Jason Cyster

Summary

Affiliation: University of California
Country: USA

Publications

  1. Cyster J, Allen C. B Cell Responses: Cell Interaction Dynamics and Decisions. Cell. 2019;177:524-540 pubmed publisher
  2. Lu E, Wolfreys F, Muppidi J, Xu Y, Cyster J. S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Nature. 2019;: pubmed publisher
    ..As the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, we speculate that GGG might have organizing and growth-regulatory roles in multiple human tissues. ..
  3. Dang E, Cyster J. Loss of sterol metabolic homeostasis triggers inflammasomes - how and why. Curr Opin Immunol. 2019;56:1-9 pubmed publisher
    ..We also discuss new mechanisms that show how macrophage cholesterol buildup can lead to inflammasome activation. ..
  4. Wu J, Wu H, An J, Ballantyne C, Cyster J. Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity. Proc Natl Acad Sci U S A. 2018;115:6786-6791 pubmed publisher
    ..These findings establish a critical role for CD11c in DC antigen uptake and activation in vivo. They may also contribute to understanding the functional mechanism of CD47-blockade therapies. ..
  5. Rodda L, Lu E, Bennett M, Sokol C, Wang X, Luther S, et al. Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity. Immunity. 2018;48:1014-1028.e6 pubmed publisher
    ..These data help define how transcriptionally distinct LN SCs support niche-restricted immune functions and provide evidence that many SCs are in an activated state. ..
  6. Rodda L, Bannard O, Ludewig B, Nagasawa T, Cyster J. Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol. 2015;195:4781-91 pubmed publisher
    ..Our findings establish CRCs as a major stromal cell type in the GC DZ and suggest that CRCs support critical activities of GC B cells in the DZ niche through Cxcl12 expression and direct cell-cell interactions. ..
  7. Cyster J. Germinal Centers: Gaining Strength from the Dark Side. Immunity. 2015;43:1026-8 pubmed publisher
    ..Two studies in this issue (Dominguez-Sola et al., 2015; Sander et al., 2015) report that Foxo1 deficiency causes an almost complete loss of dark zone cells and an inability to undergo robust antibody affinity maturation. ..
  8. Bannard O, Cyster J. Germinal centers: programmed for affinity maturation and antibody diversification. Curr Opin Immunol. 2017;45:21-30 pubmed publisher
    ..We discuss current understanding of how germinal centers are programmed to support both affinity maturation and antibody diversification. ..
  9. Yi T, Li J, Chen H, Wu J, An J, Xu Y, et al. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015;43:764-75 pubmed publisher

More Information

Publications20

  1. Muppidi J, Lu E, Cyster J. The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. J Exp Med. 2015;212:2213-22 pubmed publisher
  2. Cyster J. B cell follicles and antigen encounters of the third kind. Nat Immunol. 2010;11:989-96 pubmed publisher
    ..This Review will discuss how these factors work together in the lymph node to ensure efficient and persistent exposure of B cells to diverse forms of antigen and thus effective triggering of the humoral response. ..
  3. Laidlaw B, Cyster J. Interfer'n with antibody responses. Sci Immunol. 2016;1: pubmed publisher
    ..Type I interferon blocks the generation of neutralizing antibodies in response to chronic infection. ..
  4. Dang E, McDonald J, Russell D, Cyster J. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017;171:1057-1071.e11 pubmed publisher
    ..Therefore, activated macrophages utilize 25-HC in an anti-inflammatory circuit that maintains mitochondrial integrity and prevents spurious AIM2 inflammasome activation. ..
  5. Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster J. GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage. Sci Immunol. 2017;2: pubmed publisher
    ..These findings identify a migration-inhibitory receptor that restrains IEL-epithelial cell cross-talk and show that antagonism of this receptor can protect from intestinal barrier dysfunction. ..
  6. Laidlaw B, Schmidt T, Green J, Allen C, Okada T, Cyster J. The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells. J Exp Med. 2017;214:639-649 pubmed publisher
    ..These findings offer insight into the significant heterogeneity that exists within the GC B cell population and provide tools to further dissect signals regulating the differentiation of GC B cells. ..
  7. Lu E, Dang E, McDonald J, Cyster J. Distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen. Sci Immunol. 2017;2: pubmed publisher
    ..This work indicates that 7α,27-HC functions as a guidance cue in vivo and reveals a multitiered role for EBI2 in DC positioning. Deficiency in this organizing system results in defective CD4+ T cell responses. ..
  8. Ramírez Valle F, Gray E, Cyster J. Inflammation induces dermal Vγ4+ γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A. 2015;112:8046-51 pubmed publisher
  9. Barnes M, Li C, Xu Y, An J, Huang Y, Cyster J. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med. 2015;212:1011-20 pubmed publisher
    ..As such, GPR174 antagonists might have therapeutic potential for promoting immune regulation in the context of autoimmune disease. ..
  10. Wang X, Sumida H, Cyster J. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014;211:2351-9 pubmed publisher
    ..These findings establish a requirement for GPR18 in CD8αα and CD8αβ IELs, and we suggest the receptor has a role in augmenting the accumulation of CD8 T cells in the intraepithelial versus lamina propria compartment. ..
  11. Reboldi A, Dang E, McDonald J, Liang G, Russell D, Cyster J. Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science. 2014;345:679-84 pubmed publisher
    ..These findings identify an oxysterol, 25-HC, as a critical mediator in the negative-feedback pathway of IFN signaling on IL-1 family cytokine production and inflammasome activity...