S R Dager
Affiliation: University of Washington
- Coping strategies of panic and control subjects undergoing lactate infusion during magnetic resonance imaging confinementHamid Nazemi
Department of Psychology, Family and Community, Seattle Pacific University, Seattle, WA, USA
Compr Psychiatry 44:190-7. 2003..Among PD subjects, higher levels of suffocation fears were maintained despite emergence of more problem-focused coping in the experimental situation...
- Further commentary on mitochondrial dysfunction in autism spectrum disorder: assessment and treatment considerationsStephen R Dager
Department of Radiology, University of Washington, 1100 NE 45th St Suite 555, Seattle, WA, 98105, USA
J Autism Dev Disord 42:643-6. 2012..2011). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed...
- The vexing role of baseline: implications for neuroimaging studies of panic disorderStephen R Dager
Departments of Radiology and Bioengineering, School of Medicine, University of Washington, Seattle, Washington 98105, USA
Int J Psychophysiol 78:20-6. 2010..Examples from the panic imaging literature applying magnetic resonance spectroscopy, as well as an overview of baseline anxiety influences on functional MRI interpretation, are used to illustrate these considerations...
- Research applications of magnetic resonance spectroscopy to investigate psychiatric disordersStephen R Dager
Department of Radiology, Neuroimaging Research Group, University of Washington School of Medicine, 1100 NE 45th Street, Seattle, WA 98105, USA
Top Magn Reson Imaging 19:81-96. 2008....
- Shape mapping of the hippocampus in young children with autism spectrum disorderS R Dager
Department of Radiology, University of Washington, Seattle, WA 98105, USA
AJNR Am J Neuroradiol 28:672-7. 2007..We hypothesized the occurrence of characteristic hippocampal-shape alterations in young children with autistic spectrum disorder (ASD) who also exhibit deficits on neuropsychologic tests of medial temporal lobe (MTL) function...
- Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panicS R Dager
Department of Psychiatry, University of Washington School of Medicine, Seattle 98105 6099, USA
Psychiatry Res 76:89-99. 1997..This differential brain metabolic response did not appear to normalize when a small subset of panic patients were reinfused following resolution of panic symptoms during treatment over 3-4 months with fluoxetine...
- Brain metabolic alterations in medication-free patients with bipolar disorderStephen R Dager
Department of Radiology, University of Washington, Seattle 98105, USA
Arch Gen Psychiatry 61:450-8. 2004..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
- Brain imaging and the effects of caffeine and nicotineS R Dager
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98105 6099, USA
Ann Med 32:592-9. 2000....
- Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panicS R Dager
Department of Psychiatry, Diagnostic Imaging Sciences Center, University of Washington School of Medicine, Seattle 98105 6099, USA
Arch Gen Psychiatry 56:70-7. 1999....
- Human brain metabolic response to caffeine and the effects of toleranceS R Dager
Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, USA
Am J Psychiatry 156:229-37. 1999..They specifically measured changes in brain lactate due to the combined effects of caffeine's stimulation of glycolysis and reduction of cerebral blood flow...
- Regional brain chemical alterations in young children with autism spectrum disorderS D Friedman
Department of Radiology, University of Washington School of Medicine, Seattle 98105-6099, USA
Neurology 60:100-7. 2003..However, the direction and widespread distribution of these abnormalities do not support hypothesis of diffuse increased neuronal packing density in ASD...
- Brain metabolic changes during lactate-induced panic: effects of gabapentin treatmentM E Layton
The Center for Anxiety and Depression, University of Washington, Seattle, Washington 98105-6099, USA
Depress Anxiety 14:251-4. 2001..Additionally, two subjects were reinfused while clinically improved on double-blind placebo and demonstrated a consistent pattern of abnormal brain lactate response...
- Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxationH Petropoulos
Department of Radiology, University of Washington School of Medicine, Seattle 98105, USA
Neurology 67:632-6. 2006..Prolonged T2 in gray matter, but not white matter, observed in children with autism spectrum disorder may signify abnormal developmental processes specific to autism...
- Brain structural abnormalities in young children with autism spectrum disorderB F Sparks
Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105, USA
Neurology 59:184-92. 2002..Research currently is underway to better elucidate mechanisms underlying these structural abnormalities and their longitudinal progression...
- Reproducibility of proton MR spectroscopic imaging (PEPSI): comparison of dyslexic and normal-reading children and effects of treatment on brain lactate levels during language tasksTodd L Richards
Department of Radiology, University of Washington, Seattle, WA 98195, USA
AJNR Am J Neuroradiol 23:1678-85. 2002..However, the treatment effect was due to the morphologic component rather than the phonologic component...
- Functional MR spectroscopy of the brainT L Richards
Department of Radiology, University of Washington, Seattle 98195, USA
Neuroimaging Clin N Am 8:823-34. 1998..MR spectroscopy-detectable chemicals that are currently of greatest interest for measuring brain activation are also discussed...
- Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autismThomas H Wassink
Department of Psychiatry, The University of Iowa, USA
Arch Gen Psychiatry 64:709-17. 2007..Autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission...
- Gray and white matter brain chemistry in young children with autismSeth D Friedman
Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
Arch Gen Psychiatry 63:786-94. 2006..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
- Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 TSeth D Friedman
Department of Radiology, University of Washington Medical Center, Seattle, WA 98105, USA
J Cereb Blood Flow Metab 27:646-53. 2007..Other mitigating factors, such as anesthesia-induced deregulation of the cerebrovasculature, might have contributed to the exaggerated metabolic changes observed in previous animal investigations...
- Corpus callosum morphometrics in young children with autism spectrum disorderInbal Boger-Megiddo
Department of Radiology, 5C-1, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA
J Autism Dev Disord 36:733-9. 2006..Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD...
- Tissue pulsatility imaging of cerebral vasoreactivity during hyperventilationJohn C Kucewicz
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, USA
Ultrasound Med Biol 34:1200-8. 2008..In each subject, decreases in tissue pulsatility during hyperventilation were observed that were statistically correlated with the subject's end-tidal CO2 measurements. (..
- Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorderSara Jane Webb
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 38195, United States
Psychiatry Res 172:61-7. 2009..Within the DD group, larger cerebellar measurements were correlated with fewer impairments. The specific relation between altered cerebellar structure and symptom expression in autism remains unclear...
- Lithium and valproic acid treatment effects on brain chemistry in bipolar disorderSeth D Friedman
Department of Radiology, University of Washington, Seattle, Washington, USA
Biol Psychiatry 56:340-8. 2004..This study examined whether lithium (Li) and valproic acid (VPA) treatment modulated these chemicals...
- Improving 1H MRSI measurement of cerebral lactate for clinical applicationsNeva M Corrigan
Neuroimaging Research Group, Department of Radiology, University of Washington, Seattle, WA 98105, USA
Psychiatry Res 182:40-7. 2010..Simulation results that confirm this finding are also presented. This study additionally outlines an atlas-based approach for the systematic computation of regional distributions of chemical concentrations in large MRSI data sets...
- Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disordersWayne L Strauss
Center on Human Development and Disability, University of Washington, Seattle, 98105-6099, USA
Am J Psychiatry 159:755-60. 2002..It must be determined whether these findings can be generalized to other pediatric populations...
- Brain pH response to hyperventilation in panic disorder: preliminary evidence for altered acid-base regulationSeth D Friedman
Department of Radiology, 1100 N E 45th St, Suite 555, Seattle, WA 98105, USA
Am J Psychiatry 163:710-5. 2006..In both models, delayed pCO(2) recovery in subjects with panic disorder could reflect slower pH normalization in the recovery phase...
- Comparison of fMRI and PEPSI during language processing in childrenS Serafini
Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA
Magn Reson Med 45:217-25. 2001..Magn Reson Med 45:217-225, 2001...
- Magnetization transfer of fluoxetine in the human brain using fluorine magnetic resonance spectroscopyW L Strauss
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98105-6099, USA
Biol Psychiatry 49:798-802. 2001..Findings suggest that fluoxetine is substantially bound in the brain and that individual differences, inversely related to brain concentration, can be detected in the magnitude of MT contrast...
- Anxiety, respiration, and cerebral blood flow: implications for functional brain imagingNicholas D Giardino
Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105, USA
Compr Psychiatry 48:103-12. 2007..Approaches for addressing these effects are discussed...
- Amygdalar volume and behavioral development in autismJeffrey Munson
University of Washington Autism Center, University of Washington, Seattle, USA
Arch Gen Psychiatry 63:686-93. 2006..These results provide additional evidence that amygdalar development is implicated in the behavioral impairments found in autism...
- Neuropsychological function in retired workers with previous long-term occupational exposure to solventsW E Daniell
Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
Occup Environ Med 56:93-105. 1999..This study evaluated the risk for neuropsychological deficits among retired workers, relative to their histories of exposure to occupational solvents...
- Altered cingulate white matter connectivity in panic disorder patientsDoug Hyun Han
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
J Psychiatr Res 42:399-407. 2008..Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects...
- Basal ganglia shape alterations in bipolar disorderJaeuk Hwang
Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
Am J Psychiatry 163:276-85. 2006..The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences...
- Regional cerebral cortical thinning in bipolar disorderIn Kyoon Lyoo
McLean Hospital Brain Imaging Center, Harvarrd Medical School, Boston, MA, USA
Bipolar Disord 8:65-74. 2006..This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison subjects using cortical surface-based analysis...
- Frontal lobe gray matter density decreases in bipolar I disorderIn Kyoon Lyoo
Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 55:648-51. 2004..Decreased gray matter density in the right inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder...
- The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patientsMinue J Kim
McLean Hospital Brain Imaging Center, Harvard Medical School, Boston, MA, USA
Bipolar Disord 9:274-80. 2007..This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects...
- Offering to share: how to put heads together in autism neuroimagingMatthew K Belmonte
Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
J Autism Dev Disord 38:2-13. 2008..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
- The developmental neurobiology of autism spectrum disorderEmanuel DiCicco-Bloom
Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Neurosci 26:6897-906. 2006
- BRAIN METABOLISM AND TREATMENT OUTCOME IN PANIC DISORDERStephen Dager; Fiscal Year: 2004..abstract_text> ..
- A Longitudinal 3-D MRSI Study of Infants at High Risk for AutismStephen R Dager; Fiscal Year: 2010....