Harry Dailey

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. pmc Erythroid heme biosynthesis and its disorders
    Harry A Dailey
    Department of Microbiology, Department of Biochemistry and Molecular Biology, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602, USA
    Cold Spring Harb Perspect Med 3:a011676. 2013
  2. pmc The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase
    Harry A Dailey
    Biomedical and Health Sciences Institute, University of Georgia, Athens, Georgia, USA
    MBio 2:e00248-11. 2011
  3. pmc Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
    Harry A Dailey
    Biomedical and Health Sciences Institute, Department of Microbiology, Paul D Coverdell Center, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 46:7973-9. 2007
  4. ncbi request reprint Terminal steps of haem biosynthesis
    H A Dailey
    Biomedical and Health Sciences Institute, A222 Life Science Building, University of Georgia, Athens, GA 30602 7229, USA
    Biochem Soc Trans 30:590-5. 2002
  5. ncbi request reprint Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus
    K F Wang
    Department of Microbiology, University of Georgia, Athens, GA 30602-7229, USA
    FEMS Microbiol Lett 202:115-9. 2001
  6. ncbi request reprint Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme
    H A Dailey
    Department of Microbiology, University of Georgia, Athens, 30602 2605, USA
    J Biol Chem 271:8714-8. 1996
  7. ncbi request reprint Cloning, sequence, and expression of mouse protoporphyrinogen oxidase
    T A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Arch Biochem Biophys 324:379-84. 1995
  8. ncbi request reprint Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster
    B R Crouse
    Department of Microbiology, University of Georgia, Athens 30602, USA
    Biochemistry 35:16222-9. 1996
  9. ncbi request reprint Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases
    H A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605
    J Biol Chem 269:390-5. 1994
  10. pmc In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway
    K L Proulx
    Department of Microbiology, University of Georgia, Athens 30602 2605
    Protein Sci 2:1092-8. 1993

Research Grants

  1. TERMINAL HEME SYNTHETIC ENZYMES
    Harry Dailey; Fiscal Year: 1999
  2. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2001
  3. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2002
  4. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2003
  5. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2004
  6. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2003
  7. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2004
  8. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2005
  9. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2006
  10. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2007

Collaborators

  • M K Johnson
  • Ting Li
  • M Gary Newton
  • Irina Kataeva
  • Ming Luo
  • Anne K Dunn
  • John D Phillips
  • G C Ferreira
  • Michael W W Adams
  • Michael R Mayer
  • Tamara A Dailey
  • T A Dailey
  • V M Sellers
  • Amy E Medlock
  • Bi Cheng Wang
  • Tye O Boynton
  • Michael W W Adams
  • Amy Medlock
  • William N Lanzilotta
  • C K Wu
  • Mark Shepherd
  • Wided Najahi-Missaoui
  • K F Wang
  • John P Rose
  • Chia Kuei Wu
  • B Jacob Blackmon
  • F D Schubot
  • J P Rose
  • B C Wang
  • Sarah H Craven
  • Svetlana Gerdes
  • Ellen L Neidle
  • Larkin Swartz
  • Teresa A Ross
  • A L Day
  • Farris L Poole
  • Tamara Dailey
  • A R Prasad
  • Ashit Shah
  • John H Woodruff
  • Chi Hao Luan
  • Jeff Habel
  • Hao Xu
  • Claudia Shah
  • Francis E Jenney
  • Songlin Li
  • Frank J Sugar
  • Dawei Lin
  • Robert Bunzel
  • Han Seung Lee
  • Peter Horanyi
  • Joseph Ng
  • Lisa Nagy
  • John Rose
  • Larry DeLucas
  • Zhi Jie Liu
  • Lawrence J Delucas
  • James H Prestegard
  • Anne V Corrigall
  • Brandon P Davidson
  • Xiao Lianchun
  • A E Medlock
  • B R Crouse
  • Peter N Meissner
  • Julie F McManus
  • A Burden
  • C J Chen
  • P Meissner
  • B M Parsons
  • M G Finnegan
  • K L Proulx
  • M G Eldridge
  • S I Woodard

Detail Information

Publications40

  1. pmc Erythroid heme biosynthesis and its disorders
    Harry A Dailey
    Department of Microbiology, Department of Biochemistry and Molecular Biology, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602, USA
    Cold Spring Harb Perspect Med 3:a011676. 2013
    ....
  2. pmc The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase
    Harry A Dailey
    Biomedical and Health Sciences Institute, University of Georgia, Athens, Georgia, USA
    MBio 2:e00248-11. 2011
    ..Additionally, some genes encoding homologs of YfeX have tight association with genes encoding a bacterial cytoplasmic encapsulating protein...
  3. pmc Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis
    Harry A Dailey
    Biomedical and Health Sciences Institute, Department of Microbiology, Paul D Coverdell Center, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 46:7973-9. 2007
    ..In the substrate-bound enzyme, the formation of a hydrogen bond between H263 and a pyrrole nitrogen results in disruption of the network. The possible role of this network in catalysis is discussed...
  4. ncbi request reprint Terminal steps of haem biosynthesis
    H A Dailey
    Biomedical and Health Sciences Institute, A222 Life Science Building, University of Georgia, Athens, GA 30602 7229, USA
    Biochem Soc Trans 30:590-5. 2002
    ..Ferrochelatase, which is the best characterized of these three enzymes, will be described with particular emphasis paid to what has been learned from the crystal structure of the Bacillus subtilis and human enzymes...
  5. ncbi request reprint Expression and characterization of the terminal heme synthetic enzymes from the hyperthermophile Aquifex aeolicus
    K F Wang
    Department of Microbiology, University of Georgia, Athens, GA 30602-7229, USA
    FEMS Microbiol Lett 202:115-9. 2001
    ..subtilis proteins, both A. aeolicus enzymes are membrane-associated. Both proteins have temperature optima over 60 degrees C. This is the first demonstration of functional heme biosynthetic enzymes in an extreme thermophilic bacterium...
  6. ncbi request reprint Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme
    H A Dailey
    Department of Microbiology, University of Georgia, Athens, 30602 2605, USA
    J Biol Chem 271:8714-8. 1996
    ..6 microM and 5.2 min-1, respectively. The diphenyl ether herbicide acifluorfen at 1 microM strongly inhibits the enzyme's activity...
  7. ncbi request reprint Cloning, sequence, and expression of mouse protoporphyrinogen oxidase
    T A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Arch Biochem Biophys 324:379-84. 1995
    ..coli is sensitive to inhibition by the diphenyl ether herbicide acifluorfen. Northern blot analyses of RNA from uninduced and induced MEL cells as well as mouse hepatoma cells all show two major mRNA species of 1.8 and 3.6 kb...
  8. ncbi request reprint Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster
    B R Crouse
    Department of Microbiology, University of Georgia, Athens 30602, USA
    Biochemistry 35:16222-9. 1996
    ..Such anomalous coordination could account for the cluster lability compared to similar clusters with complete cysteinyl ligation and hence may be intrinsic to the proposed regulatory role for this cluster in mammalian ferrochelatases...
  9. ncbi request reprint Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases
    H A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605
    J Biol Chem 269:390-5. 1994
    ..Elimination of the carboxyl-terminal 30 amino acid residues (which include Phe-417) results in a protein the same length as the bacterial ferrochelatases, but it is an inactive enzyme...
  10. pmc In situ conversion of coproporphyrinogen to heme by murine mitochondria: terminal steps of the heme biosynthetic pathway
    K L Proulx
    Department of Microbiology, University of Georgia, Athens 30602 2605
    Protein Sci 2:1092-8. 1993
    ..abstract truncated at 250 words)..
  11. ncbi request reprint Expression of a cloned protoporphyrinogen oxidase
    T A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605
    J Biol Chem 269:813-5. 1994
    ..In addition the enzyme contains a putative dinucleotide binding region at the amino terminus, which is consistent with the previously demonstrated presence of a flavin moiety in the characterized mammalian enzymes...
  12. ncbi request reprint Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex
    G C Ferreira
    Department of Microbiology, University of Georgia, Athens 30602
    J Biol Chem 263:3835-9. 1988
    ..However, examination of solubilized and membrane-reconstituted enzymes shows no evidence for a stable complex. Based upon these and previous data a model for the terminal three-pathway enzymes is presented...
  13. ncbi request reprint Cloning and characterization of Gallus and Xenopus ferrochelatases: presence of the [2Fe-2S] cluster in nonmammalian ferrochelatase
    A L Day
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, 30602 7229, USA
    Arch Biochem Biophys 359:160-9. 1998
    ..The 5' UTR of Xenopus as isolated contained 135 bp and possesses no identifiable stem-loop structure...
  14. ncbi request reprint Evidence that the fourth ligand to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster
    V M Sellers
    Department of Microbiology, and the Center for Metalloenzyme Studies, University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 273:22311-6. 1998
    ....
  15. ncbi request reprint Function of the [2FE-2S] cluster in mammalian ferrochelatase: a possible role as a nitric oxide sensor
    V M Sellers
    Department of Microbiology, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 35:2699-704. 1996
    ..The potential physiological relevance of these data to the anemias that are found in individuals with chronic infections is discussed...
  16. ncbi request reprint Characteristics of human protoporphyrinogen oxidase in controls and variegate porphyrias
    H A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Cell Mol Biol (Noisy-le-grand) 43:67-73. 1997
    ..Purified R59W lacks the FAD cofactor which may be explained by the fact that this mutation resides within the dinucleotide binding motif of PPO...
  17. pmc Human protoporphyrinogen oxidase: expression, purification, and characterization of the cloned enzyme
    T A Dailey
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    Protein Sci 5:98-105. 1996
    ..Protein database searches reveal significant homology between protoporphyrinogen oxidase and monoamine oxidase...
  18. ncbi request reprint Human coproporphyrinogen oxidase is not a metalloprotein
    A E Medlock
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602 2605, USA
    J Biol Chem 271:32507-10. 1996
    ..The data presented demonstrate that human CPO contains no metal center, that it is not stimulated in vitro by iron or copper, and that addition of these metals to cultures expressing the protein has no effect...
  19. ncbi request reprint Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters
    H A Dailey
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30605 7229, USA
    Cell Mol Life Sci 57:1909-26. 2000
    ....
  20. ncbi request reprint The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis
    C K Wu
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602 7229, USA
    Nat Struct Biol 8:156-60. 2001
    ....
  21. ncbi request reprint Identification of an FAD superfamily containing protoporphyrinogen oxidases, monoamine oxidases, and phytoene desaturase. Expression and characterization of phytoene desaturase of Myxococcus xanthus
    T A Dailey
    Department of Microbiology, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602 7229, USA
    J Biol Chem 273:13658-62. 1998
    ..This region is not found among any other proteins in the current data base and, therefore, we propose that this region is a signature motif for a superfamily of FAD-containing enzymes that is comprised of PPOs, animal MAOs, and PHDs...
  22. ncbi request reprint Human ferrochelatase: characterization of substrate-iron binding and proton-abstracting residues
    V M Sellers
    Department of Microbiology, University of Georgia, Athens, Georgia 30602-7229, USA
    Biochemistry 40:9821-7. 2001
    ..This model should be general for mitochondrial membrane-associated eucaryotic ferrochelatases but may differ for bacterial ferrochelatases since the spatial orientation of the enzyme within prokaryotic cells may differ...
  23. pmc Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription
    F D Schubot
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 10:1980-8. 2001
    ..Based on the structure, we propose that the promoter specificity region is located on the mitochondrial RNA polymerase and that binding of sc-mtTFB indirectly mediates interaction of the core enzyme with the promoter site...
  24. ncbi request reprint Examination of ferrochelatase mutations that cause erythropoietic protoporphyria
    V M Sellers
    Department of Microbiology, University of Georgia, Athens, GA, USA
    Blood 91:3980-5. 1998
    ..With the exception of F417L, all lacked enzyme activity and did not contain the [2Fe-2S] cluster in vivo or as isolated in vitro...
  25. ncbi request reprint Effect of cellular location on the function of ferrochelatase
    A R Prasad
    Department of Microbiology, University of Georgia, Athens 30602 2605, USA
    J Biol Chem 270:18198-200. 1995
    ..Interestingly in cells with improperly localized ferrochelatase the amount of b-type cytochrome decreased by 80% as opposed to c- and a-type cytochromes where the decreases were only 60 and 40%, respectively...
  26. ncbi request reprint Protein production and crystallization at SECSG -- an overview
    Bi Cheng Wang
    Southeast Collaboratory for Structural Genomics, University of Georgia, Athens, GA 30602, USA
    J Struct Funct Genomics 6:233-43. 2005
    ..Details of the various pipelines in use by the SECSG for protein production and crystallization, as well as some examples of target rescue are described...
  27. pmc Yeast ferrochelatase: expression in a baculovirus system and purification of the expression protein
    M G Eldridge
    Department of Microbiology, University of Georgia, Athens 30602
    Protein Sci 1:271-7. 1992
    ..To our knowledge this is the first example of a mitochondrial membrane protein that has been expressed in a baculovirus system...
  28. pmc Discovery of a gene involved in a third bacterial protoporphyrinogen oxidase activity through comparative genomic analysis and functional complementation
    Tye O Boynton
    Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602 7394, USA
    Appl Environ Microbiol 77:4795-801. 2011
    ....
  29. ncbi request reprint Characterization of a human and mouse tetrapyrrole-binding protein
    B Jacob Blackmon
    Biomedical and Health Sciences Institute, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602 7229, USA
    Arch Biochem Biophys 407:196-201. 2002
    ..A role for p22HBP in cellular porphyrin metabolism is discussed...
  30. ncbi request reprint Characterization of the mouse protoporphyrinogen oxidase gene
    Tamara A Dailey
    The Biomedical and Health Sciences Institute, Department of Microbiology, University of Georgia, Athens 30602 7229, USA
    Cell Mol Biol (Noisy-le-grand) 48:61-9. 2002
    ..Expression of both housekeeping and erythroid-specific fusions in the transient expression systems was greatly decreased in the -5000 bp constructs suggesting the presence of repressor elements in the -1160 to -5000 bp region...
  31. pmc A pi-helix switch selective for porphyrin deprotonation and product release in human ferrochelatase
    Amy E Medlock
    Biomedical and Health Sciences Institute, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    J Mol Biol 373:1006-16. 2007
    ....
  32. pmc Substrate interactions with human ferrochelatase
    Amy Medlock
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 104:1789-93. 2007
    ..These data provide insights that will aid in the determination of the mechanism for ferrochelatase...
  33. ncbi request reprint A mouse model for South African (R59W) variegate porphyria: construction and initial characterization
    Amy E Medlock
    Biomedical and Health Sciences Institute, Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602 USA
    Cell Mol Biol (Noisy-le-grand) 48:71-8. 2002
    ..This initial characterization of these mice suggest that they are a good model for variegate porphyria at the biochemical level...
  34. pmc Production and characterization of erythropoietic protoporphyric heterodimeric ferrochelatases
    Wided Najahi-Missaoui
    Biomedical and Health Sciences Institute, University of Georgia, A222 Life Sciences Bldg, Athens GA 30602, USA
    Blood 106:1098-104. 2005
    ..These data suggest that some EPP mutations may result in clinically overt EPP in the absence of a low-expression, wild-type allele; this is of potential significance for genetic counseling of patients with EPP...
  35. pmc Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthase
    Tamara A Dailey
    Department of Microbiology, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602 7229, USA
    Biochem J 386:381-6. 2005
    ..Ferrochelatase, the terminal enzyme, possesses a typical N-terminal leader sequence and no evidence of a role for the C-terminus was found in mitochondrial targeting...
  36. pmc Identification of [2Fe-2S] clusters in microbial ferrochelatases
    Tamara A Dailey
    Department of Microbiology, Center for Metalloenzyme Studies, Biomedical and Health Sciences Institute, University of Georgia, Athens, Georgia 30602 7229, USA
    J Bacteriol 184:2460-4. 2002
    ..Thus, the microbial ferrochelatases represent a new group of [2Fe-2S] cluster-containing proteins...
  37. ncbi request reprint Expression of human proteins at the Southeast Collaboratory for Structural Genomics
    Michael R Mayer
    Southeast Collaboratory for Structural Genomics, A222 Life Sciences, Athens, GA 30602 7229, USA
    J Struct Funct Genomics 5:159-65. 2004
    ..Proteins expressed under the trc promoter, a weak promoter compared to the strong T7 promoter, are produced in a soluble form and include necessary cofactors. The details of this system will be discussed...
  38. pmc The crystal structure of augmenter of liver regeneration: A mammalian FAD-dependent sulfhydryl oxidase
    Chia Kuei Wu
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Protein Sci 12:1109-18. 2003
    ..Possible physiological roles of ALR are examined and a hypothesis that it may serve multiple roles is proposed...
  39. ncbi request reprint The Southeast Collaboratory for Structural Genomics: a high-throughput gene to structure factory
    Michael W W Adams
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA
    Acc Chem Res 36:191-8. 2003
    ..The bioinformatics group implements/develops local database interfaces, pipelined sequence/structure information search/updates, and database/bioinformatics toolkits...
  40. pmc A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases
    Mark Shepherd
    Biomedical and Health Sciences Institute, Paul D Coverdell Center, University of Georgia, Athens, GA 30602, USA
    Biochem J 397:47-52. 2006
    ..These data support a role for the [2Fe-2S] cluster in iron affinity, and strongly suggest convergent evolution of this feature in prokaryotes...

Research Grants28

  1. TERMINAL HEME SYNTHETIC ENZYMES
    Harry Dailey; Fiscal Year: 1999
    ..coli. It is hoped that molecular biological approaches in conjunction with biophysical approaches will yield significant new data on the catalytic functioning of each of these enzymes. ..
  2. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2001
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  3. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2002
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  4. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2003
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  5. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2004
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  6. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2003
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  7. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2004
    ..Studies on site-directed mutants and wildtype enzymes will employ a variety of biophysical techniques that we have utilized previously in our laboratory and the laboratories of our collaborators. ..
  8. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2005
    ..3.) identify and characterize protein-protein interactions between ferrochelatase and PPO. ..
  9. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2006
    ..3.) identify and characterize protein-protein interactions between ferrochelatase and PPO. ..
  10. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2007
    ..3.) identify and characterize protein-protein interactions between ferrochelatase and PPO. ..
  11. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry Dailey; Fiscal Year: 2009
    ..3.) identify and characterize protein-protein interactions between ferrochelatase and PPO. ..
  12. TERMINAL HEME SYNTHETIC ENZYMES
    Harry Dailey; Fiscal Year: 1999
    ..coli. It is hoped that molecular biological approaches in conjunction with biophysical approaches will yield significant new data on the catalytic functioning of each of these enzymes. ..
  13. CHARACTERIZATION OF MAMMALIAN FERROCHELATASE
    Harry Dailey; Fiscal Year: 1993
    ..They are also expected to help in explaining the nature of the defect in the relevant porphyria and may be of value in evaluating some drug and chemical induced porphyrinopathies...
  14. TERMINAL HEME SYNTHETIC ENZYMES
    Harry Dailey; Fiscal Year: 1999
    ..coli. It is hoped that molecular biological approaches in conjunction with biophysical approaches will yield significant new data on the catalytic functioning of each of these enzymes. ..
  15. CHARACTERIZATION OF MAMMALIAN FERROCHELATASE
    Harry Dailey; Fiscal Year: 1991
    ..They are also expected to help in explaining the nature of the defect in the relevant porphyria and may be of value in evaluating some drug and chemical induced porphyrinopathies...
  16. CHARACTERIZATION OF MAMMALIAN FERROCHELATASE
    Harry Dailey; Fiscal Year: 1990
    ....
  17. CHARACTERIZATION OF MAMMALIAN FERROCHELATASE
    Harry Dailey; Fiscal Year: 1992
    ..They are also expected to help in explaining the nature of the defect in the relevant porphyria and may be of value in evaluating some drug and chemical induced porphyrinopathies...
  18. TERMINAL ENZYMES OF HEME SYNTHESIS
    Harry A Dailey; Fiscal Year: 2010
    ..3.) identify and characterize protein-protein interactions between ferrochelatase and PPO. ..