John M Dagle

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Targeted elimination of zygotic messages in Xenopus laevis embryos by modified oligonucleotides possessing terminal cationic linkages
    J M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Nucleic Acids Res 28:2153-7. 2000
  2. pmc Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr 159:104-9. 2011
  3. pmc Determination of genetic predisposition to patent ductus arteriosus in preterm infants
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 123:1116-23. 2009
  4. ncbi request reprint Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 262:268-81. 2003
  5. pmc Candidate gene linkage approach to identify DNA variants that predispose to preterm birth
    Elise N A Bream
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Pediatr Res 73:135-41. 2013
  6. pmc Role of polymorphic variants as genetic modulators of infection in neonatal sepsis
    Asmaa Abu-Maziad
    Department of Pediatrics, University of Iowa, Children s Hospital, Iowa City, Iowa 52242, USA
    Pediatr Res 68:323-9. 2010
  7. pmc Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study
    Jinsil Kim
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, USA
    BMC Med Genet 14:77. 2013
  8. pmc Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates
    Kelli K Ryckman
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 70:90-5. 2011
  9. pmc The influence of maternal disease on metabolites measured as part of newborn screening
    Kelli K Ryckman
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Matern Fetal Neonatal Med 26:1380-3. 2013
  10. pmc Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn
    Heather M Byers
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatr Res 71:162-7. 2012

Collaborators

Detail Information

Publications25

  1. pmc Targeted elimination of zygotic messages in Xenopus laevis embryos by modified oligonucleotides possessing terminal cationic linkages
    J M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Nucleic Acids Res 28:2153-7. 2000
    ..These new compounds should be useful in attenuating embryonic gene expression to study the role of specific proteins in early vertebrate development...
  2. pmc Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr 159:104-9. 2011
    ..To determine genetic and clinical risk factors associated with elevated systolic blood pressure (ESBP) in preterm infants after discharge from the neonatal intensive care unit (NICU)...
  3. pmc Determination of genetic predisposition to patent ductus arteriosus in preterm infants
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 123:1116-23. 2009
    ..Our major goal was to determine if genetic risk factors play a role in patent ductus arteriosus seen in preterm infants...
  4. ncbi request reprint Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 262:268-81. 2003
    ..Many of these findings correlate with cardiac defects previously reported in pitx2 null and hypomorphic mice, but can now be assigned specifically to attenuation of the pitx2c isoform in Xenopus...
  5. pmc Candidate gene linkage approach to identify DNA variants that predispose to preterm birth
    Elise N A Bream
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Pediatr Res 73:135-41. 2013
    ..The aim of this study was to identify genetic variants contributing to preterm birth (PTB) using a linkage candidate gene approach...
  6. pmc Role of polymorphic variants as genetic modulators of infection in neonatal sepsis
    Asmaa Abu-Maziad
    Department of Pediatrics, University of Iowa, Children s Hospital, Iowa City, Iowa 52242, USA
    Pediatr Res 68:323-9. 2010
    ..05). We conclude allelic variations in PLA2G2A, TLR2, TLR5, and IL10 may moderate the predisposition to sepsis in preterm infants...
  7. pmc Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study
    Jinsil Kim
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, USA
    BMC Med Genet 14:77. 2013
    ..Multiple lines of evidence suggest that genetic factors play an important role in its etiology. This study was designed to identify genetic variation associated with PTB in oxytocin pathway genes whose role in parturition is well known...
  8. pmc Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates
    Kelli K Ryckman
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 70:90-5. 2011
    ....
  9. pmc The influence of maternal disease on metabolites measured as part of newborn screening
    Kelli K Ryckman
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Matern Fetal Neonatal Med 26:1380-3. 2013
    ..We sought to evaluate the impact of maternal complications of pregnancy and environmental stressors on NBS metabolites...
  10. pmc Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn
    Heather M Byers
    Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Pediatr Res 71:162-7. 2012
    ..Persistent pulmonary hypertension of the newborn (PPHN) is associated with substantial infant morbidity and mortality. Recently, genetic associations have been found in idiopathic pulmonary arterial hypertension...
  11. doi request reprint Improving survival of extremely preterm infants born between 22 and 25 weeks of gestation
    Kathy L Kyser
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Obstet Gynecol 119:795-800. 2012
    ..To estimate observed compared with predicted survival rates of extremely premature infants born during 2000-2009, to identify contemporary predictors of survival, and to determine if improved survival rates occurred during the decade...
  12. pmc Genetic contributions to the development of retinopathy of prematurity
    Shakir Mohamed
    Department of Pediatrics, University of Iowa, Iowa 52242, USA
    Pediatr Res 65:193-7. 2009
    ..003), AGTR1 (p = 0.005), TBX5 (p = 0.003), CETP (p = 0.004), and GP1BA (p = 0.005). Our data suggest that genetic risk factors contribute to the development of ROP...
  13. pmc Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
    Kelli K Ryckman
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr Endocrinol Metab 25:301-5. 2012
    ..Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate...
  14. pmc Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity
    Joanna S Kao
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    Acta Paediatr 100:347-51. 2011
    ..To explore the association of serum bilirubin level and breast milk feeding with retinopathy of prematurity (ROP) in preterm infants...
  15. pmc Association of amino acids with common complications of prematurity
    Kelli K Ryckman
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Pediatr Res 73:700-5. 2013
    ..Tandem mass spectrometry has been proposed as a method of diagnosing or predicting the development of common complex neonatal diseases. Our objective was to identify metabolites associated with common complications of prematurity...
  16. pmc Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth
    Lori J Day
    1Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Reprod Sci 18:286-95. 2011
    ..007), rs1218584 (P = .05), and a novel SNP at chromosome1:153099353 (P = .02). Polymorphisms in KCNN3 are associated with PTB and investigation into the functional significance of these allelic changes is warranted...
  17. ncbi request reprint Antisense inhibition of surfactant protein A decreases tubular myelin formation in human fetal lung in vitro
    Jonathan M Klein
    Departments of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    Am J Physiol Lung Cell Mol Physiol 282:L386-93. 2002
    ..We speculate that SP-A is critical to the formation of tubular myelin during human lung development and that the regulation of SP-B gene expression is independent of SP-A gene expression...
  18. ncbi request reprint Free solution mobility of DNA molecules containing variable numbers of cationic phosphoramidate internucleoside linkages
    N C Stellwagen
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    J Chromatogr A 883:267-75. 2000
    ..The mobility also varies somewhat depending on whether the modified phosphoramidate linkages are located at the 5'- or 3'-end of the DNA molecule...
  19. ncbi request reprint Antisense inhibition of epidermal growth factor receptor decreases expression of human surfactant protein A
    J M Klein
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    Am J Respir Cell Mol Biol 22:676-84. 2000
    ..These findings support the critical importance of the EGF receptor for the regulation of SP-A gene expression during human alveolar type II cell differentiation...
  20. doi request reprint Genetics of patent ductus arteriosus susceptibility and treatment
    Hanine Hajj
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Semin Perinatol 36:98-104. 2012
    ..Further advances in discovering genetic variation causing PDA will drive the more rational use of current therapies, and may help identify currently unknown targets for future therapeutic manipulation...
  21. pmc Individual and center-level factors affecting mortality among extremely low birth weight infants
    Brandon W Alleman
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 132:e175-84. 2013
    ..To examine factors affecting center differences in mortality for extremely low birth weight (ELBW) infants...
  22. ncbi request reprint Oligonucleotide-based strategies to reduce gene expression
    J M Dagle
    Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Differentiation 69:75-82. 2001
    ..Oligonucleotide-based approaches offer a variety of means to potentially disrupt normal gene expression. The basis for some of these approaches is presented in this review...
  23. ncbi request reprint Survivin mRNA is down-regulated during early Xenopus laevis embryogenesis
    Cary R Murphy
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Dev Dyn 225:597-601. 2002
    ..With the exception of the ovary, survivin mRNA was undetectable in all adult Xenopus tissues examined...
  24. ncbi request reprint Characterization of modified antisense oligonucleotides in Xenopus laevis embryos
    Kim A Lennox
    Integrated DNA Technologies, Coralville, IA 52241, USA
    Oligonucleotides 16:26-42. 2006
    ..However, at 400 nM, both of these compounds led to significant degradation of survivin mRNA, even when up to three mismatches were present in the heteroduplex...
  25. pmc TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation
    Ulrike G Jacobi
    Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    EMBO J 26:3900-9. 2007
    ..A requirement for TBP2 is linked to vertebrate-specific embryonic genes and ventral-specific expression. Therefore TBP paralogs are essential for the gene-regulatory repertoire that is directly linked to early embryogenesis...