Research Topics
Genomes and GenesSpecies | Steven R CummingsSummaryAffiliation: University of California Country: USA Publications
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Publications
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention TrialS R Cummings
Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
JAMA 280:2077-82. 1998..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...- Clinical use of bone densitometry: scientific reviewSteven R Cummings
The UCSF Coordinating Center, University of California, San Francisco, USA
JAMA 288:1889-97. 2002..Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry has become more widely available and commonly used in practice... - Issues in designing and testing a "cure" for osteoporosisS Cummings
S.F. Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
J Musculoskelet Neuronal Interact 4:408. 2004 - Summary--curing osteoporosisS Cummings
S.F. Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
J Musculoskelet Neuronal Interact 4:409. 2004 - Epidemiology and outcomes of osteoporotic fracturesSteven R Cummings
Coordinating Center, Department of Medicine, University of California, San Francisco, CA 94105, USA
Lancet 359:1761-7. 2002..Therefore, epidemiological research should be done and used to identify individuals at high-risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need... - Sex hormones, risk factors, and risk of estrogen receptor-positive breast cancer in older women: a long-term prospective studySteven R Cummings
California Pacific Medical Center, Coordinating Center, Suite 600, 74 New Montgomery Street, San Francisco, CA 94105, USA
Cancer Epidemiol Biomarkers Prev 14:1047-51. 2005..Women at high risk of ER+ cancer would be the most likely to benefit from these treatments, but the best approach to predicting ER+ cancer is uncertain... - Serum estradiol level and risk of breast cancer during treatment with raloxifeneSteven R Cummings
Coordinating Center, University of California, Suite 600, 74 New Montgomery St, San Francisco, CA 94105, USA
JAMA 287:216-20. 2002..Raloxifene competes with endogenous estrogen for binding to estrogen receptors in breast tissue. A woman's estradiol level may alter the effects of raloxifene on breast cancer and other outcomes... - The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene EvaluationS R Cummings
Department of Medicine, University of California, San Francisco, USA
JAMA 281:2189-97. 1999..Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting... - Fetuin-A and change in body composition in older personsJoachim H Ix
Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Clin Endocrinol Metab 94:4492-8. 2009..Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown... - Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1Alka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
Arch Intern Med 166:350-6. 2006..Adipose tissue produces "adipocytokines" of uncertain clinical significance... - Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition StudyDonglei Hu
Department of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 57:1213-8. 2009..To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults... - Thiazolidinedione use and bone loss in older diabetic adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, California 94107 1762, USA
J Clin Endocrinol Metab 91:3349-54. 2006..Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass in mice... - A comparison of prediction models for fractures in older women: is more better?Kristine E Ensrud
Department of Medicine, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
Arch Intern Med 169:2087-94. 2009..However, it is uncertain whether prediction with FRAX models is superior to that based on parsimonious models... - Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trialDennis M Black
San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
JAMA 296:2927-38. 2006..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain... - Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal womenDeborah Grady
University of California Women s Health Clinical Research Center, San Francisco, CA 94115, USA
Menopause 14:391-6. 2007..The purpose of this study was to determine whether 2 years of treatment with ultra-low-dose transdermal estradiol results in a change in breast density... - High-trauma fractures and low bone mineral density in older women and menDawn C Mackey
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
JAMA 298:2381-8. 2007..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively... - Clustering of strength, physical function, muscle, and adiposity characteristics and risk of disability in older adultsPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California, USA
J Am Geriatr Soc 59:781-7. 2011..To empirically identify groupings of strength, physical performance, adiposity, and lean mass and test how such groupings of these interrelated measures may relate to disability risk... - Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) studyPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
J Clin Endocrinol Metab 94:3806-15. 2009..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors... - Fat infiltration of muscle, diabetes, and clinical fracture risk in older adultsAnne L Schafer
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 95:E368-72. 2010..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture... - Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fracturesMichael C Nevitt
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:131-40. 2005..Risk factors and low BMD should be useful to help focus efforts to prevent these fractures... - Pentosidine and increased fracture risk in older adults with type 2 diabetesAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94107 1762, USA
J Clin Endocrinol Metab 94:2380-6. 2009..Type 2 diabetes is associated with higher fracture risk at a given bone mineral density. Advanced glycation endproducts (AGEs) accumulate in bone collagen with age and diabetes and may weaken bone... - Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older menPeggy M Cawthon
California Pacific Medical Center Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
J Clin Endocrinol Metab 95:4625-34. 2010..Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults... - The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)Dennis M Black
Department of Epidemiology and Biostastistics, University of California, San Francisco, CA 94107, USA
J Bone Miner Res 27:243-54. 2012..However, vertebral fracture reductions suggest that those at high fracture risk, particularly vertebral fracture, may benefit by continued treatment... - Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older womenGregory J Tranah
California Pacific Medical Center Research Institute, San Francisco, CA 94107 1728, USA
Ann Neurol 70:722-32. 2011..We determined whether circadian activity rhythms measured in community-dwelling older women are prospectively associated with incident dementia or mild cognitive impairment (MCI)... - F2-isoprostanes and adiposity in older adultsAlka M Kanaya
University of California, San Francisco, California, USA
Obesity (Silver Spring) 19:861-7. 2011..05). In conclusion, F(2)-IPs were associated with measures of total and regional adiposity in women alone and these associations were partially explained by adipocytokines. F(2)-IPs predicted loss of total adiposity over time among women... - Fetuin-A and incident diabetes mellitus in older personsJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
JAMA 300:182-8. 2008..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown... - Cystatin C and mortality risk in the elderly: the health, aging, and body composition studyMichael G Shlipak
University of San Francisco, General Internal Medicine Section, VA Medical Center (111A1, 4150 Clement Street, San Francisco, CA 94121, USA
J Am Soc Nephrol 17:254-61. 2006..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine... - Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older womenDiana M Antoniucci
Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:741-7. 2005..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures... - Estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US National Osteoporosis Foundation guidelinesMeghan G Donaldson
San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA 94107, USA
J Bone Miner Res 25:1506-11. 2010..Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown... - The effects of tibolone in older postmenopausal womenSteven R Cummings
San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
N Engl J Med 359:697-708. 2008..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain... - Circadian activity rhythms and mortality: the study of osteoporotic fracturesGregory J Tranah
California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
J Am Geriatr Soc 58:282-91. 2010..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women... - COMT genotype and cognitive function: an 8-year longitudinal study in white and black eldersA J Fiocco
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
Neurology 74:1296-302. 2010..Few studies have examined the prospective association between COMT (val(158)met) genotype and cognition in older adults... - Self-reported sleep and nap habits and risk of mortality in a large cohort of older womenKatie L Stone
Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
J Am Geriatr Soc 57:604-11. 2009..To determine the association between self-reported sleep and nap habits and mortality in a large cohort of older women... - Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1)Mary S Beattie
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
J Natl Cancer Inst 98:110-5. 2006..The purpose of this study was to determine whether sex hormone levels were associated with breast cancer risk and with response to tamoxifen in a high-risk population... - Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fracturesKatie L Stone
Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
J Am Geriatr Soc 54:1177-83. 2006..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women... - Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?Peggy Mannen Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
J Am Geriatr Soc 57:1411-9. 2009..To examine the association between strength, function, lean mass, muscle density, and risk of hospitalization... - Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) studyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
J Bone Miner Res 24:514-21. 2009..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women... - Diabetes and bone loss at the hip in older black and white adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
J Bone Miner Res 20:596-603. 2005.... - Postmenopausal hormones and sleep quality in the elderly: a population based studyGregory J Tranah
CPMC Research Institute, San Francisco, CA, USA
BMC Womens Health 10:15. 2010..Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy... - Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trialAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
J Bone Miner Res 25:976-82. 2010..5 or less but does not reduce risk of NVF in women whose T-scores are greater than -2... - Serum sclerostin and risk of hip fracture in older Caucasian womenAarthi Arasu
Department of Medicine, University of California, San Francisco, USA
J Clin Endocrinol Metab 97:2027-32. 2012..Sclerostin, a protein secreted by osteocytes, inhibits bone formation. Individuals with genetic mutations that decrease the availability of sclerostin have very high bone mass... - Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*Dawn C Mackey
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
J Bone Miner Res 22:1862-8. 2007..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men... - Once-yearly zoledronic acid for treatment of postmenopausal osteoporosisDennis M Black
University of California, San Francisco, San Francisco, CA 94107, USA
N Engl J Med 356:1809-22. 2007..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period... - Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC studyKristine Yaffe
Department of Psychiatry and Neurology, School of Medicine, San Francisco, CA 94121, USA
Neurobiol Aging 30:607-14. 2009..To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women... - Novel methods to evaluate fracture risk modelsMeghan G Donaldson
San Francisco Coordinating Center, San Francisco, CA, USA
J Bone Miner Res 26:1767-73. 2011..The Cook method (both models, both fracture outcomes) had similar fracture rates above/below the treatment thresholds. Compared with the AUC, new methods provide more detailed information about how models classify patients... - Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive modelJeffrey A Tice
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 94143 1732, USA
Ann Intern Med 148:337-47. 2008..Current models for assessing breast cancer risk are complex and do not include breast density, a strong risk factor for breast cancer that is routinely reported with mammography... - Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) studyPeggy M Cawthon
California Pacific Medical Center, Research Institute, San Francisco Coordinating Center, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107 1728, USA
J Bone Miner Res 24:1728-35. 2009..Older men and those with lower BMD lose bone more rapidly, offering potential explanation for the increasing risk of fracture with advancing age... - Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCTDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
J Bone Miner Res 23:1326-33. 2008.... - Lasofoxifene in postmenopausal women with osteoporosisSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
N Engl J Med 362:686-96. 2010..The effects of lasofoxifene on the risk of fractures, breast cancer, and cardiovascular disease are uncertain... - Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) studyEthel S Siris
Toni Stabile Osteoporosis Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Bone Miner Res 20:1514-24. 2005..CORE had limitations for assessing fracture risk. In a subset of 386 women, 7 years of raloxifene treatment significantly increased lumbar spine and femoral neck BMD compared from the baseline of MORE... - Alcohol use, physical performance, and functional limitations in older menPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
J Am Geriatr Soc 55:212-20. 2007..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men... - Actigraphy-measured sleep characteristics and risk of falls in older womenKatie L Stone
Research Institute, California Pacific Medical Center, 185 Berry St, Lobby 4, Fifth Floor, Ste 5700, San Francisco, CA 94107 1762, USA
Arch Intern Med 168:1768-75. 2008..However, no previous study, to our knowledge, has tested the independent associations of objectively estimated characteristics of sleep and risk of falls, accounting for the use of commonly prescribed treatments for insomnia... - Hyperkyphosis predicts mortality independent of vertebral osteoporosis in older womenDeborah M Kado
University of California, Los Angeles, Los Angeles, California, USA
Ann Intern Med 150:681-7. 2009..Excessive kyphosis may be associated with earlier mortality, but previous studies have not controlled for clinically silent vertebral fractures, which are a known mortality risk factor... - Sex hormone levels and risks of estrogen receptor-negative and estrogen receptor-positive breast cancersGhada N Farhat
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
J Natl Cancer Inst 103:562-70. 2011..Endogenous sex hormone levels are associated with risks of breast cancer overall and estrogen receptor (ER)-positive breast tumors; however, their associations with ER-negative tumors remain unclear... - Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal womenAlison J Huang
Veterans Affairs Medical Center, San Francisco, California, USA
J Bone Miner Res 22:1791-7. 2007..This suggests that the protective effects of ultra-low-dose estrogen therapy on the postmenopausal skeletal health may depend critically on women's endogenous estrogen levels before treatment... - Denosumab for prevention of fractures in postmenopausal women with osteoporosisSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
N Engl J Med 361:756-65. 2009..Given its unique actions, denosumab may be useful in the treatment of osteoporosis... - Clinical use of bone densitometry: clinical applicationsDavid W Bates
Department of Medicine, Brigham and Women s Hospital, and the Center for Applied Medical Information Systems Research, Partners HealthCare Systems, and Harvard Medical School, Boston, Mass 02115, USA
JAMA 288:1898-900. 2002..Clinicians need better approaches for identifying patients most likely to benefit from screening, systems that facilitate their application, and test results that are easy to interpret... - Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scansXiang Wang
Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA
J Bone Miner Res 27:808-16. 2012..82, p = 0.05). We conclude that, compared to areal BMD by DXA, vertebral compressive strength and volumetric BMD consistently improved vertebral fracture risk assessment in this cohort of elderly men... - Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older menTracie C Collins
University of Minnesota, Department of Medicine, 717 Delaware St SE, Suite 166, Minneapolis, MN 55414, USA
Circulation 119:2305-12. 2009..Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain... - A common variant in the telomerase RNA component is associated with short telomere lengthOmer T Njajou
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e13048. 2010.... - FRAX and risk of vertebral fractures: the fracture intervention trialMeghan G Donaldson
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA
J Bone Miner Res 24:1793-9. 2009..A combination of baseline radiographic vertebral fracture, FN BMD, and age is the strongest predictor of future vertebral fracture... - Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older womenRobin L Seitzman
Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 92122, USA
Am J Epidemiol 167:1217-25. 2008..02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated... - Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC StudyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA
Neurobiol Aging 32:2055-60. 2011..There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p=0.06). Thus, telomere length may serve as a biomarker for cognitive aging... - Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition studyManjula Kurella
Division of Nephrology, University of California San Francisco, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
J Am Soc Nephrol 16:2127-33. 2005..Studies aimed at understanding the mechanism(s) responsible for cognitive impairment in CKD and efforts to interrupt this decline are warranted... - Volume of mammographic density and risk of breast cancerJohn A Shepherd
Department of Radiology, University of California, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 20:1473-82. 2011.... - Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugsSteven R Cummings
Department of Medicine, University of California, San Francisco, California, USA
Am J Med 112:281-9. 2002..CONCLUSION: Improvement in spine bone mineral density during treatment with antiresorptive drugs accounts for a predictable but small part of the observed reduction in the risk of vertebral fracture... - BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older womenSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
J Bone Miner Res 21:1550-6. 2006..As in women, lumbar spine BMD in men is only weakly associated with risk of hip fracture. Regardless of whether sex-specific or female reference values were used, T scores indicated different risks of fractures in men than in women... - Effect of Raloxifene on all-cause mortalityDeborah Grady
University of California, San Francisco, CA 94115, USA
Am J Med 123:469.e1-7. 2010..To assess the risk/benefit of raloxifene as a preventative treatment, we analyzed treatment effects on overall and cause-specific mortality... - Estimating long-term effects of treatment from placebo-controlled trials with an extension period, using virtual twinsEric Vittinghoff
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94107, USA
Stat Med 29:1127-36. 2010..The proposed method is validated using simulation, and applied to data from the Fracture Intervention Trial and its extension, FLEX... - Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fracturesGregory J Tranah
CPMC Research Institute, San Francisco, CA 94120, USA
Calcif Tissue Int 83:155-66. 2008..In conclusion, polymorphisms in several candidate genes were associated with hip, vertebral, and nonhip/nonvertebral fractures but not with total hip BMD in this large population based cohort study... - Bone mineral density is not diminished by mild to moderate chronic renal insufficiencyChi yuan Hsu
Division of Nephrology, Prevention Science Group, University of California, San Francisco, San Francisco, California 94143 0532, USA
Kidney Int 61:1814-20. 2002..Persons with mild to moderate chronic renal insufficiency (CRI) may have reduced bone mineral density (BMD) as a result of abnormalities in acid-base and vitamin D-parathyroid hormone homeostasis... - Mammographic breast density and the Gail model for breast cancer risk prediction in a screening populationJeffrey A Tice
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
Breast Cancer Res Treat 94:115-22. 2005..Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve the predictive accuracy of the Gail model... - Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition StudyKirsten Bibbins-Domingo
Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
Arch Intern Med 166:1396-402. 2006..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites... - Adipocytokines attenuate the association between visceral adiposity and diabetes in older adultsAlka M Kanaya
University of California San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
Diabetes Care 27:1375-80. 2004..To examine whether adiponectin is independently associated with diabetes and whether adiponectin and other adipocytokines account for the relationship between fat and diabetes... - Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective studyKatie L Stone
Department of Medicine, University of California, San Francisco, California 94105, USA
J Clin Endocrinol Metab 89:1217-21. 2004..Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women... - Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trialKristine Yaffe
Department of Psychiatry, University of California, San Francisco, Box 181, 4150 Clement St, San Francisco, CA 94121, USA
Am J Psychiatry 162:683-90. 2005..This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease... - Primary prevention of breast cancer: new approachesSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA, United States
Maturitas 57:39-41. 2007..I propose that a woman's risk of breast cancer be assessed along with her screening mammogram with consideration of chemoprevention for those at high risk... - Association of nitrate use with risk of new radiographic features of hip osteoarthritis in elderly white women: the study of osteoporotic fracturesNancy E Lane
Division of Rheumatology, Department of Medicine, Box 0868, University of California at San Francisco, San Francisco, CA 94143, USA
Arthritis Rheum 49:752-8. 2003..To examine the association between nitrate medication use and the development of new radiographic findings of hip osteoarthritis (OA) in elderly women... - BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic FracturesKatie L Stone
Department of Medicine, University of California, San Francisco, California 94105, USA
J Bone Miner Res 18:1947-54. 2003..Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest... - A new framework for describing and quantifying the gap between proof and practiceIda Sim
Division of General Internal Medicine, Department of Medicine, and Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California 94143 0320, USA
Med Care 41:874-81. 2003..Substantial gaps often exist between every day practice and best practice as defined by research evidence. We present a framework for defining, analyzing, and quantifying such proof-to-practice gaps... - Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis studyMichael C Nevitt
Prevention Sciences, University of California, San Francisco, 94105, USA
Arthritis Rheum 46:1773-9. 2002..To compare the prevalence of osteoarthritis (OA) of the hip among elderly persons in China and the US... - An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomniaBradly P Jacobs
Department of Medicine, Osher Center for Integrative Medicine, University of California San Francisco, California, USA
Medicine (Baltimore) 84:197-207. 2005..Neither kava nor valerian relieved anxiety or insomnia more than placebo. This trial demonstrates the feasibility of conducting randomized, blinded trials entirely via the Internet... - Older women with diabetes have a higher risk of falls: a prospective studyAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Diabetes Care 25:1749-54. 2002..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk... - The relation of C-reactive protein levels to total and cardiovascular mortality in older U.S. womenJeffrey A Tice
Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, USA
Am J Med 114:199-205. 2003..To determine whether serum C-reactive protein levels, a sensitive indicator of inflammation, are associated with the risk of cardiovascular mortality among older women... - Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trialJeffrey A Tice
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco 94143, USA
JAMA 290:207-14. 2003..Dietary supplements containing isoflavones are widely used as alternatives to hormonal therapies for hot flashes, but there is a paucity of data supporting their efficacy... - Bone mineral density and the risk of incident nonspinal fractures in black and white womenJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
JAMA 293:2102-8. 2005..Black women have a lower rate of fracture than white women, but whether bone mineral density (BMD) predicts fracture risk as well in black women as it does in white women is not established... - Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian womenFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Int J Cancer 116:984-91. 2005..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women... - Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trialJane A Cauley
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
JAMA 290:1729-38. 2003..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures... - Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifeneSilvana Martino
Cancer Institute Medical Group, 2001 Santa Monica Blvd, Ste 560W, Santa Monica, CA 90404, USA
J Natl Cancer Inst 96:1751-61. 2004..We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE... - Effect of raloxifene on urinary incontinence: a randomized controlled trialL Elaine Waetjen
Department of Obstetrics and Gynecology, University of California Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA
Obstet Gynecol 103:261-6. 2004..To estimate the effect of 3 years of treatment with raloxifene on urinary incontinence in postmenopausal women... - Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fracturesBrent C Taylor
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
J Am Geriatr Soc 52:1479-86. 2004..Clinicians should be alert to factors other than BMD that place older women at a high risk of hip fracture... - Binocular visual-field loss increases the risk of future falls in older white womenAnne L Coleman
Jules Stein Eye Institute, Los Angeles, CA 90095, USA
J Am Geriatr Soc 55:357-64. 2007..To examine the relationship between binocular visual field loss and the risk of incident frequent falls in older white women... - Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health StudyLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, WA, United States
Atherosclerosis 197:922-30. 2008..If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks... - Clinical utility of laboratory testing in women with osteoporosisSophie A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
Osteoporos Int 16:534-40. 2005..4 (95% CI: 1.3-1.6). Our data suggests that when assessing healthy women with osteoporosis ordering a routine panel of laboratory tests is not useful but measuring TSH may be informative... - Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trialSophie A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Ontario M5C 2T2, Canada
J Bone Miner Res 19:1512-7. 2004..After 3 months, women randomized to ISMO had a greater decrease in bone resorption and a greater increase in bone formation compared with placebo. NO donors may prevent postmenopausal bone loss... - American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibitionRowan T Chlebowski
Health Services Research Department, American Society of Clinical Oncology, 1900 Duke Street, Suite 200, Alexandria, VA 22314, USA
J Clin Oncol 20:3328-43. 2002..To update an evidence-based technology assessment of chemoprevention strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen, raloxifene, aromatase inhibition, and fenretinide... - Incidence rates and life-time risk of hip fractures in Mexicans over 50 years of age: a population-based studyPatricia Clark
Clinical Epidemiology Unit, CMN Siglo XXI IMSS Faculty of Medicine, UNAM, Mexico City, Mexico
Osteoporos Int 16:2025-30. 2005..5% in Mexican women and 3.8% in Mexican men. We conclude that hip fractures are an important health problem in Mexico and that Mexican health authorities should consider public health programs to prevent hip fractures... - Calcium, vitamin D supplementation, and physical function in the Women's Health InitiativeRobert L Brunner
University of Nevada School of Medicine, PMB 251, MS 145, Reno, NV 89557, USA
J Am Diet Assoc 108:1472-9. 2008..Now we examine whether the treatment affected self-reported physical functioning and objective measures of physical functioning... - Serum 25-hydroxyvitamin D concentrations and risk for hip fracturesJane A Cauley
University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA
Ann Intern Med 149:242-50. 2008..The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear... - Bone mineral density and age-related maculopathy in older womenRobin L Seitzman
Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
J Am Geriatr Soc 55:740-6. 2007..To determine whether bone mineral density (BMD) is associated with age-related maculopathy (ARM) risk in older women... - Cystatin-C, renal function, and incidence of hip fracture in postmenopausal womenAndrea Z LaCroix
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Am Geriatr Soc 56:1434-41. 2008..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...