Maria F Czyzyk-Krzeska

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA
    M F Czyzyk-Krzeska
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Blood 93:2111-20. 1999
  2. ncbi The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress
    Olga Mikhaylova
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237 0505, USA
    Mol Cell Biol 28:2701-17. 2008
  3. ncbi von Hippel-Lindau tumor suppressor: not only HIF's executioner
    Maria F Czyzyk-Krzeska
    Department of Genome Science, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0505, USA
    Trends Mol Med 10:146-9. 2004
  4. ncbi von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
    Anna V Kuznetsova
    Department of Molecular and Cellular Physiology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0576, USA
    Proc Natl Acad Sci U S A 100:2706-11. 2003
  5. ncbi Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
    Phillip O Schnell
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Neurochem 85:483-91. 2003
  6. ncbi Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells
    Amy L Bauer
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0576, USA
    Cancer Res 62:1682-7. 2002
  7. ncbi von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas
    Ying Yi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Clin Cancer Res 16:5142-52. 2010
  8. ncbi Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells
    Adriana Zakrzewska
    Department of Genome Science, Division of Nephrology and Hypertension, University of Cincinnati, Ohio 45267 0505, USA
    J Neurochem 94:1288-96. 2005
  9. ncbi Calcium signaling stimulates translation of HIF-alpha during hypoxia
    Anna S Hui
    Department of Genome Science, Genome Research Institute, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0505, USA
    FASEB J 20:466-75. 2006
  10. ncbi VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma
    Olga Mikhaylova
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Cancer Cell 21:532-46. 2012

Research Grants

  1. Role of ubiquitylation in renal cancer
    Maria F Czyzyk Krzeska; Fiscal Year: 2010
  2. REGULATION OF GENE EXPRESSION BY OXYGEN
    MARIA CZYZYK KRZESKA; Fiscal Year: 2005
  3. Regulation of Cell Function by Intermittent Hypoxia
    MARIA CZYZYK KRZESKA; Fiscal Year: 2007
  4. Role of ubiquitylation in renal cancer
    MARIA CZYZYK KRZESKA; Fiscal Year: 2007
  5. Role of ubiquitylation in renal cancer
    MARIA CZYZYK KRZESKA; Fiscal Year: 2009
  6. REGULATION OF GENE EXPRESSION IN INTERMITTENT HYPOXIA
    MARIA CZYZYK KRZESKA; Fiscal Year: 2003
  7. POSTTRANSCRIPTIONAL REGULATION--CATECHOLAMINE SYNTHESIS
    MARIA CZYZYK KRZESKA; Fiscal Year: 2000

Collaborators

  • David Gozal
  • Ronald C Conaway
  • Peter Carmeliet
  • Gary Gudelsky
  • Evelyne Gozal
  • Patrick Maxwell
  • L Conforti
  • MARIA CZYZYK KRZESKA
  • Olga Mikhaylova
  • Maria F Czyzyk Krzeska
  • Phillip O Schnell
  • Justin B Striet
  • Amy L Bauer
  • Jarek Meller
  • Anna S Hui
  • Ying Yi
  • Waltke R Paulding
  • Monika L Ignacak
  • Jacek Biesiada
  • Anna V Kuznetsova
  • Brian J Siroky
  • Adriana Zakrzewska
  • James A Nash
  • Bu B Yeap
  • Emily Kellner
  • Birgit Ehmer
  • Daniel Hall
  • David R Plas
  • Angela F Drew
  • Yiwen Stratton
  • Catherine A Gallo
  • Enas Alshaikh
  • Linda Levin
  • Aygun Mamedova
  • Rachel M Sheridan
  • Prabhat Bastola
  • John J Bissler
  • Svetlana V Harbaugh
  • Martin Schneider
  • Kenneth D Greis
  • Katie van Geyte
  • Michael Wyder
  • Teresa J Barankiewicz
  • Monica P Revelo
  • Milan Petrovic
  • Jennifer R Robbins
  • Marc G Wathelet
  • Anna Hui
  • Joan W Conaway
  • Jaroslaw Meller
  • Dana Beitner-Johnson
  • Leroy R Sachleben
  • Shang-Z Guo
  • Galia K Soukhova
  • John W Haycock
  • Yolanda Sanchez
  • Jackie A Wilce
  • Matthew C J Wilce
  • Henry Furneaux
  • Peter J Leedman
  • Julian P Vivian
  • Ross K McCulloch
  • Andrew M Thomson
  • Dominic C Voon
  • Keith M Giles

Detail Information

Publications14

  1. ncbi Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA
    M F Czyzyk-Krzeska
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
    Blood 93:2111-20. 1999
    ..In Hep3B or HepG2 cells hypoxia induces neither expression of PCBP nor formation of the ribonucleoprotein complex associated with EPO mRNA that involves PCBP...
  2. ncbi The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress
    Olga Mikhaylova
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237 0505, USA
    Mol Cell Biol 28:2701-17. 2008
    ..These data indicate that through this novel pathway involving P1465 hydroxylation and Ser5 phosphorylation of Rbp1, pVHL may regulate tumor growth...
  3. ncbi von Hippel-Lindau tumor suppressor: not only HIF's executioner
    Maria F Czyzyk-Krzeska
    Department of Genome Science, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0505, USA
    Trends Mol Med 10:146-9. 2004
    ..However, the ubiquitylating role of the VHL complex extends beyond its function in regulating HIF, as it appears to regulate the stability of other proteins that might be involved in various steps of oncogenic processes...
  4. ncbi von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
    Anna V Kuznetsova
    Department of Molecular and Cellular Physiology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0576, USA
    Proc Natl Acad Sci U S A 100:2706-11. 2003
    ..This interaction is regulated by UV radiation...
  5. ncbi Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
    Phillip O Schnell
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Neurochem 85:483-91. 2003
    ..These results indicate that HIFs may play an important role in regulation of TH gene expression in oxygen-sensitive cells and also in the development of hypercatecholaminemia in pheochromocytoma tumors...
  6. ncbi Endogenous von Hippel-Lindau tumor suppressor protein regulates catecholaminergic phenotype in PC12 cells
    Amy L Bauer
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0576, USA
    Cancer Res 62:1682-7. 2002
    ..This is the first evidence that endogenous pVHL is a physiological regulator of the catecholaminergic phenotype. Thus, loss of pVHL function may be causative in pheochromocytoma-associated hypercatecholaminemia and arterial hypertension...
  7. ncbi von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas
    Ying Yi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Clin Cancer Res 16:5142-52. 2010
    ..Here, our goal was to determine the effect of this VHL function and the status of P1465 hydroxylation in human RCC tumors...
  8. ncbi Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells
    Adriana Zakrzewska
    Department of Genome Science, Division of Nephrology and Hypertension, University of Cincinnati, Ohio 45267 0505, USA
    J Neurochem 94:1288-96. 2005
    ..We propose that the NADH glycerol phosphate shuttle participates in generating a pool of ATP that serves either as a co-factor or a modulator of the kinases involved in the phosphorylation of p300/CBP during hypoxia...
  9. ncbi Calcium signaling stimulates translation of HIF-alpha during hypoxia
    Anna S Hui
    Department of Genome Science, Genome Research Institute, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0505, USA
    FASEB J 20:466-75. 2006
    ....
  10. ncbi VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma
    Olga Mikhaylova
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    Cancer Cell 21:532-46. 2012
    ..VHL, in addition to inducing endogenous miR-204, triggered the expression of LC3C, an HIF-regulated LC3B paralog, that suppressed tumor growth. These data reveal a function of VHL as a tumor-suppressing regulator of autophagic programs...
  11. ncbi Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons
    Anna S Hui
    Department of Genome Science, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0505, USA
    Hypertension 42:1130-6. 2003
    ..The effects of both types of hypoxia on expression of catecholaminergic enzymes in superior cervical neurons and adrenal glands were transient and small...
  12. ncbi Renal involvement in tuberous sclerosis complex and von Hippel-Lindau disease: shared disease mechanisms?
    Brian J Siroky
    Division of Nephrology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Nat Clin Pract Nephrol 5:143-56. 2009
    ..This Review summarizes the pathophysiologic and therapeutic overlap between tuberous sclerosis complex and von Hippel-Lindau disease and highlights the results of recent drug trials in these settings...
  13. ncbi Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen-sensitive neuroendocrine cells
    Waltke R Paulding
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0576, USA
    Microsc Res Tech 59:178-87. 2002
    ..g., intermittent vs. chronic. Construction of a hypoxia-regulated, CB-specific, subtractive cDNA library will enable us to further characterize regulation of gene expression in the CB...
  14. ncbi Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
    Bu B Yeap
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, University Department of Medicine, University of Western Australia, 50 Murray Street, Perth, WA 6000, Australia
    J Biol Chem 277:27183-92. 2002
    ..The binding of HuR, CP1, and CP2 to AR mRNA suggests a role for each of these proteins in the post-transcriptional regulation of AR expression in cancer cells...

Research Grants21

  1. Role of ubiquitylation in renal cancer
    Maria F Czyzyk Krzeska; Fiscal Year: 2010
    ....
  2. REGULATION OF GENE EXPRESSION BY OXYGEN
    MARIA CZYZYK KRZESKA; Fiscal Year: 2005
    ..An understanding of the physiological role of pVhl in regulation of gene expression during hypoxia will provide much needed information on how O2-sensitive cells respond and adapt to hypoxia. ..
  3. Regulation of Cell Function by Intermittent Hypoxia
    MARIA CZYZYK KRZESKA; Fiscal Year: 2007
    ..3) We will determine the role of proline hydroxylation in Rpb1 ubiquitination by VHL and measure the effects of IH and oxidative stress on proline hydroxylation in brain extracts from exposed animals, and in PC12 cells. ..
  4. Role of ubiquitylation in renal cancer
    MARIA CZYZYK KRZESKA; Fiscal Year: 2007
    ....
  5. Role of ubiquitylation in renal cancer
    MARIA CZYZYK KRZESKA; Fiscal Year: 2009
    ....
  6. REGULATION OF GENE EXPRESSION IN INTERMITTENT HYPOXIA
    MARIA CZYZYK KRZESKA; Fiscal Year: 2003
    ..The findings from this study may provide new insight concerning the role of intermittent hypoxia on regulation of gene expression and possible targets for mediating the pathogenesis of OSA-induced hypertension. ..
  7. POSTTRANSCRIPTIONAL REGULATION--CATECHOLAMINE SYNTHESIS
    MARIA CZYZYK KRZESKA; Fiscal Year: 2000
    ..Such system is necessary to study THE mRNA stability regulation without non- specific transcription blockers and will facilitate future studies of mRNA stability in the transgenic animals. ..