DAVID TERRY CURIEL

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Combining chemotherapy with virotherapy: a novel treatment strategy for malignant pleural mesothelioma
    David T Curiel
    Division of Human Gene Therapy, Department of Medicine, Pathology, Surgery, Ob Gyn and the Gene Therapy Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 5:236-7. 2006
  2. ncbi request reprint Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling
    Long P Le
    Division of Human Gene Therapy, Department of Medicine, University of Alabama, Birmingham, AL, USA
    J Natl Cancer Inst 98:203-14. 2006
  3. ncbi request reprint The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma
    Winan J van Houdt
    Department of Neurosurgery, VU Universiteit Medische Center, Amsterdam, The Netherlands
    J Neurosurg 104:583-92. 2006
  4. pmc Targeting lung cancer using an infectivity enhanced CXCR4-CRAd
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35291, USA
    Lung Cancer 55:145-56. 2007
  5. ncbi request reprint Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma
    Ilya V Ulasov
    Division of Neurosurgery, Department of Surgery, University of Chicago, Chicago, IL 60637, USA
    Hum Gene Ther 18:589-602. 2007
  6. pmc Evaluation of adenovirus capsid labeling versus transgene expression
    Jing Li
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294, USA
    Virol J 7:21. 2010
  7. pmc Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
    Qiana L Matthews
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
    Virol J 5:98. 2008
  8. pmc Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor
    Svetlana Komarova
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    J Ovarian Res 3:12. 2010
  9. pmc Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system
    Mariam A Stoff-Khalili
    Department of Obstetrics and Gynecology, University of Duesseldorf, Medical Center, 40225 Duesseldorf, Germany
    Breast Cancer Res 7:R1141-52. 2005
  10. ncbi request reprint Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35291, USA
    Int J Oncol 27:237-46. 2005

Detail Information

Publications90

  1. ncbi request reprint Combining chemotherapy with virotherapy: a novel treatment strategy for malignant pleural mesothelioma
    David T Curiel
    Division of Human Gene Therapy, Department of Medicine, Pathology, Surgery, Ob Gyn and the Gene Therapy Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Biol Ther 5:236-7. 2006
  2. ncbi request reprint Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling
    Long P Le
    Division of Human Gene Therapy, Department of Medicine, University of Alabama, Birmingham, AL, USA
    J Natl Cancer Inst 98:203-14. 2006
    ..Despite rapid translation into human clinical trials and demonstrated safety, the fundamental properties of oncolytic adenovirus replication and spread and host-vector interactions in vivo have not been completely evaluated...
  3. ncbi request reprint The human survivin promoter: a novel transcriptional targeting strategy for treatment of glioma
    Winan J van Houdt
    Department of Neurosurgery, VU Universiteit Medische Center, Amsterdam, The Netherlands
    J Neurosurg 104:583-92. 2006
    ..The authors hypothesized that the expression of tumor-specific survivin could be exploited for treatment of gliomas by targeting the tumors with gene therapy vectors...
  4. pmc Targeting lung cancer using an infectivity enhanced CXCR4-CRAd
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35291, USA
    Lung Cancer 55:145-56. 2007
    ..In addition, this agent has the potential of targeting multiple other tumor cell types. From these data, the CRAd-CXCR4.RGD appears to be a promising novel CRAd agent for lung cancer targeting with low host toxicity...
  5. ncbi request reprint Survivin-driven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma
    Ilya V Ulasov
    Division of Neurosurgery, Department of Surgery, University of Chicago, Chicago, IL 60637, USA
    Hum Gene Ther 18:589-602. 2007
    ..These findings demonstrate the effectiveness of CRAd-S-pk7 and provide the rationale for further development of this novel oncolytic virus for glioma gene therapy...
  6. pmc Evaluation of adenovirus capsid labeling versus transgene expression
    Jing Li
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294, USA
    Virol J 7:21. 2010
    ..To this end, we have genetically incorporated firefly luciferase within the early region 3 or at minor capsid protein IX and compared vector functionality by means of reporter readout...
  7. pmc Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach
    Qiana L Matthews
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
    Virol J 5:98. 2008
    ..Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology...
  8. pmc Targeting of mesenchymal stem cells to ovarian tumors via an artificial receptor
    Svetlana Komarova
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    J Ovarian Res 3:12. 2010
    ..We investigated the feasibility of enhancing MSC tumor targeting by expressing an artificial tumor-binding receptor on the MSC surface...
  9. pmc Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system
    Mariam A Stoff-Khalili
    Department of Obstetrics and Gynecology, University of Duesseldorf, Medical Center, 40225 Duesseldorf, Germany
    Breast Cancer Res 7:R1141-52. 2005
    ....
  10. ncbi request reprint Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35291, USA
    Int J Oncol 27:237-46. 2005
    ..These data clearly demonstrate that CRAd-Survivin-RGD is a potential novel therapeutic agent for treatment in many, but not all, human cancers...
  11. ncbi request reprint Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapy
    Martina Breidenbach
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Gene Ther 15:509-18. 2004
    ..Genetic shortening of the Ad5 fiber shaft significantly increases relative tumor/liver gene transfer. This could improve the effective tumor dose and reduce side effects, thereby increasing the bioavailability of therapeutic agents...
  12. ncbi request reprint The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy
    Shannon D Barker
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 5:300-10. 2003
    ..We hypothesize that selective adenovirus-mediated transgene expression could be achieved through the use of the secretory leukoprotease inhibitor (SLPI) promoter in the context of ovarian cancer...
  13. pmc Genetically targeted adenovirus vector directed to CD40-expressing cells
    Natalya Belousova
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, USA
    J Virol 77:11367-77. 2003
    ....
  14. ncbi request reprint Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets
    Guadalupe Bilbao
    Department of Medicine, University of Alabama at Birmingham 35294, USA
    Am J Transplant 2:237-43. 2002
    ..Incorporation of the RGD sequence in the HI loop of the fiber knob allows highly efficient transfection efficiency to nonhuman primate insulin-producing cells and adequate long-term function of the p-cell after transplantation...
  15. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  16. pmc Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenoviruses
    Zeng B Zhu
    Department of Medicine, Pathology, and Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35291, USA
    J Thorac Oncol 1:701-11. 2006
    ..These agents should provide important insights into the identification of novel therapeutic strategies for mesothelioma...
  17. ncbi request reprint Production of an EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potential
    Akseli Hemminki
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, University of Alabama at Birmingham, Alabama 35294 3300, USA
    Cancer Gene Ther 10:583-8. 2003
    ..These results suggest that the expression of biologically active proteins can be counterproductive to virus replication...
  18. ncbi request reprint Development of an optimized conditionally replicative adenoviral agent for ovarian cancer
    Zeng B Zhu
    Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Ob Gyn and the Gene Therapy Center, University of Alabama at Birmingham, AL 35291, USA
    Int J Oncol 32:1179-88. 2008
    ..F5/3 were demonstrated to have higher tumor killing effects in tumor cells and a lower viral replication rate in human liver. These agents are thus excellent candidates for clinical trials of CRAd agents against human ovarian cancer...
  19. pmc Derivation of a triple mosaic adenovirus for cancer gene therapy
    Yizhe Tang
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    PLoS ONE 4:e8526. 2009
    ..The validation of the triple mosaic Ad vectors also argues for the ability of pIX modification as a base for the development of multifunctional Ad vectors...
  20. ncbi request reprint Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression
    Akseli Hemminki
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 63:847-53. 2003
    ..Possible clinical application was tested using i.p. administration in an orthotopic ovarian cancer animal model. This approach could be useful for increasing adenoviral transgene expression in the context of clinical trials...
  21. doi request reprint Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model
    Pedro J Ramirez
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Surg 195:481-90. 2008
    ..The full realization of the therapeutic potential of conditionally replicative adenoviruses (CRAds) in the field of pancreatic cancer has been hindered by limited tumor transduction and suboptimal replication control...
  22. ncbi request reprint A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer
    Daniel T Rein
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294 2172, USA
    Clin Cancer Res 11:1327-35. 2005
    ....
  23. ncbi request reprint Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer
    Hidetaka A Ono
    Division of Human Gene Therapy, Department of Medicine, Pathology and Surgery, The Gene Therapy Center, University of Alabama at Birmingham BMR2 410, 901 19th Street South, Birmingham, AL 35294 2172, USA
    J Gastroenterol 40:31-42. 2005
    ..To overcome these problems, we proposed TSP-driven conditionally replicating adenoviruses (CRAds) with fiber modification for virotherapy of gastric cancer...
  24. pmc Enhancement of cytotoxic T-lymphocyte response in aged mice by a novel treatment with recombinant AdIL-12 and wild-type adenovirus in rapid succession
    Jian Chen
    1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Ther 16:1500-6. 2008
    ....
  25. ncbi request reprint In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model
    Miiru Izumi
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, AL 35294 2172, USA
    J Gene Med 7:1517-25. 2005
    ..Therefore, a new animal model for evaluating CD40-targeted vectors is required...
  26. ncbi request reprint A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity
    Tyler O Kirby
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    Clin Cancer Res 10:8697-703. 2004
    ..We endeavored to show a novel model system, which involves ex vivo evaluation of conditionally replicative adenovirus toxicity and therapeutic efficacy in thin, precision-cut slices of human primary tumor and liver...
  27. ncbi request reprint Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells
    Anna Kanerva
    Division of Human Gene Therapy, Departments of Medicine, Pathology, and Surgery and the Gene Therapy Center, University of Alabama at Birmingham, 35294 3300, USA
    Clin Cancer Res 8:275-80. 2002
    ..The Ad5/3 chimera displays enhanced infectivity for ovarian cancer cell lines and purified primary tumor cells, which could translate into increased efficacy in clinical trials...
  28. ncbi request reprint Tumor-busting viruses
    Dirk M Nettelbeck
    University of Alabama at Birmingham UAB, Division of Human Gene Therapy, USA
    Sci Am 289:68-75. 2003
  29. ncbi request reprint An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma
    Waleed O Arafat
    Division of Human Gene Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Radiat Oncol Biol Phys 55:1037-50. 2003
    ..We explore the utility of the adenovirus-mediated delivery of proapoptotic Bax for enhancing the cytotoxicity of radiotherapy (RT) in RT-refractory glioma cells...
  30. ncbi request reprint Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity
    Parameshwar J Mahasreshti
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Clin Cancer Res 9:2701-10. 2003
    ..v. delivered, adenovirus-mediated sFLT-1 on the survival duration in a murine ovarian tumor model and to evaluate the safety of i.v.-delivered versus i.p.-delivered adenovirus-mediated sFLT-1 in non-tumor-bearing mice...
  31. ncbi request reprint Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids
    John T Lam
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Gene Ther 10:377-87. 2003
    ..Therefore, spheroids provide a method to sustain purified unpassaged primary ovarian cancer cells for extended periods and to allow evaluation of replicative viruses in a three-dimensional model...
  32. pmc Identification of sites in adenovirus hexon for foreign peptide incorporation
    Hongju Wu
    Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 79:3382-90. 2005
    ..In addition, the His6 epitopes did not appear to mediate His6-dependent viral infection, as assessed in two His6 artificial receptor systems. Our study provided valuable information for studies involving hexon modification...
  33. ncbi request reprint Identifying the safety profile of a novel infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-RGD, in anticipation of a phase I trial for recurrent ovarian cancer
    John G Page
    Southern Research Institute, Birmingham, AL, USA
    Am J Obstet Gynecol 196:389.e1-9; discussion 389.e9-10. 2007
    ..The purpose of this study was to evaluate the biodistribution and toxicity of the tropism-modified infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-arginine-glycine-aspartate (RGD)...
  34. ncbi request reprint A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate system
    Nikolay Korokhov
    VectorLogics, Inc, 550 11th Street South, Birmingham, Alabama 35294, USA
    Mol Pharm 2:218-23. 2005
    ..This latest generation of single-component, fully targeted vectors should make feasible the clinical testing of in vivo DC-targeted vaccines...
  35. pmc Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver
    Huang Ge Zhang
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 76:5692-700. 2002
    ....
  36. ncbi request reprint Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma
    Mariam A Stoff-Khalili
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL 35294 2172, USA
    Breast Cancer Res Treat 105:157-67. 2007
    ..The present study addresses the utility of human mesenchymal stem cells (hMSCs) as intermediate carriers for conditionally replicating adenoviruses (CRAds) to target metastatic breast cancer in vivo...
  37. ncbi request reprint Combining high selectivity of replication via CXCR4 promoter with fiber chimerism for effective adenoviral oncolysis in breast cancer
    Mariam A Stoff-Khalili
    Division of Human Gene Therapy, Department of Medicine and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Int J Cancer 120:935-41. 2007
    ..In conclusion, utilization of a CRAd that combined infectivity enhancement strategies and transcriptional targeting improved the CRAd-based antineoplastic effects for breast cancer therapy...
  38. ncbi request reprint Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor
    Yasuo Adachi
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Pediatr Surg 37:588-92. 2002
    ..We present herein the efficacy of in vivo tumor regression as well as prevention of lethal hepatic toxicity by using the MK promoter in an Ad vector-based HSV-tk/GCV treatment approach...
  39. ncbi request reprint Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses
    Svetlana Komarova
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 572, Birmingham, AL 35294 3300, USA
    Mol Cancer Ther 5:755-66. 2006
    ..These data show that MPCs can serve as intermediate carriers for replicative adenoviruses and suggest that the natural homing properties of specific cell types can be used for targeted delivery of these virions...
  40. ncbi request reprint Complex mosaicism is a novel approach to infectivity enhancement of adenovirus type 5-based vectors
    Anton V Borovjagin
    VectorLogics Inc, 550 South 11th Street, CRC 122A, Birmingham, AL 35294, USA
    Cancer Gene Ther 12:475-86. 2005
    ....
  41. ncbi request reprint Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses
    Anna Kanerva
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Ther 5:695-704. 2002
    ..Thus, retargeting to the Ad3 receptor enhances gene transfer to clinically relevant ovarian cancer substrates, while the mouse toxicity and biodistribution profile of both fiber-modified Ad vectors is comparable to Ad5...
  42. pmc A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathway
    Yuko Tsuruta
    Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    Clin Cancer Res 13:2777-83. 2007
    ..We hypothesized that combined use of unique chimeric fibers in the context of novel mosaic adenovirus vectors would enhance infectivity via non-CAR pathways in ovarian cancer cells...
  43. doi request reprint Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX
    Yizhe Tang
    Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL 35294, USA
    Virology 377:391-400. 2008
    ..These results firstly validated a triple mosaic capsid configuration on pIX, and demonstrated the possibility of further radical design...
  44. ncbi request reprint The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses
    Kaori Suzuki
    Division of Human Gene Therapy, Department of Medicine and Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 2172, USA
    Clin Cancer Res 8:3348-59. 2002
    ..As an extension of our prior work, we analyzed the effect of the E3 region, which includes the adenovirus death protein, in the context of CRAd oncolytic potency...
  45. doi request reprint A fiber-modified mesothelin promoter-based conditionally replicating adenovirus for treatment of ovarian cancer
    Yuko Tsuruta
    Division of Human Gene Therapy, Department of Medicine, Obstetrics and Gynecology, The University of Alabama at Birmingham, 901 19th Street South, BMR2 508, Birmingham, AL 35294 2180, USA
    Clin Cancer Res 14:3582-8. 2008
    ..The purpose of this study was to explore the therapeutic utility of a mesothelin promoter-based CRAd in a murine model of ovarian cancer, using noninvasive in vivo imaging...
  46. pmc Noninvasive monitoring of mRFP1- and mCherry-labeled oncolytic adenoviruses in an orthotopic breast cancer model by spectral imaging
    Anton V Borovjagin
    Institute of Oral Health Research, University of Alabama at Birmingham School of Dentistry, Birmingham, AL, USA
    Mol Imaging 9:59-75. 2010
    ..Although mCherry appeared to be superior to mRFP1 as an imaging tag, both reporters showed utility for CRAd imaging applications...
  47. ncbi request reprint Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy
    John T Lam
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 6:1333-42. 2004
    ..We evaluated five CRAds as candidate clinical agents for ovarian cancer therapy: RGDCRADcox-2R, Ad5VEGFE1, Ad5/3VEGFE1, Ad5-Delta24RGD, and Ad5/3-Delta24...
  48. pmc Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control
    Mariam A Stoff-Khalili
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Breast Cancer Res Treat 108:43-55. 2008
    ..We show herein, the utility of a novel approach that combines both transcriptional and translational regulation strategies for the key goal of replicative specificity...
  49. ncbi request reprint Fluorescently labeled adenovirus with pIX-EGFP for vector detection
    Long P Le
    University of Alabama, Birmingham, USA
    Mol Imaging 3:105-16. 2004
    ..In addition, this technique has potential utility for dynamic monitoring of adenovirus replication and spread...
  50. pmc Genetic incorporation of a herpes simplex virus type 1 thymidine kinase and firefly luciferase fusion into the adenovirus protein IX for functional display on the virion
    Qiana L Matthews
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    Mol Imaging 5:510-9. 2006
    ..This dual-modality approach will allow dynamic or real-time imaging analysis of adenovirus-based interventions with maximized analytic flexibility and enhanced resolution potential...
  51. ncbi request reprint Effect of adenoviral mediated overexpression of fibromodulin on human dermal fibroblasts and scar formation in full-thickness incisional wounds
    Alexander Stoff
    Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, 901 19th Street South, BMR2 502, Birmingham, AL, 35294 2172, USA
    J Mol Med (Berl) 85:481-96. 2007
    ....
  52. pmc Strategies to enhance transductional efficiency of adenoviral-based gene transfer to primary human fibroblasts and keratinocytes as a platform in dermal wounds
    Alexander Stoff
    Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Wound Repair Regen 14:608-17. 2006
    ..Significant infectivity enhancement was achieved in keratinocytes and fibroblasts using fiber-modified adenoviral vectors. These strategies to enhance infectivity may help to achieve higher clinical efficacy of wound gene therapy...
  53. pmc A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivo
    Erin E Thacker
    Division of Human Gene Therapy, Department of Medicine, Birmingham, AL 35294, United States
    Vaccine 27:7116-24. 2009
    ..These data validate the canine model for future translational studies and suggest targeting of Ad5 vectors to CD40 for in vivo delivery of tumor antigens to DCs is a feasible approach for successful cancer therapy...
  54. doi request reprint An adenoviral vector expressing human adenovirus 5 and 3 fiber proteins for targeting heterogeneous cell populations
    Miho Murakami
    Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Virology 407:196-205. 2010
    ..We conclude that the use of fiber-mosaic HAdV vectors is a promising approach for transducing a heterogeneous cell population with different expression levels of adenovirus receptors...
  55. pmc Novel infectivity-enhanced oncolytic adenovirus with a capsid-incorporated dual-imaging moiety for monitoring virotherapy in ovarian cancer
    Kristopher J Kimball
    Department of Medicine, University of Alabama at Birmingham, USA
    Mol Imaging 8:264-77. 2009
    ..The new agent could provide incremental gains toward climbing the barriers for achieving conditionally replicated adenovirus efficacy in human trials...
  56. pmc Chimeric adenoviral vectors incorporating a fiber of human adenovirus 3 efficiently mediate gene transfer into prostate cancer cells
    Miho Murakami
    Division of Human Gene Therapy, Department of Medicine, Obstetrics and Gynecology, Pathology, Surgery, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Prostate 70:362-76. 2010
    ..We evaluated whether Ad vectors displaying species B fiber shaft and knob domains (Ad5F3Luc1, Ad5F11Luc1, and Ad5F35Luc1) would efficiently infect cancer cells of distinct origins, including prostate cancer...
  57. ncbi request reprint Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells
    Gerd J Bauerschmitz
    Department of Medicine, Division of Human Gene Therapy, Gene Therapy Center, University of Alabama at Birmingham, 35294, USA
    Mol Ther 14:164-74. 2006
    ..Thus, the proposed triple-targeting strategy may be useful for increasing the safety and efficacy of adenoviral gene therapy for ovarian cancer...
  58. pmc Artificial extension of the adenovirus fiber shaft inhibits infectivity in coxsackievirus and adenovirus receptor-positive cell lines
    Toshiro Seki
    Division of Human Gene Therapy, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3300, USA
    J Virol 76:1100-8. 2002
    ..We suggest that artificial extension of the shaft can inhibit infectivity in the context of CAR-positive cell lines without modification of knob-CAR interaction...
  59. ncbi request reprint Retargeting of adenoviral infection to melanoma: combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA
    Dirk M Nettelbeck
    Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Cancer 108:136-45. 2004
    ....
  60. ncbi request reprint Gene transfer to cervical cancer with fiber-modified adenoviruses
    Daniel T Rein
    Division of Human Gene Therapy, Departments of Medicine, Surgery and Pathology and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Int J Cancer 111:698-704. 2004
    ..The fiber-modified virus described here can help achieve higher clinical efficacy of cervical cancer gene therapy...
  61. ncbi request reprint Genetic incorporation of HSV-1 thymidine kinase into the adenovirus protein IX for functional display on the virion
    Jing Li
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 901 19th Street South, BMR2 508, Birmingham, AL 35294 2172, USA
    Virology 338:247-58. 2005
    ..In addition, the determination of an expanded upper limit of incorporable proteins on pIX highlights its unique utility as a locus for placement of functional vector constructs...
  62. ncbi request reprint Cancer gene therapy
    Masato Yamamoto
    BMR2 410, 901 19th Street South, Birmingham, AL 35294 2172, USA
    Technol Cancer Res Treat 4:315-30. 2005
    ..Tireless efforts to overcome such hurdles and continuous infusion of novel concepts into this field should lead to break through technologies and the cure of the patients...
  63. ncbi request reprint A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene
    Yosef S Haviv
    Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Cancer Ther 1:321-8. 2002
    ..In conclusion, our p53-ATV model system demonstrates the potential utility of therapeutic transgene expression by a replicating Ad after a rational selection of a candidate transgene...
  64. ncbi request reprint Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system
    Mariam A Stoff-Khalili
    Division of Human Gene Therapy, Department of Medicine and Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Biol Ther 4:1203-10. 2005
    ..These preclinical results suggest that Ad5/3 is the most useful modification to achieve higher clinical efficacy of breast cancer gene therapy and virotherapy...
  65. ncbi request reprint Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain
    Elena A Kashentseva
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
    Cancer Res 62:609-16. 2002
    ..The use of recombinant trimeric sCAR-scFv adapter proteins may augment Ad vector potency for targeting cancer cell types...
  66. ncbi request reprint Adenovirus-mediated transfer of BAX driven by the vascular endothelial growth factor promoter induces apoptosis in lung cancer cells
    Sergey A Kaliberov
    Departments of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
    Mol Ther 6:190-8. 2002
    ..These results suggest a possible therapeutic application of cancer-specific expression of the pro-apoptotic Bax gene driven by the VEGF promoter...
  67. ncbi request reprint Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cells
    Brian G Barnett
    Division of Human Gene Therapy, Department of Medicine and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Ther 6:377-85. 2002
    ....
  68. ncbi request reprint Generation and selection of targeted adenoviruses embodying optimized vector properties
    Sam C Noureddini
    VectorLogics, Inc, 550 11th Street South, Birmingham, AL 35294, USA
    Virus Res 116:185-95. 2006
    ....
  69. ncbi request reprint Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement
    Peter Nagi
    Division of Human Gene Therapy, The Gene Therapy Center at UAB, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Gastrointest Surg 7:364-71. 2003
    ..This combination has potential to overcome the obstacles to clinical application of adenoviral gene therapy in cholangiocarcinoma...
  70. ncbi request reprint Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA
    Miriam Ferrer
    Department of Medical Oncology, Division of Gene Therapy, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Gene Ther 11:539-46. 2004
    ....
  71. ncbi request reprint Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene
    Suzanne M Verwijnen
    Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
    Cancer Biother Radiopharm 19:111-20. 2004
    ..Therapy can be performed using combinations of DOTA-Tyr3-octreotate radiolabeled with 177Lu or 90Y, 131I-FIRU and/or the prodrug ganciclovir...
  72. ncbi request reprint Cell cycle arrest and apoptosis induced by SART-1 gene transduction
    Mami Hosokawa
    Blood and Stem Cell Transplantation Unit, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Anticancer Res 25:1983-90. 2005
    ..The biological function of the SART-1 gene product is demonstrated and its potential as a target for cancer gene therapy is discussed...
  73. ncbi request reprint Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo
    Adhiambo M Witlox
    Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 10:61-7. 2004
    ..The oncolytic capacity of the CRAd Ad5-Delta24RGD was tested on primary OS cells in vitro and in vivo...
  74. doi request reprint Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells
    Essam Eldin R Othman
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Am J Obstet Gynecol 199:117.e1-6. 2008
    ..The purpose of this study was to screen a panel of targeted adenoviruses as vectors for endometriosis gene therapy...
  75. ncbi request reprint Enhanced adenovirus infection of melanoma cells by fiber-modification: incorporation of RGD peptide or Ad5/3 chimerism
    Andrea L Volk
    Division of Human Gene Therapy and Gene Therapy Center, Department of Pathology, University of Alabama at Birmingham, Birmginham, Alabama USA
    Cancer Biol Ther 2:511-5. 2003
    ..In addition, we show that the infectivity of the cells correlates with the expression of CAR and Ad3 receptors determined by FACS analysis. Therefore, Ad5/3 is very attractive as a potential therapeutic vector for malignant melanoma...
  76. ncbi request reprint mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic
    Paul B Fisher
    Departments of Pathology, Neurosurgery and Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons New York, New York 1032, USA
    Cancer Biol Ther 2:S23-37. 2003
    ..This review will provide a prospectus of our current understanding of mda-7/IL-24...
  77. ncbi request reprint Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy
    Martine L M Lamfers
    Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Cancer Res 62:5736-42. 2002
    ..These results support further development of Ad5-Delta24RGD in combination with radiation therapy for treatment of these highly malignant tumors...
  78. pmc Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
    Adly Yacoub
    Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
    Mol Cancer Ther 7:297-313. 2008
    ....
  79. ncbi request reprint Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer
    Lotta Kangasniemi
    Rational Drug Design Program, University of Helsinki, Finland
    Clin Cancer Res 12:3137-44. 2006
    ..However, expression of the primary coxsackie-adenovirus receptor is variable in advanced cancers, and therefore, the use of heterologous receptors could be advantageous...
  80. pmc A conditionally replicative adenovirus that codes for a TK-GFP fusion protein (Ad5Delta24TK-GFP) for evaluation of the potency of oncolytic virotherapy combined with molecular chemotherapy
    Tanja Hakkarainen
    Rational Drug Design Program, University of Helsinki, 00014 University of Helsinki, Helsinki, Finland
    Int J Mol Med 18:751-9. 2006
    ..This suggests that in certain conditions, TK/GCV-mediated cell killing may be counterproductive to replication and oncolysis, which on the other hand might be useful feature for clinical trials in case of replication-associated toxicity...
  81. ncbi request reprint Oncolytic adenoviruses - selective retargeting to tumor cells
    J Michael Mathis
    Gene Therapy Program, Department of Cellular Biology and Anatomy, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Oncogene 24:7775-91. 2005
    ..These transductional retargeting strategies have the potential for reducing deleterious side effects, and increasing the therapeutic index of virotherapeutic agents...
  82. ncbi request reprint Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor
    Naoko Yoshio-Hoshino
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Cancer Res 67:871-5. 2007
    ..These findings indicate that NRI is a promising agent applicable to the therapeutic gene delivery approach for IL-6-driven diseases...
  83. ncbi request reprint Oncolytic adenoviral therapy in gallbladder carcinoma
    Yaman Tekant
    Hepatopancreatobiliary Surgery Unit, Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Turkey
    Surgery 137:527-35. 2005
    ....
  84. ncbi request reprint Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene
    Qianwa Liang
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
    Mol Imaging Biol 6:395-404. 2004
    ....
  85. ncbi request reprint Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein
    Qianwa Liang
    Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine, Los Angeles, CA USA
    Mol Imaging Biol 6:385-94. 2004
    ..To demonstrate that non-invasive bioluminescent imaging can monitor restricted expression from a nonreplicating adenovirus in which the cyclooxygenase-2 (COX-2) promoter drives firefly luciferase...
  86. ncbi request reprint Combination therapy with conditionally replicating adenovirus and replication defective adenovirus
    Choon Taek Lee
    Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37322 6838, USA
    Cancer Res 64:6660-5. 2004
    ..The combination of CRAD and E1-deleted ad induced tumor-specific replication of CRAD and E1-deleted ad and increased the transduction rate and therapeutic efficacy of these viruses in model tumors...
  87. pmc Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo versus in vitro models
    Winan J van Houdt
    Department of Neurosurgery, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Neuro Oncol 9:280-90. 2007
    ..Other factors, probably the extracellular matrix, stromal cells, and the three-dimensional tumor architecture, clearly play important roles in vivo and interfere with Ad-based gene delivery into glioma tumors...
  88. ncbi request reprint Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter
    Hua Jung Li
    Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
    Cancer Res 67:5354-61. 2007
    ..c. tumor grafts, and in hepatic tumor grafts. The sCAR-MFE bispecific adapter should, therefore, be a powerful agent to retarget adenovirus vectors to epithelial tumor metastases...
  89. ncbi request reprint Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses
    Stephan Schierer
    Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    Int J Cancer 122:219-29. 2008
    ..Thus additional signals are required for optimal immune activation. These could be delivered, for example, by inserting immunoregulatory transgenes into the oncolytic adenovirus genome...
  90. doi request reprint Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva
    Pankaj Gupta
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Physiol 215:827-36. 2008
    ..This approach highlights a potential new combinatorial strategy, which may prove beneficial for NSCLC patients with acquired resistance to EGFR inhibitors...

Research Grants45

  1. ADENOVIRAL MEDIATED TARGETED GENE DELIVERY
    David Curiel; Fiscal Year: 2001
    ..The derivation of this 'targetable injectable' vector system would represent a potentially powerful technical advance allowing the implementation of a variety of strategies to accomplish gene therapy for cancer. ..
  2. Monitoring of advanced virotherapy for ovarian cancer
    David Curiel; Fiscal Year: 2009
    ....
  3. Capsid-incorporation of HIV antigens as a novel adenovirus HIV vaccine approach
    David Curiel; Fiscal Year: 2007
    ..This project will design new and innovative methodologies to create HIV vaccines, in hopes of preventing the spread of HIV disease. ..
  4. CANCER GENE THERAPY TRAINING PROGRAM
    David Curiel; Fiscal Year: 2007
    ..The university also has modern animal facilities supervised by veterinarians and run by trained animal care personnel working under NIH guidelines. ..
  5. REPLICATIVE ADENOVIRUSES WITH ENHANCED INFECTIVITY
    David Curiel; Fiscal Year: 2007
    ..As well, proof-of principle studies in model systems will establish the rationale for an advanced human clinical trial for cancer of the ovary with derived advanced generation CRAd agents. ..
  6. Enhanced CRAd for Pancreatic Cancer
    David Curiel; Fiscal Year: 2006
    ..The utility of these vectors will be established from the toxicological and anti-tumor effect standpoints. ..
  7. Capsid-labeled adenovirus for virotherapy monitoring
    David Curiel; Fiscal Year: 2009
    ..Not only would this system be indispensable in developing advanced CRAds, it would also be applicable for monitoring CRAd therapy in patients. ..
  8. Development of double-targeted vectors for long-term vascular expression in vivo
    DAVID TERRY CURIEL; Fiscal Year: 2010
    ..In this proposal, we seek to engineer a safer, less immunogenic Ad vector capable of long-term gene expression. ..
  9. Monitoring of advanced virotherapy for ovarian cancer
    DAVID TERRY CURIEL; Fiscal Year: 2010
    ....
  10. Capsid-labeled adenovirus for virotherapy monitoring
    David Curiel; Fiscal Year: 2009
    ..Not only would this system be indispensable in developing advanced CRAds, it would also be applicable for monitoring CRAd therapy in patients. ..
  11. Endothelial Gene Delivery for Pulmonary Hypertension
    David Curiel; Fiscal Year: 2004
    ..abstract_text> ..
  12. DENDRITIC CELL SPECIFIC VECTOR
    David Curiel; Fiscal Year: 2004
    ..Ultimately, advances made during this study will help in translating the current knowledge into clinical practice for the treatment of cancer by inducing a tumor-specific immune response. ..
  13. REPLICATIVE ADENOVIRUSES WITH ENHANCED INFECTIVITY
    David Curiel; Fiscal Year: 2003
    ..Finally, we intend to demonstrate the oncolytic efficacy of these enhanced-infectability tumor- selective adenoviruses in murine models. ..