David J Dabbs

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Detection of estrogen receptor by immunohistochemistry in pulmonary adenocarcinoma
    David J Dabbs
    Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 73:403-5; discussion 406. 2002
  2. ncbi request reprint The clinical significance of lobular neoplasia on breast core biopsy
    Rouzan G Karabakhtsian
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:717-23. 2007
  3. ncbi request reprint Use of immunohistochemistry in diagnosis of breast epithelial lesions
    Rohit Bhargava
    Department of Pathology, Magee Women Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Adv Anat Pathol 14:93-107. 2007
  4. ncbi request reprint Sentinel lymph node micrometastasis as a predictor of axillary tumor burden
    David J Dabbs
    Department of Pathology, Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
    Breast J 10:101-5. 2004
  5. ncbi request reprint Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Mod Pathol 19:1506-11. 2006
  6. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
  7. ncbi request reprint Molecular alterations in columnar cell lesions of the breast
    David J Dabbs
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Mod Pathol 19:344-9. 2006
  8. ncbi request reprint The optimal number of sentinel lymph nodes for focused pathologic examination
    David J Dabbs
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center Health Services, Pittsburgh, Pennsylvania 15213, USA
    Breast J 10:186-9. 2004
  9. doi request reprint Predictors of pathologic complete response after standard neoadjuvant chemotherapy in triple-negative breast carcinoma
    James A Kraus
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 20:334-9. 2012
  10. ncbi request reprint The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
    Nicole N Esposito
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 20:130-8. 2007

Detail Information

Publications66

  1. ncbi request reprint Detection of estrogen receptor by immunohistochemistry in pulmonary adenocarcinoma
    David J Dabbs
    Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 73:403-5; discussion 406. 2002
    ....
  2. ncbi request reprint The clinical significance of lobular neoplasia on breast core biopsy
    Rouzan G Karabakhtsian
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:717-23. 2007
    ..We conclude that a finding of LN on breast core biopsy in a patient with a BIRADS 4 image and calcifications is associated with a risk of 8% to 19% of upstaging to a treatable disease on FUEB...
  3. ncbi request reprint Use of immunohistochemistry in diagnosis of breast epithelial lesions
    Rohit Bhargava
    Department of Pathology, Magee Women Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Adv Anat Pathol 14:93-107. 2007
    ..Because the main focus of this review is on diagnosis, receptor studies on breast carcinoma are briefly discussed and only a few general comments are made...
  4. ncbi request reprint Sentinel lymph node micrometastasis as a predictor of axillary tumor burden
    David J Dabbs
    Department of Pathology, Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
    Breast J 10:101-5. 2004
    ..Keratin IHC of breast SLNs is useful for defining these subsets...
  5. ncbi request reprint Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Mod Pathol 19:1506-11. 2006
    ....
  6. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
    ....
  7. ncbi request reprint Molecular alterations in columnar cell lesions of the breast
    David J Dabbs
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Mod Pathol 19:344-9. 2006
    ..Integrated molecular pathology analysis used here can help define the significance of columnar cell lesions and its role in breast cancer tumorigenesis on an individual patient basis...
  8. ncbi request reprint The optimal number of sentinel lymph nodes for focused pathologic examination
    David J Dabbs
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center Health Services, Pittsburgh, Pennsylvania 15213, USA
    Breast J 10:186-9. 2004
    ..It is suggested that for more than three SLNs submitted, simple routine lymph node examination would be appropriate...
  9. doi request reprint Predictors of pathologic complete response after standard neoadjuvant chemotherapy in triple-negative breast carcinoma
    James A Kraus
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 20:334-9. 2012
    ..E-cadherin expression as a predictor of pathologic complete response in triple-negative tumors should be further assessed on larger number of cases...
  10. ncbi request reprint The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
    Nicole N Esposito
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 20:130-8. 2007
    ..Tubulolobular carcinoma appears to be more aggressive than tubular carcinoma, as 16% of patients had lymph node metastases, although all were alive at a mean follow-up of 40 months...
  11. doi request reprint Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy: a single institutional experience with 359 cases
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    Cancer 116:1431-9. 2010
    ..We hypothesize that a similar response could be predicted using semiquantitative immunohistochemistry for estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2)...
  12. doi request reprint Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation
    Leo A Niemeier
    Department of Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 23:205-12. 2010
    ..Androgen receptor-targeted therapy in estrogen/progesterone receptor-negative tumors may provide an inexpensive alternative to usual high-dose chemotherapy with or without trastuzumab...
  13. ncbi request reprint Intraoperative cytologic examination of breast sentinel lymph nodes: test utility and patient impact
    David J Dabbs
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center Health Services, Pittsburgh, Pennsylvania 15213, USA
    Breast J 10:190-4. 2004
    ..4 mm). The IOCE of SLNs has a high negative predictive value, but this is a poor test for the detection of micrometastases, as this group accounts for the majority of false-negative IOCEs of breast SLNs...
  14. ncbi request reprint Pleomorphic lobular carcinoma in situ (PLCIS) on breast core needle biopsies: clinical significance and immunoprofile
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 32:1721-6. 2008
    ..PLCIS has a significant association with other high-risk lesions and invasive lobular carcinoma...
  15. doi request reprint Breast cancer molecular class ERBB2: preponderance of tumors with apocrine differentiation and expression of basal phenotype markers CK5, CK5/6, and EGFR
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 18:113-8. 2010
    ..ERBB2 tumors demonstrate some features classically ascribed to TN basal-like tumors. Epidermal growth factor receptor overexpression in ERBB2 tumors may have additional predictive value...
  16. doi request reprint Insulin-like growth factor receptor-1 (IGF-1R) expression in normal breast, proliferative breast lesions, and breast carcinoma
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 19:218-25. 2011
    ..The consistent presence of IGF-1R in ER+ tumors may explain the lower response rate to neoadjuvant chemotherapy in luminal tumors...
  17. doi request reprint Immunohistochemistry and HPV in situ hybridization in pathologic distinction between endocervical and endometrial adenocarcinoma: a comparative tissue microarray study of 76 tumors
    Mirka W Jones
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Gynecol Cancer 23:380-4. 2013
    ..When tumors are difficult to distinguish based on routine histologic sections, immunohistochemistry and human papillomavirus (HPV) in situ hybridization may be used...
  18. doi request reprint Characterization of high-grade ductal carcinoma in situ with and without regressive changes: diagnostic and biologic implications
    Mamatha Chivukula
    Department of Pathology, Division of Anatomic Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Immunohistochem Mol Morphol 17:495-9. 2009
    ..HGDCIS-RC may also be a sign of an aggressive phenotype than other HGDCIS subtypes. Further outcome studies are necessary to determine if it has a clinical impact akin to other tumors with RC...
  19. doi request reprint Concordance between semiquantitative immunohistochemical assay and oncotype DX RT-PCR assay for estrogen and progesterone receptors
    Siobhan M O'Connor
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Appl Immunohistochem Mol Morphol 18:268-72. 2010
    ..Given the additional advantages of hormone receptor IHC performed on intact tissue sections, currently there is no definitive reason to switch to RT-PCR for determination of ER and PR expressions...
  20. doi request reprint Semiquantitative hormone receptor level influences response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancer
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 24:367-74. 2011
    ..This information can be utilized to counsel patients considered for neoadjuvant chemotherapy and the same principle could be applied in the adjuvant setting...
  21. doi request reprint Morphologic features do not influence response to trastuzumab-containing neoadjuvant chemotherapy in HER2-positive breast cancer
    Xin Li
    Department of Pathology, Magee Womens Hospital of UPMC, Pittsburgh, PA
    Appl Immunohistochem Mol Morphol 21:420-5. 2013
    ..Semiquantitative scoring for hormone receptors provides useful information in terms of therapeutic response in HER2-positive tumors. ..
  22. doi request reprint Mammaglobin expression in the female genital tract: immunohistochemical analysis in benign and neoplastic endocervix and endometrium
    Kazuya Onuma
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Gynecol Pathol 27:418-25. 2008
    ..MGB may be a promising new adjunctive marker in gynecologic pathology...
  23. doi request reprint Histopathologic variables predict Oncotype DX recurrence score
    Melina B Flanagan
    Department of Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 21:1255-61. 2008
    ..Although the Oncotype DX Recurrence Score holds potential, further validation of its independent value beyond that of histopathologic analysis is necessary before it can be implemented in clinical decision making...
  24. doi request reprint The equivocally amplified HER2 FISH result on breast core biopsy: indications for further sampling do affect patient management
    Joan M Striebel
    Department of Pathology, Magee Womens Hospital, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 129:383-90. 2008
    ..These results support the recent American Society of Clinical Oncology/College of American Pathologists recommendations for further testing in cases with equivocal HER2 results...
  25. ncbi request reprint The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 15:260-6. 2007
    ..The diffuse cytoplasmic immunostaining of p120 in lobular neoplasia may be useful diagnostically as a positive marker for lobular neoplasia...
  26. pmc Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
    Jing Yu
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Diagn Pathol 5:36. 2010
    ....
  27. ncbi request reprint Pleomorphic lobular carcinoma in pleural fluid: diagnostic pitfall for atypical mesothelial cells
    Sara E Monaco
    Department of Pathology, University of Pittsburgh Medical Center Shadyside Hospital, 5230 Centre Avenue, WG02 1, Pittsburgh, PA 15232, USA
    Diagn Cytopathol 36:657-61. 2008
    ..Our case highlights the important issues and pitfalls to be aware of when making this diagnosis...
  28. ncbi request reprint Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin
    David J Dabbs
    Department of Pathology, Magee Women s Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:427-37. 2007
    ..Caution should be exercised when examining tumors in metastatic sites with P120ctn, with the incorporation of an appropriate panel of immunostains...
  29. ncbi request reprint Semiquantitative GATA-3 immunoreactivity in breast, bladder, gynecologic tract, and other cytokeratin 7-positive carcinomas
    Beth Z Clark
    From Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA
    Am J Clin Pathol 142:64-71. 2014
    ..To evaluate GATA-3 immunohistochemical expression semiquantitatively in breast, gynecologic, gastric, pancreatic-biliary tract, urothelial, and vulvar/cervical squamous cell carcinomas...
  30. doi request reprint A validation study of quantum dot multispectral imaging to evaluate hormone receptor status in ductal carcinoma in situ of the breast
    Jing Yu
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Pathol 44:394-401. 2013
    ..However, several technical and logistic issues await significant improvement before this novel technique can be justified for routine clinical application...
  31. doi request reprint Interobserver agreement among pathologists for semiquantitative hormone receptor scoring in breast carcinoma
    David A Cohen
    Department of Pathology, Magee Womens Hospital of UPMC, Pittsburgh, PA, USA
    Am J Clin Pathol 138:796-802. 2012
    ..85 (95% confidence interval [CI] = 0.79-0.90) for ER and 0.87 (95% CI = 0.82-0.92) for PR. Because the H-score provides a continuous measure of tumor hormone receptor content, we suggest universal adoption of this method...
  32. doi request reprint The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma
    Isil Z Yildiz-Aktas
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 25:1098-105. 2012
    ..The ASCO/CAP guideline of cold ischemic time period of <1 h is a prudent guideline to follow...
  33. ncbi request reprint Semi-quantitative immunohistochemical assay versus oncotype DX(®) qRT-PCR assay for estrogen and progesterone receptors: an independent quality assurance study
    James A Kraus
    Department of Pathology, Pittsburgh, PA, USA
    Mod Pathol 25:869-76. 2012
    ....
  34. ncbi request reprint PAX 2: a novel Müllerian marker for serous papillary carcinomas to differentiate from micropapillary breast carcinoma
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    Int J Gynecol Pathol 28:570-8. 2009
    ..We therefore conclude that PAX 2 is a promising new, sensitive, and specific müllerian immunomarker for ovarian serous carcinomas (primary and metastatic)...
  35. pmc Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?
    Rosemary A Recavarren
    Department of Pathology at Magee Women s Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Int J Clin Exp Pathol 3:87-97. 2009
    ..Our study suggests an intimate vascular and hormone dependent epithelial-stromal interaction exists in CCPLS lesions...
  36. ncbi request reprint NY-BR-1 and PAX8 immunoreactivity in breast, gynecologic tract, and other CK7+ carcinomas: potential use for determining site of origin
    Anna H Woodard
    Dept of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Clin Pathol 136:428-35. 2011
    ..Addition of NY-BR-1 and PAX8 in a panel would be useful in distinguishing breast cancer, gynecologic tumors, and tumors of the upper gastrointestinal tract...
  37. doi request reprint Clinicopathologic implications of "flat epithelial atypia" in core needle biopsy specimens of the breast
    Mamatha Chivukula
    Dept of Pathology, Magee Women s Hospital of UPMC, University of Pittsburgh, PA 15213, USA
    Am J Clin Pathol 131:802-8. 2009
    ..Our study concludes that there is an association of FEA with ADH on multiple levels of CNB specimens, and follow-up surgical excision findings for FEA are clinically significant...
  38. ncbi request reprint Clinical implications of the diagnosis "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" in pregnant women
    Kazuya Onuma
    Department of Pathology, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer 108:282-7. 2006
    ..The objective of this study was to investigate the clinical implications and pathologic significance of ASC-H in pregnant women, so that these patients will be managed appropriately...
  39. doi request reprint Are encapsulated papillary carcinomas of the breast in situ or invasive? A basement membrane study of 27 cases
    Nicole Nicosia Esposito
    Department of Pathology, Magee Womens Hospital of the University of Pittsburgh, Pittsburgh, PA, USA
    Am J Clin Pathol 131:228-42. 2009
    ..4 months). EPCs are in situ carcinomas with an excellent prognosis and can be managed with local therapy with or without sentinel lymph node biopsy...
  40. doi request reprint CK5 is more sensitive than CK5/6 in identifying the "basal-like" phenotype of breast carcinoma
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 130:724-30. 2008
    ..Both antibodies had comparable specificity of more than 95%. For positive cases, the percentage and intensity of staining was much higher with CK5 than with CK5/6 (P = .0001)...
  41. doi request reprint Evaluation of morphologic features to identify "basal-like phenotype" on core needle biopsies of breast
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 16:411-6. 2008
    ....
  42. ncbi request reprint The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma
    Isil Z Yildiz-Aktas
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Clin Pathol 137:691-8. 2012
    ..ER, PR, and HER2 immunohistochemical results should be considered valid for cases fixed up to 96 hours...
  43. ncbi request reprint Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases
    Nicole Nicosia Esposito
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 130:1516-21. 2006
    ..However, histologic classification does not always predict outcome. Objective.-To determine the prognostic value of a variety of clinicopathologic features and immunoreactivities in PTs...
  44. doi request reprint Clinical importance of HER2 immunohistologic heterogeneous expression in core-needle biopsies vs resection specimens for equivocal (immunohistochemical score 2+) cases
    Mamatha Chivukula
    Department of Pathology, Magee Women s Hospital of UPMC, Pittsburgh, PA 115213, USA
    Mod Pathol 21:363-8. 2008
    ..However, performing fluorescence in situ hybridization on core-needle biopsies almost completely resolves the issue of heterogeneous expression of HER2...
  45. ncbi request reprint Basal-like subtype breast cancers in women older than 40 years of age
    Cagatay Ersahin
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Int J Surg Pathol 18:42-7. 2010
    ..BL cancer patients from all age groups require further investigation for BRCA-1, as well as gene microarray analysis to compare the gene expressions with those observed in the younger population...
  46. ncbi request reprint Selective intraoperative consultation for the evaluation of sentinel lymph nodes in breast cancer
    Paul R Klepchick
    Department of Surgery, Magee Womens Hospital, 300 Halket St, Pittsburgh, PA 15213, USA
    Am J Surg 188:429-32. 2004
    ..Failure to perform immediate consultation requires node-positive patients to return for delayed dissection...
  47. doi request reprint Immunohistochemical profile of steroid cell tumor of the ovary: a study of 14 cases and a review of the literature
    Mirka W Jones
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Int J Gynecol Pathol 29:315-20. 2010
    ..As some SCTs can be positive for epithelial markers and histologically similar epithelial tumors can be positive for sex cord stromal markers, the use of multiple immunohistochemical stains is recommended...
  48. pmc Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response
    Matthew J Sikora
    Authors Affiliations Women s Cancer Research Center Departments of Biomedical Informatics, Pharmacology and Chemical Biology, Biostatistics, Human Genetics, University of Pittsburgh Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania and Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
    Cancer Res 74:1463-74. 2014
    ..Targeting growth factors using FGFR1 inhibitors may block survival pathways required by ILC and reverse tamoxifen resistance...
  49. doi request reprint Impact of progesterone receptor semiquantitative immunohistochemical result on Oncotype DX recurrence score: a quality assurance study of 1074 cases
    Beth Z Clark
    Department of Pathology, Magee Womens Hospital of UPMC, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 21:287-91. 2013
    ....
  50. doi request reprint Classical-type invasive lobular carcinoma with HER2 overexpression: clinical, histologic, and hormone receptor characteristics
    Jing Yu
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 136:88-97. 2011
    ..ER is still expressed in HER2+ classical ILCs, although the level of expression is significantly reduced compared with the HER2- cases. The implications of the findings are discussed...
  51. ncbi request reprint Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 127:103-13. 2007
    ..Positive mammaglobin staining was also seen in 44 (8.1%) of 544 nonbreast tumors. Mammaglobin is a more sensitive marker than GCDFP-15 for breast carcinoma; however, it lacks the specificity of GCDFP-15...
  52. doi request reprint High false-negative rate of HER2 quantitative reverse transcription polymerase chain reaction of the Oncotype DX test: an independent quality assurance study
    David J Dabbs
    Magee Womens Hospital of UPMC, 300 Halket St, Pittsburgh, PA, USA
    J Clin Oncol 29:4279-85. 2011
    ..Because of the lack of independent evaluation, this quality assurance study was undertaken to define the concordance rate between immunohistochemistry (IHC)/fluorescent in situ hybridization (FISH) and GHI RT-PCR HER2 assay...
  53. doi request reprint Dissemination of Lean methods to improve Pap testing quality and patient safety
    Stephen S Raab
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Low Genit Tract Dis 12:103-10. 2008
    ..To determine if the implementation of Lean methods resulted in improved Pap test quality and diagnostic accuracy in 5 clinician practices...
  54. doi request reprint Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry
    David J Dabbs
    Department of Pathology, Magee Women s Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Surg Pathol 37:e1-11. 2013
    ..This review provides an update on recent clinicopathologic and molecular data on LN and invasive lobular carcinoma and a discussion about the use and limitations of IHC with E-cadherin in diagnostic breast pathology...
  55. ncbi request reprint Utility of intraoperative consultation touch preparations
    Yulin Liu
    Department of Pathology and Laboratory Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA
    Diagn Cytopathol 26:329-33. 2002
    ..In conclusion, the use of performing TP and frozen section are complementary and result in increased diagnostic accuracy. For some pathologists, TPs may replace frozen sections in over 50% of cases...
  56. ncbi request reprint Recommendations for the reporting of tissues removed as part of the surgical treatment of malignant liver tumors
    David J Dabbs
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    Hum Pathol 35:1315-23. 2004
    ..The Association of Directors of Anatomic and Surgical Pathology (ADASP) has developed recommendations for the surgical pathology report for primary and metastatic epithelial tumors in the liver. These recommendations are reported herein...
  57. ncbi request reprint Synchronous sentinel lymph node metastasis of lobular and ductal carcinoma
    Deepak Mohan
    Department of Pathology, Division of Anatomic Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, USA
    Arch Pathol Lab Med 128:365. 2004
  58. ncbi request reprint Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women
    Reda S Saad
    Department of Pathology, Allegheny General Hospital and Drexel University College of Medicine, Pittsburgh, PA 15212, USA
    Am J Clin Pathol 126:381-8. 2006
    ..The diagnosis of ASC-H in postmenopausal women usually is associated with LSIL or a negative diagnosis on follow-up, suggesting a less aggressive surveillance and treatment regimen is needed for postmenopausal women with ASC-H...
  59. ncbi request reprint Permanently blocked stem cells derived from breast cancer cell lines
    Gangadharan B Sajithlal
    Section of Hematology Oncology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 28:1008-18. 2010
    ....
  60. doi request reprint An immunohistochemical panel to differentiate metastatic breast carcinoma to skin from primary sweat gland carcinomas with a review of the literature
    Marian Rollins-Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15261, USA
    Arch Pathol Lab Med 135:975-83. 2011
    ..Although a few studies attempt to differentiate these entities employing immunohistochemical (IHC) studies (some of which we review here), to date, no panel of IHC stains exists, to our knowledge, to distinguish these entities...
  61. pmc Prevalence, morphologic features and proliferation indices of breast carcinoma molecular classes using immunohistochemical surrogate markers
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center Pittsburgh, PA, USA
    Int J Clin Exp Pathol 2:444-55. 2009
    ..Immunohistochemistry is a reliable surrogate tool to classify breast carcinoma according to the gene expression profile classification...
  62. ncbi request reprint Epidermoid metaplasia of the cervix
    Diana N Ionescu
    Department of Pathology, Division of Anatomic Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Pathol Lab Med 128:1052-3. 2004
  63. ncbi request reprint Asymptomatic giant-cell (temporal) arteritis involving the bilateral adnexa: case report and literature review
    Kazuya Onuma
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15231, USA
    Int J Gynecol Pathol 26:352-5. 2007
    ..Giant-cell arteritis rarely involves the female genital tract and may present as an isolated form or a part of systemic disease. We discuss female genital tract giant-cell arteritis with a review of the English literature...
  64. ncbi request reprint Improving Papanicolaou test quality and reducing medical errors by using Toyota production system methods
    Stephen S Raab
    Department of Pathology, School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Am J Obstet Gynecol 194:57-64. 2006
    ..The objective of the study was to determine whether the Toyota production system process improves Papanicolaou test quality and patient safety...
  65. ncbi request reprint A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility
    William C Powell
    Ventana Medical Systems Inc, Tucson, AZ, USA
    Appl Immunohistochem Mol Morphol 15:94-102. 2007
    ..3% SI) in both cohorts. Interlaboratory reproducibility was also excellent (kappa 1.0). RMoAb 4B5 provides excellent sensitivity, specificity, and interlaboratory reproducibility for the detection of HER2 status in breast cancer...
  66. doi request reprint Re: High concordance between immunohistochemistry and fluorescence in situ hybridization testing for HER2 status in breast cancer requires a normalized IHC scoring system
    Wedad M Hanna
    Mod Pathol 21:1278-80; author reply 1280-1. 2008