabetes Obes Metab 13:126-32. 2011
  8. ncbi request reprint Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans
    Shaista Quddusi
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 26:791-8. 2003
  9. ncbi request reprint Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
    Torsten P Vahl
    Division of Endocrinology, University of Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 88:1772-9. 2003
  10. ncbi request reprint Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007

Collaborators

Detail Information

Publications19

  1. pmc Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4
    Lene Jessen
    Division of Endocrinology, University of Cincinnati, Cincinnati, OH 45237, USA
    Endocrinology 153:5735-45. 2012
    ..These findings suggest distinct potencies of GLP-1 receptor agonists on food intake that cannot be explained by plasma pharmacokinetics...
  2. ncbi request reprint Effects of glucagon-like peptide 1 on the hepatic glucose metabolism
    D D'ALESSIO
    Division of Endocrinology, University of Cincinnati, OH 45267 0547, USA
    Horm Metab Res 36:837-41. 2004
    ..This paper will review the current literature addressing hepatic effects of GLP-1 and identify important gaps in the knowledge base for this topic...
  3. ncbi request reprint Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system
    David D'Alessio
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2163-9. 2007
    ..In addition, these data raise the possibility that intestinal lymph may serve as a specialized signaling conduit for regulatory peptides secreted by gastrointestinal endocrine cells...
  4. ncbi request reprint Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes
    DAVID A D'ALESSIO
    University of Cincinnati, Division of Endocrinology, ML 0547, Cincinnati, OH 45267, USA
    Am J Physiol Endocrinol Metab 286:E882-90. 2004
    ..The application of GLP-1 to clinical use fulfills a long-standing interest in adapting endogenous insulinotropic hormones to the treatment of diabetes...
  5. ncbi request reprint Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches
    DAVID A D'ALESSIO
    University of Cincinnati, Division of Endocrinology Metabolism, ML 0547, Vontz Center, 3125 Eden Avenue, Cincinnati, OH 45220 0547, USA
    Curr Diab Rep 5:346-52. 2005
    ..These two new classes of drugs both enhance GLP-1 signaling but differ in several key characteristics that may lead to distinct roles in the treatment of diabetic patients...
  6. pmc Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes
    DAVID A D'ALESSIO
    University of Cincinnati, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, ML 0547, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 94:81-8. 2009
    ..Objective: The objective of the study was to examine the effects of DPP-4 inhibition on fasting islet function...
  7. doi request reprint The role of dysregulated glucagon secretion in type 2 diabetes
    D D'ALESSIO
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Cincinnati and Cincinnati VA Medical Center, Cincinnati, OH 45267 0547, USA
    Diabetes Obes Metab 13:126-32. 2011
    ....
  8. ncbi request reprint Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans
    Shaista Quddusi
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 26:791-8. 2003
    ....
  9. ncbi request reprint Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
    Torsten P Vahl
    Division of Endocrinology, University of Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 88:1772-9. 2003
    ..Based on these results we conclude that GLP-1-(9-36)NH(2) does not regulate insulin release or glucose metabolism in healthy humans...
  10. ncbi request reprint Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    Torsten P Vahl
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45267, USA
    Endocrinology 148:4965-73. 2007
    ..These data are consistent with an important component of neural mediation of GLP-1 action...
  11. pmc Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion
    Marzieh Salehi
    Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, Ohio 45267, USA
    J Clin Endocrinol Metab 93:4909-16. 2008
    ....
  12. ncbi request reprint Comparative analysis of ACTH and corticosterone sampling methods in rats
    Torsten P Vahl
    Dept of Internal Medicine, Division of Endocrinology and Metabolism, Univ of Cincinnati, 2170 E Galbraith Rd, Bldg 43, Rm 315, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 289:E823-8. 2005
    ..However, collection of blood under pentobarbital sodium or CO2 anesthesia is likely to confound the results of stress studies when ACTH is an important endpoint...
  13. ncbi request reprint Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats
    April D Strader
    Genome Research Institute, Department of Psychiatry, University of Cincinnati, 2071 E Galbraith Rd, Reading, OH 45237, USA
    Am J Physiol Endocrinol Metab 288:E447-53. 2005
    ..These findings support the importance of evaluating the contribution of gastrointestinal hormones to the weight loss seen with bariatric surgery...
  14. ncbi request reprint Gut peptides in the treatment of diabetes mellitus
    Torsten P Vahl
    University of Cincinnati, Department of Internal Medicine, OH 45220 0547, USA
    Expert Opin Investig Drugs 13:177-88. 2004
    ..This review focuses on the physiology of GLP-1 and GIP and the advances that have been made thus far in developing treatments based on these physiological incretins for Type 2 diabetes...
  15. pmc Meal-anticipatory glucagon-like peptide-1 secretion in rats
    Torsten P Vahl
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:569-75. 2010
    ..These findings document for the first time a cephalic increase of plasma GLP-1 and suggest that it functions to facilitate consumption of a large meal...
  16. ncbi request reprint The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    R J Seeley
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 20:1616-21. 2000
    ..The same dose of GLP-1 receptor antagonist did not reverse the LiCl-induced reduction in NaCl intake. The data indicate a role for GLP-1 receptors in the CNS pathway that mediates some of the effects of visceral illness...
  17. ncbi request reprint Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status
    Deborah L Drazen
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Endocrinology 147:23-30. 2006
    ..Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition...
  18. ncbi request reprint Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation
    John W Ensinck
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle 98195, USA
    Endocrinology 143:2599-609. 2002
    ..Its localization in both GI endocrine cells and gut neurons suggests that thrittene may function as both a hormone and neurotransmitter...
  19. ncbi request reprint CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors
    Kimberly P Kinzig
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 23:6163-70. 2003
    ..Although diverse neural circuits must necessarily process disparate stressors, the current data implicate a role for the GLP-1 system as a critical mediator of multiple stress responses...