Research Topics
Species | S R CummingsSummaryAffiliation: University of California Country: USA Publications
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Publications
Prevention of hip fractures in older women: a population-based perspectiveS R Cummings
University of California, San Francisco, USA
Osteoporos Int 8:S8-12. 1998....- Monitoring osteoporosis therapy with bone densitometry: misleading changes and regression to the mean. Fracture Intervention Trial Research GroupS R Cummings
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
JAMA 283:1318-21. 2000..The principle of "regression to the mean" predicts that patients with unusual responses to treatment might represent outliers who are likely to have more typical responses if treatment is continued without change... - Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention TrialS R Cummings
Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
JAMA 280:2077-82. 1998..Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures... 
Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep studyTerri Blackwell
Research Institute, California Pacific Medical Center, San Francisco, CA 94107, USA
Sleep 34:1347-56. 2011..To examine the association of objectively and subjectively measured sleep characteristics with cognition in older men...- Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: study of osteoporotic fracturesR D Chapurlat
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Bone 29:381-7. 2001..We conclude that older women with low endogenous hormones have somewhat higher bone turnover, but these associations are weak. Bone turnover is determined mainly by factors other than endogenous concentrations of sex hormones... - Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Fracture Intervention Trial Research GroupM C Nevitt
Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
Arch Intern Med 160:77-85. 2000..Women with new vertebral fractures have an increased risk of back pain and functional limitation because of back pain. Alendronate sodium treatment reduces the risk of new vertebral fracture by 50% in postmenopausal women with osteoporosis... - Influence of smoking on the antiosteoporotic efficacy of raloxifeneR D Chapurlat
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94105, USA
J Clin Endocrinol Metab 86:4178-82. 2001..light smokers. We conclude that smoking does not influence the antiosteoporotic effect of raloxifene. This may represent an advantage over estrogen replacement therapy... - Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetesAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
JAMA 305:2184-92. 2011..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM... - Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research GroupD M Black
Department of Epidemiology and Biostatistics, University of California San Francisco, 94105, USA
J Bone Miner Res 14:821-8. 1999..Spinal radiographs identifying prevalent vertebral deformities may be a useful additional measurement to classify further a woman's risk of future fracture... 
Lasofoxifene in postmenopausal women with osteoporosisSteven R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, and University of California, San Francisco, San Francisco, USA
N Engl J Med 362:686-96. 2010..The effects of lasofoxifene on the risk of fractures, breast cancer, and cardiovascular disease are uncertain...- A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research GroupD E Sellmeyer
Division of Endocrinology, the General Clinical Research Center, and the Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Am J Clin Nutr 73:118-22. 2001..Imbalance between dietary acid and base precursors leads to a chronic net dietary acid load that may have adverse consequences on bone... - The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene EvaluationS R Cummings
Department of Medicine, University of California, San Francisco, USA
JAMA 281:2189-97. 1999..Raloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting... - Factors that may influence the classification of sleep-wake by wrist actigraphy: the MrOS Sleep StudyTerri Blackwell
California Pacific Medical Center Research Institute, San Francisco, CA, USA
J Clin Sleep Med 7:357-67. 2011..Associations of measurement error for TST (PSG-actigraphy) with demographics, medical history, exam data, and sleep characteristics were examined... - Circadian activity rhythms and mortality: the study of osteoporotic fracturesGregory J Tranah
California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA
J Am Geriatr Soc 58:282-91. 2010..To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women... - Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly womenW S Browner
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, California 94143, USA
J Clin Endocrinol Metab 86:631-7. 2001..The association of serum OPG levels with diabetes and with cardiovascular mortality raises the possibility that OPG may be a cause of or a marker for vascular calcification... - Older women with diabetes have an increased risk of fracture: a prospective studyA V Schwartz
Department of Epidemiology, Division of Endocrinology, University of California San Francisco, San Francisco, California 94105, USA
J Clin Endocrinol Metab 86:32-8. 2001..This study indicates that diabetes is a risk factor for hip, proximal humerus, and foot fractures among older women, suggesting that fracture prevention efforts should be a consideration in the treatment of diabetes... - The association of Parkinson's disease with bone mineral density and fracture in older womenJ L Schneider
California Pacific Medical Center Research Institute, San Francisco, CA, USA
Osteoporos Int 19:1093-7. 2008..Among community-dwelling older women, compared to those without Parkinson's disease (PD), women with PD have 7.3% lower BMD and an increased risk for hip fracture (HR = 2.6)... - Changes in biochemical markers of bone turnover in women treated with raloxifene: influence of regression to the meanR D Chapurlat
Department of Epidemiology and Biostatistics, University of California, San Francisco, USA
Osteoporos Int 12:1006-14. 2001.... - Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research GroupD M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco 94105, USA
J Clin Endocrinol Metab 85:4118-24. 2000..Furthermore, reduction in risk is evident early in the course of treatment. This pooled analysis provides a more precise estimate of the antifracture efficacy of alendronate in women with osteoporosis than that in prior reports... - Cognitive decline in women in relation to non-protein-bound oestradiol concentrationsK Yaffe
Department of Psychiatry, University of California, San Francisco 94121, USA
Lancet 356:708-12. 2000..We tested the hypothesis that concentrations of non-protein-bound (free) and loosely bound (bioavailable) sex hormones are associated with cognitive function in older women... - Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research GroupS A Jamal
University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, USA
Ann Intern Med 128:829-32. 1998..Vitamin K deficiency may be associated with osteoporosis... - A normative reference database study for Pronosco X-posure SystemD M Black
University of California, San Francisco, CA 94106, USA
J Clin Densitom 4:5-12. 2001..The strong correlation of DXR-BMD from the X-posure System with DXA at the wrist from the Hologic machine suggests that the X-posure System may be an alternative to DXA at the wrist for the assessment of osteoporosis... - The biology of agingS R Cummings
Medicine and Epidemiology, San Francisco Coordinating Center, San Francisco, CA 94107-1762, USA
J Musculoskelet Neuronal Interact 7:340-1. 2007 - Continuing screening mammography in women aged 70 to 79 years: impact on life expectancy and cost-effectivenessK Kerlikowske
Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco 94121, USA
JAMA 282:2156-63. 1999..In particular, older women with low bone mineral density (BMD) have a lower risk of breast cancer and may benefit less from continued screening... - Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) studyPeggy M Cawthon
Research Institute, California Pacific Medical Center, San Francisco, California 94107 1728, USA
J Clin Endocrinol Metab 94:3806-15. 2009..As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors... - Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCTDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
J Bone Miner Res 23:1326-33. 2008.... - AgingS R Cummings
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, University of California, San Francisco, CA 94107, USA
J Musculoskelet Neuronal Interact 7:338-9. 2007 - Quitting smoking: reasons for quitting and predictors of cessation among medical patientsC L Duncan
Department of Medicine, University of California, San Francisco
J Gen Intern Med 7:398-404. 1992..Education, social pressure, provider advice, and formal programs, but not over-the-counter devices, appear to increase the chances that smokers will quit... - Chinese and U.S. internists adhere to different ethical standardsM D Feldman
Department of Medicine, University of California, San Francisco 94143-0320, USA
J Gen Intern Med 14:469-73. 1999..In general, the Chinese physicians appeared to give far greater weight to family preferences in medical decision making than did the U.S. physicians... - Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS studyD C Bauer
UCSF, San Francisco, CA 94107, USA
Osteoporos Int 18:771-7. 2007..We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone... - Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older womenS P Moffett
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
J Clin Endocrinol Metab 93:2002-8. 2008..Osteoprotegerin (OPG) is a soluble decoy receptor for receptor activator nuclear factor kappa-beta that blocks osteoclastic bone resorption... - Classification of osteoporosis based on bone mineral densitiesY Lu
Department of Radiology, University of California San Francisco, 94143-0628, USA
J Bone Miner Res 16:901-10. 2001..A risk-based osteoporosis classification does not depend on the manufacturers' reference data and may be more consistent and efficient for patient diagnosis... - Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fracturesT J Beck
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Bone Miner Res 16:1108-19. 2001..The adaptive response to declining skeletal loads, with greater rates of subperiosteal expansion and cortical thinning, may increase fragility beyond that expected from the reduction in section modulus or bone mass alone... - Effects of current and discontinued estrogen replacement therapy on hip structural geometry: the study of osteoporotic fracturesT J Beck
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Bone Miner Res 16:2103-10. 2001..Current, but not past, use of estrogen therapy in elderly women seems to increase mechanical strength of the proximal femur by improving its geometric properties. These effects are not evident from changes in femoral neck BMD... - Body mass index, serum sex hormones, and breast cancer risk in postmenopausal womenT J Key
Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
J Natl Cancer Inst 95:1218-26. 2003..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations... - Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohortK Yaffe
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Neurobiol Aging 28:171-8. 2007..Older women treated with conjugated estrogens may have an increased risk of dementia, but the effect of naturally occurring sex hormones on cognition is not certain... - PPAR-gamma Pro12Ala genotype and risk of cognitive decline in eldersK Yaffe
Department of Psychiatry and Neurology, University of California, San Francisco, CA 94121, United States
Neurobiol Aging 29:78-83. 2008..We tested whether this polymorphism is associated with cognition... - Disability after clinical fracture in postmenopausal women with low bone density: the fracture intervention trial (FIT)H A Fink
MD, MPH, VA Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
Osteoporos Int 14:69-76. 2003..Substantial disability also was reported after fractures of thoracic vertebrae, humerus, distal forearm, ankle and foot. Within fracture types, post-fracture disability was highly variable, ranging from none to more than 6 months... - Incidence and risk factors for a second hip fracture in elderly women. The Study of Osteoporotic FracturesR D Chapurlat
Prevention Sciences Group, University of California at San Francisco, California, USA
Osteoporos Int 14:130-6. 2003..5 [0.3-0.9]) up to 2 years of follow-up. We conclude that community-dwelling women with a first hip fracture have a high risk of second hip fracture, and risk factors for this second fracture are similar to those of first hip fracture... - Incident vertebral fractures and mortality in older women: a prospective studyD M Kado
Division of Geriatrics, Department of Medicine, The David Geffen School of Medicine at University of California, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095, USA
Osteoporos Int 14:589-94. 2003..06; 95% CI=0.88 1.28). Older women with incident vertebral fractures have an increased risk of mortality that may be explained by weight loss and physical frailty... - Effects of hormone replacement therapy on clinical fractures and height loss: The Heart and Estrogen/Progestin Replacement Study (HERS)J A Cauley
Department of Epidemiology (JAC, University of Pittsburgh, Pennsylvania 15261, USA
Am J Med 110:442-50. 2001..Randomized studies are needed to clarify the effect of hormone replacement therapy on fracture risk among women with and without osteoporosis... - Kidney function and markers of inflammation in elderly persons without chronic kidney disease: the health, aging, and body composition studyC R Keller
Department of Medicine, University of California, San Francisco, California, USA
Kidney Int 71:239-44. 2007..05). Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates >or=60; associations are particularly strong with TNF-alpha and the STNF-R... - Risk of fracture among women who lose bone density during treatment with alendronate. The Fracture Intervention TrialR D Chapurlat
Department of Rheumatology and Bone Diseases and INSERM U403, E Herriot Hospital, 69437 Lyon, France
Osteoporos Int 16:842-8. 2005..So, the reduction in bone turnover induced by alendronate might be more important than BMD changes. The few women who lose the most BMD (more than 4% per year) might not benefit from the treatment... - Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older womenS P Moffett
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
J Clin Endocrinol Metab 90:3491-7. 2005..The G-308A polymorphism was not associated with a reduced risk of other fractures. These results suggest a potential role of genetic variation in TNFalpha in the etiology of osteoporosis... - Association between aortic calcification and total and cardiovascular mortality in older womenN Rodondi
Cardiovascular Prevention Clinic, University Outpatient Clinic, Department of Community Medicine and Public Health, University of Lausanne, Lausanne, Switzerland
J Intern Med 261:238-44. 2007..To determine whether older women with abdominal aortic calcification had a greater cardiovascular and all-cause mortality, as such data are limited in older adults...