Research Topics
Genomes and Genes
Species | K CurtinSummaryAffiliation: University of Utah Country: USA Publications
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Detail Information
Publications
Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysisCarolyn M Hutter
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA
BMC Cancer 10:670. 2010..Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility...- Somatic alterations, metabolizing genes and smoking in rectal cancerKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
Int J Cancer 125:158-64. 2009..ETS may increase risk of KRAS2 mutations; association with TP53 mutations and ETS may be influenced by NAT2... - Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1Karen Curtin
Division of Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, 391 South Chipeta Way, Suite D, Salt Lake City, Utah 84108 1206, USA
BMC Proc 1:S12. 2007..More power to detect associations was achieved in certain analyses by using extra family-based samples, rather than restricting analyses to single cases randomly selected from each pedigree... - Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21Karen Curtin
Genetic Epidemiology, University of Utah School of Medicine, Salt Lake City, UT 84109, USA
Cancer Epidemiol Biomarkers Prev 18:616-21. 2009..K. case-control cohorts (Sheffield and Leeds) and a U.S. case-control study of CRC cases from high-risk Utah pedigrees... - PedGenie: meta genetic association testing in mixed family and case-control designsKaren Curtin
Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
BMC Bioinformatics 8:448. 2007..4 software, is significantly enhanced by incorporating meta statistics for detecting genetic association with disease using data across multiple study groups... - Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesisKaren Curtin
Genetic Epidemiology, University of Utah School of Medicine, 391 Chipeta Way Suite D2, Salt Lake City, UT 84108, USA
Cancer Epidemiol Biomarkers Prev 18:2476-84. 2009..0006). This difference was significantly different to that for proximal and distal colon cancers (P(chi2) = 0.02). Our investigation supports a role for XRCC2 in colorectal cancer tumorigenesis, conferring susceptibility to rectal tumors... - Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and womenKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Nutr Cancer 63:357-66. 2011.... - Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of dietKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
Carcinogenesis 28:1672-9. 2007..1, 95% CI = 1.3-3.4 versus AA/high risk; P-interaction = 0.03). These results provide only limited support for a role of polymorphisms in one-carbon metabolism in the etiology of CIMP colon cancer... - Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancerKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
Cancer Epidemiol Biomarkers Prev 18:3384-8. 2009..02-1.9). These findings point to the importance of studying tumor mutations when examining DNA repair polymorphisms and cigarette smoke exposure to identify potentially relevant associations with colorectal cancer... - Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructorKaren Curtin
Epidemiology, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
BMC Med Genet 11:170. 2010..Our objective was to assess its utility to guide statistical analyses of haplotypes within a candidate region (or combined genotypes across candidate genes) beyond that offered by a standard logistic regression approach... - Identifying rarer genetic variants for common complex diseases: diseased versus neutral discovery panelsK Curtin
Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
Ann Hum Genet 73:54-60. 2009..In the interim, our results suggest investigators can boost power to detect such alleles by sequencing diseased individuals for tSNP selection... 
Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, USA
J Natl Cancer Inst 92:1831-6. 2000..It is unknown whether lifestyle factors associated with colon cancer, such as physical activity, body size, cigarette smoking, or use of aspirin and/or nonsteroidal anti-inflammatory drugs, contribute to MSI in sporadic tumors...- Microsatellite instability and survival in rectal cancerWade S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
Cancer Causes Control 20:1763-8. 2009..Very few studies have evaluated the effect of MSI-H on rectal cancer survival. We assessed MSI-H and other genetic and epigenetic changes on survival of 990 individuals diagnosed with first primary rectal cancer... - Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancerM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
Cancer Res 61:126-30. 2001..HRT in these older women may, again, reduce the risk of unstable tumors. A model for the way in which estrogens (endogenous, exogenous, and obesity-associated) modify the risk of MSI+ tumors is proposed... - GSTM-1 and NAT2 and genetic alterations in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, 375 Chipeta Way, Suite A, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 13:527-34. 2002..CONCLUSIONS: These data provide support that diet and cigarette smoking may be associated with specific disease pathways, although GSTM-1 and NAT2 do not independently appear to alter susceptibility to these diet and lifestyle factors... - Lifestyle factors and Ki-ras mutations in colon cancer tumorsM L Slattery
Health Research Centre, Department of Family and Preventive Medicine, 375 Chipeta Way, Suite A, University of Utah, Salt Lake City, UT 84108, USA
Mutat Res 483:73-81. 2001..Given the limited information available on what causes Ki-ras mutations, the information generated from this study indicates that these factors previously associated with colon cancer work through other disease pathways... - The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancerWade S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
Genes Chromosomes Cancer 47:835-44. 2008.... - Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancerMartha L Slattery
Health Research Center, University of Utah, Salt Lake City, Utah 84108, USA
Cancer Epidemiol Biomarkers Prev 12:882-9. 2003..This association may be influenced by GSTM-1 genotype. Furthermore, exposure to cigarette smoke of others may increase risk of rectal cancer among men who do not smoke... - Diet activity, and lifestyle associations with p53 mutations in colon tumorsMartha L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah 84108, USA
Cancer Epidemiol Biomarkers Prev 11:541-8. 2002..These data suggest that components of a Western-style diet such as high consumption of red meat and foods that increase glycemic load are associated with a p53 disease pathway... - Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population levelW S Samowitz
Departments of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Cancer Epidemiol Biomarkers Prev 10:917-23. 2001..We conclude that microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level... - Carotenoids and colon cancerM L Slattery
University of Utah Medical School, Salt Lake City, USA
Am J Clin Nutr 71:575-82. 2000..However, except for beta-carotene, little is known about how dietary carotenoids are associated with common cancers, including colon cancer... - Dietary intake and microsatellite instability in colon tumorsM L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA
Int J Cancer 93:601-7. 2001..Most other dietary factors do not appear operate exclusively in the MSI+ disease pathway... - The colon cancer burden of genetically defined hereditary nonpolyposis colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Gastroenterology 121:830-8. 2001..We therefore determined by genetic criteria the colon cancer burden associated with HNPCC in a population-based study of 1066 individuals from Utah and California... - Uncommon TGFBRI allele is not associated with increased susceptibility to colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Genes Chromosomes Cancer 32:381-3. 2001..We conclude that the 6A TGFBRI allele is not associated with an increased susceptibility to colon cancer at the population level, and that the 6A/6A homozygote is not restricted to individuals with some form of cancer... - Use of archival tissue in epidemiologic studies: collection procedures and assessment of potential sources of biasM L Slattery
University of Utah, Department of Family and Preventive Medicine, School of Medicine, Salt Lake City 84117, USA
Mutat Res 432:7-14. 2000..However, we were less likely to be able to extract DNA if the case was diagnosed at a more advanced disease stage or at the earliest disease. Potential bias from exclusion of those with the most advanced disease stage is discussed... - Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer preventionWade S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Clin Gastroenterol Hepatol 4:894-901. 2006.... - Physical activity and colorectal cancerM L Slattery
Health Research Center, University of Utah, Salt Lake City 84108, USA
Am J Epidemiol 158:214-24. 2003..39, 0.78 for men; OR = 0.44, 95% CI: 0.30, 0.67 for women). In summary, physical activity was associated with reduced risk of rectal cancer in these data. The reduced risk was similar to that previously observed for colon cancer... - MSH6 G39E polymorphism and CpG island methylator phenotype in colon cancerKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
Mol Carcinog 48:989-94. 2009..Age at diagnosis, family history, and alcohol use did not interact with MSH6 G39E and CIMP. The MSH6 G39E germline polymorphism may be associated with CIMP+ colon cancer... - Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancerW S Samowitz
Department of Pathology, University of Utah Health Sciences Center, 50 North Medical Dr, Salt Lake City, UT 84132, USA
Am J Pathol 158:1517-24. 2001.... - Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survivalKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
Int J Cancer 120:2226-32. 2007..This study provides some support for associations between TS genotype and colon cancer tumor characteristics... - MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancerKaren Curtin
University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Cancer Epidemiol Biomarkers Prev 13:285-92. 2004..The possible interaction with hormone-replacement therapy warrants additional investigation... - A comparison of colon and rectal somatic DNA alterationsMartha L Slattery
Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA
Dis Colon Rectum 52:1304-11. 2009..Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and differences in somatic alterations in colon and rectal tumors... - Associations between family history of colorectal cancer and genetic alterations in tumorsMartha L Slattery
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA
Int J Cancer 97:823-7. 2002.... - Prognostic significance of p53 mutations in colon cancer at the population levelWade S Samowitz
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
Int J Cancer 99:597-602. 2002..However, specific classes of mutations, namely, the G245 hot spot mutation and mutations in proximal tumors, are related to significantly worse survival even after adjusting for age and stage... - p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistryKaren Curtin
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
Appl Immunohistochem Mol Morphol 12:380-6. 2004..Advantages gained by sequencing are its ability to examine specific mutations and the improved ability to discriminate between cases with p 53 mutation and wild type when evaluating associations... - Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancerMartha L Slattery
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
Int J Cancer 120:656-63. 2007..Our data suggest multiple pathways to colon cancer. They do not support a unique role for dietary folate, alcohol, vitamins B(6) and B(12) and methionine in a CpG island methylator phenotype... - Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changesMartha L Slattery
Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 21:1237-45. 2010..68 95% CI 0.47, 0.98; p linear trend 0.03). These data suggest that diet and lifestyle factors are associated with specific types of rectal tumor mutations and epigenetic changes. Findings need confirmation in other studies... - Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1Martha L Slattery
Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
Carcinogenesis 31:1604-11. 2010..These data suggest that genetic variation in a predefined candidate pathway for colorectal cancer contributes to both colon and rectal cancer risk. Associations appear to be strongest for CIMP+ and MSI+ tumors... - Alcohol consumption and rectal tumor mutations and epigenetic changesMartha L Slattery
Department of Medicine, University of Utah, Salt Lake City, Utah 84108, USA
Dis Colon Rectum 53:1182-9. 2010..In this study we further explore the association by examining specific tumor markers with alcohol consumption as well as types of alcoholic beverages consumed... - Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survivalMartha L Slattery
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
Int J Cancer 128:2726-34. 2011..These data suggest that genetic variation in the CRP gene influences risk of both colon and rectal cancer development... - Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instabilityWade S Samowitz
Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
Genes Chromosomes Cancer 35:368-71. 2002..We conclude that instability-induced mutations in BAX or TGFBRII do not have a significant impact on the good prognosis of colon cancers with microsatellite instability... - Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathwaysMartha L Slattery
Department of Medicine, University of Utah, Salt Lake City, UT 84108, USA
Mutat Res 660:12-21. 2009..The important modifying effects of aspirin/NSAIDs on associations with genetic polymorphisms reinforce the underlying role of inflammation in the etiology of colon cancer... - Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white womenM L Slattery
Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
Cancer Causes Control 16:1147-57. 2005..These differences could be due to the combined effects of genetic and behavioral factors which could account for ethnic differences in the risk of breast cancer and other chronic diseases... - PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States)Martha L Slattery
Health Research Center, University of Utah, Salt Lake City, 84108, USA
Cancer Causes Control 17:239-49. 2006..These data suggest that PPARgamma may be associated with many aspects of colorectal cancer including insulin- and inflammation-related mechanisms... - Haplotype analysis of common vitamin D receptor variants and colon and rectal cancersCarol Sweeney
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, 84108, USA
Cancer Epidemiol Biomarkers Prev 15:744-9. 2006..In this analysis, haplotypes of the VDR influenced risk of colon cancer, but haplotype variables had only slightly better ability to explain case-control differences than genotype variables... - Dietary calcium, vitamin D, VDR genotypes and colorectal cancerMartha L Slattery
Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
Int J Cancer 111:750-6. 2004..The risk associated with VDR genotype seems to depend upon the level of dietary calcium and vitamin D and tumor site... - Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancerMaureen A Murtaugh
Health Research Center, University of Utah, Salt Lake City, UT 84108, USA
Cancer Causes Control 18:153-63. 2007..Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer... - IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United StatesMartha L Slattery
Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
Cancer Epidemiol Biomarkers Prev 16:747-55. 2007..04 (for Hispanic/Native American) and SNP rs1800796 or -572G>C]. These data suggest that IL6 is associated with breast cancer risk and modifies the association between estrogen and aspirin and breast cancer risk... - Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancerMartha L Slattery
Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway... - Active and passive smoking, IL6, ESR1, and breast cancer riskMartha L Slattery
Division of Epidemiology, Department of Medicine, University of Utah, Salt Lake City, UT 84117, USA
Breast Cancer Res Treat 109:101-11. 2008..01). These data suggest that breast cancer risk is associated with active and passive smoking... - Modifying effects of IL-6 polymorphisms on body size-associated breast cancer riskMartha L Slattery
Department of Medicine, University of Utah, Salt Lake City, UT, USA
Obesity (Silver Spring) 16:339-47. 2008..The association between obesity and breast cancer risk is complex. We examined whether the association between body size and breast cancer risk is modified by interleukin-6 (IL6) genotype... - Antioxidants, carotenoids, and risk of rectal cancerMaureen A Murtaugh
Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84108, USA
Am J Epidemiol 159:32-41. 2004..Associations differed by estrogen status for beta-carotene, lycopene, and vitamin E. These results suggest that vitamin E and lycopene may modestly reduce the risk of rectal cancer in women... 
Oncogenetic tree model of somatic mutations and DNA methylation in colon tumorsCarol Sweeney
Health Sciences Center, University of Utah, Salt Lake City, UT, USA
Genes Chromosomes Cancer 48:1-9. 2009..The oncogenetic tree model assumptions are appropriate for the observed heterogeneity of colon tumors, and the model produces a useful visual schematic of the sequence of events in pathways of colon carcinogenesis...- Increased risk of colon cancer associated with a genetic polymorphism of SMAD7Martha L Slattery
Departments of Internal Medicine and Pathology, University of Utah School of Medicine, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
Cancer Res 70:1479-85. 2010..No significant associations were observed for the rs4464148 SNP or other SNPs evaluated in the SMAD7. These results corroborate the findings of GWAS in colon cancer pointing to SMAD7 and reinforce interest in SNPs in this gene... - Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancerCornelia M Ulrich
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402 Seattle, WA 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 14:2509-16. 2005..A pathway-based approach to data analysis is needed to help discern the independent and combined effects of dietary intakes and genetic variability in folate metabolism... - Microsomal epoxide hydrolase polymorphisms are not associated with colon cancer riskKim Robien
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, P.O. Box 19024, M4-B402, Seattle, WA 98109-1024, USA
Cancer Epidemiol Biomarkers Prev 14:1350-2. 2005 - Genetic association with rheumatoid arthritis-Genetic Analysis Workshop 15: summary of contributions from Group 2Marsha A Wilcox
i3 Drug Safety, 950 Winter Street, Waltham, MA 02451, USA
Genet Epidemiol 31:S12-21. 2007..Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses...