Steven R Cummings

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
  2. ncbi request reprint Summary--curing osteoporosis
    S Cummings
    S F Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
    J Musculoskelet Neuronal Interact 4:409. 2004
  3. ncbi request reprint Issues in designing and testing a "cure" for osteoporosis
    S Cummings
    S F Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
    J Musculoskelet Neuronal Interact 4:408. 2004
  4. ncbi request reprint Sex hormones, risk factors, and risk of estrogen receptor-positive breast cancer in older women: a long-term prospective study
    Steven R Cummings
    California Pacific Medical Center, Coordinating Center, Suite 600, 74 New Montgomery Street, San Francisco, CA 94105, USA
    Cancer Epidemiol Biomarkers Prev 14:1047-51. 2005
  5. ncbi request reprint Clinical use of bone densitometry: scientific review
    Steven R Cummings
    The UCSF Coordinating Center, University of California, San Francisco, USA
    JAMA 288:1889-97. 2002
  6. ncbi request reprint Epidemiology and outcomes of osteoporotic fractures
    Steven R Cummings
    Coordinating Center, Department of Medicine, University of California, San Francisco, CA 94105, USA
    Lancet 359:1761-7. 2002
  7. ncbi request reprint Serum estradiol level and risk of breast cancer during treatment with raloxifene
    Steven R Cummings
    Coordinating Center, University of California, Suite 600, 74 New Montgomery St, San Francisco, CA 94105, USA
    JAMA 287:216-20. 2002
  8. ncbi request reprint The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    S R Cummings
    Department of Medicine, University of California, San Francisco, USA
    JAMA 281:2189-97. 1999
  9. pmc Fetuin-A and change in body composition in older persons
    Joachim H Ix
    Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Clin Endocrinol Metab 94:4492-8. 2009
  10. ncbi request reprint Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
    Arch Intern Med 166:350-6. 2006

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
    ..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...
  2. ncbi request reprint Summary--curing osteoporosis
    S Cummings
    S F Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
    J Musculoskelet Neuronal Interact 4:409. 2004
  3. ncbi request reprint Issues in designing and testing a "cure" for osteoporosis
    S Cummings
    S F Coordinating Center, California Pacific Medical Center, San Francisco, CA 94105, USA
    J Musculoskelet Neuronal Interact 4:408. 2004
  4. ncbi request reprint Sex hormones, risk factors, and risk of estrogen receptor-positive breast cancer in older women: a long-term prospective study
    Steven R Cummings
    California Pacific Medical Center, Coordinating Center, Suite 600, 74 New Montgomery Street, San Francisco, CA 94105, USA
    Cancer Epidemiol Biomarkers Prev 14:1047-51. 2005
    ..Women at high risk of ER+ cancer would be the most likely to benefit from these treatments, but the best approach to predicting ER+ cancer is uncertain...
  5. ncbi request reprint Clinical use of bone densitometry: scientific review
    Steven R Cummings
    The UCSF Coordinating Center, University of California, San Francisco, USA
    JAMA 288:1889-97. 2002
    ..Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry has become more widely available and commonly used in practice...
  6. ncbi request reprint Epidemiology and outcomes of osteoporotic fractures
    Steven R Cummings
    Coordinating Center, Department of Medicine, University of California, San Francisco, CA 94105, USA
    Lancet 359:1761-7. 2002
    ..Therefore, epidemiological research should be done and used to identify individuals at high-risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need...
  7. ncbi request reprint Serum estradiol level and risk of breast cancer during treatment with raloxifene
    Steven R Cummings
    Coordinating Center, University of California, Suite 600, 74 New Montgomery St, San Francisco, CA 94105, USA
    JAMA 287:216-20. 2002
    ..Raloxifene competes with endogenous estrogen for binding to estrogen receptors in breast tissue. A woman's estradiol level may alter the effects of raloxifene on breast cancer and other outcomes...
  8. ncbi request reprint The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    S R Cummings
    Department of Medicine, University of California, San Francisco, USA
    JAMA 281:2189-97. 1999
    ..Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting...
  9. pmc Fetuin-A and change in body composition in older persons
    Joachim H Ix
    Division of Nephrology, Department of Medicine, and Division of Preventive Medicine, University of California San Diego, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
    J Clin Endocrinol Metab 94:4492-8. 2009
    ..Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown...
  10. ncbi request reprint Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
    Arch Intern Med 166:350-6. 2006
    ..Adipose tissue produces "adipocytokines" of uncertain clinical significance...
  11. pmc Change in hip bone mineral density and risk of subsequent fractures in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, CA, USA
    J Bone Miner Res 27:2179-88. 2012
    ..6; 95% CI 1.1-6.4). Total hip BMD change produced similar results. Accelerated decrease in BMD is a strong, independent risk factor for hip and other nonspine fractures in men...
  12. pmc A comparison of prediction models for fractures in older women: is more better?
    Kristine E Ensrud
    Department of Medicine, Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    Arch Intern Med 169:2087-94. 2009
    ..However, it is uncertain whether prediction with FRAX models is superior to that based on parsimonious models...
  13. pmc Clustering of strength, physical function, muscle, and adiposity characteristics and risk of disability in older adults
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California, USA
    J Am Geriatr Soc 59:781-7. 2011
    ..To empirically identify groupings of strength, physical performance, adiposity, and lean mass and test how such groupings of these interrelated measures may relate to disability risk...
  14. pmc Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study
    Donglei Hu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Am Geriatr Soc 57:1213-8. 2009
    ..To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults...
  15. ncbi request reprint Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  16. ncbi request reprint Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women
    Deborah Grady
    University of California Women s Health Clinical Research Center, San Francisco, CA 94115, USA
    Menopause 14:391-6. 2007
    ..The purpose of this study was to determine whether 2 years of treatment with ultra-low-dose transdermal estradiol results in a change in breast density...
  17. ncbi request reprint High-trauma fractures and low bone mineral density in older women and men
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    JAMA 298:2381-8. 2007
    ..It is widely believed that fractures resulting from high trauma are not osteoporotic; however, this assumption has not been studied prospectively...
  18. pmc Thiazolidinedione use and bone loss in older diabetic adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, California 94107 1762, USA
    J Clin Endocrinol Metab 91:3349-54. 2006
    ..Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass in mice...
  19. ncbi request reprint Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures
    Michael C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:131-40. 2005
    ..Risk factors and low BMD should be useful to help focus efforts to prevent these fractures...
  20. pmc Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
    Peggy M Cawthon
    California Pacific Medical Center Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Clin Endocrinol Metab 95:4625-34. 2010
    ..Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults...
  21. pmc Pentosidine and increased fracture risk in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94107 1762, USA
    J Clin Endocrinol Metab 94:2380-6. 2009
    ..Type 2 diabetes is associated with higher fracture risk at a given bone mineral density. Advanced glycation endproducts (AGEs) accumulate in bone collagen with age and diabetes and may weaken bone...
  22. pmc Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
    J Clin Endocrinol Metab 94:3806-15. 2009
    ..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors...
  23. pmc Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 95:E368-72. 2010
    ..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture...
  24. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  25. pmc Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly
    Daniel S Evans
    California Pacific Medical Center Research Institute, San Francisco, CA 94107 1728, USA
    Sleep 36:431-46. 2013
    ..To determine the association between common genetic variation in the clock gene pathway and objectively measured acti-graphic sleep and activity rhythm traits...
  26. doi request reprint Effect of alendronate for reducing fracture by FRAX score and femoral neck bone mineral density: the Fracture Intervention Trial
    Meghan G Donaldson
    San Francisco Coordinating Center, California Pacific Medical Research Institute, San Francisco, CA, USA
    J Bone Miner Res 27:1804-10. 2012
    ..A randomized controlled trial testing the effect of antifracture agents among women with high FRAX score but without osteoporosis is warranted...
  27. pmc The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
    Dennis M Black
    Department of Epidemiology and Biostastistics, University of California, San Francisco, CA 94107, USA
    J Bone Miner Res 27:243-54. 2012
    ..However, vertebral fracture reductions suggest that those at high fracture risk, particularly vertebral fracture, may benefit by continued treatment...
  28. pmc Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, CA 94107 1728, USA
    Ann Neurol 70:722-32. 2011
    ..We determined whether circadian activity rhythms measured in community-dwelling older women are prospectively associated with incident dementia or mild cognitive impairment (MCI)...
  29. pmc Self-reported sleep and nap habits and risk of mortality in a large cohort of older women
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 57:604-11. 2009
    ..To determine the association between self-reported sleep and nap habits and mortality in a large cohort of older women...
  30. ncbi request reprint Cystatin C and mortality risk in the elderly: the health, aging, and body composition study
    Michael G Shlipak
    University of San Francisco, General Internal Medicine Section, VA Medical Center 111A1, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 17:254-61. 2006
    ..39], 0.95 [0.68 to 1.32], 1.11 [0.79 to 1.57], 1.16 [0.86 to 1.58]). Cystatin C is a strong, independent risk factor for mortality in the elderly. Future studies should investigate whether cystatin C has a role in clinical medicine...
  31. pmc Estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US National Osteoporosis Foundation guidelines
    Meghan G Donaldson
    San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA 94107, USA
    J Bone Miner Res 25:1506-11. 2010
    ..Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown...
  32. pmc Circadian activity rhythms and mortality: the study of osteoporotic fractures
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
    J Am Geriatr Soc 58:282-91. 2010
    ..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women...
  33. pmc Fetuin-A and incident diabetes mellitus in older persons
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
    JAMA 300:182-8. 2008
    ..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown...
  34. pmc F2-isoprostanes and adiposity in older adults
    Alka M Kanaya
    University of California, San Francisco, California, USA
    Obesity (Silver Spring) 19:861-7. 2011
    ..05). In conclusion, F(2)-IPs were associated with measures of total and regional adiposity in women alone and these associations were partially explained by adipocytokines. F(2)-IPs predicted loss of total adiposity over time among women...
  35. pmc COMT genotype and cognitive function: an 8-year longitudinal study in white and black elders
    A J Fiocco
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94121, USA
    Neurology 74:1296-302. 2010
    ..Few studies have examined the prospective association between COMT (val(158)met) genotype and cognition in older adults...
  36. ncbi request reprint Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women
    Diana M Antoniucci
    Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:741-7. 2005
    ..There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures...
  37. pmc The effects of tibolone in older postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
    N Engl J Med 359:697-708. 2008
    ..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain...
  38. ncbi request reprint Diabetes and bone loss at the hip in older black and white adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 20:596-603. 2005
    ....
  39. pmc Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults?
    Peggy Mannen Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 57:1411-9. 2009
    ..To examine the association between strength, function, lean mass, muscle density, and risk of hospitalization...
  40. ncbi request reprint Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1)
    Mary S Beattie
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 98:110-5. 2006
    ..The purpose of this study was to determine whether sex hormone levels were associated with breast cancer risk and with response to tamoxifen in a high-risk population...
  41. pmc Postmenopausal hormones and sleep quality in the elderly: a population based study
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA, USA
    BMC Womens Health 10:15. 2010
    ..Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy...
  42. doi request reprint Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
    J Bone Miner Res 25:976-82. 2010
    ..5 or less but does not reduce risk of NVF in women whose T-scores are greater than -2...
  43. pmc Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    J Bone Miner Res 24:514-21. 2009
    ..Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women...
  44. ncbi request reprint Self-reported sleep and nap habits and risk of falls and fractures in older women: the study of osteoporotic fractures
    Katie L Stone
    Research Institute, California Pacific Medical Center, San Francisco, 94107, USA
    J Am Geriatr Soc 54:1177-83. 2006
    ..To test the association between self-reported sleep and nap habits and risk of falls and fractures in a large cohort of older women...
  45. doi request reprint Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Alzheimers Dis 32:357-72. 2012
    ....
  46. pmc Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, San Francisco, CA 94107, USA
    Biochim Biophys Acta 1817:1691-700. 2012
    ....
  47. pmc Serum sclerostin and risk of hip fracture in older Caucasian women
    Aarthi Arasu
    Department of Medicine, University of California, San Francisco, USA
    J Clin Endocrinol Metab 97:2027-32. 2012
    ..Sclerostin, a protein secreted by osteocytes, inhibits bone formation. Individuals with genetic mutations that decrease the availability of sclerostin have very high bone mass...
  48. ncbi request reprint Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    Dennis M Black
    University of California, San Francisco, San Francisco, CA 94107, USA
    N Engl J Med 356:1809-22. 2007
    ..We assessed the effects of annual infusions of zoledronic acid on fracture risk during a 3-year period...
  49. doi request reprint Lasofoxifene in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
    N Engl J Med 362:686-96. 2010
    ..The effects of lasofoxifene on the risk of fractures, breast cancer, and cardiovascular disease are uncertain...
  50. ncbi request reprint Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    J Bone Miner Res 22:1862-8. 2007
    ..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men...
  51. ncbi request reprint Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) study
    Ethel S Siris
    Toni Stabile Osteoporosis Center, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 20:1514-24. 2005
    ..CORE had limitations for assessing fracture risk. In a subset of 386 women, 7 years of raloxifene treatment significantly increased lumbar spine and femoral neck BMD compared from the baseline of MORE...
  52. pmc Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study
    Kristine Yaffe
    Department of Psychiatry and Neurology, School of Medicine, San Francisco, CA 94121, USA
    Neurobiol Aging 30:607-14. 2009
    ..To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women...
  53. pmc Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 94143 1732, USA
    Ann Intern Med 148:337-47. 2008
    ..Current models for assessing breast cancer risk are complex and do not include breast density, a strong risk factor for breast cancer that is routinely reported with mammography...
  54. pmc Novel methods to evaluate fracture risk models
    Meghan G Donaldson
    San Francisco Coordinating Center, San Francisco, CA, USA
    J Bone Miner Res 26:1767-73. 2011
    ..The Cook method (both models, both fracture outcomes) had similar fracture rates above/below the treatment thresholds. Compared with the AUC, new methods provide more detailed information about how models classify patients...
  55. pmc Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    California Pacific Medical Center, Research Institute, San Francisco Coordinating Center, 185 Berry Street, Lobby 5, Suite 5700, San Francisco, CA 94107 1728, USA
    J Bone Miner Res 24:1728-35. 2009
    ..Older men and those with lower BMD lose bone more rapidly, offering potential explanation for the increasing risk of fracture with advancing age...
  56. doi request reprint Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute and University of California, San Francisco, San Francisco, CA, USA
    N Engl J Med 361:756-65. 2009
    ..Given its unique actions, denosumab may be useful in the treatment of osteoporosis...
  57. pmc Hyperkyphosis predicts mortality independent of vertebral osteoporosis in older women
    Deborah M Kado
    University of California, Los Angeles, Los Angeles, California, USA
    Ann Intern Med 150:681-7. 2009
    ..Excessive kyphosis may be associated with earlier mortality, but previous studies have not controlled for clinically silent vertebral fractures, which are a known mortality risk factor...
  58. doi request reprint Actigraphy-measured sleep characteristics and risk of falls in older women
    Katie L Stone
    Research Institute, California Pacific Medical Center, 185 Berry St, Lobby 4, Fifth Floor, Ste 5700, San Francisco, CA 94107 1762, USA
    Arch Intern Med 168:1768-75. 2008
    ..However, no previous study, to our knowledge, has tested the independent associations of objectively estimated characteristics of sleep and risk of falls, accounting for the use of commonly prescribed treatments for insomnia...
  59. ncbi request reprint Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in postmenopausal women
    Alison J Huang
    Veterans Affairs Medical Center, San Francisco, California, USA
    J Bone Miner Res 22:1791-7. 2007
    ..This suggests that the protective effects of ultra-low-dose estrogen therapy on the postmenopausal skeletal health may depend critically on women's endogenous estrogen levels before treatment...
  60. pmc Sex hormone levels and risks of estrogen receptor-negative and estrogen receptor-positive breast cancers
    Ghada N Farhat
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    J Natl Cancer Inst 103:562-70. 2011
    ..Endogenous sex hormone levels are associated with risks of breast cancer overall and estrogen receptor (ER)-positive breast tumors; however, their associations with ER-negative tumors remain unclear...
  61. ncbi request reprint Alcohol use, physical performance, and functional limitations in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 55:212-20. 2007
    ..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men...
  62. ncbi request reprint Clinical use of bone densitometry: clinical applications
    David W Bates
    Department of Medicine, Brigham and Women s Hospital, and the Center for Applied Medical Information Systems Research, Partners HealthCare Systems, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 288:1898-900. 2002
    ..Clinicians need better approaches for identifying patients most likely to benefit from screening, systems that facilitate their application, and test results that are easy to interpret...
  63. pmc Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scans
    Xiang Wang
    Department of Mechanical Engineering, University of California, Berkeley, Berkeley, CA, USA
    J Bone Miner Res 27:808-16. 2012
    ..82, pā€‰=ā€‰0.05). We conclude that, compared to areal BMD by DXA, vertebral compressive strength and volumetric BMD consistently improved vertebral fracture risk assessment in this cohort of elderly men...
  64. doi request reprint FRAX and risk of vertebral fractures: the fracture intervention trial
    Meghan G Donaldson
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA
    J Bone Miner Res 24:1793-9. 2009
    ..A combination of baseline radiographic vertebral fracture, FN BMD, and age is the strongest predictor of future vertebral fracture...
  65. pmc Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men
    Tracie C Collins
    University of Minnesota, Department of Medicine, 717 Delaware St SE, Suite 166, Minneapolis, MN 55414, USA
    Circulation 119:2305-12. 2009
    ..Peripheral arterial disease (PAD) and osteoporosis are chronic illnesses that increase in prevalence with aging and certain metabolic disorders. The association between PAD, rates of bone loss, and fracture risk in older men is uncertain...
  66. doi request reprint Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women
    Robin L Seitzman
    Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 92122, USA
    Am J Epidemiol 167:1217-25. 2008
    ..02). The MMP2 rs2287074 A allele may be associated with a lower likelihood of ARM in older Caucasian women, particularly those who have never used hormone therapy. The role of MMP2 rs2287074 in ARM should be further elucidated...
  67. pmc A common variant in the telomerase RNA component is associated with short telomere length
    Omer T Njajou
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e13048. 2010
    ....
  68. ncbi request reprint Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study
    Manjula Kurella
    Division of Nephrology, University of California San Francisco, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118 1211, USA
    J Am Soc Nephrol 16:2127-33. 2005
    ..Studies aimed at understanding the mechanism(s) responsible for cognitive impairment in CKD and efforts to interrupt this decline are warranted...
  69. pmc Volume of mammographic density and risk of breast cancer
    John A Shepherd
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Cancer Epidemiol Biomarkers Prev 20:1473-82. 2011
    ....
  70. pmc Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study
    Kristine Yaffe
    Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA
    Neurobiol Aging 32:2055-60. 2011
    ..There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p=0.06). Thus, telomere length may serve as a biomarker for cognitive aging...
  71. ncbi request reprint BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  72. ncbi request reprint Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs
    Steven R Cummings
    Department of Medicine, University of California, San Francisco, California, USA
    Am J Med 112:281-9. 2002
    ..To estimate how much the improvement in bone mass accounts for the reduction in risk of vertebral fracture that has been observed in randomized trials of antiresorptive treatments for osteoporosis...
  73. doi request reprint Effect of Raloxifene on all-cause mortality
    Deborah Grady
    University of California, San Francisco, CA 94115, USA
    Am J Med 123:469.e1-7. 2010
    ..To assess the risk/benefit of raloxifene as a preventative treatment, we analyzed treatment effects on overall and cause-specific mortality...
  74. doi request reprint Estimating long-term effects of treatment from placebo-controlled trials with an extension period, using virtual twins
    Eric Vittinghoff
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94107, USA
    Stat Med 29:1127-36. 2010
    ..The proposed method is validated using simulation, and applied to data from the Fracture Intervention Trial and its extension, FLEX...
  75. pmc Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures
    Gregory J Tranah
    CPMC Research Institute, San Francisco, CA 94120, USA
    Calcif Tissue Int 83:155-66. 2008
    ..In conclusion, polymorphisms in several candidate genes were associated with hip, vertebral, and nonhip/nonvertebral fractures but not with total hip BMD in this large population based cohort study...
  76. ncbi request reprint BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Bone Miner Res 18:1947-54. 2003
    ..Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest...
  77. ncbi request reprint Mammographic breast density and the Gail model for breast cancer risk prediction in a screening population
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
    Breast Cancer Res Treat 94:115-22. 2005
    ..Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve the predictive accuracy of the Gail model...
  78. ncbi request reprint Effect of raloxifene on prevention of dementia and cognitive impairment in older women: the Multiple Outcomes of Raloxifene Evaluation (MORE) randomized trial
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, Box 181, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Psychiatry 162:683-90. 2005
    ..This investigation examined whether raloxifene, a selective estrogen receptor modulator, affects the risk for Alzheimer's disease...
  79. ncbi request reprint Renal function and heart failure risk in older black and white individuals: the Health, Aging, and Body Composition Study
    Kirsten Bibbins-Domingo
    Division of General Internal Medicine, San Francisco General Hospital, CA 94143 1364, USA
    Arch Intern Med 166:1396-402. 2006
    ..Our objective was to determine whether the association of chronic kidney disease with incident heart failure differs between blacks and whites...
  80. ncbi request reprint Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults
    Alka M Kanaya
    University of California San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
    Diabetes Care 27:1375-80. 2004
    ..To examine whether adiponectin is independently associated with diabetes and whether adiponectin and other adipocytokines account for the relationship between fat and diabetes...
  81. ncbi request reprint Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study
    Katie L Stone
    Department of Medicine, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 89:1217-21. 2004
    ..Serum vitamin B-12 levels were not significantly associated with calcaneal bone loss. We conclude that low serum vitamin B-12 levels are associated with increased rates of hip, but not calcaneal, bone loss in older women...
  82. ncbi request reprint Primary prevention of breast cancer: new approaches
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA, United States
    Maturitas 57:39-41. 2007
    ..I propose that a woman's risk of breast cancer be assessed along with her screening mammogram with consideration of chemoprevention for those at high risk...
  83. ncbi request reprint Association of nitrate use with risk of new radiographic features of hip osteoarthritis in elderly white women: the study of osteoporotic fractures
    Nancy E Lane
    Division of Rheumatology, Department of Medicine, Box 0868, University of California at San Francisco, San Francisco, CA 94143, USA
    Arthritis Rheum 49:752-8. 2003
    ..To examine the association between nitrate medication use and the development of new radiographic findings of hip osteoarthritis (OA) in elderly women...
  84. ncbi request reprint A new framework for describing and quantifying the gap between proof and practice
    Ida Sim
    Division of General Internal Medicine, Department of Medicine, and Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California 94143 0320, USA
    Med Care 41:874-81. 2003
    ..Substantial gaps often exist between every day practice and best practice as defined by research evidence. We present a framework for defining, analyzing, and quantifying such proof-to-practice gaps...
  85. ncbi request reprint An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia
    Bradly P Jacobs
    Department of Medicine, Osher Center for Integrative Medicine, University of California San Francisco, California, USA
    Medicine (Baltimore) 84:197-207. 2005
    ..Neither kava nor valerian relieved anxiety or insomnia more than placebo. This trial demonstrates the feasibility of conducting randomized, blinded trials entirely via the Internet...
  86. ncbi request reprint Bone mineral density is not diminished by mild to moderate chronic renal insufficiency
    Chi yuan Hsu
    Division of Nephrology, Prevention Science Group, University of California, San Francisco, San Francisco, California 94143 0532, USA
    Kidney Int 61:1814-20. 2002
    ..Persons with mild to moderate chronic renal insufficiency (CRI) may have reduced bone mineral density (BMD) as a result of abnormalities in acid-base and vitamin D-parathyroid hormone homeostasis...
  87. ncbi request reprint Older women with diabetes have a higher risk of falls: a prospective study
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Diabetes Care 25:1749-54. 2002
    ..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk...
  88. ncbi request reprint Phytoestrogen supplements for the treatment of hot flashes: the Isoflavone Clover Extract (ICE) Study: a randomized controlled trial
    Jeffrey A Tice
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco 94143, USA
    JAMA 290:207-14. 2003
    ..Dietary supplements containing isoflavones are widely used as alternatives to hormonal therapies for hot flashes, but there is a paucity of data supporting their efficacy...
  89. ncbi request reprint The relation of C-reactive protein levels to total and cardiovascular mortality in older U.S. women
    Jeffrey A Tice
    Division of General Internal Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Med 114:199-205. 2003
    ..To determine whether serum C-reactive protein levels, a sensitive indicator of inflammation, are associated with the risk of cardiovascular mortality among older women...
  90. ncbi request reprint Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study
    Michael C Nevitt
    Prevention Sciences, University of California, San Francisco, 94105, USA
    Arthritis Rheum 46:1773-9. 2002
    ..To compare the prevalence of osteoarthritis (OA) of the hip among elderly persons in China and the US...
  91. ncbi request reprint Impact of seafood and fruit consumption on bone mineral density
    Pierre A Zalloua
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Maturitas 56:1-11. 2007
    ..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population...
  92. ncbi request reprint Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene
    Silvana Martino
    Cancer Institute Medical Group, 2001 Santa Monica Blvd, Ste 560W, Santa Monica, CA 90404, USA
    J Natl Cancer Inst 96:1751-61. 2004
    ..We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE...
  93. ncbi request reprint Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study
    Jane A Cauley
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 22:1088-95. 2007
    ..We tested this hypothesis in relationship to fractures in 2985 men and women enrolled in the Health ABC study. Results showed that subjects with the greatest number of inflammatory markers have the highest risk of fracture...
  94. ncbi request reprint Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian women
    Francesmary Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Cancer 116:984-91. 2005
    ..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women...
  95. ncbi request reprint Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures
    Brent C Taylor
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Geriatr Soc 52:1479-86. 2004
    ..To identify independent risk factors for first hip fracture over 10 years of follow-up...
  96. ncbi request reprint American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibition
    Rowan T Chlebowski
    Health Services Research Department, American Society of Clinical Oncology, 1900 Duke Street, Suite 200, Alexandria, VA 22314, USA
    J Clin Oncol 20:3328-43. 2002
    ..To update an evidence-based technology assessment of chemoprevention strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen, raloxifene, aromatase inhibition, and fenretinide...
  97. ncbi request reprint Clinical utility of laboratory testing in women with osteoporosis
    Sophie A Jamal
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
    Osteoporos Int 16:534-40. 2005
    ..4 (95% CI: 1.3-1.6). Our data suggests that when assessing healthy women with osteoporosis ordering a routine panel of laboratory tests is not useful but measuring TSH may be informative...
  98. ncbi request reprint Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trial
    Sophie A Jamal
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Ontario M5C 2T2, Canada
    J Bone Miner Res 19:1512-7. 2004
    ..After 3 months, women randomized to ISMO had a greater decrease in bone resorption and a greater increase in bone formation compared with placebo. NO donors may prevent postmenopausal bone loss...
  99. ncbi request reprint Effect of raloxifene on urinary incontinence: a randomized controlled trial
    L Elaine Waetjen
    Department of Obstetrics and Gynecology, University of California Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA
    Obstet Gynecol 103:261-6. 2004
    ..To estimate the effect of 3 years of treatment with raloxifene on urinary incontinence in postmenopausal women...
  100. pmc Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures
    Naila Khalil
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 23:1417-25. 2008
    ..07, 2.45; p trend = 0.014) compared with women with lowest lead level. Blood lead levels are associated with an increased risk of falls and fractures, extending the negative health consequences of lead to include osteoporotic fractures...
  101. ncbi request reprint Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    JAMA 290:1729-38. 2003
    ..In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures...