GERHARD P DAHL

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Innexin and pannexin channels and their signaling
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA Electronic address
    FEBS Lett 588:1396-402. 2014
  2. ncbi request reprint ATP and potassium ions: a deadly combination for astrocytes
    David G Jackson
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136
    Sci Rep 4:4576. 2014
  3. pmc The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1
    Junjie Wang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 141:649-56. 2013
  4. pmc SCAM analysis of Panx1 suggests a peculiar pore structure
    Junjie Wang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 136:515-27. 2010
  5. pmc The bizarre pharmacology of the ATP release channel pannexin1
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, PO Box 016430, Miami, FL 33101, USA Electronic address
    Neuropharmacology 75:583-93. 2013
  6. pmc Pannexin: from discovery to bedside in 11±4 years?
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, PO Box 016430, Miami, FL 33101, USA
    Brain Res 1487:150-9. 2012
  7. doi request reprint Gap junction-mimetic peptides do work, but in unexpected ways
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, Miami, Florida 33136, USA
    Cell Commun Adhes 14:259-64. 2007
  8. ncbi request reprint Pannexin: to gap or not to gap, is that a question?
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, Florida 33101, USA
    IUBMB Life 58:409-19. 2006
  9. ncbi request reprint Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters
    Junjie Wang
    Dept of Physiology and Biophysics, Univ of Miami, School of Medicine, PO Box 016430, Miami FL 33101, USA
    Am J Physiol Cell Physiol 293:C1112-9. 2007
  10. pmc Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury
    Stuart E Samuels
    Neuroscience Program, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 136:425-42. 2010

Research Grants

  1. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2009
  2. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2007
  3. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2004
  4. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2003
  5. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2002
  6. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2001
  7. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2000
  8. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 1993
  9. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 1999
  10. FORMATION OF CELL-CELL CHANNELS
    GERHARD P DAHL; Fiscal Year: 2010

Collaborators

  • Robert W Keane
  • E Scemes
  • DAVID SPRAY
  • Silviu Locovei
  • Junjie Wang
  • Li Bao
  • Feng Qiu
  • Meiyun Ma
  • Yang Qu
  • Stephanie E Adamczak
  • David G Jackson
  • Juan Pablo de Rivero Vaccari
  • Stuart E Samuels
  • George A Ransford
  • William R Silverman
  • Kenneth J Muller
  • William Silverman
  • Xinge Hu
  • M Ross Bullock
  • Doris Nonner
  • Gordon Dale
  • Frank J Brand
  • W Dalton Dietrich
  • David George Jackson
  • Jeffrey B Lipitz
  • Nevis Fregien
  • Gregory E Conner
  • Steven K Carlsson
  • Matthias Salathe
  • Stuart Samuels
  • Eduardo R Macagno
  • Frederick Sachs

Detail Information

Publications25

  1. ncbi request reprint Innexin and pannexin channels and their signaling
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA Electronic address
    FEBS Lett 588:1396-402. 2014
    ....
  2. ncbi request reprint ATP and potassium ions: a deadly combination for astrocytes
    David G Jackson
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136
    Sci Rep 4:4576. 2014
    ..Additionally, Panx1 may play a second role once cells are committed to apoptosis, since Panx1 is also a substrate of caspase-3. ..
  3. pmc The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1
    Junjie Wang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 141:649-56. 2013
    ....
  4. pmc SCAM analysis of Panx1 suggests a peculiar pore structure
    Junjie Wang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 136:515-27. 2010
    ..Thus, it appears that the inner portion of the pores of Panx1 and connexin channels may be distinct...
  5. pmc The bizarre pharmacology of the ATP release channel pannexin1
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, PO Box 016430, Miami, FL 33101, USA Electronic address
    Neuropharmacology 75:583-93. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. ..
  6. pmc Pannexin: from discovery to bedside in 11±4 years?
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, PO Box 016430, Miami, FL 33101, USA
    Brain Res 1487:150-9. 2012
    ..Since Panx1 inhibitors such as probenecid are already clinically tested in different settings they should be considered for therapy in stroke and CNS trauma...
  7. doi request reprint Gap junction-mimetic peptides do work, but in unexpected ways
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, Miami, Florida 33136, USA
    Cell Commun Adhes 14:259-64. 2007
    ..Consequently, rather than indicating connexin involvement in ATP release, the GAP peptide effects represent supporting evidence for a role of pannexin1 in this process...
  8. ncbi request reprint Pannexin: to gap or not to gap, is that a question?
    Gerhard Dahl
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, Florida 33101, USA
    IUBMB Life 58:409-19. 2006
    ..Specifically, we propose that pannexins can serve as ATP release channels. This function presumptively is also performed by innexins in invertebrates, in addition to their traditional gap junction role...
  9. ncbi request reprint Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters
    Junjie Wang
    Dept of Physiology and Biophysics, Univ of Miami, School of Medicine, PO Box 016430, Miami FL 33101, USA
    Am J Physiol Cell Physiol 293:C1112-9. 2007
    ..PEG accessibility is in the size range expected for the pore of innexin gap junction channels, consistent with a functional relatedness of innexin and pannexin channels...
  10. pmc Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury
    Stuart E Samuels
    Neuroscience Program, University of Miami School of Medicine, Miami, FL 33136, USA
    J Gen Physiol 136:425-42. 2010
    ..Neither the calcium wave nor the persistent response required ATP or its release. Thus, in the leech, innexin membrane channels releasing ATP from glia are required for migration and accumulation of microglia after nerve injury...
  11. pmc Cosegregation of permeability and single-channel conductance in chimeric connexins
    Meiyun Ma
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biophys J 90:151-63. 2006
    ..The same segregation was found in a separate study for the unitary conductance of the channels. Thus, conductance and permeability/accessibility of the channels cosegregate with M1...
  12. ncbi request reprint Pyroptotic neuronal cell death mediated by the AIM2 inflammasome
    Stephanie E Adamczak
    Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    J Cereb Blood Flow Metab 34:621-9. 2014
    ..These findings suggest neuronal pyroptosis is an important cell death mechanism during CNS infection and injury that may be attenuated by probenecid. ..
  13. pmc Pannexin 1 in erythrocytes: function without a gap
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, P O Box 016430, Miami, FL 33101, USA
    Proc Natl Acad Sci U S A 103:7655-9. 2006
    ..Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels...
  14. pmc Accessibility of cx46 hemichannels for uncharged molecules and its modulation by voltage
    Yang Qu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, Florida 33136, USA
    Biophys J 86:1502-9. 2004
    ..Furthermore, the effect of sugars and the large difference in transit rates for small ions and larger molecules suggest that they may involve different permeation mechanisms...
  15. pmc Conductance of connexin hemichannels segregates with the first transmembrane segment
    Xinge Hu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, Florida 33101, USA
    Biophys J 90:140-50. 2006
    ..Thus, the M1 segment, especially the second half, contains important determinants of conductance of the connexin channel...
  16. pmc The pannexin 1 channel activates the inflammasome in neurons and astrocytes
    William R Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 284:18143-51. 2009
    ..Thus, in contrast to macrophages and monocytes in which low intracellular K(+) has been suggested to trigger inflammasome activation, in neural cells, high extracellular K(+) activates caspase-1 probably through pannexin 1...
  17. pmc Function of the voltage gate of gap junction channels: selective exclusion of molecules
    Yang Qu
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, FL 33101, USA
    Proc Natl Acad Sci U S A 99:697-702. 2002
    ..Thus, a conceivable physiological role of the voltage gate is to selectively restrict the passage of large molecules between cells while allowing electrical coupling...
  18. pmc Pannexin 1 contributes to ATP release in airway epithelia
    George A Ransford
    Division of Pulmonary and Critical Care Medicine R 47, University of Miami Miller School of Medicine, 1600 NW 10th Ave, RMSB 7058, Miami, FL 33136, USA
    Am J Respir Cell Mol Biol 41:525-34. 2009
    ..These data not only show that Panx1 is expressed apically in differentiated airway epithelial cells but also that it contributes to ATP release in these cells...
  19. pmc A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP
    Feng Qiu
    Dept of Physiology and Biophysics, Univ of Miami School of Medicine, PO Box 016430, Miami, FL 33101, USA
    Am J Physiol Cell Physiol 296:C250-5. 2009
    ..Mutational analysis identified R75 in pannexin 1 to be critical for ATP inhibition of pannexin 1 currents...
  20. pmc Innexins form two types of channels
    Li Bao
    Department of Physiology and Biophysics, University of Miami, School of Medicine, Miami, FL 33136, USA
    FEBS Lett 581:5703-8. 2007
    ..In addition, carbenoxolone reversibly blocked the loss of carboxyfluorescein dye into the bath from the giant glial cells in the connectives of the leech nerve cord, which are known to express the innexins we assayed...
  21. pmc Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 581:483-8. 2007
    ..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex...
  22. pmc Probenecid, a gout remedy, inhibits pannexin 1 channels
    William Silverman
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Physiol Cell Physiol 295:C761-7. 2008
    ..Probenecid did not affect channels formed by connexins. Thus probenecid allows for discrimination between channels formed by connexins and pannexins...
  23. ncbi request reprint Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami, School of Medicine, P O Box 016430, 1600 NW 10th Avenue, Miami, FL 33136, USA
    FEBS Lett 580:239-44. 2006
    ..Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves...
  24. ncbi request reprint Connexins are mechanosensitive
    Li Bao
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33136, USA
    Am J Physiol Cell Physiol 287:C1389-95. 2004
    ..Physiologically, Cx46 hemichannels may assist accommodation of the ocular lens by providing a transient path for volume flow as the lens changes shape...
  25. ncbi request reprint Pannexin membrane channels are mechanosensitive conduits for ATP
    Li Bao
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 572:65-8. 2004
    ..They have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive. Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress...

Research Grants16

  1. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2009
    ..Gap junction channels are known to be associated with a series of human diseases. Understanding their molecular function is therefore relevant to the diagnosis and therapy of the diseases. ..
  2. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2007
    ..Gap junction channels are known to be associated with a series of human diseases. Understanding their molecular function is therefore relevant to the diagnosis and therapy of the diseases. ..
  3. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2004
    ..In addition the pore size and its possible modulation by voltage will be tested by analyzing the accessibility of non-electrolytes to the channel. ..
  4. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2003
    ..In addition the pore size and its possible modulation by voltage will be tested by analyzing the accessibility of non-electrolytes to the channel. ..
  5. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2002
    ..In addition the pore size and its possible modulation by voltage will be tested by analyzing the accessibility of non-electrolytes to the channel. ..
  6. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2001
    ..In addition the pore size and its possible modulation by voltage will be tested by analyzing the accessibility of non-electrolytes to the channel. ..
  7. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 2000
    ..Expression of cx32 under the control of the cx33 promoter is expected to override the inhibitory role of cx33 and the ensuing phenotypic changes should reveal the physiological role of cx33 inhibition. ..
  8. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 1993
    ..Furthermore, clues about the function of cell-cell channels in nonexcitable tissues can be expected from specific interference with gene expression...
  9. FORMATION OF CELL-CELL CHANNELS
    Gerhard Dahl; Fiscal Year: 1999
    ..Expression of cx32 under the control of the cx33 promoter is expected to override the inhibitory role of cx33 and the ensuing phenotypic changes should reveal the physiological role of cx33 inhibition. ..
  10. FORMATION OF CELL-CELL CHANNELS
    GERHARD P DAHL; Fiscal Year: 2010
    ..Gap junction channels are known to be associated with a series of human diseases. Understanding their molecular function is therefore relevant to the diagnosis and therapy of the diseases. ..