Research Topics
| Christine CurcioSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis modelChristine A Curcio
Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Retina 33:265-76. 2013....
The oil spill in ageing Bruch membraneChristine A Curcio
Department of Ophthalmology, EyeSight Foundation of Alabama Vision Science Laboratories Room 360, University of Alabama School of Medicine, Birmingham, AL 35294 0019, USA
Br J Ophthalmol 95:1638-45. 2011..The authors update their model with genetic associations between AMD and genes historically associated with plasma HDL metabolism, and suggest future directions for research and therapeutic strategies based on an oil-spill analogy...- Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sectionsChristine A Curcio
Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
Invest Ophthalmol Vis Sci 52:3943-54. 2011.... - Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degenerationChristine A Curcio
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA
J Lipid Res 51:451-67. 2010..Circulation. 116:1832-1844). This view provides a conceptual basis for the development of novel treatments that may benefit ARMD patients in the future... - Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteinsChristine A Curcio
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 0009, USA
Prog Retin Eye Res 28:393-422. 2009..2007). This approach provides a wide knowledge base and sophisticated clinical armamentarium that can be readily exploited for the development of new model systems and the future benefit of ARMD patients... 
Accumulation of cholesterol with age in human Bruch's membraneC A Curcio
Departments of Ophthalmology Physiological Optics, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
Invest Ophthalmol Vis Sci 42:265-74. 2001..To determine the cholesterol composition of normal human Bruch's membrane and choroid as a function of age and retinal location...- Declining availability of human eye tissues for researchChristine A Curcio
Department of Ophthalmology, University of Alabama School of Medicine, Callahan Eye Foundation Hospital, Birmingham, Alabama 35294-0009, USA
Invest Ophthalmol Vis Sci 47:2747-9. 2006 - Imaging maculopathy in post-mortem human eyesChristine A Curcio
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, USA
Vision Res 45:3496-503. 2005..Histological verification is a necessary, albeit challenging, step in validating a grading system... - Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathyChristine A Curcio
Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street, Room H020, Birmingham AL 35294 0009, USA
Exp Eye Res 81:731-41. 2005..UC in sub-RPE deposits cannot be derived directly from OS without considerable intracellular processing within RPE, additional cholesterol sources, or both... - Photoreceptor topography in ageing and age-related maculopathyC A Curcio
Department of Ophthalmology, University of Alabama at Birmingham 35294 0009, USA
Eye (Lond) 15:376-83. 2001..The topography of rod loss in ageing and ARM is consistent with the location of early ARM lesions described in population-based studies and is not consistent with the location of fundus autofluorescence due to lipofuscin... - Histochemistry and lipid profiling combine for insights into aging and age-related maculopathyChristine A Curcio
Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, Birmingham, AL, USA
Methods Mol Biol 580:267-81. 2009..The combination of filipin histochemistry and comprehensive lipid profiling made possible this insight on a complex tissue... - Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathyGoldis Malek
Department of Ophthalmology, Vision Science Training Program, University of Alabama at Birmingham, Birmingham, AL 35294 0009, USA
Am J Pathol 162:413-25. 2003..The combination of apo B mRNA and protein in RPE raises the possibility that intraocular assembly of apo B-containing lipoproteins is a pathway involved in forming cholesterol-enriched lesions in ARM... - Distribution and composition of esterified and unesterified cholesterol in extra-macular drusenChuan ming Li
Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, 700 South 18th Street Room H020, Birmingham, AL 35294 0009, USA
Exp Eye Res 85:192-201. 2007..The relative sizes of sub-domains defined by cholesterol composition are compared to sub-domains detected in drusen by in vivo imaging methods... - Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathyChuan ming Li
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA
J Lipid Res 46:628-40. 2005..The pigmentary retinopathy and neuropathy of abetalipoproteinemia (Mendelian Inheritance of Man 200100; Bassen-Kornzwieg disease), which is caused by mutations in the MTP gene, may involve loss of function at the retina... - Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterizationChuan-Ming Li
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294-009, USA
Invest Ophthalmol Vis Sci 46:2576-86. 2005..Evidence of intraocular apoB and apoA-I expression supports an emerging hypothesis that the RPE assembles and secretes a large, possibly novel, lipoprotein particle... - Phosphatidylcholine-rich acceptors, but not native HDL or its apolipoproteins, mobilize cholesterol from cholesterol-rich insoluble components of human atherosclerotic plaquesByung Hong Chung
Gerontology Division, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Biochim Biophys Acta 1733:76-89. 2005..Our study revealed that the removal of cholesterol from ICP in vivo will be possible through a change in the level, composition, and physical state of ICP lipids mediated by PC-enriched HDL... - [Gene expression of apolipoprotein and lipids synthesis and secretion in RPE-J cells]Lan Wang
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
Yan Ke Xue Bao 22:244-51. 2006.... - Sub-retinal drusenoid deposits in human retina: organization and compositionMartin Rudolf
Department of Ophthalmology, Callahan Eye Foundation Hospital, University of Alabama School of Medicine, Birmingham, AL 35294 0009, USA
Exp Eye Res 87:402-8. 2008..In the future, drusenoid sub-retinal debris might be more frequently revealed by emerging high-resolution imaging techniques... - Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profileLan Wang
Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0009, USA
Invest Ophthalmol Vis Sci 50:870-7. 2009..In the present study, neutral lipid, phospholipids, and retinoid components of human BrM-LLP were assayed... - Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expressionChuan-Ming Li
Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama 35294-0009, USA
Invest Ophthalmol Vis Sci 47:3119-28. 2006..It is possible that a neutral lipid-rich druse shell containing Apos will be visible in the living fundus... - Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particlesChristine A Curcio
Department of Ophthalmology, University of Alabama School of Medicine, 700 South 18th Street, Birmingham, AL 35294-0009, USA
Exp Eye Res 80:761-75. 2005..These results are consistent with recent evidence implicating lipoprotein particles of intra-ocular origin as a potential source of neutral lipids, including esterified cholesterol, in the specific lesions of ARM... - Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathyMartin Rudolf
Department of Ophthalmology, University of Alabama at Birmingham, Callahan Eye Foundation Hospital, Birmingham, Alabama 35294 0009, USA
Invest Ophthalmol Vis Sci 49:1200-9. 2008..The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease... - Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retinaSusan D Vogt
Department of Ophthalmology, University of Alabama at Birmingham, 1530 3rd Avenue South, 35294, USA
Exp Eye Res 83:834-40. 2006..The complement regulators CD55 and CD59 were found primarily on the inner retina, while CD46 was present exclusively in a polarized fashion on the RPE... - Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroidMartin Rudolf
Department of Ophthalmology, University of Alabama at Birmingham, Alabama
J Histochem Cytochem 57:731-9. 2009..Because direct assays indicate that esterified cholesterol is abundantly present in BrM, we consider EC-F the most valuable choice for analyzing neutral lipid deposits in human BrM... - Phenotypic variation of retinal pigment epithelium in age-related macular degenerationClyde Guidry
Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0009, USA
Invest Ophthalmol Vis Sci 43:267-73. 2002..The absence of alphaSMA-positive cells in regions of RPE atrophy suggests that RPE are lost rather than persist in a dedifferentiated state... - Photoreceptor degeneration and dysfunction in aging and age-related maculopathyGregory R Jackson
Department of Ophthalmology, School of Medicine, University of Alabama, Birmingham, AL 35294-0009, USA
Ageing Res Rev 1:381-96. 2002.... - Drusen and lipid-filled retinal pigment epithelium cells in a rhesus maculaMark Anderson
University of Alabama, Department of Ophthalmology, Birmingham, Alabama, USA
Vet Ophthalmol 9:201-7. 2006..The clinical and histologically defined results agree if lipid-filled RPE cells are included among the clinically apparent signs of drusen... - Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etchJiahn Dar Huang
Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, USA
Exp Eye Res 85:202-18. 2007.... - The iron carrier transferrin is upregulated in retinas from patients with age-related macular degenerationItay Chowers
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Invest Ophthalmol Vis Sci 47:2135-40. 2006.... - Comparison of morphology of human macular and peripheral Bruch's membrane in older eyesMark Johnson
Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Curr Eye Res 32:791-9. 2007..The "lipid wall," reported in macular BrM, was also found occasionally in the peripheral regions. The same processes that lead to age-related accumulation of LLPs in macular BrM appear to also occur in the peripheral regions... - Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membraneJeffrey W Ruberti
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
Invest Ophthalmol Vis Sci 44:1753-9. 2003..QFDE will be useful for future modeling studies of Bruch's membrane transport and to identify those moieties responsible for deleterious age-related transport changes in Bruch's membrane... - Effects of particulates and lipids on the hydraulic conductivity of MatrigelWilliam J McCarty
Department of Biomedical Engineering, TECH Rm E378, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208, USA
J Appl Physiol 105:621-8. 2008.... - Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membraneJiahn Dar Huang
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208 3107, USA
Invest Ophthalmol Vis Sci 49:2721-7. 2008..To determine the size and regional distribution of lipoprotein-like particles (LLPs) that accumulate with age in Bruch's membrane (BrM)...
Research Grants
- QUANTITATIVE ANALYSIS OF AGING RETINAChristine Curcio; Fiscal Year: 2007..This information is required to determine if treatments that modify hepatic lipoprotein production should be considered for treating early ARM. ..
- QUANTITATIVE ANAYLSIS OF AGING RETINAChristine Curcio; Fiscal Year: 2004..This information is required in order to determine if effective treatments for atherosclerosis should be considered for the treatment of early ARM. ..
- QUANTITATIVE ANALYSIS OF AGING PRIMATE RETINAChristine Curcio; Fiscal Year: 1993..These data can be compared with the distribution of cones in the same eyes and with published estimates of the human cortical magnification factor...
- QUANTITATIVE ANALYSIS OF AGING RETINAChristine A Curcio; Fiscal Year: 2010....