Jason Cyster

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 30:69-94. 2012
  2. doi request reprint B cell follicles and antigen encounters of the third kind
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 11:989-96. 2010
  3. ncbi request reprint Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
  4. ncbi request reprint Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
  5. ncbi request reprint Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
  6. ncbi request reprint Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    Tri Giang Phan
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 8:992-1000. 2007
  7. pmc Integrin-dependence of lymphocyte entry into the splenic white pulp
    Charles G Lo
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:353-61. 2003
  8. ncbi request reprint Imaging of germinal center selection events during affinity maturation
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 315:528-31. 2007
  9. pmc Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
    Kenji Kabashima
    Howard Hughes Medical Institute HHMI and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2683-90. 2006
  10. ncbi request reprint Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 169:424-33. 2002

Research Grants

Detail Information

Publications64

  1. doi request reprint Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 30:69-94. 2012
    ..Finally, we examine current understanding of how FTY720, a drug that targets S1P receptors and is approved for the treatment of multiple sclerosis, causes immune suppression...
  2. doi request reprint B cell follicles and antigen encounters of the third kind
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 11:989-96. 2010
    ..This Review will discuss how these factors work together in the lymph node to ensure efficient and persistent exposure of B cells to diverse forms of antigen and thus effective triggering of the humoral response...
  3. ncbi request reprint Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
    ....
  4. ncbi request reprint Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0414, USA
    Science 309:1735-9. 2005
    ..We conclude that lymphocyte egress is mediated by S1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target...
  5. ncbi request reprint Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  6. ncbi request reprint Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    Tri Giang Phan
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 8:992-1000. 2007
    ....
  7. pmc Integrin-dependence of lymphocyte entry into the splenic white pulp
    Charles G Lo
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:353-61. 2003
    ..These observations suggest that chemokine receptor signaling and the integrins LFA-1 and alpha 4 beta 1 function together to promote lymphocyte transit from the marginal zone into white pulp cords...
  8. ncbi request reprint Imaging of germinal center selection events during affinity maturation
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 315:528-31. 2007
    ..On the basis of these observations, we propose a model in which competition for T cell help plays a more dominant role in the selection of GC B cells than previously appreciated...
  9. pmc Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
    Kenji Kabashima
    Howard Hughes Medical Institute HHMI and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2683-90. 2006
    ....
  10. ncbi request reprint Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 169:424-33. 2002
    ....
  11. pmc T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
    Craig N Jenne
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:2469-81. 2009
    ..In summary, these findings identify S1P5 as a T-bet-induced gene that is required for NK cell egress from LNs and BM...
  12. ncbi request reprint Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    Rajita Pappu
    Cardiovascular Research Institute, University of California, San Francisco, 600 16th Street S472D, San Francisco, CA 94143 2240, USA
    Science 316:295-8. 2007
    ..Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives...
  13. ncbi request reprint Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 5:943-52. 2004
    ..In contrast, CXCR5 helped direct cells to the light zone and deficiency in CXCL13 was associated with aberrant light zone localization...
  14. ncbi request reprint Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells
    Eric H Ekland
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 172:4700-8. 2004
    ..These findings characterize the mechanism for follicular exclusion of autoantigen-binding B cells and they indicate that B cells compete for survival by mechanisms that are separate from competition for the follicular niche...
  15. ncbi request reprint Finding a way out: lymphocyte egress from lymphoid organs
    Susan R Schwab
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 8:1295-301. 2007
    ..In this review we discuss the body of evidence supporting a model in which lymphocyte egress is promoted by encounter with S1P at exit sites. We relate this model to work examining the effects of S1P receptor agonists on endothelium...
  16. pmc Follicular shuttling of marginal zone B cells facilitates antigen transport
    Guy Cinamon
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    Nat Immunol 9:54-62. 2008
    ..Marginal zone-follicle shuttling of marginal zone B cells provides an efficient mechanism for systemic antigen capture and delivery to follicular dendritic cells...
  17. pmc Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
    Marcus A Zachariah
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, HSE1001, San Francisco, CA 94143, USA
    Science 328:1129-35. 2010
    ..Lymphatic endothelial cell-derived S1P was not required. These studies identify the major thymic egress route and suggest a role for pericytes in promoting reverse transmigration of cells across blood vessel endothelium...
  18. ncbi request reprint Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
    Karin Reif
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 416:94-9. 2002
    ..These findings define the mechanism of B-cell relocalization in response to antigen, and establish that cell position in vivo can be determined by the balance of responsiveness to chemoattractants made in separate but adjacent zones...
  19. pmc Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    Trung H M Pham
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:17-27. 2010
    ..Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and suggest a role for S1P in lymphatic vessel maturation...
  20. ncbi request reprint Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
    Guy Cinamon
    Howard Hughes Medical Institute, Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nat Immunol 5:713-20. 2004
    ..These data suggest that marginal zone B cell localization to the marginal zone depends on responsiveness to the blood lysophospholipid S1P, with S1P(1) signaling overcoming the recruiting activity of CXCL13...
  21. pmc Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells
    Irina L Grigorova
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 10:58-65. 2009
    ....
  22. ncbi request reprint Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells
    Kenji Kabashima
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Immunity 22:439-50. 2005
    ..We conclude that LT alpha 1 bet a2 acts on DCs or DC precursors to promote DC homeostasis, and we suggest that DC proliferation is an important pathway for locally maintaining these cells in the steady state...
  23. pmc Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit
    Charles G Lo
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 201:291-301. 2005
    ..We propose that cyclical ligand-induced modulation of S1P(1) on circulating lymphocytes contributes to establishing their lymphoid organ transit time...
  24. ncbi request reprint CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node
    Takaharu Okada
    Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 178:2973-8. 2007
    ..These results reveal a role for CCR7 in promoting T cell migration within lymphoid organ T zones, and they suggest the additional involvement of novel Gi-coupled receptors in promoting T cell motility at these sites...
  25. pmc S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress
    Trung H M Pham
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Immunity 28:122-33. 2008
    ..Furthermore, by simultaneously upregulating S1P1 and downregulating CCR7, T cells that have divided multiple times switch to a state favoring egress over retention...
  26. pmc Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses
    João Pedro Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Int Immunol 22:413-9. 2010
    ..In this review, we discuss current understanding of the roles played by chemokines, S1P and EBI2 in the migration events that underlie humoral immune responses...
  27. pmc Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
    Joao P Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:403-11. 2009
    ..Our findings identify unique requirements for the retention of B cells in the bone marrow sinusoidal niche and suggest involvement of CB2 in the generation of the B cell repertoire...
  28. ncbi request reprint Specifying the patterns of immune cell migration
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Novartis Found Symp 281:54-61; discussion 61-4, 208-9. 2007
    ..We have recently identified CD69 as a regulator of SIP1 and controller of lymphocyte egress. Current molecular understanding of the lymphocyte egress process will be discussed...
  29. pmc Germinal-center organization and cellular dynamics
    Christopher D C Allen
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    Immunity 27:190-202. 2007
    ....
  30. pmc Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function
    Christopher D C Allen
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, 513 Parnassus Avenue, Box 0414, University of California, San Francisco, CA 94143 0414, USA
    Semin Immunol 20:14-25. 2008
    ..We will then discuss current understanding of how they help support the B cell immune response...
  31. pmc A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow
    João Pedro Pereira
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e9277. 2010
    ..We conclude that the S1P1-S1P pathway contributes to egress of immature-B cells from BM, and that this mechanism is partially redundant with other undefined pathways...
  32. pmc CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4
    Alexander J Bankovich
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    J Biol Chem 285:22328-37. 2010
    ....
  33. ncbi request reprint CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 440:540-4. 2006
    ..These observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream of IFN-alpha/beta, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs...
  34. ncbi request reprint Lymphoid organ development and cell migration
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Immunol Rev 195:5-14. 2003
    ....
  35. ncbi request reprint CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
    Wendy Peters
    Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141, USA
    J Immunol 172:7647-53. 2004
    ..Further investigation revealed a critical role for CCR2 in the recruitment of F4/80(dim) macrophages and CD11c(dim/intermediate) DCs to the infected lung...
  36. ncbi request reprint Homing of antibody secreting cells
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Immunol Rev 194:48-60. 2003
    ..The function of CCR9 and CCR10 in IgA ASC homing and contributions made by integrins and lectins are also discussed...
  37. ncbi request reprint Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
    Karin Reif
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 173:2236-40. 2004
    ..These observations establish that p110gamma and p110delta function in lymphocyte chemotaxis, and show differential roles for PI3K family members in B and T cell migration...
  38. ncbi request reprint Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    Jason G Cyster
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:127-59. 2005
    ..Here, we review the steps associated with the initiation of adaptive immune responses in secondary lymphoid organs, highlighting the roles of chemokines and S1P...
  39. ncbi request reprint CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity
    K Mark Ansel
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Immunity 16:67-76. 2002
    ..These findings provide insight into the mechanism of B1 cell homing and establish a critical role for B1 cell compartmentalization in the production of natural antibodies and for body cavity immunity...
  40. ncbi request reprint Integrin-mediated long-term B cell retention in the splenic marginal zone
    Theresa T Lu
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 297:409-12. 2002
    ..These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization...
  41. ncbi request reprint B cell migration and interactions in the early phase of antibody responses
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Curr Opin Immunol 18:278-85. 2006
    ..Taken together, these studies have provided a more detailed map of the steps involved in B cell migration to encounter antigen and helper T cells early during the adaptive immune response...
  42. pmc Chemokine requirements for B cell entry to lymph nodes and Peyer's patches
    Takaharu Okada
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 196:65-75. 2002
    ..These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches...
  43. pmc Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    Sanjiv A Luther
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    J Exp Med 197:1191-8. 2003
    ..These findings indicate that CXCL13 and CCR7 ligands promote accumulation of CD4+ CD3- IL-7R alpha hi cells, delivering IL-7R alpha-dependent LT alpha 1 beta 2 signals critical for LN development...
  44. pmc The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 9:1307-15. 2008
    ....
  45. pmc EBI2 mediates B cell segregation between the outer and centre follicle
    Joao P Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, California 94143, USA
    Nature 460:1122-6. 2009
    ....
  46. ncbi request reprint Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    Robin Lesley
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 USA
    Immunity 20:441-53. 2004
    ..These findings indicate that under conditions where BAFF levels are elevated, autoantigen-engaged cells will be rescued from rapid competitive elimination, predisposing to the development of autoimmune disease...
  47. pmc Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells
    Takaharu Okada
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, California, USA
    PLoS Biol 3:e150. 2005
    ..These findings provide evidence of lymphocyte chemotaxis in vivo, and they begin to define the spatiotemporal cellular dynamics associated with T cell-dependent antibody responses...
  48. pmc Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope
    Annette Bistrup
    Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Am J Pathol 164:1635-44. 2004
    ..Analysis of the progeny of RIP-BLC by HEC-GlcNAc6ST-null mice establishes that the enzyme is responsible for the MECA-79 defined luminal ligands...
  49. pmc Chemorepulsion and thymocyte emigration
    Jason G Cyster
    Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0414, USA
    J Clin Invest 109:1011-2. 2002
  50. pmc A p38 MAPK-MEF2C pathway regulates B-cell proliferation
    Dustin Khiem
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 105:17067-72. 2008
    ..p38 directly phosphorylates MEF2C via three residues in the C-terminal transactivation domain, establishing MEF2C as a direct transcriptional effector of BCR signaling via p38 MAPK...
  51. pmc Visualizing B cell capture of cognate antigen from follicular dendritic cells
    Kazuhiro Suzuki
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:1485-93. 2009
    ....
  52. ncbi request reprint The CDM protein DOCK2 in lymphocyte migration
    Karin Reif
    Howard Hughes Medical Institute, Dept of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Trends Cell Biol 12:368-73. 2002
    ..Here, we review the role of DOCK2 in lymphocyte homing to lymphoid tissues and discuss recent findings for other CDM family molecules that provide a basis for understanding how DOCK2 might function in lymphocytes...
  53. pmc TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    Thomas T Chen
    Veterans Administration Medical Center, San Francisco, CA 94121, USA
    J Exp Med 202:955-65. 2005
    ..This is the first identification of a receptor for ferritin and reveals a new role for TIM-2...
  54. pmc Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion
    Lawrence R Shiow
    Biomedical Sciences Graduate Program, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0519, USA
    Clin Immunol 131:24-30. 2009
    ..This case highlights the first link between actin cytoskeleton regulation and SCID...
  55. pmc Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
    Robin Lesley
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143 7242, USA
    Proc Natl Acad Sci U S A 103:10717-22. 2006
    ..We propose that constitutive CD40L expression by naive CD4 T cells influences the composition of the B cell repertoire and may also affect the homeostasis of other cell types such as regulatory T cells in lymphoid organs...
  56. pmc Visualization of the genesis and fate of isotype-switched B cells during a primary immune response
    Kathryn A Pape
    Department of Microbiology and Center for Immunology, University of Minnesota Medical School, MMC334, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Exp Med 197:1677-87. 2003
    ..Antigen-experienced IgM B cells were rarely found in GCs, indicating that these cells switched rapidly after entering GCs or did not persist in this environment...
  57. ncbi request reprint Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces
    Eilon Woolf
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Immunol 8:1076-85. 2007
    ..Thus, lymph node chemokines that promote motility and strongly activate lymphocyte integrins under shear forces fail to stimulate stable integrin adhesiveness in extravascular shear-free environments...
  58. ncbi request reprint Traffic patterns of B cells and plasma cells
    Jason G Cyster
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Adv Exp Med Biol 512:35-41. 2002
  59. ncbi request reprint FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
    Volker Brinkmann
    Transplantation and Immunology, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Am J Transplant 4:1019-25. 2004
    ..The available data establish S1P(1) as a key target for FTY720, and further point to therapeutically relevant effects of the drug on lymphocytes and vascular endothelium...
  60. ncbi request reprint Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice
    Karlee Silver
    Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK
    Eur J Immunol 36:2920-7. 2006
    ..Under these circumstances, spontaneous activation of hyperactive B cells leads to isotype switching and the development of high titres of IgG autoantibodies against intracellular proteins...
  61. ncbi request reprint Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13
    Tom Cupedo
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 173:4889-96. 2004
    ....
  62. ncbi request reprint Overview of the Alliance for Cellular Signaling
    Alfred G Gilman
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 420:703-6. 2002
    ..One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community...
  63. ncbi request reprint Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
    Alexander Link
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Nat Immunol 8:1255-65. 2007
    ..Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors...
  64. ncbi request reprint Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...

Research Grants22

  1. Beta Lymphocyte Migration and Homeostasis
    Jason Cyster; Fiscal Year: 2007
    ..abstract_text> ..
  2. Chemokines and Lymphoid Tissue Organization and Function
    Jason Cyster; Fiscal Year: 2007
    ..abstract_text> ..
  3. Cellular and Genetic Analysis of Lymphocyte Egress
    Jason Cyster; Fiscal Year: 2007
    ..The information obtained through these studies should point to new targets for the development of immunomodulatory molecules. ..
  4. Chemokines and Lymphoid Tissue Organization and Function
    Jason Cyster; Fiscal Year: 2009
    ....
  5. Chemokines and Lymphoid Tissue Organization and Function
    Jason G Cyster; Fiscal Year: 2010
    ....
  6. B LYMPHOCYTE MIGRATION AND HOMEOSTASIS
    Jason Cyster; Fiscal Year: 2001
    ..As well as improving our understanding of normal B-cell function, these studies are likely to provide important insight into defects in B-cell trafficking and homeostasis that contribute to autoimmunity or immunodeficiency. ..
  7. BLC AND BLR1 AND IMMUNE FUNCTION AND DYSFUNCTION
    Jason Cyster; Fiscal Year: 2003
    ....
  8. Cellular and Genetic Analysis of Lymphocyte Egress
    Jason G Cyster; Fiscal Year: 2010
    ..The information obtained through these studies should point to new targets for the development of immunomodulatory molecules. ..