Affiliation: University of California
- Macromolecular dynamic contrast-enhanced (DCE)-MRI detects reduced vascular permeability in a prostate cancer bone metastasis model following anti-platelet-derived growth factor receptor (PDGFR) therapy, indicating a drop in vascular endothelial growth faHagit Dafni
Department of Experimental Diagnostic Imaging, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Magn Reson Med 60:822-33. 2008..Our study therefore demonstrates that macromolecular DCE-MRI can be used to detect early vascular effects associated with response to therapy targeted to PDGFR, and provides insight into the role played by VEGF in anti-PDGFR therapy...
- Monitoring histone deacetylase inhibition in vivo: noninvasive magnetic resonance spectroscopy methodMadhuri Sankaranarayanapillai
Experimental Diagnostic Imaging, Imaging Physics, and Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Mol Imaging 7:92-100. 2008..However, difference in tumor size reached significance only on day 6 of treatment. Thus, this work identifies BLT as a potential molecular imaging agent for the early noninvasive MRS detection of HDAC inhibition in vivo...