Marina Cuchel

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi Microsomal transfer protein inhibition in humans
    Marina Cuchel
    Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Lipidol 24:246-50. 2013
  2. doi Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet 381:40-6. 2013
  3. pmc Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Maloney Building, Room 8039, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 30:526-32. 2010
  4. ncbi Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    Marina Cuchel
    University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 356:148-56. 2007
  5. pmc The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages
    Margarita de la Llera-Moya
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 30:796-801. 2010
  6. ncbi Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 113:2548-55. 2006
  7. pmc Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
    Amit V Khera
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 364:127-35. 2011
  8. pmc Inflammation induces fibrinogen nitration in experimental human endotoxemia
    Sean P Heffron
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 47:1140-6. 2009
  9. ncbi The role of high density lipoproteins in thrombosis
    Marina Cuchel
    University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA
    ScientificWorldJournal 2:89-95. 2002
  10. doi Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia
    Daniel M Kolansky
    Cardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Cardiol 102:1438-43. 2008

Collaborators

Detail Information

Publications12

  1. doi Microsomal transfer protein inhibition in humans
    Marina Cuchel
    Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Lipidol 24:246-50. 2013
    ..However, the clinical use of MTP inhibitors has been uncertain because of the gastrointestinal adverse events and the increase in liver fat content observed during their administration...
  2. doi Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Lancet 381:40-6. 2013
    ..Patients with homozygous familial hypercholesterolaemia respond inadequately to existing drugs. We aimed to assess the efficacy and safety of the microsomal triglyceride transfer protein inhibitor lomitapide in adults with this disease...
  3. pmc Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Maloney Building, Room 8039, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 30:526-32. 2010
    ..We performed studies to identify the underlying molecular mechanisms by which rHDL promote FC mobilization from whole body in vivo and macrophages in vitro...
  4. ncbi Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    Marina Cuchel
    University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 356:148-56. 2007
    ..Inhibition of the microsomal triglyceride transfer protein may be effective in reducing cholesterol levels in these patients...
  5. pmc The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages
    Margarita de la Llera-Moya
    Division of Gastroenterology, Hepatology and Nutrition, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 30:796-801. 2010
    ..Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I)...
  6. ncbi Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?
    Marina Cuchel
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 113:2548-55. 2006
  7. pmc Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
    Amit V Khera
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 364:127-35. 2011
    ..We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden...
  8. pmc Inflammation induces fibrinogen nitration in experimental human endotoxemia
    Sean P Heffron
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 47:1140-6. 2009
    ..Inflammation-induced fibrinogen nitration may be a risk factor for promoting CVD events...
  9. ncbi The role of high density lipoproteins in thrombosis
    Marina Cuchel
    University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA
    ScientificWorldJournal 2:89-95. 2002
    ..This paper reviews scientific data on the potential role of HDL as modulator of thrombotic processes...
  10. doi Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia
    Daniel M Kolansky
    Cardiovascular Medicine Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Cardiol 102:1438-43. 2008
    ..Careful coronary and valvular surveillance strategies and coronary revascularization when appropriate are also warranted in this high-risk population...
  11. ncbi The frequency of the cholesteryl ester transfer protein-TaqI B2 allele is lower in African Americans than in Caucasians
    Marina Cuchel
    Department of Medicine, University of Pennsylvania, School of Medicine, 654 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Atherosclerosis 163:169-74. 2002
    ....
  12. doi Treatment of familial hypercholesterolemia: is there a need beyond statin therapy?
    Anna Raper
    Institute of Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 14:11-6. 2012
    ..We conclude that there is a need beyond statins for patients with FH, especially in cases of statin intolerance, and when even the highest doses of statin do not get patients to goal cholesterol levels...

Research Grants5

  1. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2006
    ..This study would serve as basis for approval of BMS-201038 for hoFH. ..
  2. Mechanistic study of CHD risk in subjects with high HDLC
    Marina Cuchel; Fiscal Year: 2007
    b>Marina Cuchel is an Instructor in the Department of Medicine that in the course of the years has acquired clinical and laboratory skills in the field of lipid and lipoprotein metabolism...
  3. MPT INHIBITOR IND 50,820 IN FAMILIAL HYPERCHOLESTEROLEM*
    Marina Cuchel; Fiscal Year: 2009
    ..This study would serve as basis for approval of BMS-201038 for hoFH. ..