Gerald Cunha

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Development of the penile urethra
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Adv Exp Med Biol 545:87-102. 2004
  2. ncbi request reprint Role of mesenchymal-epithelial interactions in mammary gland development
    G R Cunha
    Anatomy Department and Reproductive Endocrinology Center, University of California, San Francisco 94143, USA
    J Mammary Gland Biol Neoplasia 1:21-35. 1996
  3. ncbi request reprint Role of the stromal microenvironment in carcinogenesis of the prostate
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Int J Cancer 107:1-10. 2003
  4. ncbi request reprint Role of stromal-epithelial interactions in hormonal responses
    Gerald R Cunha
    University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, USA
    Arch Histol Cytol 67:417-34. 2004
  5. ncbi request reprint Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological study
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Morphol 256:205-18. 2003
  6. ncbi request reprint The ontogeny of the urogenital system of the spotted hyena (Crocuta crocuta Erxleben)
    Gerald R Cunha
    Departments of Anatomy, University of California, San Francisco, CA 94143, USA
    Biol Reprod 73:554-64. 2005
  7. ncbi request reprint Role of stroma in carcinogenesis of the prostate
    Gerald R Cunha
    Departments of Anatomy and Urology, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 70:473-85. 2002
  8. ncbi request reprint Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development
    Gerald R Cunha
    Department of Anatomy, University of California, Box 0452, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    J Steroid Biochem Mol Biol 92:221-36. 2004
  9. pmc Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiation
    Mei Cao
    Department of Urology, University of California, San Francisco, Frank Hinman Jr Urological Research Laboratory, 513 Parnassus Avenue, HSW 1434, San Francisco, CA, USA
    Differentiation 79:244-50. 2010
  10. pmc Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens
    Esequiel Rodriguez
    Division of Pediatric Urology, University of California, San Francisco, California 94143, United States
    Differentiation 84:269-79. 2012

Research Grants

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Development of the penile urethra
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Adv Exp Med Biol 545:87-102. 2004
  2. ncbi request reprint Role of mesenchymal-epithelial interactions in mammary gland development
    G R Cunha
    Anatomy Department and Reproductive Endocrinology Center, University of California, San Francisco 94143, USA
    J Mammary Gland Biol Neoplasia 1:21-35. 1996
    ..As a corollary, perturbation of stromal-epithelial interactions in adulthood may play a role in mammary carcinogenesis and in turn may provide opportunities for differentiation therapy...
  3. ncbi request reprint Role of the stromal microenvironment in carcinogenesis of the prostate
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Int J Cancer 107:1-10. 2003
    ..Thus, the stromal microenvironment is a critical determinant of benign versus malignant growth...
  4. ncbi request reprint Role of stromal-epithelial interactions in hormonal responses
    Gerald R Cunha
    University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, USA
    Arch Histol Cytol 67:417-34. 2004
    ..The mechanistic basis of these stromal-epithelial interactions is poorly understood, but growth factors appear to be mediators of these cell-cell interactions...
  5. ncbi request reprint Urogenital system of the spotted hyena (Crocuta crocuta Erxleben): a functional histological study
    Gerald R Cunha
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    J Morphol 256:205-18. 2003
    ..Taken together, it is evident that the unusual sexual behaviors of the male and female spotted hyenas are facilitated by unique structural modifications of the relevant organs...
  6. ncbi request reprint The ontogeny of the urogenital system of the spotted hyena (Crocuta crocuta Erxleben)
    Gerald R Cunha
    Departments of Anatomy, University of California, San Francisco, CA 94143, USA
    Biol Reprod 73:554-64. 2005
    ..Androgens secreted by the maternal ovaries and metabolized by the placenta do not appear to be involved in gross masculinization or in most of the sex differences in internal phallic structure...
  7. ncbi request reprint Role of stroma in carcinogenesis of the prostate
    Gerald R Cunha
    Departments of Anatomy and Urology, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 70:473-85. 2002
    ..Thus, alteration in the stromal microenvironment was sufficient to promote malignant transformation of human prostatic epithelial cells...
  8. ncbi request reprint Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development
    Gerald R Cunha
    Department of Anatomy, University of California, Box 0452, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    J Steroid Biochem Mol Biol 92:221-36. 2004
    ..Thus, stromal-epithelial interactions play critical roles in the hormonal, cellular, and molecular regulation of normal and neoplastic prostatic development...
  9. pmc Urothelium-derived Sonic hedgehog promotes mesenchymal proliferation and induces bladder smooth muscle differentiation
    Mei Cao
    Department of Urology, University of California, San Francisco, Frank Hinman Jr Urological Research Laboratory, 513 Parnassus Avenue, HSW 1434, San Francisco, CA, USA
    Differentiation 79:244-50. 2010
    ..In fetal mouse bladders, urothelium-derived Shh is necessary for mesenchymal proliferation and smooth muscle differentiation. Shh concentration affects mesenchymal proliferation and patterning of bladder smooth muscle...
  10. pmc Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens
    Esequiel Rodriguez
    Division of Pediatric Urology, University of California, San Francisco, California 94143, United States
    Differentiation 84:269-79. 2012
    ..Emergence of differentiated clitoral features occurs postnatally in either intact or ovariectomized females. It is likely that each penile and clitoral feature has a unique time-course of hormonal dependency/sensitivity...
  11. ncbi request reprint Steroid hormones stimulate human prostate cancer progression and metastasis
    William A Ricke
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Int J Cancer 118:2123-31. 2006
    ..Use of mUGM in this system will allow future studies to utilize the power of mouse genetics to identify paracrine factors involved in human prostatic carcinogenesis...
  12. ncbi request reprint The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen
    Takeshi Kurita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Differentiation 73:313-22. 2005
    ..Moreover, we show that genetically engineered mouse models could potentially aid in dissecting molecular pathways of stromal epithelial interactions in the human uterus...
  13. pmc Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiation
    Dana A Weiss
    Division of Pediatric Urology, University of California, San Francisco Children s Hospital, San Francisco, CA 94143, USA
    Mol Cell Endocrinol 354:94-102. 2012
    ....
  14. pmc Urothelium patterns bladder smooth muscle location
    Mei Cao
    Department of Urology, University of California, San Francisco, California 94143, USA
    Pediatr Res 64:352-7. 2008
    ....
  15. ncbi request reprint Anatomical studies of the fibroblast growth factor-10 mutant, Sonic Hedge Hog mutant and androgen receptor mutant mouse genital tubercle
    Selcuk Yucel
    Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Adv Exp Med Biol 545:123-48. 2004
    ..1.1...
  16. ncbi request reprint Role of p63 and basal cells in the prostate
    Takeshi Kurita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Development 131:4955-64. 2004
    ..However, regressed p63(-/-) prostate did regenerate in response to androgen administration, indicating that basal cells were not essential for prostatic regeneration...
  17. pmc Morphology of mouse external genitalia: implications for a role of estrogen in sexual dimorphism of the mouse genital tubercle
    Jennifer H Yang
    Division of Pediatric Urology, University of California, San Francisco Children s Hospital, CA 94143, USA
    J Urol 184:1604-9. 2010
    ..We tested the hypothesis that external genitalia development depends on androgen and estrogen action...
  18. doi request reprint Mesenchymal-epithelial interactions: past, present, and future
    Gerald R Cunha
    Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA
    Differentiation 76:578-86. 2008
    ..Present and future studies reviewed in this issue deal with the molecular mechanisms in this developmental communication between epithelium and mesenchyme...
  19. ncbi request reprint A neuroanatomical comparison of humans and spotted hyena, a natural animal model for common urogenital sinus: clinical reflections on feminizing genitoplasty
    Laurence S Baskin
    Division of Pediatric Urology, UCSF Children s Hospital, San Francisco, USA
    J Urol 175:276-83. 2006
    ..We also examined the implications of the pattern of clitoral innervation for the unique challenges faced by female spotted hyenas, the only extant species of mammal that mates and gives birth through the clitoris...
  20. ncbi request reprint Steroid receptors and mammalian penile development: an unexpected role for progesterone receptor?
    Emily Willingham
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 176:728-33. 2006
    ..We investigated the role of steroid receptors in normal and abnormal genital tubercle development in males and females. We hypothesized that progesterone receptor expression might be involved in abnormal development in both sexes...
  21. ncbi request reprint Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis
    Takeshi Kurita
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Development 131:1639-49. 2004
    ..However, some cervicovaginal epithelial cells failed to express p63, remained columnar and persisted into adulthood as adenosis...
  22. ncbi request reprint FGF-10 plays an essential role in the growth of the fetal prostate
    Annemarie A Donjacour
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Dev Biol 261:39-54. 2003
    ..FGF-10 alone did not stimulate prostatic bud formation in control or FGF-10(-/-) UGS. Thus, FGF-10 appears to act as a growth factor which is required for development of the prostate and several other accessory sex organs...
  23. ncbi request reprint Quantitation of apoptotic activity following castration in human prostatic tissue in vivo
    Andrea Staack
    Department of Urology, University of California, San Francisco, California, USA
    Prostate 54:212-9. 2003
    ..Androgen deprivation induces apoptosis in the prostate. Representative data, quantitating apoptotic activity in human prostatic epithelium following androgen ablation, are lacking...
  24. pmc Smooth muscle differentiation and patterning in the urinary bladder
    Gregory Tasian
    Department of Urology, University of California, San Francisco, Frank Hinman Jr Urological Research Laboratory, 513 Parnassus Avenue, HSW 1434, San Francisco, CA 94143, USA
    Differentiation 80:106-17. 2010
    ..We also discuss emerging signaling molecules, transcription factors, and mesenchyme properties that might be fruitful areas of future research in the process of smooth muscle formation in the bladder...
  25. ncbi request reprint Hormonal, cellular, and molecular control of prostatic development
    Paul C Marker
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Biol 253:165-74. 2003
    ....
  26. ncbi request reprint Mammalian sexual differentiation: lessons from the spotted hyena
    Stephen E Glickman
    Departments of Psychology and Integrative Biology, University of California, Berkeley, CA 94720, USA
    Trends Endocrinol Metab 17:349-56. 2006
    ..Naturally circulating androgens, acting prenatally, reduce reproductive success in adult female spotted hyenas. Effects on aggression and dominance might offset these reproductive 'costs' of female androgenization in utero...
  27. ncbi request reprint Epithelial-stromal interactions in the mouse and human mammary gland in vivo
    Hema Parmar
    University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, CA 94143, USA
    Endocr Relat Cancer 11:437-58. 2004
    ..This observation raises the possibility of using mouse mammary fibroblasts from various mutant mice to assess the role of specific paracrine-acting gene products in human mammary gland biology and carcinogenesis...
  28. ncbi request reprint Mouse urogenital development: a practical approach
    Andrea Staack
    Department of Anatomy, HSW 1323, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Differentiation 71:402-13. 2003
    ....
  29. ncbi request reprint Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra
    Kun Suk Kim
    Department of Urology, University of California, San Francisco, San Francisco, California 94143, USA
    Cell Tissue Res 307:145-53. 2002
    ....
  30. ncbi request reprint A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts
    Hema Parmar
    Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Endocrinology 143:4886-96. 2002
    ..This model allows for a variety of epithelial and stromal cells to be used in combination, which would aid in understanding key factors that regulate normal human mammary gland development...
  31. pmc Signalling molecules involved in mouse bladder smooth muscle cellular differentiation
    Benchun Liu
    Department of Urology, University of California, San Francisco, San Francisco, CA, USA
    Int J Dev Biol 54:175-80. 2010
    ..Genes downstream of Shh are differentially expressed in the prospective submucosa vs. the peripheral bladder mesenchyme as a function gestation age and smooth muscle differentiation...
  32. ncbi request reprint Spontaneous mutation in mice provides new insight into the genetic mechanisms that pattern the seminal vesicles and prostate gland
    Paul C Marker
    Department of Anatomy, University of California San Francisco, San Francisco, California 94143, USA
    Dev Dyn 226:643-53. 2003
    ....
  33. doi request reprint Differential expression of microRNAs in mouse embryonic bladder
    Benchun Liu
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 385:528-33. 2009
    ..The identification of unique miRNAs expression before and after smooth muscle differentiation in site-specific area of the bladder indicates their roles in embryogenesis and may aid in future clinical intervention...
  34. pmc Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter
    Tetsuro Watabe
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:401-6. 2002
    ....
  35. pmc Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer
    Teresa Chiaverotti
    Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
    Am J Pathol 172:236-46. 2008
    ..Adenocarcinomas were not seen in our cohort. Thus, neuroendocrine carcinomas are the principal malignancy in this model and may develop from bipotential progenitor cells at an early stage of prostate tumorigenesis...
  36. ncbi request reprint Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    Sreenivasan Paruthiyil
    Department of Obstetrics, University of California, San Francisco, CA 94143 0556, USA
    Cancer Res 64:423-8. 2004
    ..Natural or synthetic ERbeta-selective estrogens may lack breast cancer promoting properties exhibited by estrogens in hormone replacement regimens and may be useful for chemoprevention of breast cancer...
  37. ncbi request reprint Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens
    Kun Suk Kim
    UCSF Children s Medical Center, Departments of Urology, Anatomy and Pediatrics, University of California, San Francisco, CA 94143, USA
    Environ Res 94:267-75. 2004
    ..Exposure to synthetic estrogens during pregnancy affects the normal development of the urethra in the mouse. We conclude that endocrine disrupters play an important role in genital tubercle anomalies...
  38. ncbi request reprint Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
    Shang Li
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 64:4833-40. 2004
    ..Hence, anti-wild-type-hTER short-interfering RNA and MT-hTers may act through distinct pathways and, particularly in combination, represent a promising approach to anticancer therapies...
  39. ncbi request reprint Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase
    Hema Parmar
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Breast 14:256-63. 2005
    ..These findings suggest that excess oxidative stress from loss of SOD2 function can arrest mammary gland maturation and induce hyperplastic epithelium with early premalignant features...
  40. ncbi request reprint Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling
    William A Ricke
    Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    FASEB J 22:1512-20. 2008
    ..This mouse model provides a means to examine genetic gain and loss of function and determine the efficacy of therapeutics on prostatic carcinogenesis...
  41. ncbi request reprint The role of smooth muscle in regulating prostatic induction
    Axel A Thomson
    MRC Human Reproductive Sciences Unit, 37 Chalmers Street, Edinburgh, EH3 9ET, UK
    Development 129:1905-12. 2002
    ..Taken together, our data suggest that differentiation of a smooth muscle layer regulates signalling between mesenchyme and epithelium, and comprises part of the mechanism regulating prostatic induction...
  42. ncbi request reprint Development and characterization of efficient xenograft models for benign and malignant human prostate tissue
    Yuzhuo Wang
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, Canada
    Prostate 64:149-59. 2005
    ..Furthermore, xenografts could only be established using high-grade, advanced stage, but not low- or moderate-grade prostate cancer tissues...
  43. ncbi request reprint Stem/progenitor and intermediate cell types and the origin of human prostate cancer
    Erik J Tokar
    Department of Zoology, Michigan State University, East Lansing, MI 48824 1312, USA
    Differentiation 73:463-73. 2005
    ..Establishment and characterization of clones of human prostatic epithelial cells provide novel models for determining cell lineages, the origin of prostate cancer, and for developing new strategies for tumor prevention and treatment...
  44. ncbi request reprint Cellular and molecular mechanisms of development of the external genitalia
    Gen Yamada
    Center for Animal Resources and Development CARD and Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto 860 0811, Japan
    Differentiation 71:445-60. 2003
    ....
  45. ncbi request reprint Sonic hedgehog regulates prostatic growth and epithelial differentiation
    Sarah H Freestone
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Dev Biol 264:352-62. 2003
    ....
  46. ncbi request reprint Steroid hormones and carcinogenesis of the prostate: the role of estrogens
    William A Ricke
    Department of Urology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    Differentiation 75:871-82. 2007
    ..Answers to these questions will further our understanding of the mechanisms of estrogen/ER signaling and will serve as a basis for chemopreventive and/or chemotherapeutic strategies for prostate cancer...
  47. ncbi request reprint Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis
    Xi De Wang
    Department of Molecular Biology, MS 72, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Differentiation 75:219-34. 2007
    ....
  48. ncbi request reprint Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis
    Kathleen C Day
    Department of Urology, Flow Cytometry Core, University of Michigan Comprehensive Cancer Center, The University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 277:44475-84. 2002
    ..Additionally, the development of this technology will allow similar studies in other tissues and cell populations rescued from Rb-/- fetuses...
  49. ncbi request reprint Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis
    Minjung J Kim
    Department of Neuroscience, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Cancer Res 62:2999-3004. 2002
    ..1 mutant mice accurately model early stages of prostate carcinogenesis. More generally, our tissue recombination assay provides an empirical test to examine the relationship of PIN to prostate carcinoma...
  50. ncbi request reprint Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus
    Tomomi Sato
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Endocrinology 143:2673-9. 2002
    ..Local IGF-I is not a direct mediator of E2 action in uterus, and systemic IGF-I may be more important than previously thought for growth of the uterus and other tissues...
  51. ncbi request reprint Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    Margaret S Joesting
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 65:10423-30. 2005
    ..These data suggest that overexpression of SFRP1 by prostatic tumor stroma may account for the previously reported capacity of prostatic tumor stroma to provide a pro-proliferative paracrine signal to adjacent epithelial cells...
  52. ncbi request reprint Formation of human prostate tissue from embryonic stem cells
    Renea A Taylor
    Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton, Victoria, Australia 3168
    Nat Methods 3:179-81. 2006
    ..This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues...
  53. ncbi request reprint Differential expression of p63 isoforms in female reproductive organs
    Takeshi Kurita
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3
    Mech Dev 122:1043-55. 2005
    ..Therefore, inhibition of p63 expression by DES should change the cell fate of human Müllerian duct epithelial cells and cause cervical/vaginal adenosis as previously demonstrated in mouse...
  54. ncbi request reprint An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line
    Yuwei Wang
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, British Columbia, Canada
    Lab Invest 85:1392-404. 2005
    ..Orthotopic xenografts of the transplantable tumor lines and metastatic sublines can be used for studying various aspects of metastatic prostate cancer, including metastasis to bone...
  55. pmc Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression
    Jianyong Shou
    Department of Molecular Oncology, MS No 72, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 99:2830-5. 2002
    ..These findings suggest IFN-inducible molecules as potential therapeutic targets for the treatment of prostate cancer...
  56. ncbi request reprint Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy
    Daniel W Doxsee
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, British Columbia, Canada
    Prostate 67:162-71. 2007
    ..Here we examined advanced human prostate cancer cell lines, DU-145 and PC-3, for dependence on extracellular cystine and sensitivity to sulfasalazine (SASP), a potent inhibitor of the x(c)(-) cystine transporter...
  57. ncbi request reprint Stable maintenance of 5alpha-reductase activity in long-term subcultures of fibroblasts derived from the foreskin
    Kazumi Nakae
    Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan
    Int J Urol 9:347-53. 2002
    ..It was therefore attempted in this study to establish an assay method which produced stable 5alpha-reductase activity in long-term subcultured foreskin fibroblasts...
  58. ncbi request reprint Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration
    Andrea Staack
    Department of Urology, University Medical Center Charite, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Differentiation 73:121-33. 2005
    ....
  59. ncbi request reprint It's not my fault, blame it on my microenvironment
    Gerald R Cunha
    Differentiation 70:469-72. 2002

Research Grants22

  1. CELL-CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 1993
    ..While most of the studies will use animal models, in the last year of the project we will apply new emerging concepts and techniques to human prostate cancers, which constitute one of the most serious medical problems for the aging male...
  2. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  3. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  4. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  5. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..