Affiliation: University of California
Haensel D, Sun P, Maclean A, Ma X, Zhou Y, Stemmler M, et al
. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 2018;: pubmed publisher
Haensel D, McNeil M, Dai X. Ex Vivo Imaging and Genetic Manipulation of Mouse Hair Follicle Bulge Stem Cells. Methods Mol Biol. 2018;: pubmed publisher
..Here we describe detailed methods for culturing, immunostaining, live cell imaging, and adenoviral infection of bulge stem cells for downstream applications such as in vitro clonal and in vivo patch assays. ..
Lee B, Villarreal Ponce A, Fallahi M, Ovadia J, Sun P, Yu Q, et al
. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014;29:47-58 pubmed publisher
..Collectively, our findings reveal Ovol-Zeb1-?-catenin sequential repression and highlight Ovol1 and Ovol2 as gatekeepers of epithelial adhesion and differentiation by inhibiting progenitor-like traits and epithelial plasticity. ..
Watanabe K, Villarreal Ponce A, Sun P, Salmans M, Fallahi M, Andersen B, et al
. Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell. 2014;29:59-74 pubmed publisher
..Our findings underscore the critical importance of exquisitely regulating epithelial plasticity in development and cancer. ..
Sun P, Watanabe K, Fallahi M, Lee B, Afetian M, Rhéaume C, et al
. Pygo2 regulates ?-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014;111:10215-20 pubmed publisher
..These findings identify Pygo2 as an important regulator of Wnt/?-catenin function in skin epithelia and p53 activation as a prominent downstream event of ?-catenin/Pygo2 action in stem cell activation. ..
Li Q, Li Y, Gu B, Fang L, Zhou P, Bao S, et al
. Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. J Biol Chem. 2015;290:21553-67 pubmed publisher
Xu P, Dang Y, Wang L, Liu X, Ren X, Gu J, et al
. Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways. Cancer Lett. 2016;383:161-170 pubmed publisher
..Collectively, our findings identify Lgr4 as a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/β-catenin pathways. ..