Soheil S Dadras

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint A Novel Role for Microphthalmia-Associated Transcription Factor-Regulated Pigment Epithelium-Derived Factor during Melanoma Progression
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts Electronic address
    Am J Pathol 185:252-65. 2015
  2. pmc Up-regulated Dicer expression in patients with cutaneous melanoma
    Zhihai Ma
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e20494. 2011
  3. ncbi request reprint An unexpected role for EGF in lymphangiogenesis-mediated melanoma metastasis to sentinel lymph nodes
    Soheil S Dadras
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT, USA
    J Invest Dermatol 133:14-6. 2013
  4. ncbi request reprint Molecular diagnostics in melanoma: current status and perspectives
    Soheil S Dadras
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut 06302, USA
    Arch Pathol Lab Med 135:860-9. 2011
  5. ncbi request reprint Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma
    Aude Rimella Le Huu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Am J Surg Pathol 34:1563-73. 2010
  6. ncbi request reprint Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mod Pathol 18:1232-42. 2005
  7. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
  8. ncbi request reprint Angiogenesis and lymphangiogenesis of skin cancers
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 18:1059-70, viii. 2004
  9. ncbi request reprint Prox-1 promotes invasion of kaposiform hemangioendotheliomas
    Soheil S Dadras
    Department of Dermatology, Cutaneous Biology Research Center, Boston, Massachusetts, USA
    J Invest Dermatol 128:2798-806. 2008
  10. ncbi request reprint Analyses of T cell-mediated immune response to a human melanoma-associated antigen by the young and the elderly
    Nitya G Chakraborty
    Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1628, USA
    Hum Immunol 74:640-7. 2013

Collaborators

Detail Information

Publications21

  1. ncbi request reprint A Novel Role for Microphthalmia-Associated Transcription Factor-Regulated Pigment Epithelium-Derived Factor during Melanoma Progression
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts Electronic address
    Am J Pathol 185:252-65. 2015
    ..These findings suggest that loss of PEDF expression promotes early invasive melanoma growth. ..
  2. pmc Up-regulated Dicer expression in patients with cutaneous melanoma
    Zhihai Ma
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e20494. 2011
    ..Emerging evidence shows that Dicer expression is deregulated in some human malignancies and it correlates with tumor progression, yet this role has not yet been investigated in skin cancers...
  3. ncbi request reprint An unexpected role for EGF in lymphangiogenesis-mediated melanoma metastasis to sentinel lymph nodes
    Soheil S Dadras
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT, USA
    J Invest Dermatol 133:14-6. 2013
    ..The latest discovery of Bracher et al. (2012) further supports a dynamic role for lymphatics-mediated melanoma metastasis to sentinel lymph node prompted by tumor-derived epidermal growth factor...
  4. ncbi request reprint Molecular diagnostics in melanoma: current status and perspectives
    Soheil S Dadras
    Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut 06302, USA
    Arch Pathol Lab Med 135:860-9. 2011
    ..Advancement in current technologies is such that one can now examine ribonucleic acid (RNA), deoxyribonucleic acid (DNA), and protein directly from the patient's own tumor...
  5. ncbi request reprint Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma
    Aude Rimella Le Huu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Am J Surg Pathol 34:1563-73. 2010
    ..Overall, our results show, for the first time, that Prox1 is an immunohistochemical biomarker helpful in confirming the diagnosis of KHE/TA and in distinguishing it from infantile hemangioma and pyogenic granuloma...
  6. ncbi request reprint Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mod Pathol 18:1232-42. 2005
    ..Assessment of lymphangiogenesis in primary melanomas may be a more effective approach than the currently used technique of measuring tumor thickness in selecting patients with early metastatic disease for aggressive therapy...
  7. pmc Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Am J Pathol 166:913-21. 2005
    ....
  8. ncbi request reprint Angiogenesis and lymphangiogenesis of skin cancers
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hematol Oncol Clin North Am 18:1059-70, viii. 2004
    ..A better molecular understanding of the lymphatic system may provide new insights into the biology of tumor metastasis and may provide novel prognostic and therapeutic tools in metastatic disease...
  9. ncbi request reprint Prox-1 promotes invasion of kaposiform hemangioendotheliomas
    Soheil S Dadras
    Department of Dermatology, Cutaneous Biology Research Center, Boston, Massachusetts, USA
    J Invest Dermatol 128:2798-806. 2008
    ..Together, these results indicate that Prox1 plays an important, previously unanticipated role in mediating the aggressive behavior of vascular neoplasms such as KS...
  10. ncbi request reprint Analyses of T cell-mediated immune response to a human melanoma-associated antigen by the young and the elderly
    Nitya G Chakraborty
    Carole and Ray Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030 1628, USA
    Hum Immunol 74:640-7. 2013
    ..These findings indicate that elderly patients might be capable of responding to tumor antigens, and need not be excluded from immune-based therapies or clinical trials...
  11. ncbi request reprint Infantile hemangiomas are arrested in an early developmental vascular differentiation state
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mod Pathol 17:1068-79. 2004
    ..The immature, incompletely differentiated immunophenotype of proliferating infantile hemangiomas may contribute to their rapid growth during the first few months of life...
  12. pmc In-depth characterization of microRNA transcriptome in melanoma
    James Kozubek
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 8:e72699. 2013
    ..Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics...
  13. pmc Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Pathol 162:1951-60. 2003
    ..Our results reveal tumor lymphangiogenesis as a novel prognostic indicator for the risk of lymph node metastasis in cutaneous melanoma...
  14. ncbi request reprint An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo
    Yun Hee Noh
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Invest Dermatol 121:1536-43. 2003
    ..These findings identify TSP-2/NTF as a potent systemic inhibitor of tumor growth and angiogenesis, acting by direct inhibition of several endothelial cell functions involved in neovascularization...
  15. pmc Profiling and discovery of novel miRNAs from formalin-fixed, paraffin-embedded melanoma and nodal specimens
    Zhihai Ma
    Departments of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Mol Diagn 11:420-9. 2009
    ..This methodology can therefore be used to facilitate miRNA discovery from archived human cancers...
  16. ncbi request reprint Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis
    Katie Doeden
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305 5324, USA
    J Cutan Pathol 36:772-80. 2009
    ..Sentinel lymph node (SLN) metastasis is a major determinant for staging, prognostication and clinical management of patients with cutaneous melanoma. However, the role of lymphatic vs. vascular invasion (VI) for SLN spread remains unclear...
  17. ncbi request reprint Verrucous hemangioma: a report of two cases and review of the literature
    Marimeg Q Clairwood
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT 06032, USA
    J Cutan Pathol 38:740-6. 2011
    ..We present two cases of verrucous hemangioma and discuss the clinicopathologic and immunohistochemical findings...
  18. ncbi request reprint Melanoma and melanocytic tumors of uncertain malignant potential in children, adolescents and young adults--the Stanford experience 1995-2008
    David R Berk
    Department of Dermatology, Pigmented Lesion and Melanoma Program, Stanford University Medical Center, Stanford, California 94063, USA
    Pediatr Dermatol 27:244-54. 2010
    ..Our data highlight the rarity, female predominance, and significant rate of SLN positivity of pediatric melanoma. The high rate of MelTUMPs with regional nodal disease reinforces the need for close follow-up...
  19. ncbi request reprint A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion
    Sankhiros Babapoor
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 9:e107502. 2014
    ..Surprisingly, these effects were not mediated by calcium binding protein 39 (CAB39), a proven miR451a gene target. miR-144/miR-451a cluster is a novel miRNA locus with tumor suppressive activity in melanoma...
  20. ncbi request reprint SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar
    Frances Ivette Ramos-Herberth
    Department of Pathology, Stanford University, Stanford, CA, USA
    J Cutan Pathol 37:944-52. 2010
    ..Distinguishing melanoma cells from immature fibrocytes or histiocytes is made more challenging in desmoplastic melanoma excision specimens...
  21. ncbi request reprint What's new in prognostication of melanoma in the dermatopathology laboratory?
    Haider K Bangash
    Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT 06032, USA
    Clin Dermatol 31:317-23. 2013
    ....