Research Topics
Species | M CushmanSummaryAffiliation: University of Vermont Country: USA Publications
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Detail Information
Publications
The association of vitamin K status with warfarin sensitivity at the onset of treatmentM Cushman
Department of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
Br J Haematol 112:572-7. 2001..05). We concluded that dietary and biochemical measures of vitamin K status were associated with early warfarin sensitivity...- Post-menopausal hormone therapy and concentrations of protein C and antithrombin in elderly womenM Cushman
Department of Medicine, University of Vermont, Burlington, VT, USA
Br J Haematol 114:162-8. 2001..This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT-induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required... - Hormone replacement therapy, inflammation, and hemostasis in elderly womenM Cushman
Departments of Medicine, University of Vermont, Burlington, USA
Arterioscler Thromb Vasc Biol 19:893-9. 1999..Associations with hemostasis markers indicated no association with evidence of procoagulation and a possible association with increased fibrinolytic activity... - Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) StudyM Cushman
Departments of Medicine, and Biochemistry, University of Vermont, Burlington, VT 05446, USA
Circulation 100:717-22. 1999..Because higher levels of inflammation factors predict vascular disease outcomes, the effect of hormones on these factors is of interest... - Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion ProjectR P Tracy
University of Vermont, Colchester 05446, USA
Arterioscler Thromb Vasc Biol 17:1121-7. 1997..7 (CI = 1.10 to 6.60). In conclusion, CRP was associated with incident events in the elderly, especially in those with subclinical disease at baseline... - Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health StudyN A Zakai
Department of Medicine, Brown University and Boston University, Providence, RI, USA
J Thromb Haemost 5:1128-35. 2007..There are few studies of inflammation and hemostasis biomarkers and cardiovascular disease risk (CVD) in older adults... - Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjectsR P Tracy
Department of Pathology and Biochemistry, University of Vermont, Colchester 05446, USA
Arterioscler Thromb Vasc Biol 17:2167-76. 1997..Moreover, exposure to smoking affects the relation of CRP to these other factors... - Tamoxifen and cardiac risk factors in healthy women: Suggestion of an anti-inflammatory effectM Cushman
Department of Medicine and Pathology, University of Vermont, Burlington 05446, USA
Arterioscler Thromb Vasc Biol 21:255-61. 2001..These findings are in contrast to recent reports of increased C-reactive protein associated with postmenopausal estrogen. The potential for beneficial cardiovascular effects of tamoxifen in healthy women is suggested... 
Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosisD Vaidya
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Eur J Clin Nutr 65:818-25. 2011..We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress...- Risk factors for peripheral venous disease resemble those for venous thrombosis: the San Diego Population StudyM Cushman
Department of Medicine, University of Vermont, Burlington, VT, USA
J Thromb Haemost 8:1730-5. 2010..Clinically silent deep vein thrombosis (DVT) is common and may cause chronic venous disease that resembles post-thrombotic syndrome... - Evaluation of very low-dose subcutaneous vitamin K during postoperative warfarin therapyC J Possidente
Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont, USA
Pharmacotherapy 21:295-300. 2001..Investigations in other populations and assessment of the effect of low-dose SCVK on postoperative bleeding are indicated... - Effects of estrogen and selective estrogen receptor modulators on hemostasis and inflammation: potential differences among drugsM Cushman
Department of Medicine, University of Vermont, Colchester 05446, USA
Ann N Y Acad Sci 949:175-80. 2001..From the vascular perspective, future studies need to focus on interactions of treatment with these biochemical parameters and their genetic correlates in order to define low- or high-risk subgroups for intervention with these therapies... - Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health StudyN A Zakai
Department of Medicine, University of Vermont, Burlington, VT, USA
J Thromb Haemost 9:267-74. 2011..Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are inconclusive... - Plasma concentration of C-reactive protein and risk of developing peripheral vascular diseaseP M Ridker
Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
Circulation 97:425-8. 1998..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown... - Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trialM Cushman
Department of Medicine, University of Vermont, Burlington, VT 05446, USA
J Thromb Haemost 4:2199-203. 2006..In some but not all studies, men with venous thrombosis had a higher risk of recurrence than women. Information on women with initial hormone-related thrombosis is scant... - Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature)A C Andreescu
Department of Medicine, University of Vermont, Burlington 05401, USA
J Thromb Thrombolysis 11:33-7. 2001..To our knowledge this case represents the longest reported use of subcutaneous lepirudin... - Tissue factor pathway inhibitor, vascular risk factors and subclinical atherosclerosis: the Multi-Ethnic Study of AtherosclerosisC T Mitchell
Department of Medicine, University of Vermont, Burlington, VT 05446, USA
Atherosclerosis 207:277-83. 2009..Tissue factor pathway inhibitor (TFPI) is an endothelial membrane-associated anticoagulant protein. Higher circulating levels might reflect endothelial damage... 
Venous thrombosis risk assessment in medical inpatients: the medical inpatients and thrombosis (MITH) studyN A Zakai
University of Vermont College of Medicine and Fletcher Allen Health Care, Colchester, VT, USA
J Thromb Haemost 11:634-41. 2013..We sought to define the risk factors present at admission for venous thromboembolism (VTE) in medical inpatients and develop a risk model for clinical use...- Subclinical atherosclerosis and the risk of future venous thrombosis in the Cardiovascular Health StudyP B van der Hagen
Department of Medicine, University of Vermont, Burlington, 05446, USA
J Thromb Haemost 4:1903-8. 2006..Carotid plaques and arterial events during follow up were inversely associated, a finding that requires further study... - Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health StudyD W Kitzman
Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA
Am J Cardiol 87:413-9. 2001..The finding that a large proportion of elderly with CHF have preserved LV systolic function is important because there is a paucity of data to guide management in this dominant subset... - Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk scoreN A Zakai
Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT 05446, USA
J Thromb Haemost 2:2156-61. 2004..Only one of three published risk scores was associated with risk of inpatient VT. Future study should improve upon risk prediction models for in-hospital VT among medical patients... - D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolismS Shrivastava
Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA
J Thromb Haemost 4:1208-14. 2006..CONCLUSIONS: Among patients with idiopathic VTE, measurement of D-dimer, but not FVIIIc, might be useful for risk stratification. The efficacy of extended low-intensity warfarin therapy did not vary by biomarker level... - Prospective study of subclinical atherosclerosis as a risk factor for venous thromboembolismL M Reich
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, 55454-1015, USA
J Thromb Haemost 4:1909-13. 2006..72-1.29. CONCLUSION: Increased carotid IMT or presence of carotid plaque was not associated with an increased incidence of VTE in this middle-aged cohort, suggesting subclinical atherosclerosis itself is not a VTE risk factor... - Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE StudyN Aleksic
Division of Hematology, University of Texas Medical School, Houston, TX 77030, USA
J Thromb Haemost 1:88-94. 2003..There were no associations of age-adjusted sTM or TMA455V genotype with overall venous thromboembolism or with thrombosis in any subtype of venous thromboembolism... - Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collabS Kaptoge
Am J Epidemiol 166:867-79. 2007..These findings substantially advance understanding of the correlates and possible determinants of fibrinogen levels... - Factor VII coagulant activity, factor VII -670A/C and -402G/A polymorphisms, and risk of venous thromboembolismA R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
J Thromb Haemost 5:1674-8. 2007..Our Longitudinal Investigation of Thromboembolism Etiology (LITE) had, in contrast, reported an independent, increased risk of VTE after 7.8 years of follow-up for those with high baseline levels of FVII:C... - ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE)T Ohira
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
J Thromb Haemost 5:1455-61. 2007..Numerous case-control studies have reported higher prevalence of non-O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established... - Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: the MESA studyP L Lutsey
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA
J Thromb Haemost 4:2629-35. 2006..No soluble thrombomodulin differences were observed. CONCLUSIONS: In this large cohort, hemostatic factor and endothelial marker mean levels varied by race/ethnicity, even after adjustment for traditional CVD risk factors... - Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysisJohn Danesh
Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
JAMA 294:1799-809. 2005..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...