Research TopicsSpecies | David E CummingsSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
|
Detail Information
Publications
Elevated plasma ghrelin levels in Prader Willi syndromeDavid E Cummings
Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
Nat Med 8:643-4. 2002- Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgeryDavid E Cummings
Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
N Engl J Med 346:1623-30. 2002..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion... - Regulation of ghrelin in physiologic and pathophysiologic statesDiana L Williams
Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA
J Nutr 135:1320-5. 2005..We also consider potential hormonal and neural mediators of the effects of nutrients and weight change on ghrelin levels... - Human plasma ghrelin levels increase during a one-year exercise programKaren E Foster-Schubert
Department of Medicine, Division of Metabolism, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Clin Endocrinol Metab 90:820-5. 2005..In summary, ghrelin levels increase with weight loss achieved without reduced food intake, consistent with a role for ghrelin in the adaptive response constraining weight loss and, thus, in long-term body weight regulation... - Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controlsTracey McLaughlin
Division of Endocrinology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Clin Endocrinol Metab 89:1630-5. 2004..Thus, insulin resistance or related metabolic abnormalities may constitute part of a feedback mechanism by which body weight is regulated in humans... - Ghrelin levels in young children with Prader-Willi syndromeChristine R Erdie-Lalena
Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, Madigan Army Medical Center, Fort Lewis, USA
J Pediatr 149:199-204. 2006..It is possible that ghrelin levels increase suddenly before hyperphagia develops... - Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndromeAndrea M Haqq
Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
J Clin Endocrinol Metab 88:3573-6. 2003..Further investigation is warranted to determine whether long-term octreotide treatment causes sustained ghrelin suppression, changes eating behavior, and induces weight loss in this population... - Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone releaseDenton Hirsh
Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
Horm Res 63:111-8. 2005..Because glucagon stimulates the promoter of the ghrelin gene in vitro as well as ghrelin secretion by the perfused rat stomach, we sought to determine whether ghrelin mediates glucagon-induced GH secretion... 
Relationship of body mass index with demographic and clinical characteristics in the Longitudinal Assessment of Bariatric Surgery (LABS)Steven H Belle
Surg Obes Relat Dis 4:474-80. 2008..Outcomes analyses should consider the potential for the confounding of BMI with demographic and clinical characteristics...- Ghrelin plasma levels during psychopharmacological treatmentHubertus Himmerich
Max Planck Institute of Psychiatry, Munich, Germany
Neuropsychobiology 52:11-6. 2005..Psychotropic drugs with different propensities to induce body weight gain are associated with similar concentrations of plasma ghrelin in psychiatric patients after a short period of treatment... - Gastric bypass and nesidioblastosis--too much of a good thing for islets?David E Cummings
N Engl J Med 353:300-2. 2005 - Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndromeKelly C Allison
University of Pennsylvania School of Medicine, Department of Psychiatry, Weight and Eating Disorders Program, 3535 Market Street, Suite 3021, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 90:6214-7. 2005..Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable... - Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbensAmy M Naleid
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA
Peptides 26:2274-9. 2005..These results suggest interaction of a metabolic factor with the reward system in feeding behavior, indicating that hedonic responses can be modulated by homeostatic factors... - Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetesSteven C Griffen
Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
J Clin Endocrinol Metab 91:485-91. 2006..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity... - Gastrointestinal surgery as a treatment for diabetesDavid E Cummings
JAMA 299:341-3. 2008 - Ghrelin: a link between energy homeostasis and drug abuse?David E Cummings
Addict Biol 12:1-5. 2007 - Direct stimulation of ghrelin secretion by sympathetic nervesThomas O Mundinger
Deparyment of Medicine, Division of Metabolism, Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Endocrinology 147:2893-901. 2006..Epinephrine failed to stimulate ghrelin secretion (Delta = +4 +/- 35%). We conclude that the neural, but not the neurohumoral, branch of the sympathetic nervous system can directly stimulate ghrelin secretion... - Effect of aging on the response of ghrelin to acute weight lossMichi Yukawa
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 54:648-53. 2006..To determine whether the failure of the orexigenic hormone ghrelin to increase as it normally does with weight loss contributes to impaired weight recovery in older persons... - Ghrelin and the short- and long-term regulation of appetite and body weightDavid E Cummings
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, WA 98108, USA
Physiol Behav 89:71-84. 2006..Extant evidence favors roles for ghrelin in both short-term meal initiation and long-term energy homeostasis, making it an attractive target for drugs to treat obesity and/or wasting disorders... - Role of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgeryDavid E Cummings
Surg Obes Relat Dis 3:109-15. 2007 - Gastrointestinal regulation of food intakeDavid E Cummings
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Clin Invest 117:13-23. 2007..The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes... - Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgeryDavid E Cummings
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Surg Obes Relat Dis 1:358-68. 2005 - Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatmentJeetesh V Patel
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine and Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands, UK
J Negat Results Biomed 5:14. 2006..Little is known about the effects of short-term glucocorticoid treatment on levels of these hormones... - Prospects for an anti-ghrelin vaccine to treat obesityMolly J Carlson
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Mol Interv 6:249-52. 2006..More broadly, the work of Zorilla et al. supports the feasibility of vaccinations directed against specific autologous targets--immunopharmacotherapy that could potentially be developed to target a wide array of medical conditions... - Emerging therapeutic strategies for obesityKaren E Foster-Schubert
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
Endocr Rev 27:779-93. 2006.... - Ghrelin and energy balance: focus on current controversiesDavid E Cummings
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Curr Drug Targets 6:153-69. 2005..We suggest that ghrelin is a "saginary" hormone, from the Latin, saginare, which means, "to fatten"... - Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouseKathryn J Newhall
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
Mol Endocrinol 19:982-91. 2005..These findings indicate that PKA modifies the phenotype of the leptin-deficient mouse, leading to increases in both thermogenesis and energy expenditure... - Growth hormone therapy in adultsDavid E Cummings
Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
Annu Rev Med 54:513-33. 2003..In critical illness, high-dose GH therapy has proven clearly harmful, and the balance of risks and benefits of GH administration in most adult contexts other than AGHD has not been defined... - Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate dietDavid S Weigle
University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98104, USA
J Clin Endocrinol Metab 88:1577-86. 2003..Fat restriction avoids the increase in ghrelin levels caused by dietary energy restriction... - Roles for ghrelin in the regulation of appetite and body weightDavid E Cummings
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, S-111-Endo, Seattle, WA 98108, USA
Arch Surg 138:389-96. 2003 - Ghrelin-leptin tango in body-weight regulationDavid E Cummings
Gastroenterology 124:1532-5. 2003 - Meal-related ghrelin suppression requires postgastric feedbackDiana L Williams
Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
Endocrinology 144:2765-7. 2003..We conclude that the meal-related suppression of plasma ghrelin requires postgastric (pre- or postabsorptive) stimulation... - Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss?David E Cummings
Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Clin Endocrinol Metab 88:2999-3002. 2003 - Melanocortin signaling and anorexia in chronic disease statesBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Ann N Y Acad Sci 994:275-81. 2003..The data presented in this paper summarize findings that implicate neuronal melanocortin signaling in inflammatory anorexia... - Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile ratsBarry E Levin
Neurology Service, Department of Veterans Affairs Medical Center, 127C VA Medical Center, 385 Tremont Ave, E Orange, NJ 07018 1095, USA
Am J Physiol Endocrinol Metab 285:E949-57. 2003..These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role... - Hyperphagic effects of brainstem ghrelin administrationLucy F Faulconbridge
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Diabetes 52:2260-5. 2003..Taken together, the results affirm a caudal brainstem site of action and recommend further investigation into multisite interactions underlying the modulation of ingestive behavior by ghrelin... - Vagotomy dissociates short- and long-term controls of circulating ghrelinDiana L Williams
Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
Endocrinology 144:5184-7. 2003..The dissociation between nutrient load- and deprivation-related ghrelin responses indicates that the regulation of circulating ghrelin levels involves separate mechanisms operating through anatomically distinct pathways... - Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humansJonathan Q Purnell
Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
J Clin Endocrinol Metab 88:5747-52. 2003..Our data are consistent with the hypotheses that insulin may negatively regulate ghrelin and that high-density lipoprotein may be a carrier particle for circulating ghrelin... - Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humansHolly S Callahan
University of Washington School of Medicine, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 89:1319-24. 2004..We conclude that the depth of postprandial ghrelin suppression is proportional to ingested caloric load but that recovery of plasma ghrelin is not a critical determinant of intermeal interval... - Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feedingRichard W Gelling
Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359657, Seattle, Washington 98104, USA
Endocrinology 145:4575-82. 2004..Although plasma ghrelin levels fall in response to hyperphagic feeding, these findings support the hypothesis that increased ghrelin signaling contributes to the pathogenesis of diabetic hyperphagia... - Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasisBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
Am J Physiol Endocrinol Metab 287:E1107-13. 2004..05 vs. vehicle), an effect similar to that of ADX. These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin... - Helicobacter pylori and ghrelin: Interrelated players in body-weight regulation?David E Cummings
Am J Med 117:436-9. 2004 - Role of the duodenum and macronutrient type in ghrelin regulationJoost Overduin
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, Washington 98108, USA
Endocrinology 146:845-50. 2005..The relatively weak suppression of ghrelin by lipids compared with glucose or amino acids could represent one mechanism promoting high-fat dietary weight gain... - Gastric bypass for obesity: mechanisms of weight loss and diabetes resolutionDavid E Cummings
Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 89:2608-15. 2004 - Genetics and pathophysiology of human obesityDavid E Cummings
Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA
Annu Rev Med 54:453-71. 2003..This article highlights some of these recent findings and their implications for the future of obesity treatment...