Christine Curcio

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Abundant lipid and protein components of drusen
    Lan Wang
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e10329. 2010
  2. pmc Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model
    Christine A Curcio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Retina 33:265-76. 2013
  3. ncbi request reprint Imaging maculopathy in post-mortem human eyes
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, USA
    Vision Res 45:3496-503. 2005
  4. ncbi request reprint Declining availability of human eye tissues for research
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Callahan Eye Foundation Hospital, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 47:2747-9. 2006
  5. ncbi request reprint Accumulation of cholesterol with age in human Bruch's membrane
    C A Curcio
    Departments of Ophthalmology Physiological Optics, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Invest Ophthalmol Vis Sci 42:265-74. 2001
  6. ncbi request reprint Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 0009, USA
    Prog Retin Eye Res 28:393-422. 2009
  7. pmc Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA
    J Lipid Res 51:451-67. 2010
  8. pmc Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections
    Christine A Curcio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Invest Ophthalmol Vis Sci 52:3943-54. 2011
  9. pmc The oil spill in ageing Bruch membrane
    Christine A Curcio
    Department of Ophthalmology, EyeSight Foundation of Alabama Vision Science Laboratories Room 360, University of Alabama School of Medicine, Birmingham, AL 35294 0019, USA
    Br J Ophthalmol 95:1638-45. 2011
  10. ncbi request reprint Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy
    Christine A Curcio
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street, Room H020, Birmingham AL 35294 0009, USA
    Exp Eye Res 81:731-41. 2005

Research Grants

  1. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2007
  2. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2006
  3. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2004
  4. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2004
  5. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2003
  6. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2002
  7. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2002
  8. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2001
  9. QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINA
    Christine Curcio; Fiscal Year: 1993
  10. QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINA
    Christine Curcio; Fiscal Year: 1992

Collaborators

Detail Information

Publications34

  1. pmc Abundant lipid and protein components of drusen
    Lan Wang
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e10329. 2010
    ....
  2. pmc Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model
    Christine A Curcio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Retina 33:265-76. 2013
    ....
  3. ncbi request reprint Imaging maculopathy in post-mortem human eyes
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, USA
    Vision Res 45:3496-503. 2005
    ..Histological verification is a necessary, albeit challenging, step in validating a grading system...
  4. ncbi request reprint Declining availability of human eye tissues for research
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Callahan Eye Foundation Hospital, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 47:2747-9. 2006
  5. ncbi request reprint Accumulation of cholesterol with age in human Bruch's membrane
    C A Curcio
    Departments of Ophthalmology Physiological Optics, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Invest Ophthalmol Vis Sci 42:265-74. 2001
    ..To determine the cholesterol composition of normal human Bruch's membrane and choroid as a function of age and retinal location...
  6. ncbi request reprint Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 0009, USA
    Prog Retin Eye Res 28:393-422. 2009
    ..2007). This approach provides a wide knowledge base and sophisticated clinical armamentarium that can be readily exploited for the development of new model systems and the future benefit of ARMD patients...
  7. pmc Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA
    J Lipid Res 51:451-67. 2010
    ..Circulation. 116:1832-1844). This view provides a conceptual basis for the development of novel treatments that may benefit ARMD patients in the future...
  8. pmc Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections
    Christine A Curcio
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Invest Ophthalmol Vis Sci 52:3943-54. 2011
    ....
  9. pmc The oil spill in ageing Bruch membrane
    Christine A Curcio
    Department of Ophthalmology, EyeSight Foundation of Alabama Vision Science Laboratories Room 360, University of Alabama School of Medicine, Birmingham, AL 35294 0019, USA
    Br J Ophthalmol 95:1638-45. 2011
    ..The authors update their model with genetic associations between AMD and genes historically associated with plasma HDL metabolism, and suggest future directions for research and therapeutic strategies based on an oil-spill analogy...
  10. ncbi request reprint Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy
    Christine A Curcio
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street, Room H020, Birmingham AL 35294 0009, USA
    Exp Eye Res 81:731-41. 2005
    ..UC in sub-RPE deposits cannot be derived directly from OS without considerable intracellular processing within RPE, additional cholesterol sources, or both...
  11. ncbi request reprint Photoreceptor topography in ageing and age-related maculopathy
    C A Curcio
    Department of Ophthalmology, University of Alabama at Birmingham 35294 0009, USA
    Eye (Lond) 15:376-83. 2001
    ..The topography of rod loss in ageing and ARM is consistent with the location of early ARM lesions described in population-based studies and is not consistent with the location of fundus autofluorescence due to lipofuscin...
  12. pmc Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy
    Goldis Malek
    Department of Ophthalmology, Vision Science Training Program, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
    Am J Pathol 162:413-25. 2003
    ..The combination of apo B mRNA and protein in RPE raises the possibility that intraocular assembly of apo B-containing lipoproteins is a pathway involved in forming cholesterol-enriched lesions in ARM...
  13. doi request reprint Histochemistry and lipid profiling combine for insights into aging and age-related maculopathy
    Christine A Curcio
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, Birmingham, AL, USA
    Methods Mol Biol 580:267-81. 2009
    ..The combination of filipin histochemistry and comprehensive lipid profiling made possible this insight on a complex tissue...
  14. ncbi request reprint Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen
    Chuan ming Li
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street Room H020, Birmingham, AL 35294 0009, USA
    Exp Eye Res 85:192-201. 2007
    ..The relative sizes of sub-domains defined by cholesterol composition are compared to sub-domains detected in drusen by in vivo imaging methods...
  15. ncbi request reprint Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy
    Chuan ming Li
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA
    J Lipid Res 46:628-40. 2005
    ..The pigmentary retinopathy and neuropathy of abetalipoproteinemia (Mendelian Inheritance of Man 200100; Bassen-Kornzwieg disease), which is caused by mutations in the MTP gene, may involve loss of function at the retina...
  16. ncbi request reprint Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization
    Chuan ming Li
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 009, USA
    Invest Ophthalmol Vis Sci 46:2576-86. 2005
    ..To isolate and characterize cholesteryl ester-containing, lipoprotein-like particles (LLPs) from normal aged human Bruch's membrane (BrM)/choroid (Ch)...
  17. ncbi request reprint [Gene expression of apolipoprotein and lipids synthesis and secretion in RPE-J cells]
    Lan Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
    Yan Ke Xue Bao 22:244-51. 2006
    ....
  18. ncbi request reprint Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaques
    Byung Hong Chung
    Gerontology Division, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1733:76-89. 2005
    ..Our study revealed that the removal of cholesterol from ICP in vivo will be possible through a change in the level, composition, and physical state of ICP lipids mediated by PC-enriched HDL...
  19. ncbi request reprint Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression
    Chuan ming Li
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 47:3119-28. 2006
    ..To evaluate apolipoprotein (Apo) gene expression in native human retinal pigment epithelium (RPE) and neurosensory retina and to detect apolipoproteins within age-related, extramacular drusen...
  20. ncbi request reprint Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles
    Christine A Curcio
    Department of Ophthalmology, University of Alabama School of Medicine, 700 South 18th Street, Birmingham, AL 35294 0009, USA
    Exp Eye Res 80:761-75. 2005
    ..These results are consistent with recent evidence implicating lipoprotein particles of intra-ocular origin as a potential source of neutral lipids, including esterified cholesterol, in the specific lesions of ARM...
  21. pmc Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile
    Lan Wang
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 50:870-7. 2009
    ..In the present study, neutral lipid, phospholipids, and retinoid components of human BrM-LLP were assayed...
  22. pmc Sub-retinal drusenoid deposits in human retina: organization and composition
    Martin Rudolf
    Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, Birmingham, AL 35294 0009, USA
    Exp Eye Res 87:402-8. 2008
    ..In the future, drusenoid sub-retinal debris might be more frequently revealed by emerging high-resolution imaging techniques...
  23. ncbi request reprint Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina
    Susan D Vogt
    Department of Ophthalmology, University of Alabama at Birmingham, 1530 3rd Avenue South, 35294, USA
    Exp Eye Res 83:834-40. 2006
    ..The complement regulators CD55 and CD59 were found primarily on the inner retina, while CD46 was present exclusively in a polarized fashion on the RPE...
  24. pmc Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy
    Martin Rudolf
    Department of Ophthalmology, University of Alabama at Birmingham, Callahan Eye Foundation Hospital, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 49:1200-9. 2008
    ..The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease...
  25. ncbi request reprint Drusen and lipid-filled retinal pigment epithelium cells in a rhesus macula
    Mark Anderson
    University of Alabama, Department of Ophthalmology, Birmingham, Alabama, USA
    Vet Ophthalmol 9:201-7. 2006
    ..The clinical and histologically defined results agree if lipid-filled RPE cells are included among the clinically apparent signs of drusen...
  26. pmc Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid
    Martin Rudolf
    Department of Ophthalmology, University of Alabama at Birmingham, Alabama
    J Histochem Cytochem 57:731-9. 2009
    ..Because direct assays indicate that esterified cholesterol is abundantly present in BrM, we consider EC-F the most valuable choice for analyzing neutral lipid deposits in human BrM...
  27. ncbi request reprint Phenotypic variation of retinal pigment epithelium in age-related macular degeneration
    Clyde Guidry
    Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0009, USA
    Invest Ophthalmol Vis Sci 43:267-73. 2002
    ..To determine whether retinal pigment epithelium (RPE) in eyes with age-related macular degeneration (ARMD) express vimentin and alpha smooth muscle actin (alphaSMA), two cytoskeletal proteins associated with phenotypic variation in culture...
  28. ncbi request reprint Photoreceptor degeneration and dysfunction in aging and age-related maculopathy
    Gregory R Jackson
    Department of Ophthalmology, School of Medicine, University of Alabama, Birmingham, AL 35294 0009, USA
    Ageing Res Rev 1:381-96. 2002
    ....
  29. pmc Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etch
    Jiahn Dar Huang
    Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
    Exp Eye Res 85:202-18. 2007
    ....
  30. pmc Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membrane
    Jiahn Dar Huang
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208 3107, USA
    Invest Ophthalmol Vis Sci 49:2721-7. 2008
    ..To determine the size and regional distribution of lipoprotein-like particles (LLPs) that accumulate with age in Bruch's membrane (BrM)...
  31. pmc Effects of particulates and lipids on the hydraulic conductivity of Matrigel
    William J McCarty
    Department of Biomedical Engineering, TECH Rm E378, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA
    J Appl Physiol (1985) 105:621-8. 2008
    ....
  32. ncbi request reprint Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membrane
    Jeffrey W Ruberti
    Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Invest Ophthalmol Vis Sci 44:1753-9. 2003
    ..To examine age-related changes in the ultrastructure of Bruch's membrane with quick-freeze/deep-etch (QFDE) and conventional thin-section transmission electron microscopy (TEM)...
  33. pmc Comparison of morphology of human macular and peripheral Bruch's membrane in older eyes
    Mark Johnson
    Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Curr Eye Res 32:791-9. 2007
    ..The "lipid wall," reported in macular BrM, was also found occasionally in the peripheral regions. The same processes that lead to age-related accumulation of LLPs in macular BrM appear to also occur in the peripheral regions...
  34. ncbi request reprint The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration
    Itay Chowers
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 47:2135-40. 2006
    ..The purpose of this study was to assess transferrin involvement in AMD by determining the expression profile of transferrin in retinas with AMD compared with retinas without evidence of disease...

Research Grants17

  1. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2007
    ..This information is required to determine if treatments that modify hepatic lipoprotein production should be considered for treating early ARM. ..
  2. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2006
    ..This information is required to determine if treatments that modify hepatic lipoprotein production should be considered for treating early ARM. ..
  3. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2004
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  4. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2004
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  5. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2003
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  6. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2002
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  7. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2002
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  8. QUANTITATIVE ANAYLSIS OF AGING RETINA
    Christine Curcio; Fiscal Year: 2001
    ..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
  9. QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINA
    Christine Curcio; Fiscal Year: 1993
    ..These data can be compared with the distribution of cones in the same eyes and with published estimates of the human cortical magnification factor...
  10. QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINA
    Christine Curcio; Fiscal Year: 1992
    ..These data can be compared with the distribution of cones in the same eyes and with published estimates of the human cortical magnification factor...
  11. QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINA
    Christine Curcio; Fiscal Year: 1991
    ..These data can be compared with the distribution of cones in the same eyes and with published estimates of the human cortical magnification factor...
  12. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2010
    ....