Research Topics
Genomes and GenesSpecies | Gerald CunhaSummaryAffiliation: University of California Country: USA Publications
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Publications
Development of the penile urethraGerald R Cunha
Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA
Adv Exp Med Biol 545:87-102. 2004- Role of mesenchymal-epithelial interactions in mammary gland developmentG R Cunha
Anatomy Department and Reproductive Endocrinology Center, University of California, San Francisco 94143, USA
J Mammary Gland Biol Neoplasia 1:21-35. 1996..As a corollary, perturbation of stromal-epithelial interactions in adulthood may play a role in mammary carcinogenesis and in turn may provide opportunities for differentiation therapy... - Role of the stromal microenvironment in carcinogenesis of the prostateGerald R Cunha
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Int J Cancer 107:1-10. 2003..Thus, the stromal microenvironment is a critical determinant of benign versus malignant growth... - Role of stromal-epithelial interactions in hormonal responsesGerald R Cunha
University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, USA
Arch Histol Cytol 67:417-34. 2004..The mechanistic basis of these stromal-epithelial interactions is poorly understood, but growth factors appear to be mediators of these cell-cell interactions... - Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological studyGerald R Cunha
Department of Anatomy, University of California, San Francisco, California 94143, USA
J Morphol 256:205-18. 2003..Taken together, it is evident that the unusual sexual behaviors of the male and female spotted hyenas are facilitated by unique structural modifications of the relevant organs... - The ontogeny of the urogenital system of the spotted hyena (Crocuta crocuta Erxleben)Gerald R Cunha
Departments of Anatomy, University of California, San Francisco, CA 94143, USA
Biol Reprod 73:554-64. 2005..Androgens secreted by the maternal ovaries and metabolized by the placenta do not appear to be involved in gross masculinization or in most of the sex differences in internal phallic structure... - Role of stroma in carcinogenesis of the prostateGerald R Cunha
Departments of Anatomy and Urology, University of California, San Francisco, CA 94143 0452, USA
Differentiation 70:473-85. 2002..Thus, alteration in the stromal microenvironment was sufficient to promote malignant transformation of human prostatic epithelial cells... - Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic developmentGerald R Cunha
Department of Anatomy, University of California, Box 0452, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
J Steroid Biochem Mol Biol 92:221-36. 2004..Thus, stromal-epithelial interactions play critical roles in the hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development... - Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiationMei Cao
Department of Urology, University of California, San Francisco, Frank Hinman Jr Urological Research Laboratory, 513 Parnassus Avenue, HSW 1434, San Francisco, CA, USA
Differentiation 79:244-50. 2010..In fetal mouse bladders, urothelium-derived Shh is necessary for mesenchymal proliferation and smooth muscle differentiation. Shh concentration affects mesenchymal proliferation and patterning of bladder smooth muscle... - Steroid hormones stimulate human prostate cancer progression and metastasisWilliam A Ricke
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Int J Cancer 118:2123-31. 2006..Use of mUGM in this system will allow future studies to utilize the power of mouse genetics to identify paracrine factors involved in human prostatic carcinogenesis... - The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogenTakeshi Kurita
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Differentiation 73:313-22. 2005..Moreover, we show that genetically engineered mouse models could potentially aid in dissecting molecular pathways of stromal epithelial interactions in the human uterus... - Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogensEsequiel Rodriguez
Division of Pediatric Urology, University of California, San Francisco, California 94143, United States
Differentiation 84:269-79. 2012..Emergence of differentiated clitoral features occurs postnatally in either intact or ovariectomized females. It is likely that each penile and clitoral feature has a unique time-course of hormonal dependency/sensitivity... - Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiationDana A Weiss
Division of Pediatric Urology, University of California, San Francisco Children s Hospital, San Francisco, CA 94143, USA
Mol Cell Endocrinol 354:94-102. 2012.... - Urothelium patterns bladder smooth muscle locationMei Cao
Department of Urology, University of California, San Francisco, California 94143, USA
Pediatr Res 64:352-7. 2008.... - Anatomical studies of the fibroblast growth factor-10 mutant, Sonic Hedge Hog mutant and androgen receptor mutant mouse genital tubercleSelcuk Yucel
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
Adv Exp Med Biol 545:123-48. 2004..1.1... - Role of p63 and basal cells in the prostateTakeshi Kurita
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Development 131:4955-64. 2004..However, regressed p63(-/-) prostate did regenerate in response to androgen administration, indicating that basal cells were not essential for prostatic regeneration... - Morphology of mouse external genitalia: implications for a role of estrogen in sexual dimorphism of the mouse genital tubercleJennifer H Yang
Division of Pediatric Urology, University of California, San Francisco Children s Hospital, CA 94143, USA
J Urol 184:1604-9. 2010..We tested the hypothesis that external genitalia development depends on androgen and estrogen action... - Mesenchymal-epithelial interactions: past, present, and futureGerald R Cunha
Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
Differentiation 76:578-86. 2008..Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme... - A neuroanatomical comparison of humans and spotted hyena, a natural animal model for common urogenital sinus: clinical reflections on feminizing genitoplastyLaurence S Baskin
Division of Pediatric Urology, UCSF Children s Hospital, San Francisco, USA
J Urol 175:276-83. 2006..We also examined the implications of the pattern of clitoral innervation for the unique challenges faced by female spotted hyenas, the only extant species of mammal that mates and gives birth through the clitoris... - Steroid receptors and mammalian penile development: an unexpected role for progesterone receptor?Emily Willingham
Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
J Urol 176:728-33. 2006..We investigated the role of steroid receptors in normal and abnormal genital tubercle development in males and females. We hypothesized that progesterone receptor expression might be involved in abnormal development in both sexes... - Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosisTakeshi Kurita
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Development 131:1639-49. 2004..However, some cervicovaginal epithelial cells failed to express p63, remained columnar and persisted into adulthood as adenosis... - FGF-10 plays an essential role in the growth of the fetal prostateAnnemarie A Donjacour
Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Dev Biol 261:39-54. 2003..FGF-10 alone did not stimulate prostatic bud formation in control or FGF-10(-/-) UGS. Thus, FGF-10 appears to act as a growth factor which is required for development of the prostate and several other accessory sex organs... - Quantitation of apoptotic activity following castration in human prostatic tissue in vivoAndrea Staack
Department of Urology, University of California, San Francisco, California, USA
Prostate 54:212-9. 2003..CONCLUSIONS: Post-castration apoptosis in human prostatic epithelium was low but was sufficient to account for the loss of nearly 90% of epithelial cells... - Smooth muscle differentiation and patterning in the urinary bladderGregory Tasian
Department of Urology, University of California, San Francisco, Frank Hinman Jr Urological Research Laboratory, 513 Parnassus Avenue, HSW 1434, San Francisco, CA 94143, USA
Differentiation 80:106-17. 2010..We also discuss emerging signaling molecules, transcription factors, and mesenchyme properties that might be fruitful areas of future research in the process of smooth muscle formation in the bladder... - Hormonal, cellular, and molecular control of prostatic developmentPaul C Marker
Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
Dev Biol 253:165-74. 2003.... - Mammalian sexual differentiation: lessons from the spotted hyenaStephen E Glickman
Departments of Psychology and Integrative Biology, University of California, Berkeley, CA 94720, USA
Trends Endocrinol Metab 17:349-56. 2006..Naturally circulating androgens, acting prenatally, reduce reproductive success in adult female spotted hyenas. Effects on aggression and dominance might offset these reproductive 'costs' of female androgenization in utero... - Epithelial-stromal interactions in the mouse and human mammary gland in vivoHema Parmar
University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, CA 94143, USA
Endocr Relat Cancer 11:437-58. 2004..This observation raises the possibility of using mouse mammary fibroblasts from various mutant mice to assess the role of specific paracrine-acting gene products in human mammary gland biology and carcinogenesis... - Mouse urogenital development: a practical approachAndrea Staack
Department of Anatomy, HSW-1323, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Differentiation 71:402-13. 2003.... - Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethraKun Suk Kim
Department of Urology, University of California, San Francisco, San Francisco, California 94143, USA
Cell Tissue Res 307:145-53. 2002.... - A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblastsHema Parmar
Department of Anatomy, University of California, San Francisco, California 94143-0130, USA
Endocrinology 143:4886-96. 2002..This model allows for a variety of epithelial and stromal cells to be used in combination, which would aid in understanding key factors that regulate normal human mammary gland development... - Signalling molecules involved in mouse bladder smooth muscle cellular differentiationBenchun Liu
Department of Urology, University of California, San Francisco, San Francisco, CA, USA
Int J Dev Biol 54:175-80. 2010..Genes downstream of Shh are differentially expressed in the prospective submucosa vs. the peripheral bladder mesenchyme as a function gestation age and smooth muscle differentiation... - Spontaneous mutation in mice provides new insight into the genetic mechanisms that pattern the seminal vesicles and prostate glandPaul C Marker
Department of Anatomy, University of California San Francisco, San Francisco, California 94143, USA
Dev Dyn 226:643-53. 2003.... - Differential expression of microRNAs in mouse embryonic bladderBenchun Liu
Department of Urology, University of California, San Francisco, CA 94143, USA
Biochem Biophys Res Commun 385:528-33. 2009..The identification of unique miRNAs expression before and after smooth muscle differentiation in site-specific area of the bladder indicates their roles in embryogenesis and may aid in future clinical intervention... - Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoterTetsuro Watabe
Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
Proc Natl Acad Sci U S A 99:401-6. 2002.... - Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancerTeresa Chiaverotti
Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
Am J Pathol 172:236-46. 2008..Adenocarcinomas were not seen in our cohort. Thus, neuroendocrine carcinomas are the principal malignancy in this model and may develop from bipotential progenitor cells at an early stage of prostate tumorigenesis... - Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrestSreenivasan Paruthiyil
Department of Obstetrics, University of California, San Francisco, CA 94143 0556, USA
Cancer Res 64:423-8. 2004..Natural or synthetic ERbeta-selective estrogens may lack breast cancer promoting properties exhibited by estrogens in hormone replacement regimens and may be useful for chemoprevention of breast cancer... - Induction of hypospadias in a murine model by maternal exposure to synthetic estrogensKun Suk Kim
UCSF Children's Medical Center, Departments of Urology, Anatomy and Pediatrics, University of California, San Francisco, CA 94143, USA
Environ Res 94:267-75. 2004..Exposure to synthetic estrogens during pregnancy affects the normal development of the urethra in the mouse. We conclude that endocrine disrupters play an important role in genital tubercle anomalies... - Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNAShang Li
Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143, USA
Cancer Res 64:4833-40. 2004..Hence, anti-wild-type-hTER short-interfering RNA and MT-hTers may act through distinct pathways and, particularly in combination, represent a promising approach to anticancer therapies... - Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutaseHema Parmar
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Breast 14:256-63. 2005..These findings suggest that excess oxidative stress from loss of SOD2 function can arrest mammary gland maturation and induce hyperplastic epithelium with early premalignant features... - Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signalingWilliam A Ricke
Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
FASEB J 22:1512-20. 2008..This mouse model provides a means to examine genetic gain and loss of function and determine the efficacy of therapeutics on prostatic carcinogenesis... - The role of smooth muscle in regulating prostatic inductionAxel A Thomson
MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh, EH3 9ET, UK
Development 129:1905-12. 2002..Taken together, our data suggest that differentiation of a smooth muscle layer regulates signalling between mesenchyme and epithelium, and comprises part of the mechanism regulating prostatic induction... - Development and characterization of efficient xenograft models for benign and malignant human prostate tissueYuzhuo Wang
Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, Canada
Prostate 64:149-59. 2005..CONCLUSIONS: These data suggest that sub-renal capsule and orthotopic grafting of human prostate tissue can be used for many basic scientific and translational studies... - Stem/progenitor and intermediate cell types and the origin of human prostate cancerErik J Tokar
Department of Zoology, Michigan State University, East Lansing, MI 48824 1312, USA
Differentiation 73:463-73. 2005..Establishment and characterization of clones of human prostatic epithelial cells provide novel models for determining cell lineages, the origin of prostate cancer, and for developing new strategies for tumor prevention and treatment... - Cellular and molecular mechanisms of development of the external genitaliaGen Yamada
Center for Animal Resources and Development CARD and Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto 860 0811, Japan
Differentiation 71:445-60. 2003.... - Sonic hedgehog regulates prostatic growth and epithelial differentiationSarah H Freestone
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Dev Biol 264:352-62. 2003.... - Steroid hormones and carcinogenesis of the prostate: the role of estrogensWilliam A Ricke
Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
Differentiation 75:871-82. 2007..Answers to these questions will further our understanding of the mechanisms of estrogen/ER signaling and will serve as a basis for chemopreventive and/or chemotherapeutic strategies for prostate cancer... - Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesisXi De Wang
Department of Molecular Biology, MS 72, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Differentiation 75:219-34. 2007.... - Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesisKathleen C Day
Department of Urology, Flow Cytometry Core, University of Michigan Comprehensive Cancer Center, The University of Michigan, Ann Arbor 48109, USA
J Biol Chem 277:44475-84. 2002..Additionally, the development of this technology will allow similar studies in other tissues and cell populations rescued from Rb-/- fetuses... - Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesisMinjung J Kim
Department of Neuroscience, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
Cancer Res 62:2999-3004. 2002..1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma... - Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterusTomomi Sato
Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
Endocrinology 143:2673-9. 2002..Local IGF-I is not a direct mediator of E2 action in uterus, and systemic IGF-I may be more important than previously thought for growth of the uterus and other tissues... - Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancerMargaret S Joesting
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer Res 65:10423-30. 2005..These data suggest that overexpression of SFRP1 by prostatic tumor stroma may account for the previously reported capacity of prostatic tumor stroma to provide a pro-proliferative paracrine signal to adjacent epithelial cells... - Formation of human prostate tissue from embryonic stem cellsRenea A Taylor
Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia 3168
Nat Methods 3:179-81. 2006..This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues... - Differential expression of p63 isoforms in female reproductive organsTakeshi Kurita
Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3
Mech Dev 122:1043-55. 2005..Therefore, inhibition of p63 expression by DES should change the cell fate of human Müllerian duct epithelial cells and cause cervical/vaginal adenosis as previously demonstrated in mouse... - An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor lineYuwei Wang
Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, British Columbia, Canada
Lab Invest 85:1392-404. 2005..Orthotopic xenografts of the transplantable tumor lines and metastatic sublines can be used for studying various aspects of metastatic prostate cancer, including metastasis to bone... - Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progressionJianyong Shou
Department of Molecular Oncology, MS No. 72, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 99:2830-5. 2002..These findings suggest IFN-inducible molecules as potential therapeutic targets for the treatment of prostate cancer... - Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapyDaniel W Doxsee
Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, British Columbia, Canada
Prostate 67:162-71. 2007..Here we examined advanced human prostate cancer cell lines, DU-145 and PC-3, for dependence on extracellular cystine and sensitivity to sulfasalazine (SASP), a potent inhibitor of the x(c)(-) cystine transporter... - Stable maintenance of 5alpha-reductase activity in long-term subcultures of fibroblasts derived from the foreskinKazumi Nakae
Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan
Int J Urol 9:347-53. 2002..Therefore, this assay method can be used for differential diagnosis of 5alpha-reductase deficiency from other relevant entities... - Molecular, cellular and developmental biology of urothelium as a basis of bladder regenerationAndrea Staack
Department of Urology, University Medical Center Charite, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
Differentiation 73:121-33. 2005.... - It's not my fault, blame it on my microenvironmentGerald R Cunha
Differentiation 70:469-72. 2002
Research Grants
- CELL-CELL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 1993..While most of the studies will use animal models, in the last year of the project we will apply new emerging concepts and techniques to human prostate cancers, which constitute one of the most serious medical problems for the aging male...
- CELL CELL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 2001..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
- SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 2001..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
- HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTHGerald Cunha; Fiscal Year: 2001..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
- Stromal Epithelial Interactions in Breast CancerGerald Cunha; Fiscal Year: 2004..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..