Research Topics
Species | DAVID TERRY CURIELSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Combining chemotherapy with virotherapy: a novel treatment strategy for malignant pleural mesotheliomaDavid T Curiel
Division of Human Gene Therapy, Department of Medicine, Pathology, Surgery, OB/Gyn and the Gene Therapy Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
Cancer Biol Ther 5:236-7. 2006- Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labelingLong P Le
Division of Human Gene Therapy, Department of Medicine, University of Alabama, Birmingham, AL, USA
J Natl Cancer Inst 98:203-14. 2006..CONCLUSIONS: Genetic capsid labeling provides a promising approach for the dynamic assessment of oncolytic adenovirus function in vivo... - The human survivin promoter: a novel transcriptional targeting strategy for treatment of gliomaWinan J van Houdt
Department of Neurosurgery, VU Universiteit Medische Center, Amsterdam, The Netherlands
J Neurosurg 104:583-92. 2006..The strategy of using survivin-CRAds may thus translate into an experimental therapeutic approach that can be used in human clinical trials... 
Targeting lung cancer using an infectivity enhanced CXCR4-CRAdZeng B Zhu
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35291, USA
Lung Cancer 55:145-56. 2007..In addition, this agent has the potential of targeting multiple other tumor cell types. From these data, the CRAd-CXCR4.RGD appears to be a promising novel CRAd agent for lung cancer targeting with low host toxicity...- Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial gliomaIlya V Ulasov
Division of Neurosurgery, Department of Surgery, University of Chicago, Chicago, IL 60637, USA
Hum Gene Ther 18:589-602. 2007..These findings demonstrate the effectiveness of CRAd-S-pk7 and provide the rationale for further development of this novel oncolytic virus for glioma gene therapy... - Evaluation of adenovirus capsid labeling versus transgene expressionJing Li
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294, USA
Virol J 7:21. 2010..To this end, we have genetically incorporated firefly luciferase within the early region 3 or at minor capsid protein IX and compared vector functionality by means of reporter readout... - Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approachQiana L Matthews
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
Virol J 5:98. 2008..Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology... - Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptorSvetlana Komarova
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
J Ovarian Res 3:12. 2010..We investigated the feasibility of enhancing MSC tumor targeting by expressing an artificial tumor-binding receptor on the MSC surface... - Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model systemMariam A Stoff-Khalili
Department of Obstetrics and Gynecology, University of Duesseldorf, Medical Center, 40225 Duesseldorf, Germany
Breast Cancer Res 7:R1141-52. 2005..CONCLUSION: These data suggest that the CXCR4 promoter has an ideal 'breast cancer-on/liver-off' profile, and could, therefore, be a powerful tool in Ad vector based gene therapy or virotherapy of the carcinoma of the breast... - Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivoZeng B Zhu
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35291, USA
Int J Oncol 27:237-46. 2005..These data clearly demonstrate that CRAd-Survivin-RGD is a potential novel therapeutic agent for treatment in many, but not all, human cancers... - Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapyMartina Breidenbach
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Gene Ther 15:509-18. 2004..Genetic shortening of the Ad5 fiber shaft significantly increases relative tumor/liver gene transfer. This could improve the effective tumor dose and reduce side effects, thereby increasing the bioavailability of therapeutic agents... - The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapyShannon D Barker
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Gene Med 5:300-10. 2003..CONCLUSIONS: The SLPI promoter is a potentially useful TSP for ovarian cancer and facilitates further development of targeting strategies for improved gene therapy of ovarian carcinomas... - Genetically targeted adenovirus vector directed to CD40-expressing cellsNatalya Belousova
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, USA
J Virol 77:11367-77. 2003.... - Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic isletsGuadalupe Bilbao
Department of Medicine, University of Alabama at Birmingham 35294, USA
Am J Transplant 2:237-43. 2002..Incorporation of the RGD sequence in the HI loop of the fiber knob allows highly efficient transfection efficiency to nonhuman primate insulin-producing cells and adequate long-term function of the p-cell after transplantation... - Transcriptional targeting of tumors with a novel tumor-specific survivin promoterZeng B Zhu
Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
Cancer Gene Ther 11:256-62. 2004.... - Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenovirusesZeng B Zhu
Department of Medicine, Pathology, and Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35291, USA
J Thorac Oncol 1:701-11. 2006..These agents should provide important insights into the identification of novel therapeutic strategies for mesothelioma... - Production of an EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potentialAkseli Hemminki
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, University of Alabama at Birmingham, Alabama 35294 3300, USA
Cancer Gene Ther 10:583-8. 2003..These results suggest that the expression of biologically active proteins can be counterproductive to virus replication... - Development of an optimized conditionally replicative adenoviral agent for ovarian cancerZeng B Zhu
Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Ob Gyn and the Gene Therapy Center, University of Alabama at Birmingham, AL 35291, USA
Int J Oncol 32:1179-88. 2008..F5/3 were demonstrated to have higher tumor killing effects in tumor cells and a lower viral replication rate in human liver. These agents are thus excellent candidates for clinical trials of CRAd agents against human ovarian cancer... - Derivation of a triple mosaic adenovirus for cancer gene therapyYizhe Tang
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
PLoS ONE 4:e8526. 2009..The validation of the triple mosaic Ad vectors also argues for the ability of pIX modification as a base for the development of multifunctional Ad vectors... - Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expressionAkseli Hemminki
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer Res 63:847-53. 2003..Possible clinical application was tested using i.p. administration in an orthotopic ovarian cancer animal model. This approach could be useful for increasing adenoviral transgene expression in the context of clinical trials... 
Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft modelPedro J Ramirez
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Surg 195:481-90. 2008..The full realization of the therapeutic potential of conditionally replicative adenoviruses (CRAds) in the field of pancreatic cancer has been hindered by limited tumor transduction and suboptimal replication control...- A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancerDaniel T Rein
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294-2172, USA
Clin Cancer Res 11:1327-35. 2005..Ad5/3SLPI showed comparatively low liver toxicity and therefore holds potential for patient use in the clinic... - Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancerHidetaka A Ono
Division of Human Gene Therapy, Department of Medicine, Pathology and Surgery, The Gene Therapy Center, University of Alabama at Birmingham BMR2-410, 901 19th Street South, Birmingham, AL 35294-2172, USA
J Gastroenterol 40:31-42. 2005..CONCLUSIONS: Cox-2 CRAds with 5/3 chimeric fiber modification are promising for virotherapy of gastric cancer... - Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid successionJian Chen
1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Mol Ther 16:1500-6. 2008.... - In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic modelMiiru Izumi
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294-2172, USA
J Gene Med 7:1517-25. 2005..Our data also establishes the utility of transcriptionally targeted, Ad-mediated transient expression of human target molecules in the pulmonary vasculature of hCAR mice as models for in vivo analysis of targeted gene therapy vectors... - A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicityTyler O Kirby
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-2172, USA
Clin Cancer Res 10:8697-703. 2004.... - Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cellsAnna Kanerva
Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery and the Gene Therapy Center, University of Alabama at Birmingham, 35294-3300, USA
Clin Cancer Res 8:275-80. 2002..The Ad5/3 chimera displays enhanced infectivity for ovarian cancer cell lines and purified primary tumor cells, which could translate into increased efficacy in clinical trials... - Tumor-busting virusesDirk M Nettelbeck
University of Alabama at Birmingham (UAB, Division of Human Gene Therapy, USA
Sci Am 289:68-75. 2003 - An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant gliomaWaleed O Arafat
Division of Human Gene Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int J Radiat Oncol Biol Phys 55:1037-50. 2003..Remarkably, combined treatment induced regression of tumors in mice. CONCLUSIONS: Ad/Bax synergistically radiosensitizes glioma, with a seemingly favorable therapeutic index... - Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicityParameshwar J Mahasreshti
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 9:2701-10. 2003..Tumor-specific targeting of the vectors and tumor-specific expression strategies should be used to ensure a clinically useful antiangiogenesis gene therapy... - Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroidsJohn T Lam
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer Gene Ther 10:377-87. 2003..Therefore, spheroids provide a method to sustain purified unpassaged primary ovarian cancer cells for extended periods and to allow evaluation of replicative viruses in a three-dimensional model... - Identification of sites in adenovirus hexon for foreign peptide incorporationHongju Wu
Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Virol 79:3382-90. 2005..In addition, the His6 epitopes did not appear to mediate His6-dependent viral infection, as assessed in two His6 artificial receptor systems. Our study provided valuable information for studies involving hexon modification... - Identifying the safety profile of a novel infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-RGD, in anticipation of a phase I trial for recurrent ovarian cancerJohn G Page
Southern Research Institute, Birmingham, AL, USA
Am J Obstet Gynecol 196:389.e1-9; discussion 389.e9-10. 2007..The purpose of this study was to evaluate the biodistribution and toxicity of the tropism-modified infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-arginine-glycine-aspartate (RGD)... - A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate systemNikolay Korokhov
VectorLogics, Inc, 550 11th Street South, Birmingham, Alabama 35294, USA
Mol Pharm 2:218-23. 2005..This latest generation of single-component, fully targeted vectors should make feasible the clinical testing of in vivo DC-targeted vaccines... - Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liverHuang-Ge Zhang
Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Virol 76:5692-700. 2002.... - Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinomaMariam A Stoff Khalili
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL 35294 2172, USA
Breast Cancer Res Treat 105:157-67. 2007..The present study addresses the utility of human mesenchymal stem cells (hMSCs) as intermediate carriers for conditionally replicating adenoviruses (CRAds) to target metastatic breast cancer in vivo... - Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancerMariam A Stoff Khalili
Division of Human Gene Therapy, Department of Medicine and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Int J Cancer 120:935-41. 2007..In conclusion, utilization of a CRAd that combined infectivity enhancement strategies and transcriptional targeting improved the CRAd-based antineoplastic effects for breast cancer therapy... - Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumorYasuo Adachi
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Pediatr Surg 37:588-92. 2002.... - Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenovirusesSvetlana Komarova
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2-572, Birmingham, AL 35294-3300, USA
Mol Cancer Ther 5:755-66. 2006..These data show that MPCs can serve as intermediate carriers for replicative adenoviruses and suggest that the natural homing properties of specific cell types can be used for targeted delivery of these virions... - Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectorsAnton V Borovjagin
VectorLogics Inc, 550 South 11th Street, CRC 122A, Birmingham, AL 35294, USA
Cancer Gene Ther 12:475-86. 2005.... - Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenovirusesAnna Kanerva
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Mol Ther 5:695-704. 2002..Thus, retargeting to the Ad3 receptor enhances gene transfer to clinically relevant ovarian cancer substrates, while the mouse toxicity and biodistribution profile of both fiber-modified Ad vectors is comparable to Ad5... - A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathwayYuko Tsuruta
Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
Clin Cancer Res 13:2777-83. 2007..We hypothesized that combined use of unique chimeric fibers in the context of novel mosaic adenovirus vectors would enhance infectivity via non-CAR pathways in ovarian cancer cells... - Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IXYizhe Tang
Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL 35294, USA
Virology 377:391-400. 2008..These results firstly validated a triple mosaic capsid configuration on pIX, and demonstrated the possibility of further radical design... - The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenovirusesKaori Suzuki
Division of Human Gene Therapy, Department of Medicine and Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-2172, USA
Clin Cancer Res 8:3348-59. 2002..CONCLUSIONS: These results indicate that the presence of E3 can enhance the antitumor potency of CRAds over and above the levels conferred by the enhancement of infectivity via Arg-Gly-Asp (RGD)... - A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancerYuko Tsuruta
Division of Human Gene Therapy, Department of Medicine, Obstetrics and Gynecology, The University of Alabama at Birmingham, 901 19th Street South, BMR2 508, Birmingham, AL 35294 2180, USA
Clin Cancer Res 14:3582-8. 2008..The purpose of this study was to explore the therapeutic utility of a mesothelin promoter-based CRAd in a murine model of ovarian cancer, using noninvasive in vivo imaging... - Noninvasive monitoring of mRFP1- and mCherry-labeled oncolytic adenoviruses in an orthotopic breast cancer model by spectral imagingAnton V Borovjagin
Institute of Oral Health Research, University of Alabama at Birmingham School of Dentistry, Birmingham, AL, USA
Mol Imaging 9:59-75. 2010..Although mCherry appeared to be superior to mRFP1 as an imaging tag, both reporters showed utility for CRAd imaging applications... - Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapyJohn T Lam
Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Gene Med 6:1333-42. 2004..Evaluation of such factors may become important to optimize cancer therapy for individual patients... - Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational controlMariam A Stoff-Khalili
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
Breast Cancer Res Treat 108:43-55. 2008..We show herein, the utility of a novel approach that combines both transcriptional and translational regulation strategies for the key goal of replicative specificity... - Fluorescently labeled adenovirus with pIX-EGFP for vector detectionLong P Le
University of Alabama, Birmingham, USA
Mol Imaging 3:105-16. 2004..In addition, this technique has potential utility for dynamic monitoring of adenovirus replication and spread... - Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virionQiana L Matthews
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
Mol Imaging 5:510-9. 2006..This dual-modality approach will allow dynamic or real-time imaging analysis of adenovirus-based interventions with maximized analytic flexibility and enhanced resolution potential... - Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional woundsAlexander Stoff
Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL, 35294 2172, USA
J Mol Med (Berl) 85:481-96. 2007.... - Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal woundsAlexander Stoff
Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Wound Repair Regen 14:608-17. 2006..Significant infectivity enhancement was achieved in keratinocytes and fibroblasts using fiber-modified adenoviral vectors. These strategies to enhance infectivity may help to achieve higher clinical efficacy of wound gene therapy... - A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivoErin E Thacker
Division of Human Gene Therapy, Department of Medicine, Birmingham, AL 35294, United States
Vaccine 27:7116-24. 2009..These data validate the canine model for future translational studies and suggest targeting of Ad5 vectors to CD40 for in vivo delivery of tumor antigens to DCs is a feasible approach for successful cancer therapy... - An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populationsMiho Murakami
Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Virology 407:196-205. 2010..We conclude that the use of fiber-mosaic HAdV vectors is a promising approach for transducing a heterogeneous cell population with different expression levels of adenovirus receptors... - Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancerKristopher J Kimball
Department of Medicine, University of Alabama at Birmingham, USA
Mol Imaging 8:264-77. 2009..The new agent could provide incremental gains toward climbing the barriers for achieving conditionally replicated adenovirus efficacy in human trials... - Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cellsMiho Murakami
Division of Human Gene Therapy, Department of Medicine, Obstetrics and Gynecology, Pathology, Surgery, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Prostate 70:362-76. 2010..We evaluated whether Ad vectors displaying species B fiber shaft and knob domains (Ad5F3Luc1, Ad5F11Luc1, and Ad5F35Luc1) would efficiently infect cancer cells of distinct origins, including prostate cancer... - Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cellsGerd J Bauerschmitz
Department of Medicine, Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, 35294, USA
Mol Ther 14:164-74. 2006..Thus, the proposed triple-targeting strategy may be useful for increasing the safety and efficacy of adenoviral gene therapy for ovarian cancer... - Artificial extension of the adenovirus fiber shaft inhibits infectivity in coxsackievirus and adenovirus receptor-positive cell linesToshiro Seki
Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294-3300, USA
J Virol 76:1100-8. 2002..We suggest that artificial extension of the shaft can inhibit infectivity in the context of CAR-positive cell lines without modification of knob-CAR interaction... - Retargeting of adenoviral infection to melanoma: combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAADirk M Nettelbeck
Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA
Int J Cancer 108:136-45. 2004.... - Gene transfer to cervical cancer with fiber-modified adenovirusesDaniel T Rein
Division of Human Gene Therapy, Departments of Medicine, Surgery and Pathology and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA
Int J Cancer 111:698-704. 2004..The fiber-modified virus described here can help achieve higher clinical efficacy of cervical cancer gene therapy... - Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virionJing Li
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 901 19th Street South, BMR2 508, Birmingham, AL 35294 2172, USA
Virology 338:247-58. 2005..In addition, the determination of an expanded upper limit of incorporable proteins on pIX highlights its unique utility as a locus for placement of functional vector constructs... - Cancer gene therapyMasato Yamamoto
BMR2-410, 901 19th Street South, Birmingham, AL 35294-2172, USA
Technol Cancer Res Treat 4:315-30. 2005..Tireless efforts to overcome such hurdles and continuous infusion of novel concepts into this field should lead to break through technologies and the cure of the patients... - A model system for the design of armed replicating adenoviruses using p53 as a candidate transgeneYosef S Haviv
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Mol Cancer Ther 1:321-8. 2002..In conclusion, our p53-ATV model system demonstrates the potential utility of therapeutic transgene expression by a replicating Ad after a rational selection of a candidate transgene... - Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model systemMariam A Stoff-Khalili
Division of Human Gene Therapy, Department of Medicine and Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Cancer Biol Ther 4:1203-10. 2005..These preclinical results suggest that Ad5/3 is the most useful modification to achieve higher clinical efficacy of breast cancer gene therapy and virotherapy... - Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomainElena A Kashentseva
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35294-3300, USA
Cancer Res 62:609-16. 2002..The use of recombinant trimeric sCAR-scFv adapter proteins may augment Ad vector potency for targeting cancer cell types... - Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cellsSergey A Kaliberov
Departments of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
Mol Ther 6:190-8. 2002..These results suggest a possible therapeutic application of cancer-specific expression of the pro-apoptotic Bax gene driven by the VEGF promoter... - Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cellsBrian G Barnett
Division of Human Gene Therapy, Department of Medicine and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Mol Ther 6:377-85. 2002.... - Generation and selection of targeted adenoviruses embodying optimized vector propertiesSam C Noureddini
VectorLogics, Inc, 550 11th Street South, Birmingham, AL 35294, USA
Virus Res 116:185-95. 2006.... - Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancementPeter Nagi
Division of Human Gene Therapy, The Gene Therapy Center at UAB, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Gastrointest Surg 7:364-71. 2003..This combination has potential to overcome the obstacles to clinical application of adenoviral gene therapy in cholangiocarcinoma... - Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCAMiriam Ferrer
Department of Medical Oncology, Division of Gene Therapy, VU University Medical Center, Amsterdam, The Netherlands
Cancer Gene Ther 11:539-46. 2004.... - Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 geneSuzanne M Verwijnen
Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
Cancer Biother Radiopharm 19:111-20. 2004..Therapy can be performed using combinations of DOTA-Tyr3-octreotate radiolabeled with 177Lu or 90Y, 131I-FIRU and/or the prodrug ganciclovir... - Cell cycle arrest and apoptosis induced by SART-1 gene transductionMami Hosokawa
Blood and Stem Cell Transplantation Unit, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
Anticancer Res 25:1983-90. 2005..The biological function of the SART-1 gene product is demonstrated and its potential as a target for cancer gene therapy is discussed... - Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivoAdhiambo M Witlox
Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
Clin Cancer Res 10:61-7. 2004..CONCLUSIONS: Targeting adenovirus toward integrins rendered OS cells more sensitive to killing by Ad5-Delta24RGD. These findings suggest that Ad5-Delta24RGD has potential for use in OS treatment... - Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cellsEssam Eldin R Othman
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
Am J Obstet Gynecol 199:117.e1-6. 2008..The purpose of this study was to screen a panel of targeted adenoviruses as vectors for endometriosis gene therapy... - Enhanced adenovirus infection of melanoma cells by fiber-modification: incorporation of RGD peptide or Ad5/3 chimerismAndrea L Volk
Division of Human Gene Therapy and Gene Therapy Center, Department of Pathology, University of Alabama at Birmingham, Birmginham, Alabama USA
Cancer Biol Ther 2:511-5. 2003..In addition, we show that the infectivity of the cells correlates with the expression of CAR and Ad3 receptors determined by FACS analysis. Therefore, Ad5/3 is very attractive as a potential therapeutic vector for malignant melanoma... - mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinicPaul B Fisher
Departments of Pathology, Neurosurgery and Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons New York, New York 1032, USA
Cancer Biol Ther 2:S23-37. 2003..This review will provide a prospectus of our current understanding of mda-7/IL-24... - Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapyMartine L M Lamfers
Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Cancer Res 62:5736-42. 2002..These results support further development of Ad5-Delta24RGD in combination with radiation therapy for treatment of these highly malignant tumors... - Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cellsAdly Yacoub
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
Mol Cancer Ther 7:297-313. 2008.... - Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancerLotta Kangasniemi
Rational Drug Design Program, University of Helsinki, Finland
Clin Cancer Res 12:3137-44. 2006..CONCLUSIONS: These preclinical data set the stage for the clinical evaluation of safety and efficacy in patients with disease refractory to current modalities... - A conditionally replicative adenovirus that codes for a TK-GFP fusion protein (Ad5Delta24TK-GFP) for evaluation of the potency of oncolytic virotherapy combined with molecular chemotherapyTanja Hakkarainen
Rational Drug Design Program, University of Helsinki, 00014 University of Helsinki, Helsinki, Finland
Int J Mol Med 18:751-9. 2006..This suggests that in certain conditions, TK/GCV-mediated cell killing may be counterproductive to replication and oncolysis, which on the other hand might be useful feature for clinical trials in case of replication-associated toxicity... - Oncolytic adenoviruses - selective retargeting to tumor cellsJ Michael Mathis
Gene Therapy Program, Department of Cellular Biology and Anatomy, LSU Health Sciences Center, Shreveport, LA 71130, USA
Oncogene 24:7775-91. 2005..These transductional retargeting strategies have the potential for reducing deleterious side effects, and increasing the therapeutic index of virotherapeutic agents... - Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumorNaoko Yoshio Hoshino
Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita City, Osaka 565 0871, Japan
Cancer Res 67:871-5. 2007..These findings indicate that NRI is a promising agent applicable to the therapeutic gene delivery approach for IL-6-driven diseases... - Oncolytic adenoviral therapy in gallbladder carcinomaYaman Tekant
Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Turkey
Surgery 137:527-35. 2005..CONCLUSIONS: The 5/3 fiber-modified, COX-2 promoter-driven CRAds may prove to be a new agent for the treatment of gallbladder carcinoma... - Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter geneQianwa Liang
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
Mol Imaging Biol 6:395-404. 2004..CONCLUSION: Both liver "untargeting" and tumor "retargeting" of adenovirus by recombinant sCAR-EGF can be imaged non-invasively using a luciferase reporter gene... - Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion proteinQianwa Liang
Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
Mol Imaging Biol 6:385-94. 2004..CONCLUSION: Both tissue restricted expression and transcriptional redirection to tumors expressing COX-2 can be imaged non-invasively following injection of Adenovirus expressing firefly luciferase from the COX-2 promoter... - Combination therapy with conditionally replicating adenovirus and replication defective adenovirusChoon-Taek Lee
Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37322-6838, USA
Cancer Res 64:6660-5. 2004..The combination of CRAD and E1-deleted ad induced tumor-specific replication of CRAD and E1-deleted ad and increased the transduction rate and therapeutic efficacy of these viruses in model tumors... - Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo versus in vitro modelsWinan J van Houdt
Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Neuro Oncol 9:280-90. 2007..Other factors, probably the extracellular matrix, stromal cells, and the three-dimensional tumor architecture, clearly play important roles in vivo and interfere with Ad-based gene delivery into glioma tumors... - Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapterHua Jung Li
Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
Cancer Res 67:5354-61. 2007..c. tumor grafts, and in hepatic tumor grafts. The sCAR-MFE bispecific adapter should, therefore, be a powerful agent to retarget adenovirus vectors to epithelial tumor metastases... - Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenovirusesStephan Schierer
Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
Int J Cancer 122:219-29. 2008..Thus additional signals are required for optimal immune activation. These could be delivered, for example, by inserting immunoregulatory transgenes into the oncolytic adenovirus genome... - Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with TarcevaPankaj Gupta
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Physiol 215:827-36. 2008..This approach highlights a potential new combinatorial strategy, which may prove beneficial for NSCLC patients with acquired resistance to EGFR inhibitors...
Research Grants
- ADENOVIRAL MEDIATED TARGETED GENE DELIVERYDavid Curiel; Fiscal Year: 2001..The derivation of this 'targetable injectable' vector system would represent a potentially powerful technical advance allowing the implementation of a variety of strategies to accomplish gene therapy for cancer. ..
- Monitoring of advanced virotherapy for ovarian cancerDavid Curiel; Fiscal Year: 2009....
- Capsid-incorporation of HIV antigens as a novel adenovirus HIV vaccine approachDavid Curiel; Fiscal Year: 2007..This project will design new and innovative methodologies to create HIV vaccines, in hopes of preventing the spread of HIV disease. ..
- CANCER GENE THERAPY TRAINING PROGRAMDavid Curiel; Fiscal Year: 2007..The university also has modern animal facilities supervised by veterinarians and run by trained animal care personnel working under NIH guidelines. ..
- REPLICATIVE ADENOVIRUSES WITH ENHANCED INFECTIVITYDavid Curiel; Fiscal Year: 2007..As well, proof-of principle studies in model systems will establish the rationale for an advanced human clinical trial for cancer of the ovary with derived advanced generation CRAd agents. ..
- Enhanced CRAd for Pancreatic CancerDavid Curiel; Fiscal Year: 2006..The utility of these vectors will be established from the toxicological and anti-tumor effect standpoints. ..
- Capsid-labeled adenovirus for virotherapy monitoringDavid Curiel; Fiscal Year: 2009..Not only would this system be indispensable in developing advanced CRAds, it would also be applicable for monitoring CRAd therapy in patients. ..
- Development of double-targeted vectors for long-term vascular expression in vivoDAVID TERRY CURIEL; Fiscal Year: 2010..In this proposal, we seek to engineer a safer, less immunogenic Ad vector capable of long-term gene expression. ..
- Monitoring of advanced virotherapy for ovarian cancerDAVID TERRY CURIEL; Fiscal Year: 2010....
- Capsid-labeled adenovirus for virotherapy monitoringDavid Curiel; Fiscal Year: 2009..Not only would this system be indispensable in developing advanced CRAds, it would also be applicable for monitoring CRAd therapy in patients. ..
- Endothelial Gene Delivery for Pulmonary HypertensionDavid Curiel; Fiscal Year: 2004..abstract_text> ..
- DENDRITIC CELL SPECIFIC VECTORDavid Curiel; Fiscal Year: 2004..Ultimately, advances made during this study will help in translating the current knowledge into clinical practice for the treatment of cancer by inducing a tumor-specific immune response. ..
- REPLICATIVE ADENOVIRUSES WITH ENHANCED INFECTIVITYDavid Curiel; Fiscal Year: 2003..Finally, we intend to demonstrate the oncolytic efficacy of these enhanced-infectability tumor- selective adenoviruses in murine models. ..