M Cushman

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis
    Ruth Dubin
    Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    BMC Nephrol 12:3. 2011
  2. ncbi Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    BMC Nephrol 9:9. 2008
  3. ncbi The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
  4. ncbi Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, USA
    Am J Med 117:19-25. 2004
  5. ncbi Effect of tamoxifen on venous thrombosis risk factors in women without cancer: the Breast Cancer Prevention Trial
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Br J Haematol 120:109-16. 2003
  6. ncbi Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US
    Mary Cushman
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT, USA
    Clin Chem 55:1627-36. 2009
  7. ncbi Risk factors for peripheral venous disease resemble those for venous thrombosis: the San Diego Population Study
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 8:1730-5. 2010
  8. ncbi Eligibility for statin therapy by the JUPITER trial criteria and subsequent mortality
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Am J Cardiol 105:77-81. 2010
  9. ncbi Fibrin fragment D-dimer and the risk of future venous thrombosis
    Mary Cushman
    Laboratory for Clinical Biochemistry Research and Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Blood 101:1243-8. 2003
  10. ncbi Epidemiology and risk factors for venous thrombosis
    Mary Cushman
    Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT, USA
    Semin Hematol 44:62-9. 2007

Research Grants

  1. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2007

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosis
    Ruth Dubin
    Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    BMC Nephrol 12:3. 2011
    ..73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that reduced kidney function would be characterized by abnormalities of hemostasis...
  2. ncbi Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    BMC Nephrol 9:9. 2008
    ..Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort...
  3. ncbi The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
    ....
  4. ncbi Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, USA
    Am J Med 117:19-25. 2004
    ..To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States...
  5. ncbi Effect of tamoxifen on venous thrombosis risk factors in women without cancer: the Breast Cancer Prevention Trial
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Br J Haematol 120:109-16. 2003
    ..Reductions of antithrombin and protein S, but not protein C or APC resistance, might relate to the increased risk of venous thrombosis associated with tamoxifen treatment...
  6. ncbi Implications of increased C-reactive protein for cardiovascular risk stratification in black and white men and women in the US
    Mary Cushman
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT, USA
    Clin Chem 55:1627-36. 2009
    ..We evaluated prevalence and correlates of increased high-sensitivity C-reactive protein (hsCRP) in a large population of blacks and whites, and the impact of hsCRP measurement on coronary heart disease risk reclassification...
  7. ncbi Risk factors for peripheral venous disease resemble those for venous thrombosis: the San Diego Population Study
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 8:1730-5. 2010
    ..Clinically silent deep vein thrombosis (DVT) is common and may cause chronic venous disease that resembles post-thrombotic syndrome...
  8. ncbi Eligibility for statin therapy by the JUPITER trial criteria and subsequent mortality
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Am J Cardiol 105:77-81. 2010
    ..5 (95% confidence interval 1.1 to 2.2) for total mortality. In conclusion, 21% not otherwise eligible would be newly eligible for lipid lowering treatment on the basis of JUPITER trial eligibility...
  9. ncbi Fibrin fragment D-dimer and the risk of future venous thrombosis
    Mary Cushman
    Laboratory for Clinical Biochemistry Research and Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Blood 101:1243-8. 2003
    ..D-dimer is strongly and positively related to the occurrence of future venous thrombosis...
  10. ncbi Epidemiology and risk factors for venous thrombosis
    Mary Cushman
    Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT, USA
    Semin Hematol 44:62-9. 2007
    ..This review focuses on epidemiology of venous thrombosis and the general implications of this in patient management...
  11. ncbi Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Haemost 4:2199-203. 2006
    ..In some but not all studies, men with venous thrombosis had a higher risk of recurrence than women. Information on women with initial hormone-related thrombosis is scant...
  12. ncbi C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Circulation 112:25-31. 2005
    ..High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available...
  13. ncbi Associations of the beta-fibrinogen Hae III and factor XIII Val34Leu gene variants with venous thrombosis
    Mary Cushman
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05446, USA
    Thromb Res 121:339-45. 2007
    ..The factor XIII Val34Leu (100 G-->T) and beta-fibrinogen Hae III (-455 G-->A) gene variants have been associated with reduced risk of venous thrombosis, but not in all studies...
  14. ncbi Estrogen plus progestin and risk of venous thrombosis
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington 05446, USA
    JAMA 292:1573-80. 2004
    ..Postmenopausal hormone therapy increases the risk of venous thrombosis. It is not known whether other factors influencing thrombosis add to this risk...
  15. ncbi Hormone therapies and vascular outcomes: who is at risk?
    Mary Cushman
    Department of Medicine and Pathology, University of Vermont, College of Medicine, Burlington, VT 05401, USA
    J Thromb Thrombolysis 16:87-90. 2003
    ..Further research is needed to identify pathophysiological mechanisms of vascular harm from these hormones...
  16. ncbi Effects of hormone replacement therapy and estrogen receptor modulators on markers of inflammation and coagulation
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
    Am J Cardiol 90:7F-10F. 2002
    ..In this article, the effects of various types of HRT and estrogen receptor modulators on inflammation and coagulation markers are reviewed, and their potential impact on clinical outcomes is considered...
  17. ncbi Hormone replacement therapy, inflammation, and hemostasis in elderly women
    M Cushman
    Departments of Medicine, University of Vermont, Burlington, USA
    Arterioscler Thromb Vasc Biol 19:893-9. 1999
    ..Associations with hemostasis markers indicated no association with evidence of procoagulation and a possible association with increased fibrinolytic activity...
  18. ncbi Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study
    N A Zakai
    Department of Medicine, Brown University and Boston University, Providence, RI, USA
    J Thromb Haemost 5:1128-35. 2007
    ..There are few studies of inflammation and hemostasis biomarkers and cardiovascular disease risk (CVD) in older adults...
  19. ncbi Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study
    M Cushman
    Departments of Medicine, and Biochemistry, University of Vermont, Burlington, VT 05446, USA
    Circulation 100:717-22. 1999
    ..Because higher levels of inflammation factors predict vascular disease outcomes, the effect of hormones on these factors is of interest...
  20. ncbi Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project
    R P Tracy
    University of Vermont, Colchester 05446, USA
    Arterioscler Thromb Vasc Biol 17:1121-7. 1997
    ..7 (CI = 1.10 to 6.60). In conclusion, CRP was associated with incident events in the elderly, especially in those with subclinical disease at baseline...
  21. ncbi Tamoxifen and cardiac risk factors in healthy women: Suggestion of an anti-inflammatory effect
    M Cushman
    Department of Medicine and Pathology, University of Vermont, Burlington 05446, USA
    Arterioscler Thromb Vasc Biol 21:255-61. 2001
    ..These findings are in contrast to recent reports of increased C-reactive protein associated with postmenopausal estrogen. The potential for beneficial cardiovascular effects of tamoxifen in healthy women is suggested...
  22. ncbi Post-menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Br J Haematol 114:162-8. 2001
    ..This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT-induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required...
  23. ncbi The association of vitamin K status with warfarin sensitivity at the onset of treatment
    M Cushman
    Department of Medicine, University of Vermont, 208 South Park Drive, Suite 2, Colchester, VT 05446, USA
    Br J Haematol 112:572-7. 2001
    ..05). We concluded that dietary and biochemical measures of vitamin K status were associated with early warfarin sensitivity...
  24. ncbi Effects of estrogen and selective estrogen receptor modulators on hemostasis and inflammation: potential differences among drugs
    M Cushman
    Department of Medicine, University of Vermont, Colchester 05446, USA
    Ann N Y Acad Sci 949:175-80. 2001
    ..From the vascular perspective, future studies need to focus on interactions of treatment with these biochemical parameters and their genetic correlates in order to define low- or high-risk subgroups for intervention with these therapies...
  25. ncbi Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects
    R P Tracy
    Department of Pathology and Biochemistry, University of Vermont, Colchester 05446, USA
    Arterioscler Thromb Vasc Biol 17:2167-76. 1997
    ..Moreover, exposure to smoking affects the relation of CRP to these other factors...
  26. ncbi Lipoprotein-associated phospholipase A(2) and risk of congestive heart failure in older adults: the Cardiovascular Health Study
    Takeki Suzuki
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Circ Heart Fail 2:429-36. 2009
    ..One previous study showed an association of Lp-PLA(2) activity with CHF risk, but there were only 94 CHF cases and Lp-PLA(2) antigen, which is available clinically in the United States, was not measured...
  27. ncbi Association of endothelial and oxidative stress with metabolic syndrome and subclinical atherosclerosis: multi-ethnic study of atherosclerosis
    D Vaidya
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Eur J Clin Nutr 65:818-25. 2011
    ..We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress...
  28. ncbi Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, USA
    J Gerontol A Biol Sci Med Sci 65:1208-14. 2010
    ....
  29. ncbi Metabolic syndrome, inflammation, and incident heart failure in the elderly: the cardiovascular health study
    Takeki Suzuki
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    Circ Heart Fail 1:242-8. 2008
    ..We evaluated whether combining inflammation markers and MetS provided additive information for incident CHF and if incorporating inflammation markers to the MetS definition added prognostic information...
  30. ncbi D-dimer as a risk factor for deep vein thrombosis: the Leiden Thrombophilia Study
    Astrid C M Andreescu
    Department of Medicine, University of Vermont, Burlington, USA
    Thromb Haemost 87:47-51. 2002
    ..Persistence of this association in the absence of other hemostatic risk factors for DVT suggests that high D-dimer may be related to other, as yet unknown, risk factors for venous thrombosis. Confirmation of these findings is desirable...
  31. ncbi Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study
    N A Zakai
    Department of Medicine, University of Vermont, Burlington, VT, USA
    J Thromb Haemost 9:267-74. 2011
    ..Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are inconclusive...
  32. ncbi Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
    ..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown...
  33. ncbi Inflammatory biomarkers and decline in kidney function in the elderly: the Cardiovascular Health Study
    Christopher Keller
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nephrol Dial Transplant 25:119-24. 2010
    ..The objective of this study was to determine whether elevated markers of inflammation are independently associated with longitudinal kidney function decline...
  34. ncbi Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study
    Joachim H Ix
    Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Am Coll Cardiol 51:2347-54. 2008
    ..This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans...
  35. ncbi Cardiology patient page. Factor V Leiden
    Deborah L Ornstein
    Department of Medicine, Hematology/Oncology Unit, University of Vermont/Fletcher Allen Health Care, Burlington, VT 05401, USA
    Circulation 107:e94-7. 2003
  36. ncbi No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study
    Adam M Smiles
    Department of Pathology, College of Medicine, University of Vermont, Burlington, USA
    Thromb Haemost 87:614-21. 2002
    ..This is consistent with the lack of association of prothrombin levels with measures of underlying CVD or procoagulant markers...
  37. ncbi Effects of oral and transdermal hormonal contraception on vascular risk markers: a randomized controlled trial
    Julia V Johnson
    Department of Obstetrics and Gynecology, University of Vermont, Burlington, Vermont 0450, USA
    Obstet Gynecol 111:278-84. 2008
    ..To compare the effects of oral and transdermal contraceptives containing similar hormone formulations on vascular risk markers...
  38. ncbi Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients
    Margaret Kennedy
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    Br J Haematol 128:386-8. 2005
    ..7 (95% confidence interval (CI) 0.3-10.7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6.7 (95% CI 0.9-infinity). Prothrombin 20210A may be associated with VT risk among cancer patients...
  39. ncbi Tissue factor pathway inhibitor, vascular risk factors and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis
    C T Mitchell
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    Atherosclerosis 207:277-83. 2009
    ..Tissue factor pathway inhibitor (TFPI) is an endothelial membrane-associated anticoagulant protein. Higher circulating levels might reflect endothelial damage...
  40. ncbi Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature)
    A C Andreescu
    Department of Medicine, University of Vermont, Burlington 05401, USA
    J Thromb Thrombolysis 11:33-7. 2001
    ..To our knowledge this case represents the longest reported use of subcutaneous lepirudin...
  41. ncbi Evaluation of very low-dose subcutaneous vitamin K during postoperative warfarin therapy
    C J Possidente
    Department of Pharmacotherapy, Fletcher Allen Health Care, Burlington, Vermont, USA
    Pharmacotherapy 21:295-300. 2001
    ..Investigations in other populations and assessment of the effect of low-dose SCVK on postoperative bleeding are indicated...
  42. ncbi Total tissue factor pathway inhibitor and venous thrombosis. The Longitudinal Investigation of Thromboembolism Etiology
    Neil A Zakai
    Department of Medicine and Pathology, Colchester Research Facility, University of Vermont College of Medicine, Colchester, VT 05446, USA
    Thromb Haemost 104:207-12. 2010
    ..93 (1.05, 3.53). Further addition of D-dimer and BMI to this model decreased the OR to 1.70 (0.98, 2.93). Low TFPI did not demonstrate greater than additive interaction with other VTE risk factors...
  43. ncbi Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal
    Cynthia K Sites
    Department of Obstetrics and Gynecology, The University of Vermont College of Medicne, Burlington, Vermont 05405, USA
    Fertil Steril 77:128-35. 2002
    ..To determine whether postmenopausal status is associated with elevated plasma inflammation markers compared to premenopausal status, and how this explains differences in fat distribution and insulin-stimulated glucose disposal...
  44. ncbi Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity
    Brian C Cooper
    Department of Obstetrics and Gynecology, The University of Vermont College of Medicine, Burlington, VT, USA
    Am J Obstet Gynecol 196:123.e1-7. 2007
    ..This study was undertaken to determine whether insulin resistance associated with combination hormone replacement therapy (HRT) is mediated by changes in serum markers of inflammation or in serum adipocyte hormones...
  45. ncbi Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and risk of cardiovascular disease in older adults: results from the Cardiovascular Health Study
    Nancy Swords Jenny
    Department of Pathology, College of Medicine, University of Vermont, Burlington, 208 South Park Drive, Colchester, VT 05446, United States
    Atherosclerosis 209:528-32. 2010
    ..To examine associations between lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) antigen level (mass) and enzymatic activity (activity) and cardiovascular disease (CVD) in older adults...
  46. ncbi Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Stroke 36:1830-4. 2005
    ..The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype...
  47. ncbi Inflammatory markers and longitudinal lung function decline in the elderly
    Rui Jiang
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Am J Epidemiol 168:602-10. 2008
    ..An alternative approach to missing data yielded similar results. In conclusion, higher levels of fibrinogen, but not CRP, independently predicted greater FEV(1)/FVC decline in the elderly...
  48. ncbi The clinical diagnosis of heparin-induced thrombocytopenia in patients receiving continuous renal replacement therapy
    Chris E Holmes
    Department of Medicine, Division of Hematology and Oncology, University of Vermont College of Medicine, Burlington, VT 05401, USA
    J Thromb Thrombolysis 27:406-12. 2009
    ..No data regarding the clinical diagnosis of HIT is available for patients receiving continuous renal replacement therapy...
  49. ncbi Subclinical atherosclerosis and the risk of future venous thrombosis in the Cardiovascular Health Study
    P B van der Hagen
    Department of Medicine, University of Vermont, Burlington, 05446, USA
    J Thromb Haemost 4:1903-8. 2006
    ..Carotid plaques and arterial events during follow up were inversely associated, a finding that requires further study...
  50. ncbi Risk factors for venous thrombosis in medical inpatients: validation of a thrombosis risk score
    N A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, VT 05446, USA
    J Thromb Haemost 2:2156-61. 2004
    ..Only one of three published risk scores was associated with risk of inpatient VT. Future study should improve upon risk prediction models for in-hospital VT among medical patients...
  51. ncbi Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study
    Jason L Sanders
    Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:421-6. 2010
    ..To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age...
  52. ncbi Estimated 10-year stroke risk by region and race in the United States: geographic and racial differences in stroke risk
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    Ann Neurol 64:507-13. 2008
    ..We assessed geographic and racial differences in estimated 10-year stroke risk...
  53. ncbi Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology
    Mary Cushman
    Department of Medicine and Pathology, University of Vermont, Burlington, VT, USA
    Blood 114:2878-83. 2009
    ..3-2.7). Associations were similar by study and whether the thrombosis was idiopathic or secondary. Factor XII deficiency was not related to VTE risk. Among these procoagulant factors, only elevated factor XI was a risk factor for VTE...
  54. ncbi Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study
    D W Kitzman
    Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA
    Am J Cardiol 87:413-9. 2001
    ..The finding that a large proportion of elderly with CHF have preserved LV systolic function is important because there is a paucity of data to guide management in this dominant subset...
  55. ncbi Sensitivity of a questionnaire for data collection on venous thrombosis
    Carla Y Vossen
    Department of Pathology, University of Vermont, Given Building #E208, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Thromb Res 114:259-63. 2004
  56. ncbi Prevalence of chronic kidney disease and anemia among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study: baseline results
    David G Warnock
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 68:1427-31. 2005
  57. ncbi Correlates of anemia in American blacks and whites: the REGARDS Renal Ancillary Study
    Neil A Zakai
    Department of Medicine, University of Vermont, Burlington, VT, USA
    Am J Epidemiol 169:355-64. 2009
    ..Race differences in anemia prevalence were not explained by the factors studied. Future research into the causes and consequences of anemia in different racial groups is needed...
  58. ncbi The association between A1C and subclinical cardiovascular disease: the multi-ethnic study of atherosclerosis
    Marguerite J McNeely
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1727-33. 2009
    ..To test the hypothesis that A1C is associated with subclinical cardiovascular disease (CVD) in a population without evident diabetes, after adjusting for traditional CVD risk factors and BMI...
  59. ncbi Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study
    David G Warnock
    Division of Nephrology, Department of Medicine, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Kidney Dis 56:861-71. 2010
    ..Chronic kidney disease and albuminuria are associated with increased risk of all-cause mortality...
  60. ncbi Lipoprotein-associated phospholipase A2 and risk of venous thrombosis in older adults
    Nels Olson
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA
    Am J Hematol 83:524-7. 2008
    ..Results were robust to several definitions of low or high Lp-PLA2. While the association of Lp-PLA(2) levels with arterial disease events implies a role for this enzyme in atherogenesis, our findings suggest that it is not prothrombotic...
  61. ncbi Obtaining informed consent for genetic studies: The multiethnic study of atherosclerosis
    David Green
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Epidemiol 164:845-51. 2006
    ..The authors concluded that a small percentage of participants in epidemiologic studies refuse consent for DNA studies, and the majority are concerned about sharing their DNA data with industry...
  62. ncbi Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study
    Margaret Kennedy
    Department of Medicine, University of Vermont, Burlington, USA
    Arch Intern Med 165:1896-902. 2005
    ..74 (95% CI, 1.05-2.89). CONCLUSION: Worsening lower extremity arterial disease, assessed as ABI decline, occurred in 9.5% of this elderly cohort over 6 years and was associated with modifiable vascular disease risk factors...
  63. ncbi A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study
    Neil A Zakai
    Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
    Arch Intern Med 165:2214-20. 2005
    ..Additional study is needed on the clinically valid definition for and causes of anemia in the elderly and on the increased mortality at the extremes of hemoglobin concentrations...
  64. ncbi Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study
    ANN M O'HARE
    Nephrology Division, Department of Medicine, VA Medical Center San Francisco, University of California, San Francisco, CA, USA
    Circulation 113:388-93. 2006
    ..A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population...
  65. ncbi Alcohol consumption and lower extremity arterial disease among older adults: the cardiovascular health study
    Kenneth J Mukamal
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA
    Am J Epidemiol 167:34-41. 2008
    ..01). Alcohol consumption of 1-13 drinks per week in older adults may be associated with lower risk of LEAD, but heavier drinking is not associated with lower risk...
  66. ncbi Anemia is associated with the progression of white matter disease in older adults with high blood pressure: the cardiovascular health study
    Marco Inzitari
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1867-72. 2008
    ..To investigate whether anemia predicts worsening white matter hyperintensities (WMHs) in older community-dwellers...
  67. ncbi Chronic kidney disease and venous thromboembolism: epidemiology and mechanisms
    Keattiyoat Wattanakit
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Pulm Med 15:408-12. 2009
    ..An estimated 13% of Americans have kidney disease. We sought to describe the association of kidney disease with risk of venous thromboembolism and discuss possible mechanisms explaining this association...
  68. ncbi Activated partial thromboplastin time and risk of future venous thromboembolism
    Neil A Zakai
    Department of Medicine, Brown University and Boston University, Providence, RI, USA
    Am J Med 121:231-8. 2008
    ..Lower activated partial thromboplastin times are associated with higher levels of some coagulation factors and may represent a procoagulant tendency...
  69. ncbi Women's issues in venous thromboembolism
    Deborah L Ornstein
    Department of Medicine, University of Vermont College of Medicine Fletcher Allen Health Care, University Health Center Campus, 1 South Prospect Street, Burlington, VT 05401, USA
    Curr Hematol Rep 3:382-8. 2004
    ..In this paper, we review VTE in women, using cases from our clinical practice to illustrate some of the unique aspects of caring for this population...
  70. ncbi Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort
    Jared D Sturgeon
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454 1015, USA
    Stroke 39:2268-73. 2008
    ..The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH)...
  71. ncbi Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA
    Arch Intern Med 162:1182-9. 2002
    ..In addition, the findings suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses...
  72. ncbi Chronic kidney disease prevalence estimates among racial/ethnic groups: the Multi-Ethnic Study of Atherosclerosis
    Holly Kramer
    Department of Preventive Medicine and Epidemiology, Loyola Medical Center, 2160 First Avenue, Maywood, IL 60153, USA
    Clin J Am Soc Nephrol 3:1391-7. 2008
    ..Muscle mass is not a major determinant of serum cystatin C levels, and its use to estimate GFR may lead to more congruent estimates of chronic kidney disease (CKD) across gender and racial/ethnic groups...
  73. ncbi High-density lipoprotein cholesterol and venous thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE)
    Alanna M Chamberlain
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA
    Blood 112:2675-80. 2008
    ..In the ARIC study, there was no trend of VTE hazard ratios across quartiles of HDL(2), HDL(3), or apoA-I. Low HDL-c does not appear to be an important VTE risk factor...
  74. ncbi Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Med 113:636-42. 2002
    ..Venous thromboembolism, unlike arterial disease, was not related to inflammatory markers...
  75. ncbi A prospective study of venous thromboembolism in relation to factor V Leiden and related factors
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Blood 99:2720-5. 2002
    ....
  76. ncbi Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
    Am J Hematol 71:285-90. 2002
    ..38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites...
  77. ncbi Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study
    Alexander P Reiner
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 181:175-83. 2005
    ..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity...
  78. ncbi Protein C, antithrombin, and venous thromboembolism incidence: a prospective population-based study
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
    Arterioscler Thromb Vasc Biol 22:1018-22. 2002
    ..Attributable risk estimates suggest that low protein C levels account for approximately 2.5% of venous thromboembolic events in the ARIC population...
  79. ncbi Anticardiolipin antibodies as a risk factor for venous thromboembolism in a population-based prospective study
    Shauna S Runchey
    Division of Epidemiology, School of Public Health, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454-1015, USA
    Br J Haematol 119:1005-10. 2002
    ..43, 1.78) for greater than versus less than the 95th percentile of anticardiolipin IgG. In conclusion, in this general population sample, an elevated anticardiolipin antibody level was not a risk factor for venous thromboembolism...
  80. ncbi Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 152:593-8. 2006
    ..Determining gender-specific differences in CRP may alter how CRP levels are interpreted and used to determine risk...
  81. ncbi Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 348:1425-34. 2003
    ..0 and 3.0. However, for long-term management, no therapeutic agent has shown an acceptable benefit-to-risk ratio...
  82. ncbi Inflammatory markers and progression of subclinical atherosclerosis in healthy postmenopausal women (from the Estrogen in the Prevention of Atherosclerosis Trial)
    Howard N Hodis
    Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 101:1131-3. 2008
    ..In conclusion, although unopposed 17beta-estradiol significantly altered hs-CRP and sICAM-1, neither marker was associated with progression of subclinical atherosclerosis...
  83. ncbi Distribution and correlates of lipoprotein-associated phospholipase A2 in an elderly cohort: the Cardiovascular Health Study
    Curt D Furberg
    Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157 1063, USA
    J Am Geriatr Soc 56:792-9. 2008
    ....
  84. ncbi Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology
    Lyn M Steffen
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA
    Circulation 115:188-95. 2007
    ..We tested the hypothesis that foods rich in B vitamins and omega-3 fatty acids are negatively associated and meat intake is positively associated with incidence of VTE...
  85. ncbi Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
    ..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
  86. ncbi Hormone replacement therapy and the risk of incident congestive heart failure: the Cardiovascular Health Study
    Thomas D Rea
    Cardiovascular Health Research Unit, University of Washington, Metropolitan Park, East Tower, 1730 Minor Avenue, Seattle, WA 98101, USA
    J Womens Health (Larchmt) 12:341-50. 2003
    ..Hormone replacement therapy (HRT) affects several of the pathways that may be important in the development of CHF. We hypothesized that HRT would be associated with a decreased risk of incident CHF...
  87. ncbi Point: high-sensitivity C-reactive protein and cardiac C-reactive protein assays: is there a need to differentiate?
    Nader Rifai
    Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 52:1254-6. 2006
  88. ncbi Racial and geographic differences in awareness, treatment, and control of hypertension: the REasons for Geographic And Racial Differences in Stroke study
    George Howard
    Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Stroke 37:1171-8. 2006
    ..Because hypertension is the leading risk factor for stroke, hypertension management (raising awareness, increasing treatment, and improving control) may reduce these disparities...
  89. ncbi Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Am Geriatr Soc 54:30-7. 2006
    ..To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome...
  90. ncbi Cystatin-C and inflammatory markers in the ambulatory elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, Calif 94121, USA
    Am J Med 118:1416. 2005
    ..We compared cystatin-C, a novel marker of renal function, with creatinine and estimated glomerular filtration rate (eGFR) as predictors of C-reactive protein and fibrinogen levels...
  91. ncbi C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study
    Jie J Cao
    Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 108:166-70. 2003
    ..We investigated whether elevated CRP is a risk factor for ischemic stroke independent of carotid IMT and studied the interaction between CRP and IMT...
  92. ncbi Prospective study of fibrinolytic markers and venous thromboembolism
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
    J Clin Epidemiol 56:598-603. 2003
    ..There was weak evidence for an interaction of PAP with elevated factor VIIIc and elevated D-dimer in augmenting VTE risk. We conclude that, for the most part, these fibrinolytic markers do not identify healthy subjects at risk for VTE...
  93. ncbi Estrogen plus progestin and the risk of coronary heart disease
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 349:523-34. 2003
    ..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...
  94. ncbi The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
    ..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...
  95. ncbi Traditional and novel risk factors in older adults: cardiovascular risk assessment late in life
    Kenneth J Mukamal
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Geriatr Cardiol 13:69-80. 2004
    ..Future Cardiovascular Health Study investigations will help to clarify which combination of traditional and newer risk factors provides the best estimate of cardiovascular risk for older adults...
  96. ncbi Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis
    Nalini Ranjit
    Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor 48104, USA
    Arch Intern Med 167:174-81. 2007
    ....
  97. ncbi Prospective study of polymorphisms of the protein Z-dependent protease inhibitor and risk of venous thromboembolism
    Aaron R Folsom
    Thromb Haemost 97:493-4. 2007
  98. ncbi Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort study
    William McClellan
    Georgia Medical Care Foundation, Emory University, Suite 200, Executive Park South NE, Atlanta, GA 30329 2224, USA
    J Am Soc Nephrol 18:1344-52. 2007
    ..If confirmed, then these findings suggest that individuals with FH-ESRD may benefit from interventions to improve the detection and treatment of chronic kidney disease risk factors such as diabetes and obesity...
  99. ncbi Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study
    Cara L Carty
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1760 Minor Avenue, Seattle, WA 98101, USA
    Thromb Haemost 99:388-95. 2008
    ..9 (95%CI: 1.3-2.7). In conclusion, while fibrinogen genetic variation was strongly associated with fibrinogen levels, there was less evidence of association with the more complex outcomes of IMT and CVD events...
  100. ncbi Inflammation and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis
    Junichiro Takasu
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, USA
    Atherosclerosis 199:201-6. 2008
    ..We examined whether C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with DTAC...
  101. ncbi The relationship between exercise and risk of venous thrombosis in elderly people
    Karlijn J van Stralen
    Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Geriatr Soc 56:517-22. 2008
    ..To study whether exercise is associated with the risk of venous thrombosis in elderly people...

Research Grants3

  1. Association of Thrombophilia and Inflammation with Post-Thrombotic Syndrome
    Mary Cushman; Fiscal Year: 2007
    ..Resultant disability is estimated at 2 million lost workdays/year and medical costs as $300 million yearly. Findings here can form the basis for development of new therapies to treat, and moreover prevent, PTS. ..