D E Cummings

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Ghrelin increases the motivation to eat, but does not alter food palatability
    Joost Overduin
    Veterans Administration Puget Sound Health Care System, Office of Research and Development Medical Research Service, Seattle, Washington, USA
    Am J Physiol Regul Integr Comp Physiol 303:R259-69. 2012
  2. pmc Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity
    Ricardo V Cohen
    The Center of Excellence in Bariatric and Metabolic Surgery, Oswaldo Cruz Hospital, Sao Paulo, Brazil
    Diabetes Care 35:1420-8. 2012
  3. doi request reprint Metabolic surgery for type 2 diabetes
    David E Cummings
    University of Washington, Seattle, USA
    Nat Med 18:656-8. 2012
  4. ncbi request reprint Roles for ghrelin in the regulation of appetite and body weight
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, S 111 Endo, Seattle, WA 98108, USA
    Arch Surg 138:389-96. 2003
  5. ncbi request reprint Ghrelin and energy balance: focus on current controversies
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Curr Drug Targets 6:153-69. 2005
  6. ncbi request reprint Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss?
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 88:2999-3002. 2003
  7. doi request reprint Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery
    D E Cummings
    University of Washington School of Medicine, Seattle, WA 98195, USA
    Int J Obes (Lond) 33:S33-40. 2009
  8. ncbi request reprint Ghrelin and the short- and long-term regulation of appetite and body weight
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, WA 98108, USA
    Physiol Behav 89:71-84. 2006
  9. ncbi request reprint Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
    D E Cummings
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Physiol Endocrinol Metab 287:E297-304. 2004
  10. ncbi request reprint Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution
    David E Cummings
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 89:2608-15. 2004

Detail Information

Publications116 found, 100 shown here

  1. pmc Ghrelin increases the motivation to eat, but does not alter food palatability
    Joost Overduin
    Veterans Administration Puget Sound Health Care System, Office of Research and Development Medical Research Service, Seattle, Washington, USA
    Am J Physiol Regul Integr Comp Physiol 303:R259-69. 2012
    ..These results indicate that ghrelin increases the motivation to eat via D1 receptor-dependent mechanisms, without affecting perceived food palatability...
  2. pmc Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity
    Ricardo V Cohen
    The Center of Excellence in Bariatric and Metabolic Surgery, Oswaldo Cruz Hospital, Sao Paulo, Brazil
    Diabetes Care 35:1420-8. 2012
    ..We determined the long-term impact of RYGB on patients with diabetes and only class I obesity...
  3. doi request reprint Metabolic surgery for type 2 diabetes
    David E Cummings
    University of Washington, Seattle, USA
    Nat Med 18:656-8. 2012
    ..The concept of 'metabolic surgery' to treat diabetes has taken a big step forward...
  4. ncbi request reprint Roles for ghrelin in the regulation of appetite and body weight
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, S 111 Endo, Seattle, WA 98108, USA
    Arch Surg 138:389-96. 2003
  5. ncbi request reprint Ghrelin and energy balance: focus on current controversies
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Curr Drug Targets 6:153-69. 2005
    ..We suggest that ghrelin is a "saginary" hormone, from the Latin, saginare, which means, "to fatten"...
  6. ncbi request reprint Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss?
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 88:2999-3002. 2003
  7. doi request reprint Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery
    D E Cummings
    University of Washington School of Medicine, Seattle, WA 98195, USA
    Int J Obes (Lond) 33:S33-40. 2009
    ..Research designed to prioritize these mechanisms and identify potential additional mechanisms promises to help optimize surgical design and might also reveal novel pharmaceutical targets for diabetes treatment...
  8. ncbi request reprint Ghrelin and the short- and long-term regulation of appetite and body weight
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, S 111 Endo, Seattle, WA 98108, USA
    Physiol Behav 89:71-84. 2006
    ..Extant evidence favors roles for ghrelin in both short-term meal initiation and long-term energy homeostasis, making it an attractive target for drugs to treat obesity and/or wasting disorders...
  9. ncbi request reprint Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
    D E Cummings
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Physiol Endocrinol Metab 287:E297-304. 2004
    ....
  10. ncbi request reprint Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution
    David E Cummings
    Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 89:2608-15. 2004
  11. ncbi request reprint Growth hormone therapy in adults
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Annu Rev Med 54:513-33. 2003
    ..In critical illness, high-dose GH therapy has proven clearly harmful, and the balance of risks and benefits of GH administration in most adult contexts other than AGHD has not been defined...
  12. ncbi request reprint Genetics and pathophysiology of human obesity
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:453-71. 2003
    ..This article highlights some of these recent findings and their implications for the future of obesity treatment...
  13. ncbi request reprint A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    D E Cummings
    University of Washington, VA Puget Sound Health Care System and Harborview Medical Center, Seattle, Washington 98108, USA
    Diabetes 50:1714-9. 2001
    ..Circulating ghrelin also correlated positively with age (r = 0.701). The clear preprandial rise and postprandial fall in plasma ghrelin levels support the hypothesis that ghrelin plays a physiological role in meal initiation in humans...
  14. ncbi request reprint Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002
    ..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion...
  15. ncbi request reprint Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice
    S A Schreyer
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    Diabetes 50:2555-62. 2001
    ..Taken together, these data demonstrate that loss of RIIbeta protects mice from diet-induced obesity, insulin resistance, and dyslipidemia...
  16. ncbi request reprint Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting
    D S Weigle
    Department of Medicine, University of Washington, Harborview Medical Center, Seattle 98104, USA
    Diabetes 47:298-302. 1998
    ..This seemingly paradoxical induction of UCP3 may be linked to the use of free fatty acid as a fuel rather than an increased need of the organism to dissipate energy...
  17. ncbi request reprint Reversal of cancer anorexia by blockade of central melanocortin receptors in rats
    B E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Washington 98108, USA
    Endocrinology 142:3292-301. 2001
    ..This suggests that new targets for the treatment of cancer anorexia may be found in the melanocortin pathways...
  18. ncbi request reprint Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue
    J V Planas
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7750, USA
    J Biol Chem 274:36281-7. 1999
    ..We suggest that the R subunit isoform switch disrupts the subcellular localization of PKA that is required for efficient transduction of signals that modulate lipolysis but not for those that mediate gene expression...
  19. ncbi request reprint Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice
    P S Amieux
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7750, USA
    J Biol Chem 272:3993-8. 1997
    ..Compensation by RIalpha stabilization may represent an important biological mechanism that safeguards cells from unregulated catalytic subunit activity...
  20. doi request reprint Temporal trends in the management of potentially resectable lung cancer
    Farhood Farjah
    Surgical Outcomes Research Center, University of Washington, Seattle, Washington, USA
    Ann Thorac Surg 85:1850-5; discussion 1856. 2008
    ..We hypothesized that the proportion of patients operated on would increase over time coincident with increasing adherence to practice guidelines and improved patient/provider education over time...
  21. ncbi request reprint Management of pleural space infections: a population-based analysis
    Farhood Farjah
    Division of General Surgery, Department of Surgery, University of Washington, Seattle, Wash 98195 6310, USA
    J Thorac Cardiovasc Surg 133:346-51. 2007
    ..Management options for pleural space infections have changed over the last 2 decades. This study evaluated trends over time in the incidence of disease and use of different management strategies and their associated outcomes...
  22. doi request reprint Surgeon knowledge, behavior, and opinions regarding intraoperative cholangiography
    Nader N Massarweh
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 207:821-30. 2008
    ..Routine IOC is not universal, and barriers to its use, including surgeon knowledge, behavior, and attitudes, should be understood in developing quality-improvement interventions aimed at increasing IOC use...
  23. pmc Multi-modality mediastinal staging for lung cancer among medicare beneficiaries
    Farhood Farjah
    Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Thorac Oncol 4:355-63. 2009
    ..It is unknown how frequently multimodality mediastinal staging is used, or whether its use is associated with better health outcomes...
  24. ncbi request reprint Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
    D E Cummings
    Department of Pharmacology, University of Washington School of Medicine, Seattle, 98195 7750, USA
    Nature 382:622-6. 1996
    ..This causes induction of uncoupling protein and elevations of metabolic rate and body temperature, contributing to the lean phenotype. Our results demonstrate a role for the RII beta holoenzyme in regulating energy balance and adiposity...
  25. ncbi request reprint Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats
    D L Williams
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    J Endocrinol Invest 29:863-8. 2006
    ..Having discounted diet composition and differences in gastric contents at the time of blood sampling, the decrease in ghrelin levels with overfeeding can be unambiguously attributed to physiological correlates of weight gain...
  26. ncbi request reprint Impact of gastric bypass operation on survival: a population-based analysis
    David R Flum
    Department of Surgery, University of Washington, Seattle, WA 98195 7183, USA
    J Am Coll Surg 199:543-51. 2004
    ..Bariatric procedures are increasingly performed but their impact on survival is unknown...
  27. ncbi request reprint Choosing your words carefully: how physicians would disclose harmful medical errors to patients
    Thomas H Gallagher
    Departments of Medicine and Medical History and Ethics, University of Washington School of Medicine, 4311 11th Avenue NW, Seattle, WA 98105, USA
    Arch Intern Med 166:1585-93. 2006
    ..Little is known about how physicians approach disclosure. The objective of the present study was to describe how physicians disclose errors to patients...
  28. ncbi request reprint Washington State's approach to variability in surgical processes/Outcomes: Surgical Clinical Outcomes Assessment Program (SCOAP)
    David R Flum
    Department of Surgery and the Surgical Outcomes Research Center, and the Department of Health Services, University of Washington, Seattle, Washington 98195 6410, USA
    Surgery 138:821-8. 2005
  29. ncbi request reprint Early mortality among Medicare beneficiaries undergoing bariatric surgical procedures
    David R Flum
    Department of Surgery, University of Washington, Seattle, Wash 98195 7183, USA
    JAMA 294:1903-8. 2005
    ..Case series demonstrate that bariatric surgery can be performed with a low rate of perioperative mortality (0.5%), but the rate among high-risk patients and the community at large is unknown...
  30. ncbi request reprint Evaluating diagnostic accuracy in appendicitis using administrative data
    David R Flum
    Department of Surgery, University of Washington, School of Medicine, Seattle, WA 98195 7183, USA
    J Surg Res 123:257-61. 2005
    ..This study assessed the validity of a research technique using administrative data to determine whether patients undergoing an appendectomy actually had appendicitis or if they had a negative appendectomy (NA)...
  31. ncbi request reprint Primary operative versus nonoperative therapy for pediatric empyema: a meta-analysis
    Jeffrey R Avansino
    Department of Surgery, University of Washington, Box 356410, Seattle, WA 98105, USA
    Pediatrics 115:1652-9. 2005
    ..The optimal treatment of children with empyema remains controversial. The purpose of this review was to compare reported results of nonoperative and primary operative therapy for the treatment of pediatric empyema...
  32. ncbi request reprint Wide local excision or abdominoperineal resection as the initial treatment for anorectal melanoma?
    John T Droesch
    Department of Surgery, University of Washington, 1959 N E Pacific St, Box 356410, Seattle, WA 98195 6410, USA
    Am J Surg 189:446-9. 2005
    ..Anorectal melanoma (AM) is a rare tumor with a poor prognosis. Treatment with abdominoperineal resection (APR) over wide local excision (WLE) is still debated. This study aimed to compare median survival of WLE and APR in patients with AM...
  33. ncbi request reprint Risk of emergency colectomy and colostomy in patients with diverticular disease
    Daniel A Anaya
    Department of Surgery, University of Washington, Seattle 98195, USA
    Arch Surg 140:681-5. 2005
    ..Patients with diverticulitis are at a lifetime risk for emergency colectomy and colostomy. Age and recurrence characteristics can serve to predict the risk for these adverse outcomes...
  34. ncbi request reprint Perioperative rofecoxib plus local anesthetic field block diminishes pain and recovery time after outpatient inguinal hernia repair
    Dorothy J Pavlin
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA, USA
    Anesth Analg 101:83-9, table of contents. 2005
    ..We conclude that perioperative rofecoxib with PL reduces in-hospital recovery time, decreases pain scores and opioid use, and improves satisfaction scores in the first 24 h after surgery...
  35. ncbi request reprint Lower extremity angioplasty for claudication: a population-level analysis of 30-day outcomes
    Todd R Vogel
    Department of Surgery, Surgical Outcomes Research Center, Division of Vascular Surgery, Harborview Medical Center, Seattle, WA 98104, USA
    J Vasc Surg 45:762-7. 2007
    ..This study evaluated changes in the use and short-term outcomes of PTA among patients with claudication and other manifestations of peripheral arterial disease (PAD)...
  36. ncbi request reprint Role of intraoperative cholangiography in avoiding bile duct injury
    Nader N Massarweh
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 204:656-64. 2007
  37. ncbi request reprint Toward the rational and equitable use of bariatric surgery
    David R Flum
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    JAMA 298:1442-4. 2007
  38. ncbi request reprint The clinical and economic correlates of misdiagnosed appendicitis: nationwide analysis
    David R Flum
    Department of Surgery, Robert Wood Johnson Clinical Scholars Program, University of Washington, H 220 Health Sciences Center, Box 357183, Seattle, WA 98195 7183, USA
    Arch Surg 137:799-804; discussion 804. 2002
    ..Negative appendectomy (NA)--the nonincidental removal of a normal appendix--occurs commonly but the associated clinical- and system-level costs are not well studied...
  39. pmc Have outcomes of incisional hernia repair improved with time? A population-based analysis
    David R Flum
    Robert Wood Johnson Clinical Scholars Program, Seattle, Washington, USA
    Ann Surg 237:129-35. 2003
    ..To determine if certain outcomes of incisional hernia repair have improved in recent eras...
  40. ncbi request reprint Intraoperative cholangiography and risk of common bile duct injury during cholecystectomy
    David R Flum
    The Robert Wood Johnson Clinical Scholars Program, The Department of Surgery, University of Washington, Seattle 98195 6410, USA
    JAMA 289:1639-44. 2003
    ..Intraoperative cholangiography (IOC) may decrease the risk of common bile duct (CBD) injury during cholecystectomy by helping to avoid misidentification of the CBD...
  41. doi request reprint A critical evaluation of the impact of Leapfrog's evidence-based hospital referral
    Nader N Massarweh
    Department of Surgery Surgical Outcomes Research Center, University ofWashington, Seattle, WA, USA
    J Am Coll Surg 212:150-159.e1. 2011
    ..It has yet to be determined if EBHR has led to regionalized surgical care and whether it has improved patient outcomes...
  42. doi request reprint Impact of advancing age on abdominal surgical outcomes
    Nader N Massarweh
    Department of Surgery, Surgical Outcomes Research Center, University of Washington School of Medicine, Seattle, WA 98195 6410, USA
    Arch Surg 144:1108-14. 2009
    ..To describe the population-level risk of adverse outcomes among older adults undergoing common abdominal surgical procedures...
  43. doi request reprint Risk tolerance and bile duct injury: surgeon characteristics, risk-taking preference, and common bile duct injuries
    Nader N Massarweh
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 209:17-24. 2009
    ..Risk-taking preferences can influence physician behavior and practice. We evaluated self-reported differences in characteristics and risk-taking preference among surgeons with and without a reported history of CBDI...
  44. doi request reprint Adverse events after radiofrequency ablation of unresectable liver tumors: a single-center experience
    Oliver B Lao
    Department of Surgery, University of Washington, Seattle, WA 98195, USA
    Am J Surg 198:76-82. 2009
    ..Radiofrequency ablation (RFA) is a relatively new modality to treat liver tumors that is being incorporated into practice despite the fact that its risk profile has not been well described...
  45. ncbi request reprint Bile duct injury during cholecystectomy and survival in medicare beneficiaries
    David R Flum
    Department of Surgery, University of Washington, Seattle, Washington 98195 6410, USA
    JAMA 290:2168-73. 2003
    ..Common bile duct (CBD) injury during cholecystectomy is a significant source of patient morbidity, but its impact on survival is unclear...
  46. doi request reprint Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA, USA
    Ann Surg 248:557-63. 2008
    ..The Surgical Care and Outcomes Assessment Program (SCOAP) gathers chart-abstracted process of care data (such as CT/US accuracy) for general surgical procedures (including appendectomy) at most Washington State hospitals...
  47. ncbi request reprint Development of a porcine Roux-en-Y gastric bypass survival model for the study of post-surgical physiology
    David R Flum
    Department of Surgery, University of Washington, Seattle, WA 98195 7183, USA
    Obes Surg 17:1332-9. 2007
    ..The aim of this study was to establish a survival model of Roux-en-Y gastric bypass (RYGBP) in swine and to evaluate its potential in studies of physiology...
  48. doi request reprint Normal feeding and body weight in Fischer 344 rats lacking the cholecystokinin-1 receptor gene
    J E Blevins
    Office of Research and Development Medical Research Service, Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA
    Brain Res 1255:98-112. 2009
    ....
  49. ncbi request reprint Central nervous system control of food intake and body weight
    G J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    Nature 443:289-95. 2006
    ..This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research...
  50. ncbi request reprint A cost-effectiveness analysis of intraoperative cholangiography in the prevention of bile duct injury during laparoscopic cholecystectomy
    David R Flum
    Robert Wood Johnson Clinical Scholars Program, Department of Surgery, University of Washington, Seattle, WA 98195 7183, USA
    J Am Coll Surg 196:385-93. 2003
    ..The cost implications of a management strategy involving routine IOC use have not been adequately evaluated...
  51. doi request reprint Trends in the operative management and outcomes of T4 lung cancer
    Farhood Farjah
    Department of Surgery, Surgical Outcomes Research Center, University of Washington, Seattle, Washington 98195 6310, USA
    Ann Thorac Surg 86:368-74. 2008
    ..This study describes temporal trends and variables in the operative management and outcomes of patients with T4 lung tumors in the general community...
  52. pmc Cost-effectiveness analysis of laparoscopic gastric bypass, adjustable gastric banding, and nonoperative weight loss interventions
    Leon Salem
    Department of Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6410, USA
    Surg Obes Relat Dis 4:26-32. 2008
    ..We designed a model to evaluate the incremental cost-effectiveness of these procedures compared with nonoperative weight loss interventions and with each other...
  53. ncbi request reprint The impact of low health literacy on surgical practice
    Lisa D Chew
    VA Puget Sound Health Care System, Health Services Research and Development S 152, 1660 S Columbian Way, Seattle, WA 98108, USA
    Am J Surg 188:250-3. 2004
    ..We sought to determine the prevalence of low health literacy (LHL) among patients in a preoperative clinic, the characteristics associated with LHL, and the association between LHL and adherence to preoperative instructions...
  54. doi request reprint Safety and efficacy of video-assisted versus conventional lung resection for lung cancer
    Farhood Farjah
    Department of Surgery, Surgical Outcomes Research Center, University of Washington, Seattle, Wash 98195 6310, USA
    J Thorac Cardiovasc Surg 137:1415-21. 2009
    ..We sought to evaluate the use of video-assisted thoracoscopy among patients with lung cancer and its safety and effectiveness relative to conventional resection...
  55. doi request reprint Health care utilization among surgically treated Medicare beneficiaries with lung cancer
    Farhood Farjah
    Department of Surgery, University of Washington, Seattle, Washington 98195 6410, USA
    Ann Thorac Surg 88:1749-56. 2009
    ..Markers of increased health care utilization are surrogates for adverse events, and one such metric--prolonged length of stay greater than 14 days (PLOS)--was recently endorsed as a provider-level performance measure...
  56. doi request reprint Surgeon specialty and long-term survival after pulmonary resection for lung cancer
    Farhood Farjah
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Ann Thorac Surg 87:995-1004; discussion 1005-6. 2009
    ..Long-term outcomes and processes of care in patients undergoing pulmonary resection for lung cancer may vary by surgeon type. Associations between surgeon specialty and processes of care and long-term survival have not been described...
  57. ncbi request reprint Risk taking and tolerance of uncertainty: implications for surgeons
    Eric P Tubbs
    Department of Surgery, University of Washington, Seattle, Washington 98195 6410, USA
    J Surg Res 131:1-6. 2006
    ..It is unclear if surgeons' risk attitudes and reactions to uncertainty influence their use of these or other interventions...
  58. ncbi request reprint Impact of surgical clipping on survival in unruptured and ruptured cerebral aneurysms: a population-based study
    Gavin W Britz
    Department of Neurosurgery, University of Washington, Seattle, Wash 98195 6410, USA
    Stroke 35:1399-403. 2004
    ..This study was designed to evaluate long-term survival of patients with aneurysms undergoing clipping in a statewide population...
  59. ncbi request reprint Hartmann's colectomy and reversal in diverticulitis: a population-level assessment
    Leon Salem
    Department of Surgery, University of Washington, Seattle, Washington 98195 6410, USA
    Dis Colon Rectum 48:988-95. 2005
    ..This study was designed to assess the costs and outcomes of colostomy and colostomy reversal in patients with diverticulitis and examine the impact of such procedures on the health care system...
  60. ncbi request reprint The nationwide frequency of major adverse outcomes in antireflux surgery and the role of surgeon experience, 1992-1997
    David R Flum
    Department of Surgery, University of Washington, Seattle 98195 7183, USA
    J Am Coll Surg 195:611-8. 2002
    ..The population level frequency of adverse events after antireflux procedures and its relationship to surgical experience has not been well studied...
  61. ncbi request reprint Misdiagnosis of appendicitis and the use of diagnostic imaging
    David R Flum
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 201:933-9. 2005
    ..The objective of this study was to determine the relationship between CT/US and NA in common practice...
  62. ncbi request reprint The timing of elective colectomy in diverticulitis: a decision analysis
    Leon Salem
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 199:904-12. 2004
    ..We used decision and cost analysis to simulate the clinical and economic outcomes after recovery from an episode of nonsurgically treated diverticulitis to determine the preferable management strategy...
  63. doi request reprint The significance of discharge to skilled care after abdominopelvic surgery in older adults
    Victor J Legner
    Department of Medicine, University of Washington School of Medicine, Seattle, 98195 6410, USA
    Ann Surg 249:250-5. 2009
    ..Older adults frequently undergo abdominopelvic surgical operations, yet the risk and significance of postoperative discharge disposition has not been well characterized...
  64. pmc Racial disparities among patients with lung cancer who were recommended operative therapy
    Farhood Farjah
    Surgical Outcomes Research Center, University of Washington, Seattle, Washington 98195 6410, USA
    Arch Surg 144:14-8. 2009
    ..We hypothesized that there would be no significant evidence of racial disparities among patients with early-stage lung cancer who are recommended surgical therapy...
  65. doi request reprint Epithelioid sarcoma: the University of Washington experience
    Patrick S Wolf
    University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Surg 196:407-12. 2008
    ..Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes. We reviewed our experience with adjuvant therapy in patients with this disease...
  66. pmc Trends in the utilization and impact of radiofrequency ablation for hepatocellular carcinoma
    Nader N Massarweh
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 210:441-8. 2010
    ..The incidence of hepatocellular carcinoma (HCC) is rising and radiofrequency ablation (RFA) appears to be increasingly used. The nationwide use and impact of RFA have not been well characterized...
  67. ncbi request reprint Temporal changes in the management of diverticulitis
    Leon Salem
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Surg Res 124:318-23. 2005
    ..This study was designed to evaluate temporal trends in the use and type of operative and non-operative interventions in the management of diverticulitis...
  68. ncbi request reprint Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery
    Charles Beymer
    Department of Internal Medicine, University of Washington School of Medicine, Seattle 98195 6410, USA
    Arch Surg 138:1240-4. 2003
    ..Nonalcoholic steatohepatitis (NASH) is a form of fatty liver disease that is increasingly recognized. There are limited data on the prevalence of NASH and the role of risk factors for NASH among the morbidly obese...
  69. ncbi request reprint A systematic review of whether oral contrast is necessary for the computed tomography diagnosis of appendicitis in adults
    Brock A Anderson
    Department of Surgery, University of Washington, BB 431, Seattle, WA 98195, USA
    Am J Surg 190:474-8. 2005
    ..There are several methods of contrast administration when performing computed tomography (CT) scanning for suspected appendicitis. In this systematic review we evaluated the diagnostic performance of CT with and without contrast material...
  70. ncbi request reprint Do antireflux operations decrease the rate of reflux-related hospitalizations in children?
    Adam B Goldin
    Division of Pediatric General and Thoracic Surgery, Children s Hospital and Regional Medical Center, W 7729, PO Box 5371, Seattle, WA 98105 0371, USA
    Pediatrics 118:2326-33. 2006
    ..The objective of this study was to determine whether pediatric antireflux procedures are associated with a decreased rate of reflux-related hospitalizations...
  71. doi request reprint Pulmonary function in the morbidly obese
    Joshua A Saliman
    Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    Surg Obes Relat Dis 4:632-9; discussion 639. 2008
    ..To assess the relationship between lung function tests and clinical characteristics in a cohort of morbidly obese patients undergoing evaluation for bariatric procedures in a university hospital in the United States...
  72. ncbi request reprint The costs of nonsurgical and surgical weight loss interventions: is an ounce of prevention really worth a pound of cure?
    Christine Jensen
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    Surg Obes Relat Dis 1:353-7. 2005
  73. ncbi request reprint Primary anastomosis or Hartmann's procedure for patients with diverticular peritonitis? A systematic review
    Leon Salem
    Department of Surgery, University of Washington, Seattle, Washington 98195 6410, USA
    Dis Colon Rectum 47:1953-64. 2004
    ..This systematic literature review was designed to summarize and compare the reported outcomes of one-stage and two-stage operations for the treatment of perforated diverticulitis with peritonitis...
  74. ncbi request reprint Are bariatric surgical outcomes worth their cost? A systematic review
    Leon Salem
    Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Am Coll Surg 200:270-8. 2005
  75. ncbi request reprint Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:5747-52. 2003
    ..Our data are consistent with the hypotheses that insulin may negatively regulate ghrelin and that high-density lipoprotein may be a carrier particle for circulating ghrelin...
  76. ncbi request reprint Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans
    Holly S Callahan
    University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 89:1319-24. 2004
    ..We conclude that the depth of postprandial ghrelin suppression is proportional to ingested caloric load but that recovery of plasma ghrelin is not a critical determinant of intermeal interval...
  77. doi request reprint Metabolism: food alert
    Joshua P Thaler
    Nature 452:941-2. 2008
  78. doi request reprint Gastrointestinal surgery as a treatment for diabetes
    David E Cummings
    JAMA 299:341-3. 2008
  79. ncbi request reprint Emerging therapeutic strategies for obesity
    Karen E Foster-Schubert
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    Endocr Rev 27:779-93. 2006
    ....
  80. ncbi request reprint Hyperphagic effects of brainstem ghrelin administration
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Diabetes 52:2260-5. 2003
    ..Taken together, the results affirm a caudal brainstem site of action and recommend further investigation into multisite interactions underlying the modulation of ingestive behavior by ghrelin...
  81. ncbi request reprint Elevated plasma ghrelin levels in Prader Willi syndrome
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
    Nat Med 8:643-4. 2002
  82. ncbi request reprint Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome
    Andrea M Haqq
    Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:3573-6. 2003
    ..Further investigation is warranted to determine whether long-term octreotide treatment causes sustained ghrelin suppression, changes eating behavior, and induces weight loss in this population...
  83. ncbi request reprint Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats
    Barry E Levin
    Neurology Service, Department of Veterans Affairs Medical Center, 127C VA Medical Center, 385 Tremont Ave, E Orange, NJ 07018 1095, USA
    Am J Physiol Endocrinol Metab 285:E949-57. 2003
    ..These data suggest that increased ghrelin signaling is not a proximate cause of DIO, whereas reduced leptin sensitivity might play a causal role...
  84. ncbi request reprint Vagotomy dissociates short- and long-term controls of circulating ghrelin
    Diana L Williams
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
    Endocrinology 144:5184-7. 2003
    ..The dissociation between nutrient load- and deprivation-related ghrelin responses indicates that the regulation of circulating ghrelin levels involves separate mechanisms operating through anatomically distinct pathways...
  85. ncbi request reprint Melanocortin signaling and anorexia in chronic disease states
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 994:275-81. 2003
    ..The data presented in this paper summarize findings that implicate neuronal melanocortin signaling in inflammatory anorexia...
  86. ncbi request reprint Ghrelin-leptin tango in body-weight regulation
    David E Cummings
    Gastroenterology 124:1532-5. 2003
  87. ncbi request reprint Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet
    David S Weigle
    University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:1577-86. 2003
    ..Fat restriction avoids the increase in ghrelin levels caused by dietary energy restriction...
  88. pmc Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates
    Karen E Foster-Schubert
    University of Washington School of Medicine, Seattle, WA 98195, USA
    J Clin Endocrinol Metab 93:1971-9. 2008
    ..Its circulating levels increase before meals and are suppressed after food ingestion. Understanding the effects of specific types of ingested macronutrients on ghrelin regulation could facilitate the design of weight-reducing diets...
  89. pmc Association of cognitive restraint with ghrelin, leptin, and insulin levels in subjects who are not weight-reduced
    Ellen A Schur
    Division of General Internal Medicine, University of Washington, Harborview Medical Center, Seattle, WA 98104, USA
    Physiol Behav 93:706-12. 2008
    ..007). No relationships were found between restraint scores and either leptin (P=0.75) or insulin (P=0.36). These findings show an orexigenic hormonal profile in restrained eaters, independent of changes in body weight...
  90. ncbi request reprint Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls
    Tracey McLaughlin
    Division of Endocrinology, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:1630-5. 2004
    ..Thus, insulin resistance or related metabolic abnormalities may constitute part of a feedback mechanism by which body weight is regulated in humans...
  91. ncbi request reprint Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery
    David E Cummings
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Surg Obes Relat Dis 1:358-68. 2005
  92. ncbi request reprint Human plasma ghrelin levels increase during a one-year exercise program
    Karen E Foster-Schubert
    Department of Medicine, Division of Metabolism, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 90:820-5. 2005
    ..In summary, ghrelin levels increase with weight loss achieved without reduced food intake, consistent with a role for ghrelin in the adaptive response constraining weight loss and, thus, in long-term body weight regulation...
  93. ncbi request reprint Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse
    Kathryn J Newhall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    Mol Endocrinol 19:982-91. 2005
    ..These findings indicate that PKA modifies the phenotype of the leptin-deficient mouse, leading to increases in both thermogenesis and energy expenditure...
  94. ncbi request reprint Effect of aging on the response of ghrelin to acute weight loss
    Michi Yukawa
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 54:648-53. 2006
    ..To determine whether the failure of the orexigenic hormone ghrelin to increase as it normally does with weight loss contributes to impaired weight recovery in older persons...
  95. ncbi request reprint Direct stimulation of ghrelin secretion by sympathetic nerves
    Thomas O Mundinger
    Deparyment of Medicine, Division of Metabolism, Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Endocrinology 147:2893-901. 2006
    ..Epinephrine failed to stimulate ghrelin secretion (Delta = +4 +/- 35%). We conclude that the neural, but not the neurohumoral, branch of the sympathetic nervous system can directly stimulate ghrelin secretion...
  96. ncbi request reprint Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes
    Steven C Griffen
    Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 91:485-91. 2006
    ..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity...
  97. ncbi request reprint Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens
    Amy M Naleid
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA
    Peptides 26:2274-9. 2005
    ..These results suggest interaction of a metabolic factor with the reward system in feeding behavior, indicating that hedonic responses can be modulated by homeostatic factors...
  98. ncbi request reprint Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome
    Kelly C Allison
    University of Pennsylvania School of Medicine, Department of Psychiatry, Weight and Eating Disorders Program, 3535 Market Street, Suite 3021, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 90:6214-7. 2005
    ..Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable...
  99. ncbi request reprint Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release
    Denton Hirsh
    Endocrinology and Diabetes Unit, British Columbia s Children s Hospital, University of British Columbia, Vancouver, Canada
    Horm Res 63:111-8. 2005
    ..Because glucagon stimulates the promoter of the ghrelin gene in vitro as well as ghrelin secretion by the perfused rat stomach, we sought to determine whether ghrelin mediates glucagon-induced GH secretion...
  100. ncbi request reprint Ghrelin plasma levels during psychopharmacological treatment
    Hubertus Himmerich
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 52:11-6. 2005
    ..Psychotropic drugs with different propensities to induce body weight gain are associated with similar concentrations of plasma ghrelin in psychiatric patients after a short period of treatment...
  101. pmc Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment
    Jeetesh V Patel
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine and Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands, UK
    J Negat Results Biomed 5:14. 2006
    ..Little is known about the effects of short-term glucocorticoid treatment on levels of these hormones...

Research Grants9

  1. Meal Initiation and Energy Homeostasis: Role of Ghrelin
    David Cummings; Fiscal Year: 2009
    ..parenteral nutrients, gastric distension, specific classes of macronutrients, leptin, fasting, and other meal-regulated gut peptides. 4) Is ghrelin effective as a drug to treat cancer anorexia in a rat model? ..
  2. Feasibility, Efficacy, and Mechanisms of Surgical vs Medical Diabetes Treatment
    David R Flum; Fiscal Year: 2010
    ..e., systemic and adipose-tissue inflammation) and adaptive immunity (i.e., islet-reactive T lymphocytes) in the anti-diabetic effects of RYGB, and evaluate the value of related metrics for future clinical trials. ..