S R Dager

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Coping strategies of panic and control subjects undergoing lactate infusion during magnetic resonance imaging confinement
    Hamid Nazemi
    Department of Psychology, Family and Community, Seattle Pacific University, Seattle, WA, USA
    Compr Psychiatry 44:190-7. 2003
  2. ncbi Further commentary on mitochondrial dysfunction in autism spectrum disorder: assessment and treatment considerations
    Stephen R Dager
    Department of Radiology, University of Washington, 1100 NE 45th St Suite 555, Seattle, WA, 98105, USA
    J Autism Dev Disord 42:643-6. 2012
  3. ncbi The vexing role of baseline: implications for neuroimaging studies of panic disorder
    Stephen R Dager
    Departments of Radiology and Bioengineering, School of Medicine, University of Washington, Seattle, Washington 98105, USA
    Int J Psychophysiol 78:20-6. 2010
  4. ncbi Research applications of magnetic resonance spectroscopy to investigate psychiatric disorders
    Stephen R Dager
    Department of Radiology, Neuroimaging Research Group, University of Washington School of Medicine, 1100 NE 45th Street, Seattle, WA 98105, USA
    Top Magn Reson Imaging 19:81-96. 2008
  5. ncbi Shape mapping of the hippocampus in young children with autism spectrum disorder
    S R Dager
    Department of Radiology, University of Washington, Seattle, WA 98105, USA
    AJNR Am J Neuroradiol 28:672-7. 2007
  6. ncbi Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic
    S R Dager
    Department of Psychiatry, University of Washington School of Medicine, Seattle 98105 6099, USA
    Psychiatry Res 76:89-99. 1997
  7. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
  8. ncbi Brain imaging and the effects of caffeine and nicotine
    S R Dager
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98105 6099, USA
    Ann Med 32:592-9. 2000
  9. ncbi Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic
    S R Dager
    Department of Psychiatry, Diagnostic Imaging Sciences Center, University of Washington School of Medicine, Seattle 98105 6099, USA
    Arch Gen Psychiatry 56:70-7. 1999
  10. ncbi Human brain metabolic response to caffeine and the effects of tolerance
    S R Dager
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, USA
    Am J Psychiatry 156:229-37. 1999

Research Grants

  1. BRAIN METABOLISM AND TREATMENT OUTCOME IN PANIC DISORDER
    Stephen Dager; Fiscal Year: 2004
  2. A Longitudinal 3-D MRSI Study of Infants at High Risk for Autism
    Stephen R Dager; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. ncbi Coping strategies of panic and control subjects undergoing lactate infusion during magnetic resonance imaging confinement
    Hamid Nazemi
    Department of Psychology, Family and Community, Seattle Pacific University, Seattle, WA, USA
    Compr Psychiatry 44:190-7. 2003
    ..Among PD subjects, higher levels of suffocation fears were maintained despite emergence of more problem-focused coping in the experimental situation...
  2. ncbi Further commentary on mitochondrial dysfunction in autism spectrum disorder: assessment and treatment considerations
    Stephen R Dager
    Department of Radiology, University of Washington, 1100 NE 45th St Suite 555, Seattle, WA, 98105, USA
    J Autism Dev Disord 42:643-6. 2012
    ..2011). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed...
  3. ncbi The vexing role of baseline: implications for neuroimaging studies of panic disorder
    Stephen R Dager
    Departments of Radiology and Bioengineering, School of Medicine, University of Washington, Seattle, Washington 98105, USA
    Int J Psychophysiol 78:20-6. 2010
    ..Examples from the panic imaging literature applying magnetic resonance spectroscopy, as well as an overview of baseline anxiety influences on functional MRI interpretation, are used to illustrate these considerations...
  4. ncbi Research applications of magnetic resonance spectroscopy to investigate psychiatric disorders
    Stephen R Dager
    Department of Radiology, Neuroimaging Research Group, University of Washington School of Medicine, 1100 NE 45th Street, Seattle, WA 98105, USA
    Top Magn Reson Imaging 19:81-96. 2008
    ....
  5. ncbi Shape mapping of the hippocampus in young children with autism spectrum disorder
    S R Dager
    Department of Radiology, University of Washington, Seattle, WA 98105, USA
    AJNR Am J Neuroradiol 28:672-7. 2007
    ..We hypothesized the occurrence of characteristic hippocampal-shape alterations in young children with autistic spectrum disorder (ASD) who also exhibit deficits on neuropsychologic tests of medial temporal lobe (MTL) function...
  6. ncbi Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic
    S R Dager
    Department of Psychiatry, University of Washington School of Medicine, Seattle 98105 6099, USA
    Psychiatry Res 76:89-99. 1997
    ..This differential brain metabolic response did not appear to normalize when a small subset of panic patients were reinfused following resolution of panic symptoms during treatment over 3-4 months with fluoxetine...
  7. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    ..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
  8. ncbi Brain imaging and the effects of caffeine and nicotine
    S R Dager
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98105 6099, USA
    Ann Med 32:592-9. 2000
    ....
  9. ncbi Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic
    S R Dager
    Department of Psychiatry, Diagnostic Imaging Sciences Center, University of Washington School of Medicine, Seattle 98105 6099, USA
    Arch Gen Psychiatry 56:70-7. 1999
    ....
  10. ncbi Human brain metabolic response to caffeine and the effects of tolerance
    S R Dager
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Seattle, USA
    Am J Psychiatry 156:229-37. 1999
    ..They specifically measured changes in brain lactate due to the combined effects of caffeine's stimulation of glycolysis and reduction of cerebral blood flow...
  11. ncbi Regional brain chemical alterations in young children with autism spectrum disorder
    S D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle 98105-6099, USA
    Neurology 60:100-7. 2003
    ..However, the direction and widespread distribution of these abnormalities do not support hypothesis of diffuse increased neuronal packing density in ASD...
  12. ncbi Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment
    M E Layton
    The Center for Anxiety and Depression, University of Washington, Seattle, Washington 98105-6099, USA
    Depress Anxiety 14:251-4. 2001
    ..Additionally, two subjects were reinfused while clinically improved on double-blind placebo and demonstrated a consistent pattern of abnormal brain lactate response...
  13. ncbi Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation
    H Petropoulos
    Department of Radiology, University of Washington School of Medicine, Seattle 98105, USA
    Neurology 67:632-6. 2006
    ..Prolonged T2 in gray matter, but not white matter, observed in children with autism spectrum disorder may signify abnormal developmental processes specific to autism...
  14. ncbi Brain structural abnormalities in young children with autism spectrum disorder
    B F Sparks
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Neurology 59:184-92. 2002
    ..Research currently is underway to better elucidate mechanisms underlying these structural abnormalities and their longitudinal progression...
  15. ncbi Reproducibility of proton MR spectroscopic imaging (PEPSI): comparison of dyslexic and normal-reading children and effects of treatment on brain lactate levels during language tasks
    Todd L Richards
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    AJNR Am J Neuroradiol 23:1678-85. 2002
    ..However, the treatment effect was due to the morphologic component rather than the phonologic component...
  16. ncbi Functional MR spectroscopy of the brain
    T L Richards
    Department of Radiology, University of Washington, Seattle 98195, USA
    Neuroimaging Clin N Am 8:823-34. 1998
    ..MR spectroscopy-detectable chemicals that are currently of greatest interest for measuring brain activation are also discussed...
  17. ncbi Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism
    Thomas H Wassink
    Department of Psychiatry, The University of Iowa, USA
    Arch Gen Psychiatry 64:709-17. 2007
    ..Autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission...
  18. ncbi Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  19. ncbi Brain changes to hypocapnia using rapidly interleaved phosphorus-proton magnetic resonance spectroscopy at 4 T
    Seth D Friedman
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98105, USA
    J Cereb Blood Flow Metab 27:646-53. 2007
    ..Other mitigating factors, such as anesthesia-induced deregulation of the cerebrovasculature, might have contributed to the exaggerated metabolic changes observed in previous animal investigations...
  20. ncbi Corpus callosum morphometrics in young children with autism spectrum disorder
    Inbal Boger-Megiddo
    Department of Radiology, 5C-1, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA, 98105, USA
    J Autism Dev Disord 36:733-9. 2006
    ..Results could reflect decreased inter-hemispheric connectivity or cerebral enlargement due to increase in tissues less represented in the corpus callosum in ASD...
  21. ncbi Tissue pulsatility imaging of cerebral vasoreactivity during hyperventilation
    John C Kucewicz
    Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, USA
    Ultrasound Med Biol 34:1200-8. 2008
    ..In each subject, decreases in tissue pulsatility during hyperventilation were observed that were statistically correlated with the subject's end-tidal CO2 measurements. (..
  22. ncbi Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder
    Sara Jane Webb
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 38195, United States
    Psychiatry Res 172:61-7. 2009
    ..Within the DD group, larger cerebellar measurements were correlated with fewer impairments. The specific relation between altered cerebellar structure and symptom expression in autism remains unclear...
  23. ncbi Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
    Seth D Friedman
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 56:340-8. 2004
    ..This study examined whether lithium (Li) and valproic acid (VPA) treatment modulated these chemicals...
  24. ncbi Improving 1H MRSI measurement of cerebral lactate for clinical applications
    Neva M Corrigan
    Neuroimaging Research Group, Department of Radiology, University of Washington, Seattle, WA 98105, USA
    Psychiatry Res 182:40-7. 2010
    ..Simulation results that confirm this finding are also presented. This study additionally outlines an atlas-based approach for the systematic computation of regional distributions of chemical concentrations in large MRSI data sets...
  25. ncbi Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders
    Wayne L Strauss
    Center on Human Development and Disability, University of Washington, Seattle, 98105-6099, USA
    Am J Psychiatry 159:755-60. 2002
    ..It must be determined whether these findings can be generalized to other pediatric populations...
  26. ncbi Brain pH response to hyperventilation in panic disorder: preliminary evidence for altered acid-base regulation
    Seth D Friedman
    Department of Radiology, 1100 N E 45th St, Suite 555, Seattle, WA 98105, USA
    Am J Psychiatry 163:710-5. 2006
    ..In both models, delayed pCO(2) recovery in subjects with panic disorder could reflect slower pH normalization in the recovery phase...
  27. ncbi Comparison of fMRI and PEPSI during language processing in children
    S Serafini
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA
    Magn Reson Med 45:217-25. 2001
    ..Magn Reson Med 45:217-225, 2001...
  28. ncbi Magnetization transfer of fluoxetine in the human brain using fluorine magnetic resonance spectroscopy
    W L Strauss
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98105-6099, USA
    Biol Psychiatry 49:798-802. 2001
    ..Findings suggest that fluoxetine is substantially bound in the brain and that individual differences, inversely related to brain concentration, can be detected in the magnitude of MT contrast...
  29. ncbi Anxiety, respiration, and cerebral blood flow: implications for functional brain imaging
    Nicholas D Giardino
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105, USA
    Compr Psychiatry 48:103-12. 2007
    ..Approaches for addressing these effects are discussed...
  30. ncbi Amygdalar volume and behavioral development in autism
    Jeffrey Munson
    University of Washington Autism Center, University of Washington, Seattle, USA
    Arch Gen Psychiatry 63:686-93. 2006
    ..These results provide additional evidence that amygdalar development is implicated in the behavioral impairments found in autism...
  31. ncbi Neuropsychological function in retired workers with previous long-term occupational exposure to solvents
    W E Daniell
    Department of Environmental Health, University of Washington, Seattle 98195 7234, USA
    Occup Environ Med 56:93-105. 1999
    ..This study evaluated the risk for neuropsychological deficits among retired workers, relative to their histories of exposure to occupational solvents...
  32. ncbi Altered cingulate white matter connectivity in panic disorder patients
    Doug Hyun Han
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Psychiatr Res 42:399-407. 2008
    ..Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects...
  33. ncbi Basal ganglia shape alterations in bipolar disorder
    Jaeuk Hwang
    Department of Psychiatry, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea
    Am J Psychiatry 163:276-85. 2006
    ..The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences...
  34. ncbi Regional cerebral cortical thinning in bipolar disorder
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center, Harvarrd Medical School, Boston, MA, USA
    Bipolar Disord 8:65-74. 2006
    ..This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison subjects using cortical surface-based analysis...
  35. ncbi Frontal lobe gray matter density decreases in bipolar I disorder
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 55:648-51. 2004
    ..Decreased gray matter density in the right inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder...
  36. ncbi The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients
    Minue J Kim
    McLean Hospital Brain Imaging Center, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:274-80. 2007
    ..This study was conducted to evaluate the prevalence of cavum septi pellucidi (CSP) enlargement in patients with bipolar disorder (BD) and healthy comparison subjects...
  37. ncbi Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
  38. ncbi The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006

Research Grants10

  1. BRAIN METABOLISM AND TREATMENT OUTCOME IN PANIC DISORDER
    Stephen Dager; Fiscal Year: 2004
    ..abstract_text> ..
  2. A Longitudinal 3-D MRSI Study of Infants at High Risk for Autism
    Stephen R Dager; Fiscal Year: 2010
    ....