Research Topics
Species | S DacicSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Nodular amyloidoma and primary pulmonary lymphoma with amyloid production: a differential diagnostic problemS Dacic
Department of Pathology, University of Pittsburgh Medical Center and Presbyterian University Hospital, Pennsylvania 15213, USA
Mod Pathol 13:934-40. 2000..Amyloid tumors with a reactive lymphoplasmacytic infiltrate can be separated from low-grade malignant lymphomas utilizing both histologic and immunohistochemical features...- Molecular pathogenesis of pulmonary carcinosarcoma as determined by microdissection-based allelotypingSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania, USA
Am J Surg Pathol 26:510-6. 2002..The data support the efficacy of microdissection-based allelic fingerprinting to delineate the relationship between different morphologic components of a single neoplasm... - Genotypic analysis of pulmonary Langerhans cell histiocytosisS Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, PA 15213, USA
Hum Pathol 34:1345-9. 2003.... 
EGFR assays in lung cancerSanja Dacic
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Adv Anat Pathol 15:241-7. 2008..This review will address practical aspects of each of the currently proposed assays. Difficulties in standardization of these assays in a clinical practice will be discussed...- Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancerLaura P Stabile
Department of Pharmacology, University of Pittsburgh Cancer Institute, PA 15261, USA
Carcinogenesis 27:1547-55. 2006.... - Significance of EGFR protein expression and gene amplification in non-small cell lung carcinomaSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Clin Pathol 125:860-5. 2006..EGFR protein expression was uncoupled from gene amplification in most cases, although good correlation occurred in a subset of SCCs... - Molecular profiling of lung carcinoma: identifying clinically useful tumor markers for diagnosis and prognosisSanja Dacic
University of Pittsburgh Medical Center, Department of Pathology, PUH A610, Pittsburgh, PA 15213, USA
Expert Rev Mol Diagn 7:77-86. 2007..Although the impact of translating new technologies into clinical practice on survival has not been completely determined, they offer a new avenue of exciting novel approaches to early diagnosis of this deadly disease... - Microsatellite instability is uncommon in lymphoepithelioma-like carcinoma of the lungSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Clin Pathol 127:282-6. 2007..55). MSI is very uncommon in LELC, indicating that MSI is not an important event in carcinogenesis for this tumor subtype. The presence of LOH suggests a probable role of tumor suppressor genes in LELC carcinogenesis... - Overexpression of Dicer in precursor lesions of lung adenocarcinomaSimion Chiosea
Department of Pathology, University of Pittsburgh Medical Center Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Cancer Res 67:2345-50. 2007..The status of the endogenous miR machinery in various histologic subtypes and stages of lung cancer may help to predict the toxicity of and susceptibility to future RNA interference-based therapy... - Pulmonary preneoplasiaSanja Dacic
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 132:1073-8. 2008..Recognition of these lesions is very important to prevent potential diagnostic mistakes that may result in inadequate patient management. Future molecular studies may provide clinically useful diagnostic and prognostic gene markers... - Molecular alterations in atypical adenomatous hyperplasia occurring in benign and cancer-bearing lungsJoel F Gradowski
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Diagn Mol Pathol 16:87-90. 2007..Therefore, AAH may represent a smoking induced low-grade neoplastic lesion that may be a precursor lesion of only a subset of invasive lung adenocarcinoma... - Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylationWen Yue
Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Clin Cancer Res 13:4336-44. 2007..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer... - Gross cystic disease fluid protein-(GCDFP-15): expression in primary lung adenocarcinomaJoan M Striebel
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
Am J Surg Pathol 32:426-32. 2008..This report details the first 11 cases of pulmonary adenocarcinoma to express GCDFP-15 and their distinctive morphology with frequent mucin production and coexpression of thyroid transcription factor-1 and synaptophysin... - Patterns of allelic loss of synchronous adenocarcinomas of the lungSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Am J Surg Pathol 29:897-902. 2005..Our study showed that discordant and concordant genotypic profiles exist in morphologically similar synchronous ADC of the lung... - Persistent fever in a lung transplant patientDiana N Ionescu
Department of Pathology, Division of Anatomical Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 129:e153-4. 2005 - Small-cell neuroendocrine carcinoma displays unique profiles of tumor-suppressor gene loss in relationship to the primary site of formationSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, PA 15213, USA
Hum Pathol 33:927-32. 2002..These attributes can be effectively used for primary localization of metastatic SCNC, thereby assisting in the diagnosis and classification of this neoplasm... - Idiopathic bronchiolocentric interstitial pneumoniaSamuel A Yousem
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213, USA
Mod Pathol 15:1148-53. 2002.... - Widespread molecular alterations present in stage I non-small cell lung carcinoma fail to predict tumor recurrenceFabien K Baksh
Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania 15213, USA
Mod Pathol 16:28-34. 2003..The approach of investigating a panel of genes for alterations can be applied to any given tumor type, and provides information on patterns of mutations/LOH that can help us better understand the molecular biology of tumorigenesis... 
Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesisLaura P Stabile
Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mol Cancer Ther 7:1913-22. 2008..These preclinical results show that blocking the HGF/c-Met interaction with a single monoclonal antibody delivered systemically can have profound inhibitory effects on development of lung tumors...- Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesisSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Arch Pathol Lab Med 128:880-4. 2004..Most cases of SH are benign, but they can metastasize to the regional lymph nodes... - Pulmonary lymphohistiocytic reactions temporally related to etanercept therapySamuel A Yousem
The Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
Mod Pathol 18:651-5. 2005..The association with etanercept therapy and granulomatous reactions is discussed along with the differential diagnosis... - Clonal selection of adenocarcinoma of the lung as determined by loss of heterozygositySanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, 200 Lothrop Street, PUH A610 2, Pittsburgh, PA 15213, USA
Exp Mol Pathol 78:135-9. 2005..A trend towards lower overall FAL in advanced stage tumors and in their metastases suggests that clonal selection may play a role in lung adenocarcinoma progression... - Protein expression and gene amplification of epidermal growth factor receptor in thymomasDiana N Ionescu
Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania, USA
Cancer 103:630-6. 2005..There is little information in the literature regarding the biologic role of EGFR in thymomas that are characterized by variable clinical presentations, histologic heterogeneity, and unpredictable behavior... - Immunohistochemical profile of cystosarcoma phyllodes of the breast: a study of 23 casesSanja Dacic
Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Breast J 8:376-81. 2002..The positive immunostaining for bFGF, urokinase, Ki67, and p53 in stroma and epithelium of the majority of CP supports the existence of epithelial-stromal interactions and recognizes epithelium as an integral part of this tumor... - Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomasSimion Chiosea
Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Mod Pathol 21:742-7. 2008..A discrepancy between p16 protein expression and homozygous deletion suggests that other molecular mechanisms may play a role in p16 protein expression in mesothelial proliferations... - Significance of a solitary perivascular mononuclear infiltrate in lung allograft recipients with mild acute cellular rejectionDong-Won Kim
Department of Pathology and Pulmonary Medicine, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
J Heart Lung Transplant 24:152-5. 2005..Solitary mononuclear infiltrates showed persistence or progression without therapy and therefore need to be treated as, not segregated from, the "usual" forms of mild acute allograft rejection... - Array comparative genomic hybridization analysis of solid pseudopapillary neoplasms of the pancreasChad R Rund
Department of Pathology, Presbyterian Shadyside Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Mod Pathol 21:559-64. 2008..Additional study and longer follow-up are needed to determine if these genetic abnormalities could help predict clinical behavior in these neoplasms... - Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancerWen Yue
Department of Pharmacology
Carcinogenesis 29:84-92. 2008..These observations suggested that epigenetic inactivation of Dkk3 activates the Wnt/beta-catenin pathway, thereby promoting the growth of lung cancer cells... - 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertensionStevan P Tofovic
Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, PA 15219, United States
Vascul Pharmacol 45:358-67. 2006..This study suggests that 2-methoxyestradiol (a major non-estrogenic metabolite of E2) may mediate the protective effects of estradiol in MCT-induced PH, and warrants further evaluation of 2ME for treatment of PH... - Histologic classification of idiopathic chronic interstitial pneumoniasSanja Dacic
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, Pennsylvania, USA
Am J Respir Cell Mol Biol 29:S5-9. 2003 - Immunohistological determination of ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and 5'-nucleotidase in rat hippocampus reveals overlapping distributionIvana Bjelobaba
Department of Neurochemistry and Immunonology, Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia
Cell Mol Neurobiol 27:731-43. 2007..Obtained results suggest that the broad overlapping distribution of these enzymes in neurons and glial cells reflects the functional importance of ectonucleotidase actions in the nervous system...