Rochelle Cunningham

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    J Am Soc Nephrol 18:1419-25. 2007
  2. doi request reprint Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice
    Rochelle Cunningham
    Univ of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 294:F1001-7. 2008
  3. pmc Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells
    Rochelle Cunningham
    Dept of Medicine, Division of Nephrology, Univ of Maryland, School of Medicine, Rm N3W143, UHM, 22 South Greene St, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 296:F355-61. 2009
  4. doi request reprint Role of NHERF and scaffolding proteins in proximal tubule transport
    Rochelle Cunningham
    Division of Nephrology, Department of Medicine, University of Maryland, School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Urol Res 38:257-62. 2010
  5. pmc Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 117:3412-20. 2007
  6. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
  7. ncbi request reprint Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media
    Rochelle Cunningham
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 289:F933-8. 2005
  8. ncbi request reprint Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:37815-21. 2004
  9. ncbi request reprint NHERF-1 is required for renal adaptation to a low-phosphate diet
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Rm N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 285:F1225-32. 2003
  10. ncbi request reprint Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 291:F896-901. 2006

Detail Information

Publications17

  1. ncbi request reprint Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    J Am Soc Nephrol 18:1419-25. 2007
    ..These findings indicate that NHERF-1 exerts a significant effect on the renal tubular reabsorption of uric acid in the mouse by modulating the BBM abundance of mURAT1 and possibly other BBM uric acid transporters...
  2. doi request reprint Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice
    Rochelle Cunningham
    Univ of Maryland School of Medicine, 22 S Greene St, N3W143, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 294:F1001-7. 2008
    ....
  3. pmc Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells
    Rochelle Cunningham
    Dept of Medicine, Division of Nephrology, Univ of Maryland, School of Medicine, Rm N3W143, UHM, 22 South Greene St, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 296:F355-61. 2009
    ..Our results also suggest that activation of MAPK is not critically involved in PTH- or dopamine-mediated inhibition of phosphate transport in mouse renal proximal tubule cells in culture...
  4. doi request reprint Role of NHERF and scaffolding proteins in proximal tubule transport
    Rochelle Cunningham
    Division of Nephrology, Department of Medicine, University of Maryland, School of Medicine, Room N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Urol Res 38:257-62. 2010
    ..This review focuses primarily on NHERF-1, as the prototypical PDZ protein and will give a brief summary of its role in phosphate transport and the development of some forms of nephrolithiasis...
  5. pmc Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Invest 117:3412-20. 2007
    ..These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes...
  6. pmc Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 285:13454-60. 2010
    ..These studies suggest a novel role for the PDZ adapter protein NHERF-1 in coordinating dopamine signals that inhibit renal phosphate transport...
  7. ncbi request reprint Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media
    Rochelle Cunningham
    Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, Maryland, USA
    Am J Physiol Renal Physiol 289:F933-8. 2005
    ..These studies also suggest that there is a blunted phosphaturic effect of PTH in cells adapted to low-phosphate media...
  8. ncbi request reprint Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:37815-21. 2004
    ..NHERF-1(-/-) cells also do not adapt to alterations in the phosphate content of the media indicating that the defect resides within the cells of the proximal tubule and is not dependent on systemic factors...
  9. ncbi request reprint NHERF-1 is required for renal adaptation to a low-phosphate diet
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Rm N3W143, UHM, 22 South Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Renal Physiol 285:F1225-32. 2003
    ..These experiments demonstrate that full renal adaptation to a low-phosphate diet requires NHERF-1, which serves to increase BBM expression of Npt2...
  10. ncbi request reprint Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone
    Rochelle Cunningham
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Renal Physiol 291:F896-901. 2006
    ..Together, these results highlight the requirement for NHERF-1 for physiological control of Npt2a trafficking and suggest that the Npt2a/NHERF-1 complex represents a unique PTH-responsive pool of Npt2a in renal microvilli...
  11. ncbi request reprint Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21202, USA
    Am J Physiol Renal Physiol 290:F838-43. 2006
    ..These studies indicate defects in the renal tubule transport of phosphate, calcium, and uric acid in NHERF-1(-/-) male and female mice that could account for the increased deposition of calcium in the papilla of null mice...
  12. ncbi request reprint NHERF and regulation of the renal sodium-hydrogen exchanger NHE3
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pflugers Arch 450:137-44. 2005
    ..In this review, we trace the discovery of NHERF-1 and NHERF-2, and update our current understanding of the relation between these proteins and the regulation and trafficking of NHE3...
  13. pmc PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP
    Edward J Weinman
    Dept of Medicine, Div of Nephrology, Univ of Maryland School of Medicine, Baltimore, MD 21202, USA
    Am J Physiol Renal Physiol 297:F1560-5. 2009
    ..Treatment with PTH, presumably by dissociating NHERF-1/Npt2a complexes, transiently increases the mobility of Npt2a, suggesting that freeing of Npt2a from the cytoskeleton precedes PTH-mediated endocytosis...
  14. pmc The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a
    Edward J Weinman
    Department of Medicine, Division of Nephrology, University of Maryland, School of Medicine, 22, South Greene Street, Baltimore, MD 21202, USA
    J Physiol 567:27-32. 2005
    ..These studies indicate a unique requirement for NHERF-1 in cAMP regulation of NHE3 and in the trafficking of Npt2a...
  15. ncbi request reprint Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse
    James B Wade
    Dept of Physiology, 655 W, Baltimore St, Univ of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 285:C1494-503. 2003
    ..These findings suggest that the organized subcellular distribution of the NHERF isoforms may play a role in the specific interactions mediating physiological control of transporter function...
  16. doi request reprint The regulation of renal phosphate transport
    Judith Blaine
    Department of Medicine, University of Colorado, Denver, 80045, USA
    Adv Chronic Kidney Dis 18:77-84. 2011
    ....
  17. ncbi request reprint Regulation of ion transport by the NHERF family of PDZ proteins
    Shirish Shenolikar
    Department Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiology (Bethesda) 19:362-9. 2004
    ....