Joseph Cuschieri

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 21:182-8. 2004
  2. ncbi Implications of proteasome inhibition: an enhanced macrophage phenotype
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558 Cincinnati, OH 45267 0558, USA
    Cell Immunol 227:140-7. 2004
  3. ncbi Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 20:176-82. 2003
  4. ncbi Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    Shock 23:99-106. 2005
  5. ncbi Modulation of endotoxin-induced endothelial activity by microtubule depolymerization
    Joseph Cuschieri
    Department of Surgery, Division of Trauma Critical Care, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Trauma 54:104-12; discussion 112-3. 2003
  6. pmc Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis
    Joshua B Brown
    Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 74:1207-12; discussion 1212-4. 2013
  7. pmc Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients
    Alex G Cuenca
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA
    Crit Care Med 41:1175-85. 2013
  8. ncbi Insulin regulates macrophage activation through activin A
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 29:285-90. 2008
  9. ncbi Platelet-activating factor priming of inflammatory cell activity requires cellular adherence
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    Surgery 132:157-66. 2002
  10. ncbi Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012

Detail Information

Publications59

  1. ncbi Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 21:182-8. 2004
    ..Therefore, IRAK-1 appears to be the central kinase involved in the activation of the macrophage at distant sites during septic shock but is not necessary for activation in areas of local infection...
  2. ncbi Implications of proteasome inhibition: an enhanced macrophage phenotype
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558 Cincinnati, OH 45267 0558, USA
    Cell Immunol 227:140-7. 2004
    ..Thus, this study demonstrates that cellular proteasome is critical to regulation of LPS-induced signaling within the macrophage, and inhibition of the proteasome results in a conversion to an anti-inflammatory phenotype...
  3. ncbi Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Shock 20:176-82. 2003
    ..Therefore, CaMK inhibition of endothelial cells, characteristic of sustained increases in intracellular calcium, appears to result in a dysregulated proadhesive phenotype...
  4. ncbi Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    Shock 23:99-106. 2005
    ..This priming event is mediated in part by modulation of ERK 1/2, JNK/SAPK, NF-kappaB, and AP-1 activation. CaMK IV, on the other hand, is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events...
  5. ncbi Modulation of endotoxin-induced endothelial activity by microtubule depolymerization
    Joseph Cuschieri
    Department of Surgery, Division of Trauma Critical Care, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Trauma 54:104-12; discussion 112-3. 2003
    ..The potential role of this polymerization event, however, is unknown...
  6. pmc Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis
    Joshua B Brown
    Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 74:1207-12; discussion 1212-4. 2013
    ..Optimal PH crystalloid resuscitation strategies remain unclear in blunt trauma as does the influence of PH hypotension. The objective was to characterize outcomes for PH crystalloid volume in patients with and without PH hypotension...
  7. pmc Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients
    Alex G Cuenca
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA
    Crit Care Med 41:1175-85. 2013
    ..We report on the development and retrospective validation of a simple genomic composite score that can be rapidly used to predict clinical outcomes...
  8. ncbi Insulin regulates macrophage activation through activin A
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 29:285-90. 2008
    ..As a result, we set out to investigate the role and means of activation of this pathway by insulin on endotoxin-mediated activation of tissue-fixed macrophages...
  9. ncbi Platelet-activating factor priming of inflammatory cell activity requires cellular adherence
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Ohio 45267 0558, USA
    Surgery 132:157-66. 2002
    ..The purpose of this study was to investigate whether cellular adherence plays a role in PAF priming of inflammatory cells...
  10. ncbi Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012
    ..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred...
  11. ncbi Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    J Trauma 52:434-42. 2002
    ..This study investigates the possible intracellular mechanisms responsible for calcium antagonist protection in tissue-fixed macrophages, a central modulator of the proinflammatory phenotype...
  12. pmc Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response
    Robert D Winfield
    Department of Surgery, Laboratory of Inflammation Biology and Surgical Science, University of Florida College of Medicine, Gainesville, FL, USA
    Crit Care Med 38:51-8. 2010
    ..The effect of obesity on severely injured patients, however, remains incompletely defined. We sought to unravel potential physiologic and genomic alterations induced by obesity in severely injured blunt trauma patients...
  13. doi Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury
    Rebecca D Edmonds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:292-8. 2011
    ..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients...
  14. ncbi Acid sphingomyelinase is required for lipid Raft TLR4 complex formation
    Joseph Cuschieri
    Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Surg Infect (Larchmt) 8:91-106. 2007
    ..However, the mechanism responsible for these events remains unknown...
  15. doi Timing of intubation and ventilator-associated pneumonia following injury
    Heather L Evans
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, 98104, USA
    Arch Surg 145:1041-6. 2010
    ....
  16. pmc Obese patients show a depressed cytokine profile following severe blunt injury
    Robert D Winfield
    Laboratory of Inflammation Biology and Surgical Science, Department of Surgery, University of Florida College of Medicine, Gainesville, USA
    Shock 37:253-6. 2012
    ..This may confer increased susceptibility to nosocomial infection and later MOF. Further study of immune dysfunction in the postinjury obese patient should assess the possibility of early immune suppression...
  17. pmc Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...
  18. ncbi PKC-zeta is essential for endotoxin-induced macrophage activation
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 558, Cincinnati, OH 45267 0558, USA
    J Surg Res 121:76-83. 2004
    ..The aim of the current study was to further clarify the mechanism of LPS activation through the TLR4 receptor complex by examining the roles of the various isoforms of PKC...
  19. pmc Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure
    Joseph Cuschieri
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Shock 34:346-51. 2010
    ..This measurement may be useful as a biomarker for prognosis and serve to identify patients at higher risk of adverse outcome that would benefit from novel therapeutic interventions...
  20. pmc Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma Acute Care Surg 73:1395-400. 2012
    ..It remains unclear whether presence of ATC alters sex-based outcomes after injury. This study's objective was to characterize the sex dimorphism after severe injury in the presence and absence of ATC...
  21. doi Ventilator-associated pneumonia: bacteremia and death after traumatic injury
    GRANT E O'KEEFE
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    J Trauma Acute Care Surg 72:713-9. 2012
    ..We tested the hypothesis that bacteremia was associated with death in trauma patients who developed VAP...
  22. pmc Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:892-8. 2012
    ..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT...
  23. ncbi The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway
    Valerie Schaeffer
    Department of Surgery, Harborview Medical Center, Seattle, Washington 98104, USA
    Shock 27:623-30. 2007
    ..On the contrary, in PBMCs, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production...
  24. pmc Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Crit Care Med 41:399-404. 2013
    ..To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients...
  25. doi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  26. pmc Oxidant alterations in CD16 expression are cytoskeletal induced
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 32:572-7. 2009
    ....
  27. ncbi Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin
    Joseph Cuschieri
    Department of Surgery, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Immunol 168:1389-96. 2002
    ..e., urea) had no significant effect. Hypertonic saline or mannitol resuscitation, therefore, may help protect against multiple-organ dysfunction syndrome as a result of this reduced proinflammatory responsiveness...
  28. ncbi Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
    Shock 20:17-22. 2003
    ..This effect of PAF-AH may be mediated by the inhibition of intracellular signaling via inhibition of ERK kinase and NF-kappaB activation...
  29. pmc Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury
    Wolfgang G Junger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School and Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria Defence Research and Development Canada, Toronto Research Centre and Departments of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and American College of Surgeons, Department of Surgery, University of California, Irvine, California
    Shock 40:366-74. 2013
    ..Since hypertonic fluids can inhibit PMN activation, we studied whether hypertonic fluid resuscitation can reduce excessive PMN activation in TBI patients...
  30. pmc Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients
    Matthew J Sena
    Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA
    J Am Coll Surg 207:459-67. 2008
    ..The purpose of this study is to determine whether early administration of parenteral nutrition is associated with an increased risk for infection after severe injury...
  31. doi Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  32. ncbi Implications of lipid raft disintegration: enhanced anti-inflammatory macrophage phenotype
    Joseph Cuschieri
    Department of Surgery, University of Cincinnati, Ohio USA
    Surgery 136:169-75. 2004
    ..Lipid rafts are membrane microdomains characterized by an enriched cholesterol environment and appear to serve as a platform for signaling. Their role within the macrophage during endotoxin exposure is unknown...
  33. pmc A genomic storm in critically injured humans
    Wenzhong Xiao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 208:2581-90. 2011
    ..Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury...
  34. pmc Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury
    Scott C Brakenridge
    Department of Surgery, Division of Burn Trauma Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 71:299-305. 2011
    ..We sought to further delineate the relevance of the major individual components of early volume resuscitation to onset of MOD after severe blunt traumatic injury...
  35. ncbi Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, USA
    Surgery 138:158-64. 2005
    ....
  36. ncbi Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid rafts
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Shock 27:19-24. 2007
    ..Antioxidant exposure in the form of vitamin E seems to attenuate endotoxin-mediated SHIP activation resulting in increased AKT activity, and attenuated MAPK activation and TNF-alpha production...
  37. pmc Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    J Trauma 65:944-50. 2008
  38. pmc Changes in massive transfusion over time: an early shift in the right direction?
    Benjamin C Kautza
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:106-11. 2012
    ..We sought to characterize changes in resuscitation which have occurred over time in a cohort severely injured patients requiring MT...
  39. ncbi Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    J Leukoc Biol 80:407-14. 2006
    ..This study demonstrates that TLR4 assembly and activation following LPS exposure require the production of ceramide by PC-PLC, which appears to be CD14-dependent...
  40. pmc Pre-hospital intubation factors and pneumonia in trauma patients
    Heather L Evans
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Surg Infect (Larchmt) 12:339-44. 2011
    ..A subset of PH intubations with continuous quality assessment was re-examined to identify the intubation factors associated with VAP...
  41. doi Emergency department ventilation effects outcome in severe traumatic brain injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington, USA
    J Trauma 64:341-7. 2008
    ..We sought to determine whether achieving ventilation into a target range would translate into better outcomes in patients with TBI...
  42. ncbi Oxidative stress, lipid rafts, and macrophage reprogramming
    Joseph Cuschieri
    University of Washington, Department of Surgery, Seattle, Washington 98104, USA
    Antioxid Redox Signal 9:1485-97. 2007
    ..Within this review, the complexity of oxidant-induced reprogramming within the tissue fixed macrophage as currently understood is explained...
  43. pmc Clinical microfluidics for neutrophil genomics and proteomics
    Kenneth T Kotz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1042-7. 2010
    ....
  44. pmc Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Shock 36:435-9. 2011
    ..Hypertonic saline increases A3 expression of PMNs from healthy volunteers and less severely injured patients...
  45. pmc Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock
    Eileen M Bulger
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Ann Surg 245:635-41. 2007
    ..To determine the effect of resuscitation with hypertonic saline/dextran (HSD) on the innate immune response after injury...
  46. pmc Assessment of functional limitation after necrotizing soft tissue infection
    Tam N Pham
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington, USA
    J Burn Care Res 30:301-6. 2009
    ..Development of validated functional assessment tools and accurate longitudinal follow-up are necessary to measure the functional impact of NSTI...
  47. doi Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Trauma 67:45-50. 2009
    ..We hypothesized that etomidate may alter the occurrence of acute respiratory distress syndrome (ARDS) in injury victims...
  48. doi Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infections
    Sharmila Dissanaike
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    J Am Coll Surg 207:690-7. 2008
    ..Despite increased use, uncertainty exists about the safety and timing of enteral nutrition. The purpose of this study was to determine the safety and effect of immediate enteral nutrition...
  49. doi Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients
    Heather L Evans
    Department of Surgery, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA
    Arch Surg 145:240-6. 2010
    ..To demonstrate whether daily bathing with cloths impregnated with 2% chlorhexidine gluconate will decrease colonization of resistant bacteria and reduce the rates of health care-associated infections in critically injured patients...
  50. pmc Traditional resuscitative practices fail to resolve metabolic acidosis in morbidly obese patients after severe blunt trauma
    Robert D Winfield
    Laboratory of Inflammation Biology and Surgical Science, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA
    J Trauma 68:317-30. 2010
    ..Evaluation of differences in resuscitative practices altered by body mass index (BMI) might provide an explanation for the increased risk of MOF seen in these high-risk patients...
  51. doi Sew it up! A Western Trauma Association multi-institutional study of enteric injury management in the postinjury open abdomen
    Clay Cothren Burlew
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, Colorado 80204, USA
    J Trauma 70:273-7. 2011
    ..The purpose of this study was to determine outcomes on the basis of management of enteric injuries in patients relegated to the postinjury open abdomen...
  52. ncbi NADPH oxidase activation in fibronectin adherent human neutrophils: A potential role for beta1 integrin ligation
    Konstantin Umanskiy
    Division of Trauma and Critical Care, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Surgery 134:378-83. 2003
    ..We hypothesized that signaling proceeded through focal, adhesionlike structures...
  53. ncbi Mitogen-activated protein kinase (MAPK)
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    Crit Care Med 33:S417-9. 2005
  54. ncbi Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient
    Brian G Harbrecht
    Department of Surgery, University of Louisville, Louisville, Kentucky, USA
    J Trauma 63:703-8. 2007
  55. doi Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    Ann Surg 248:557-63. 2008
    ..The Surgical Care and Outcomes Assessment Program (SCOAP) gathers chart-abstracted process of care data (such as CT/US accuracy) for general surgical procedures (including appendectomy) at most Washington State hospitals...
  56. pmc Surgical management of acute necrotizing lung infections
    Beth Ann Reimel
    Department of Surgery, Harborview Medical Center, Seattle, USA
    Can Respir J 13:369-73. 2006
    ..Surgical resection for acute necrotizing lung infections is not widely accepted due to unclear indications and high risk...
  57. doi Necrotizing soft tissue infection
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, Washington, USA
    Surg Infect (Larchmt) 9:559-62. 2008
    ..Necrotizing soft tissue infections (NSTIs) continue to pose major problems in diagnosis and management...
  58. ncbi The impact of prehospital ventilation on outcome after severe traumatic brain injury
    Keir J Warner
    Department of Surgery, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    J Trauma 62:1330-6; discussion 1336-8. 2007
    ..We sought to determine the incidence of hyperventilation among a cohort of trauma patients undergoing prehospital intubation and the impact of ventilation on outcome after severe TBI...
  59. ncbi Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation
    Joseph Cuschieri
    University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359796, Seattle, WA 98104, USA
    J Leukoc Biol 80:1289-97. 2006
    ..Thus, endotoxin tolerance appears to be induced through attenuated TLR4 formation following LPS stimulation. This complex formation appears to be PKC-dependent, and restoration of PKC activity reverses tolerance...