Research Topics
| Heike E Daldrup-LinkSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Unusual association of alveolar rhabdomyosarcoma with pancreatic metastasis: emerging role of PET-CT in tumor stagingPriyanka Jha
Department of Radiology and Biomedical Imaging, University of California, San Francisco Medical Center, San Francisco, CA 94143 0628, USA
Pediatr Radiol 40:1380-6. 2010..Pancreatic metastases in childhood cancer have been rarely reported in the radiology literature although ample evidence exists in pathology reports for its occurrence in patients with alveolar rhabdomyosarcomas (RMS)...- Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapyElizabeth J Sutton
Department of Radiology, Mount Auburn Hospital, Harvard University, Cambridge, MA, USA
Pediatr Radiol 39:1194-202. 2009.... 
MR imaging of therapy-induced changes of bone marrowHeike E Daldrup-Link
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143 0628, USA
Eur Radiol 17:743-61. 2007..Future developments are directed to yield comprehensive information about bone marrow structure, function and microenvironment...
Imaging of tumor angiogenesis: current approaches and future prospectsHeike E Daldrup-Link
Department of Radiology, UCSF Medical Center, San Francisco, CA 94143, USA
Curr Pharm Des 12:2661-72. 2006..Superimposed data from MR imaging with spectroscopy, PET with CT, and PET with MR should be able to integrate advantages of different modalities yielding comprehensive information about tumor structure, function and microenvironment...
New perspectives on bone marrow contrast agents and molecular imagingHeike E Daldrup-Link
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143 0628, USA
Semin Musculoskelet Radiol 13:145-56. 2009..Future developments of fusion imaging techniques and bifunctional contrast agents are directed to combine comprehensive information about bone marrow structure and function with targeted and image-guided therapies...- Comparison of iron oxide labeling properties of hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking in a xenotransplant mouse model XXXHeike E Daldrup-Link
Department of Radiology, University of California San Francisco, UCSF Medical Center, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Acad Radiol 12:502-10. 2005..To compare and optimize ferumoxides labeling of human hematopoietic progenitor cells from umbilical cord blood and from peripheral blood for subsequent in vivo tracking with a clinical 1.5 T MR scanner... - Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: in vivo monitoring with 1.5-T MR imaging equipmentHeike E Daldrup-Link
Department of Radiology, Technical University, Munich, Germany
Radiology 234:197-205. 2005..To evaluate the use of clinical 1.5-T magnetic resonance (MR) imaging equipment to depict the in vivo distribution of iron oxide-labeled human hematopoietic progenitor cells in athymic mice... - In vivo tracking of genetically engineered, anti-HER2/neu directed natural killer cells to HER2/neu positive mammary tumors with magnetic resonance imagingHeike E Daldrup-Link
Department of Radiology, UCSF Medical Center, 513 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Eur Radiol 15:4-13. 2005.... - Receptor imaging of pediatric tumors: clinical practice and new developmentsHeike E Daldrup-Link
Department of Radiology, University of California at San Francisco, San Francisco, CA 94131, USA
Pediatr Radiol 38:1154-61. 2008.... - Cell tracking with gadophrin-2: a bifunctional contrast agent for MR imaging, optical imaging, and fluorescence microscopyHeike E Daldrup-Link
Department of Radiology, UCSF Medical Center, University of California in San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Eur J Nucl Med Mol Imaging 31:1312-21. 2004.... - Targeting of hematopoietic progenitor cells with MR contrast agentsHeike E Daldrup-Link
Department of Radiology, Technical University, Ismaninger Str 22, 81675 Munich, Germany
Radiology 228:760-7. 2003..To label human hematopoietic progenitor cells with various magnetic resonance (MR) imaging contrast agents and to obtain 1.5-T MR images of them... - Breast cancers: MR imaging of folate-receptor expression with the folate-specific nanoparticle P1133Reinhard Meier
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Radiology 255:527-35. 2010..To assess the capability of the folate receptor (FR)-targeted ultrasmall superparamagnetic iron oxide (USPIO) P1133 to provide FR-specific enhancement of breast cancers on magnetic resonance (MR) images... - MRI of arthritis: comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPAGerhard H Simon
Department of Radiology, UCSF Medical Center, University of California San Francisco, San Francisco, California 94143, USA
J Magn Reson Imaging 23:720-7. 2006..To compare the ability of the ultrasmall superparamagnetic iron oxide (USPIO) SHU555C vs. gadopentetate dimeglumine (Gd-DTPA) to detect antigen-induced monoarthritis with MRI... - Ultrasmall superparamagnetic iron-oxide-enhanced MR imaging of normal bone marrow in rodents: original research original researchGerhard H Simon
University of California at San Francisco Medical Center, Department of Radiology, S 372, Center for Pharmaceutical and Molecular Imaging, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Acad Radiol 12:1190-7. 2005..The objective is to compare three different ultrasmall superparamagnetic iron oxides (USPIOs) for magnetic resonance (MR) imaging of normal bone marrow in rodents... - Tracking of [18F]FDG-labeled natural killer cells to HER2/neu-positive tumorsReinhard Meier
Department of Radiology, University of California San Francisco, CA, USA
Nucl Med Biol 35:579-88. 2008..The objective of this study was to label the human natural killer (NK) cell line NK-92 with [(18)F]fluoro-deoxy-glucose (FDG) for subsequent in vivo tracking to HER2/neu-positive tumors... - Ultrasmall supraparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU 555 C, ferumoxtran-10, and ferumoxytolGerhard H Simon
Department of Radiology, UCSF Medical Center, University of California, San Francisco, 94143, USA
Invest Radiol 41:45-51. 2006..We sought to compare the ability of 3 ultrasmall superparamagnetic iron oxides (USPIOs) to detect and characterize antigen-induced arthritis with MR imaging... - Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigationsTobias D Henning
Department of Radiology, University of Cologne, Cologne, Germany
Mol Imaging 11:197-209. 2012..The engraftment of iron oxide-labeled MASIs by simple incubation can be monitored over several weeks with MRI. Viable and apoptotic MASIs can be distinguished via imaging signs of cell proliferation at the transplantation site... - Indocyanine green-enhanced imaging of antigen-induced arthritis with an integrated optical imaging/radiography systemReinhard Meier
University of California, San Francisco, USA
Arthritis Rheum 62:2322-7. 2010..To evaluate a combined indocyanine green-enhanced optical imaging/radiography system for the detection of arthritic joints in a rat model of antigen-induced arthritis... - Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitroStephan Metz
Department of Diagnostic Radiology, Technical University Munich, Munich, Germany
Eur Radiol 14:1851-8. 2004..In vitro labeling of human monocytes for MR imaging is most effectively obtained with the approved SPIO Ferucarbotran. Potential subsequent in vivo cell tracking applications comprise, e.g. specific targeting of inflammatory processes... - An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritisElizabeth J Sutton
Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
Opt Express 17:24403-13. 2009..The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints... - Labeling human mesenchymal stem cells with fluorescent contrast agents: the biological impactSophie E Boddington
Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
Mol Imaging Biol 13:3-9. 2011..This study aims to determine the effect of human mesenchymal stem cell (hMSC) labeling with the fluorescent dye DiD and the iron oxide nanoparticle ferucarbotran on chondrogenesis... - Macromolecular contrast medium (feruglose) versus small molecular contrast medium (gadopentetate) enhanced magnetic resonance imaging: differentiation of benign and malignant breast lesionsHeike E Daldrup-Link
Department of Radiology, Technical University of Munich, Insmaningerstr 22, 81675 Munich, Germany
Acad Radiol 10:1237-46. 2003..239; P = .3264). CONCLUSION: Compared with gadopentetate, the new blood pool agent feruglose provided an improved characterization of the evaluated breast lesions; however, at the cost of weaker overall tumor enhancement... - T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5T and 3T clinical MR scanningGerhard H Simon
Department of Radiology, UCSF Medical Center, University of California San Francisco, San Francisco, California 94143, USA
Eur Radiol 16:738-45. 2006..5T. In conclusion, cellular compartmentalization of ferumoxtran-10 changes proton relaxivity... - Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferaseSophie E Boddington
Department of Radiology, University of California, San Francisco, CA 94107 0946, USA
Cell Transplant 19:55-65. 2010..The technique may be useful for assessing different delivery routes in order to improve the engraftment of transplanted hESC-CMs or other stem cell progenitors... - Monitoring of natural killer cell immunotherapy using noninvasive imaging modalitiesPriyanka Jha
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94107, USA
Cancer Res 70:6109-13. 2010..This review summarizes various new and evolving imaging techniques employed for tracking and monitoring of adoptive natural killer cell immunotherapies... - Iron-oxide-enhanced MR imaging of bone marrow in patients with non-Hodgkin's lymphoma: differentiation between tumor infiltration and hypercellular bone marrowHeike E Daldrup-Link
Department of Radiology, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
Eur Radiol 12:1557-66. 2002.... - Highly efficient paramagnetic labelling of embryonic and neuronal stem cellsMartina Rudelius
Division of Neuropathology, Institute of Pathology, Technical University, Ismaningerstrasse 22, 81675, Munich, Germany
Eur J Nucl Med Mol Imaging 30:1038-44. 2003.... - Accelerated stem cell labeling with ferucarbotran and protamineDaniel M Golovko
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
Eur Radiol 20:640-8. 2010..To develop and characterize a clinically applicable, fast and efficient method for stem cell labeling with ferucarbotran and protamine for depiction with clinical MRI... - Optical imaging of the peri-tumoral inflammatory response in breast cancerAkhilesh K Sista
Department of Radiology and Biomedical Engineering, University of California, San Francisco, USA
J Transl Med 7:94. 2009..The purpose of this study was to determine whether injected fluorescently-labeled monocytes accumulate within murine breast tumors and are visible with optical imaging... - Ferumoxtran-10-enhanced MR imaging of the bone marrow before and after conditioning therapy in patients with non-Hodgkin lymphomasStephan Metz
Department of Diagnostic Radiology, Technische Universitaet Muenchen, Ismaninger Str 22, 81675, Munich, Germany
Eur Radiol 16:598-607. 2006..Ferumoxtran-10 improved the detection of focal bone marrow lesions significantly (P<0.05)... - Optical imaging of experimental arthritis using allogeneic leukocytes labeled with a near-infrared fluorescent probeGerhard H Simon
The Department of Radiology, S 372, UCSF Medical Center, University of California in San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Eur J Nucl Med Mol Imaging 33:998-1006. 2006..The purpose of this study was to assess the feasibility of inflammation detection in an antigen-induced arthritis model using fluorescent leukocytes and optical imaging... - MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agentOlaf Saborowski
Department of Radiology, UCSF Medical Center, University of California San Francisco, USA
Contrast Media Mol Imaging 2:72-81. 2007..05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor-targeted Gd-chelate P866 in this arthritis model... - Macromolecular contrast agents for MR mammography: current statusHeike E Daldrup-Link
Department of Radiology, Technical University, Ismaninger Strasse 22, 81675 Munich, Germany
Eur Radiol 13:354-65. 2003..Potential mammographic applications and limitations of various MMCM, defined by either experimental animal testing or clinical testing in patients, are reviewed in this article... - The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cellsTobias D Henning
Department of Radiology, UCSF Medical Center, University of California, San Francisco, CA 94143 0628, USA
Contrast Media Mol Imaging 4:165-73. 2009..Magnetic labeling of hMSC with ferucarbotran inhibits chondrogenesis in a dose-dependent manner when using simple incubation techniques. When decreasing the incubation time to 4 h, inhibition of chondrogenesis was not significant... - MRI of tumor-associated macrophages with clinically applicable iron oxide nanoparticlesHeike E Daldrup-Link
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California, USA
Clin Cancer Res 17:5695-704. 2011.... - Detection of postoperative granulation tissue with an ICG-enhanced integrated OI-/X-ray SystemReinhard Meier
Department of Radiology, University of California, San Francisco, USA
J Transl Med 6:73. 2008.... - Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulationHeike E Daldrup-Link
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California, San Francisco, California 94143-0628, USA
Microcirculation 11:387-96. 2004..MRI assays of microvascular status as performed here may be useful to clinically monitor responses to anti-angiogenesis drugs and to optimize the choice and timing of cytotoxic drug administration... - MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritisAlexander Nedopil
Department of Radiology and Biomedical Imaging, UCSF Medical Center, University of California, San Francisco, CA 94143, USA
Invest Radiol 45:634-40. 2010..To compare magnetic resonance (MR) signal characteristics of contrast agent-labeled apoptotic and viable human mesenchymal stem cells (hMSCs) in matrix-associated stem cell implants... - Intravenous ferumoxytol allows noninvasive MR imaging monitoring of macrophage migration into stem cell transplantsAman Khurana
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, 725 Welch Rd, Room 1665, Stanford, CA 94305 5654, USA
Radiology 264:803-11. 2012..To develop a clinically applicable imaging technique for monitoring differential migration of macrophages into viable and apoptotic matrix-associated stem cell implants (MASIs) in arthritic knee joints... - Imaging characteristics of DHOG, a hepatobiliary contrast agent for preclinical microCT in miceTobias Henning
University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
Acad Radiol 15:342-9. 2008..This study was performed to assess the imaging characteristics and pharmacokinetics of 1,3-Bis-[7-(3-amino-2,4,6-triiodophenyl)-heptanoyl]-2-oleoyl glycerol (DHOG, Fenestra LC), a hepatobiliary contrast agent for microCT... - Optical imaging of cellular immunotherapy against prostate cancerSidhartha Tavri
Department of Radiology, University of California San Francisco, San Francisco, CA 941143 0628, USA
Mol Imaging 8:15-26. 2009..Tumor-targeted NK-92-scFv(MOC31)-zeta cells could be tracked to prostate cancer xenografts with OI... - Cell tracking with optical imagingElizabeth J Sutton
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
Eur Radiol 18:2021-32. 2008..Advantages and limitations of these new OI-based cell-tracking techniques will be discussed. Non-invasive mapping of cells labeled with fluorochromes or OI marker genes has the potential to evolve further within the clinical realm... - Comparison between gadopentetate and feruglose (Clariscan)-enhanced MR-mammography: preliminary clinical experienceHeike E Daldrup-Link
Department of Radiology, Technical University of Munich, Germany
Acad Radiol 9:S343-7. 2002 - Cell labeling with the positive MR contrast agent Gadofluorine MTobias D Henning
Department of Radiology, University of California in San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, USA
Eur Radiol 17:1226-34. 2007..Potential in vivo cell-tracking applications include targeting of inflammatory processes with Gadofluorine-labeled leukocytes or monitoring of stem cell therapies for the treatment of arthritis... - Improved fluorescence of indocyanine green in vitro and in vivo after simple cooling proceduresSophie Boddington
Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
Contrast Media Mol Imaging 3:191-7. 2008..This simple cooling method may be immediately helpful to increase the fluorescence signal yield in current ICG-enhanced OI-studies in patients... - Ectopic ureter associated with uterine didelphys and obstructed hemivagina: preoperative diagnosis by MRIZhen J Wang
Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Pediatr Radiol 40:358-60. 2010..Accurate preoperative diagnosis of ectopic ureteral insertion associated with this syndrome is important for surgical planning... - MR imaging of ovarian tumors using folate-receptor-targeted contrast agentsZhen J Wang
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Pediatr Radiol 38:529-37. 2008..Because of its over-expression in many human tumors, the folate receptor (FR) is a promising target for tumor-specific imaging... - Differentiation of normal thymus from anterior mediastinal lymphoma and lymphoma recurrence at pediatric PET/CTRakhee S Gawande
Department of Radiology, Stanford University School of Medicine, and Pediatric Radiology Section, Lucile Packard Children s Hospital, 725 Welch Rd, Stanford, CA 94305 5654, USA
Radiology 262:613-22. 2012..To evaluate the role of positron emission tomography (PET)/computed tomography (CT) in the differentiation of normal thymus from mediastinal lymphoma and lymphoma recurrence in pediatric patients... - MR imaging of pediatric arthritisHeike E Daldrup-Link
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 512 Parnassus Avenue, San Francisco, CA 94143 0628, USA
Magn Reson Imaging Clin N Am 17:451-67, vi. 2009.... - High-resolution MR imaging of the orbit in patients with retinoblastomaAndreas M Rauschecker
Department of Radiology, Lucile Packard Children s Hospital, Stanford University School of Medicine, Palo Alto, CA 94304 1614, USA
Radiographics 32:1307-26. 2012.... - Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cellsTobias D Henning
Department of Radiology, University of California, San Francisco UCSF Medical Center, UCSF, San Francisco, CA 94143 0628, USA
Magn Reson Med 62:325-32. 2009..These results show that viable cells with compartmentalized iron oxides may-in principle-be distinguished from lysed cells or released iron oxides... - Pediatric liver tumors--a pictorial reviewPriyanka Jha
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
Eur Radiol 19:209-19. 2009..The purpose of this review is to report typical clinical and imaging characteristics of benign and malignant primary liver tumors in children... - Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trialHeike E Daldrup-Link
Dept of Radiology, Univ Hosp, Technical Univ of Munich, Ismaningerstr 22, 81675 Munich, Germany
Radiology 229:885-92. 2003..To investigate use of the macromolecular contrast agent feruglose for differentiating and grading of human benign and malignant breast tumors on the basis of their microvascular characteristics... - Mixture model approach to tumor classification based on pharmacokinetic measures of tumor permeabilityMary E Spilker
Resource Facility for Population Kinetics, Department of Bioengineering, University of Washington, Seattle, Washington 98195-2255, USA
J Magn Reson Imaging 22:549-58. 2005..Although the present results are promising, additional research is needed to further evaluate this technique for diagnostic purposes...
Research Grants
- Monitoring of Stem Cell Engraftment in Arthritic Joints with MR ImagingHeike Daldrup Link; Fiscal Year: 2009....
- Monitoring of Stem Cell Engraftment in Arthritic Joints with MR ImagingHEIKE ELIZABETH DALDRUP LINK; Fiscal Year: 2010....