K R Cutroneo

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Comparison and evaluation of gene therapy and epigenetic approaches for wound healing
    K R Cutroneo
    Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA
    Wound Repair Regen 8:494-502. 2000
  2. ncbi request reprint Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 211:585-9. 2007
  3. ncbi request reprint Phenotypic expression of human hepatoma cells in culture
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 100:1081-5. 2007
  4. ncbi request reprint Silencing or knocking out eukaryotic gene expression by oligodeoxynucleotide decoys
    Kenneth R Cutroneo
    Department of Biochemistry, University of Vermont, College of Medicine, 89 Beaumont Avenue, Burlington, 05405, USA
    Crit Rev Eukaryot Gene Expr 16:23-30. 2006
  5. ncbi request reprint Tissue fibrosis and carcinogenesis: divergent or successive pathways dictate multiple molecular therapeutic targets for oligo decoy therapies
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 97:1161-74. 2006
  6. ncbi request reprint How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics?
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine and the Cell and Molecular Biology Program, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 92:6-15. 2004
  7. ncbi request reprint How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis
    Kenneth R Cutroneo
    College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 90:1-5. 2003
  8. ncbi request reprint TGF-beta1-induced Smad 3 binding to the Smad 7 gene: knockout of Smad 7 gene transcription by sense phosphorothioate oligos, autoregulation, and effect on TGF-beta1 secretion: bleomycin acts through TGF-beta1
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 89:474-83. 2003
  9. ncbi request reprint Gene therapy for tissue regeneration
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 88:418-25. 2003
  10. ncbi request reprint Human SP1 but not human AP1 binding to the TGF-beta element in the 5' flanking region of the rat PROalpha1(I) collagen gene
    K R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405, USA
    Mol Biol Rep 27:191-4. 2000

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Comparison and evaluation of gene therapy and epigenetic approaches for wound healing
    K R Cutroneo
    Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA
    Wound Repair Regen 8:494-502. 2000
    ..Both genetic and epigenetic approaches for regulating the wound healing process, either normal or aberrant wound healing, have certain advantages and disadvantages which are discussed in the present article...
  2. ncbi request reprint Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 211:585-9. 2007
    ..Lung fibroblasts exist as subpopulations with one subset predominantly responding to fibrogenic stimuli which could be a specific cell therapeutic target for the onset and development of pulmonary fibrosis...
  3. ncbi request reprint Phenotypic expression of human hepatoma cells in culture
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 100:1081-5. 2007
    ..Our positive results affords an in vitro model system to test hypoxia inhibitors on the expression and the intracellular compartmentalization or the secretion of these hypoxia-inducible proteins...
  4. ncbi request reprint Silencing or knocking out eukaryotic gene expression by oligodeoxynucleotide decoys
    Kenneth R Cutroneo
    Department of Biochemistry, University of Vermont, College of Medicine, 89 Beaumont Avenue, Burlington, 05405, USA
    Crit Rev Eukaryot Gene Expr 16:23-30. 2006
    ..The rest of the genes in the cluster contain the cis-elements homologous to this consensus element, which allows for dsODN decoy regulation of a gene cluster at one time...
  5. ncbi request reprint Tissue fibrosis and carcinogenesis: divergent or successive pathways dictate multiple molecular therapeutic targets for oligo decoy therapies
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 97:1161-74. 2006
    ..How can oligo decoys may be used to attenuate carcinogenesis and which oligo decoys specifically attenuate fibrogenesis as a prelude to carcinogenesis? What are other molecular targets for oligo decoy therapy in carcinogenesis?..
  6. ncbi request reprint How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics?
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine and the Cell and Molecular Biology Program, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 92:6-15. 2004
    ....
  7. ncbi request reprint How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis
    Kenneth R Cutroneo
    College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 90:1-5. 2003
    ....
  8. ncbi request reprint TGF-beta1-induced Smad 3 binding to the Smad 7 gene: knockout of Smad 7 gene transcription by sense phosphorothioate oligos, autoregulation, and effect on TGF-beta1 secretion: bleomycin acts through TGF-beta1
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 89:474-83. 2003
    ....
  9. ncbi request reprint Gene therapy for tissue regeneration
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Cell Biochem 88:418-25. 2003
    ..Fibrosis is an abnormal response to tissue injury...
  10. ncbi request reprint Human SP1 but not human AP1 binding to the TGF-beta element in the 5' flanking region of the rat PROalpha1(I) collagen gene
    K R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405, USA
    Mol Biol Rep 27:191-4. 2000
    ....
  11. ncbi request reprint Relationship between glucocorticoid-mediated early decrease of protein synthesis and the steady state decreases of glucocorticoid receptor and TGF-beta activator protein
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Int J Biochem Cell Biol 34:194-203. 2002
    ....
  12. ncbi request reprint Rational basis for oligodeoxynucleotides to inhibit collagen synthesis in lung fibroblasts and primary fibroblasts from liver granulomas of Schistosoma mansoni-infected mice
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Cancer Lett 180:145-51. 2002
    ..TGF-beta element containing single-stranded phosphorothioate oligodeoxynucleotides and their double-stranded counterparts may be successful therapeutic agents to inhibit hepatic fibrogenesis and associated hepatocellular carcinoma...
  13. ncbi request reprint Sense oligonucleotide competition for gene promoter binding and activation
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT 05405 0068, USA
    Int J Biochem Cell Biol 35:32-8. 2003
    ..The oligonucleotide approaches, both antisense and sense therapies, may be used to regulate over-expression of growth factors and thereby either eliminate or lessen the potential adverse effects of gene therapy...
  14. ncbi request reprint Evidence for TGF-beta1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, 89 Beaumont Avenue, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Biochem 97:933-9. 2006
    ....
  15. pmc Tissue stretch decreases soluble TGF-beta1 and type-1 procollagen in mouse subcutaneous connective tissue: evidence from ex vivo and in vivo models
    Nicole A Bouffard
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 214:389-95. 2008
    ..These results have potential relevance to the mechanisms of treatments applying brief mechanical stretch to tissues (e.g., physical therapy, respiratory therapy, mechanical ventilation, massage, yoga, acupuncture)...
  16. ncbi request reprint TGF-beta-induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarring
    Kenneth R Cutroneo
    Department of Biochemistry, College of Medicine, University of Vermont, Burlington, Vermont, USA
    Wound Repair Regen 15:S54-60. 2007
    ..In this review, we will specifically ask if TGF-beta-induced collagen synthesis is inhibited in cell culture and in vivo by using the double-stranded oligodeoxynucleotide decoys, will this inhibit fibrogenesis and ultimately scarring?..
  17. ncbi request reprint Oligodeoxynucleotide decoy therapy blocks type 1 procollagen transcription and the prolyl hydroxylase beta subunit translation
    Chun Nam Lok
    Department of Anatomy, Hong Kong University, Peoples Republic of China
    J Cell Biochem 103:1066-75. 2008
    ..These findings taken together support the notion that the dsdecoy inhibits type 1 collagen synthesis at both the transcriptional and translational levels...
  18. ncbi request reprint Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis
    Kenneth M Sterling
    Dartmouth College, Department of Physics and Astronomy, 6127 Wilder Laboratory, Hanover, New Hampshire 03755 3528, USA
    J Cell Biochem 86:440-50. 2002
    ....