S R Cummings

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Prevention of hip fractures in older women: a population-based perspective
    S R Cummings
    University of California, San Francisco, USA
    Osteoporos Int 8:S8-12. 1998
  2. ncbi request reprint Monitoring osteoporosis therapy with bone densitometry: misleading changes and regression to the mean. Fracture Intervention Trial Research Group
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    JAMA 283:1318-21. 2000
  3. ncbi request reprint Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
  4. pmc Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA
    Sleep 34:1347-56. 2011
  5. ncbi request reprint Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Bone 29:381-7. 2001
  6. ncbi request reprint Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research Group
    M C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    Arch Intern Med 160:77-85. 2000
  7. ncbi request reprint Influence of smoking on the antiosteoporotic efficacy of raloxifene
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:4178-82. 2001
  8. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
  9. ncbi request reprint Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group
    D M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
    J Bone Miner Res 14:821-8. 1999
  10. ncbi request reprint A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group
    D E Sellmeyer
    Division of Endocrinology, the General Clinical Research Center, and the Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Am J Clin Nutr 73:118-22. 2001

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Prevention of hip fractures in older women: a population-based perspective
    S R Cummings
    University of California, San Francisco, USA
    Osteoporos Int 8:S8-12. 1998
    ....
  2. ncbi request reprint Monitoring osteoporosis therapy with bone densitometry: misleading changes and regression to the mean. Fracture Intervention Trial Research Group
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    JAMA 283:1318-21. 2000
    ..The principle of "regression to the mean" predicts that patients with unusual responses to treatment might represent outliers who are likely to have more typical responses if treatment is continued without change...
  3. ncbi request reprint Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial
    S R Cummings
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    JAMA 280:2077-82. 1998
    ..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures...
  4. pmc Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study
    Terri Blackwell
    Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA
    Sleep 34:1347-56. 2011
    ..To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men...
  5. ncbi request reprint Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fractures
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Bone 29:381-7. 2001
    ..We conclude that older women with low endogenous hormones have somewhat higher bone turnover, but these associations are weak. Bone turnover is determined mainly by factors other than endogenous concentrations of sex hormones...
  6. ncbi request reprint Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research Group
    M C Nevitt
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    Arch Intern Med 160:77-85. 2000
    ..Women with new vertebral fractures have an increased risk of back pain and functional limitation because of back pain. Alendronate sodium treatment reduces the risk of new vertebral fracture by 50% in postmenopausal women with osteoporosis...
  7. ncbi request reprint Influence of smoking on the antiosteoporotic efficacy of raloxifene
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:4178-82. 2001
    ..light smokers. We conclude that smoking does not influence the antiosteoporotic effect of raloxifene. This may represent an advantage over estrogen replacement therapy...
  8. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
    ..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM...
  9. ncbi request reprint Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group
    D M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
    J Bone Miner Res 14:821-8. 1999
    ..Spinal radiographs identifying prevalent vertebral deformities may be a useful additional measurement to classify further a woman's risk of future fracture...
  10. ncbi request reprint A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group
    D E Sellmeyer
    Division of Endocrinology, the General Clinical Research Center, and the Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Am J Clin Nutr 73:118-22. 2001
    ..Imbalance between dietary acid and base precursors leads to a chronic net dietary acid load that may have adverse consequences on bone...
  11. ncbi request reprint The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    S R Cummings
    Department of Medicine, University of California, San Francisco, USA
    JAMA 281:2189-97. 1999
    ..Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting...
  12. doi request reprint Lasofoxifene in postmenopausal women with osteoporosis
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
    N Engl J Med 362:686-96. 2010
    ..The effects of lasofoxifene on the risk of fractures, breast cancer, and cardiovascular disease are uncertain...
  13. pmc Factors that may influence the classification of sleep-wake by wrist actigraphy: the MrOS Sleep Study
    Terri Blackwell
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Clin Sleep Med 7:357-67. 2011
    ..Associations of measurement error for TST (PSG-actigraphy) with demographics, medical history, exam data, and sleep characteristics were examined...
  14. ncbi request reprint Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women
    W S Browner
    General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 86:631-7. 2001
    ..The association of serum OPG levels with diabetes and with cardiovascular mortality raises the possibility that OPG may be a cause of or a marker for vascular calcification...
  15. ncbi request reprint Older women with diabetes have an increased risk of fracture: a prospective study
    A V Schwartz
    Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
    J Clin Endocrinol Metab 86:32-8. 2001
    ..This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes...
  16. pmc Circadian activity rhythms and mortality: the study of osteoporotic fractures
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
    J Am Geriatr Soc 58:282-91. 2010
    ..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women...
  17. doi request reprint The association of Parkinson's disease with bone mineral density and fracture in older women
    J L Schneider
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    Osteoporos Int 19:1093-7. 2008
    ..Among community-dwelling older women, compared to those without Parkinson's disease (PD), women with PD have 7.3% lower BMD and an increased risk for hip fracture (HR = 2.6)...
  18. ncbi request reprint Changes in biochemical markers of bone turnover in women treated with raloxifene: influence of regression to the mean
    R D Chapurlat
    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
    Osteoporos Int 12:1006-14. 2001
    ....
  19. ncbi request reprint Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group
    S A Jamal
    University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, USA
    Ann Intern Med 128:829-32. 1998
    ..Vitamin K deficiency may be associated with osteoporosis...
  20. ncbi request reprint Cognitive decline in women in relation to non-protein-bound oestradiol concentrations
    K Yaffe
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Lancet 356:708-12. 2000
    ..We tested the hypothesis that concentrations of non-protein-bound (free) and loosely bound (bioavailable) sex hormones are associated with cognitive function in older women...
  21. ncbi request reprint Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group
    D M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
    J Clin Endocrinol Metab 85:4118-24. 2000
    ..Furthermore, reduction in risk is evident early in the course of treatment. This pooled analysis provides a more precise estimate of the antifracture efficacy of alendronate in women with osteoporosis than that in prior reports...
  22. pmc Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
    J Clin Endocrinol Metab 94:3806-15. 2009
    ..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors...
  23. ncbi request reprint A normative reference database study for Pronosco X-posure System
    D M Black
    University of California, San Francisco, CA 94106, USA
    J Clin Densitom 4:5-12. 2001
    ..The strong correlation of DXR-BMD from the X-posure System with DXA at the wrist from the Hologic machine suggests that the X-posure System may be an alternative to DXA at the wrist for the assessment of osteoporosis...
  24. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  25. ncbi request reprint The biology of aging
    S R Cummings
    Medicine and Epidemiology, San Francisco Coordinating Center, San Francisco, CA 94107 1762, USA
    J Musculoskelet Neuronal Interact 7:340-1. 2007
  26. ncbi request reprint Continuing screening mammography in women aged 70 to 79 years: impact on life expectancy and cost-effectiveness
    K Kerlikowske
    Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco 94121, USA
    JAMA 282:2156-63. 1999
    ..In particular, older women with low bone mineral density (BMD) have a lower risk of breast cancer and may benefit less from continued screening...
  27. pmc Shorter telomeres are associated with obesity and weight gain in the elderly
    O T Njajou
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Int J Obes (Lond) 36:1176-9. 2012
    ..Therefore, we set out to test the hypothesis that TL may be a risk factor for increased adiposity using data from a large population-based cohort study...
  28. ncbi request reprint Quitting smoking: reasons for quitting and predictors of cessation among medical patients
    C L Duncan
    Department of Medicine, University of California, San Francisco
    J Gen Intern Med 7:398-404. 1992
    ..Education, social pressure, provider advice, and formal programs, but not over-the-counter devices, appear to increase the chances that smokers will quit...
  29. pmc Chinese and U.S. internists adhere to different ethical standards
    M D Feldman
    Department of Medicine, University of California, San Francisco 94143-0320, USA
    J Gen Intern Med 14:469-73. 1999
    ..In general, the Chinese physicians appeared to give far greater weight to family preferences in medical decision making than did the U.S. physicians...
  30. ncbi request reprint Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
    D C Bauer
    UCSF, San Francisco, CA 94107, USA
    Osteoporos Int 18:771-7. 2007
    ..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone...
  31. ncbi request reprint Aging
    S R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA 94107, USA
    J Musculoskelet Neuronal Interact 7:338-9. 2007
  32. ncbi request reprint Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures
    T J Beck
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Bone Miner Res 16:1108-19. 2001
    ..The adaptive response to declining skeletal loads, with greater rates of subperiosteal expansion and cortical thinning, may increase fragility beyond that expected from the reduction in section modulus or bone mass alone...
  33. pmc Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women
    S P Moffett
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Clin Endocrinol Metab 93:2002-8. 2008
    ..Osteoprotegerin (OPG) is a soluble decoy receptor for receptor activator nuclear factor kappa-beta that blocks osteoclastic bone resorption...
  34. ncbi request reprint Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
    ..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
  35. ncbi request reprint Effects of current and discontinued estrogen replacement therapy on hip structural geometry: the study of osteoporotic fractures
    T J Beck
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Bone Miner Res 16:2103-10. 2001
    ..Current, but not past, use of estrogen therapy in elderly women seems to increase mechanical strength of the proximal femur by improving its geometric properties. These effects are not evident from changes in femoral neck BMD...
  36. ncbi request reprint Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort
    K Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 28:171-8. 2007
    ..Older women treated with conjugated estrogens may have an increased risk of dementia, but the effect of naturally occurring sex hormones on cognition is not certain...
  37. pmc PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders
    K Yaffe
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94121, United States
    Neurobiol Aging 29:78-83. 2008
    ..We tested whether this polymorphism is associated with cognition...
  38. ncbi request reprint Classification of osteoporosis based on bone mineral densities
    Y Lu
    Department of Radiology, University of California San Francisco, 94143-0628, USA
    J Bone Miner Res 16:901-10. 2001
    ..A risk-based osteoporosis classification does not depend on the manufacturers' reference data and may be more consistent and efficient for patient diagnosis...
  39. ncbi request reprint Incident vertebral fractures and mortality in older women: a prospective study
    D M Kado
    Division of Geriatrics, Department of Medicine, The David Geffen School of Medicine at University of California, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA
    Osteoporos Int 14:589-94. 2003
    ..06; 95% CI=0.88 1.28). Older women with incident vertebral fractures have an increased risk of mortality that may be explained by weight loss and physical frailty...
  40. ncbi request reprint Effects of hormone replacement therapy on clinical fractures and height loss: The Heart and Estrogen/Progestin Replacement Study (HERS)
    J A Cauley
    Department of Epidemiology (JAC, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Med 110:442-50. 2001
    ..Randomized studies are needed to clarify the effect of hormone replacement therapy on fracture risk among women with and without osteoporosis...
  41. ncbi request reprint Disability after clinical fracture in postmenopausal women with low bone density: the fracture intervention trial (FIT)
    H A Fink
    MD, MPH, VA Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
    Osteoporos Int 14:69-76. 2003
    ..Substantial disability also was reported after fractures of thoracic vertebrae, humerus, distal forearm, ankle and foot. Within fracture types, post-fracture disability was highly variable, ranging from none to more than 6 months...
  42. ncbi request reprint Risk of fracture among women who lose bone density during treatment with alendronate. The Fracture Intervention Trial
    R D Chapurlat
    Department of Rheumatology and Bone Diseases and INSERM U403, E Herriot Hospital, 69437 Lyon, France
    Osteoporos Int 16:842-8. 2005
    ..So, the reduction in bone turnover induced by alendronate might be more important than BMD changes. The few women who lose the most BMD (more than 4% per year) might not benefit from the treatment...
  43. ncbi request reprint Association between aortic calcification and total and cardiovascular mortality in older women
    N Rodondi
    Cardiovascular Prevention Clinic, University Outpatient Clinic, Department of Community Medicine and Public Health, University of Lausanne, Lausanne, Switzerland
    J Intern Med 261:238-44. 2007
    ..To determine whether older women with abdominal aortic calcification had a greater cardiovascular and all-cause mortality, as such data are limited in older adults...
  44. ncbi request reprint Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition study
    C R Keller
    Department of Medicine, University of California, San Francisco, California, USA
    Kidney Int 71:239-44. 2007
    ..05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates >or=60; associations are particularly strong with TNF-alpha and the STNF-R...
  45. ncbi request reprint Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women
    S P Moffett
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 90:3491-7. 2005
    ..The G-308A polymorphism was not associated with a reduced risk of other fractures. These results suggest a potential role of genetic variation in TNFalpha in the etiology of osteoporosis...
  46. ncbi request reprint Incidence and risk factors for a second hip fracture in elderly women. The Study of Osteoporotic Fractures
    R D Chapurlat
    Prevention Sciences Group, University of California at San Francisco, California, USA
    Osteoporos Int 14:130-6. 2003
    ..5 [0.3-0.9]) up to 2 years of follow-up. We conclude that community-dwelling women with a first hip fracture have a high risk of second hip fracture, and risk factors for this second fracture are similar to those of first hip fracture...