Michael L Cuccaro

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Autism in African American families: clinical-phenotypic findings
    Michael L Cuccaro
    Duke University Medical Center, Durham, NC, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1022-6. 2007
  2. doi request reprint Exploring the relationship between autism spectrum disorder and epilepsy using latent class cluster analysis
    Michael L Cuccaro
    Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Autism Dev Disord 42:1630-41. 2012
  3. ncbi request reprint Lack of association between autism and SLC25A12
    Raquel Rabionet
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, 595 LaSalle St, Durham, NC 27710, USA
    Am J Psychiatry 163:929-31. 2006
  4. doi request reprint Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Autism Res 2:258-66. 2009
  5. pmc Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
    Ann L Collins
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:167-74. 2006
  6. pmc Novel variants identified in methyl-CpG-binding domain genes in autistic individuals
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136, USA
    Neurogenetics 11:291-303. 2010
  7. pmc A de novo 1.5 Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis
    Anthony J Griswold
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
    Autism Res 4:221-7. 2011
  8. pmc Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
    Anthony J Griswold
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Mol Genet 21:3513-23. 2012
  9. ncbi request reprint Factor analysis of the aberrant behavior checklist in individuals with autism spectrum disorders
    Jason Brinkley
    Center for Human Genetics, Duke University Medical Center, DUMC Box 3445, Durham, NC 27710, USA
    J Autism Dev Disord 37:1949-59. 2007
  10. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Autism in African American families: clinical-phenotypic findings
    Michael L Cuccaro
    Duke University Medical Center, Durham, NC, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1022-6. 2007
    ..Such considerations will aid greatly in the search for genetic variants in autism...
  2. doi request reprint Exploring the relationship between autism spectrum disorder and epilepsy using latent class cluster analysis
    Michael L Cuccaro
    Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Autism Dev Disord 42:1630-41. 2012
    ....
  3. ncbi request reprint Lack of association between autism and SLC25A12
    Raquel Rabionet
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, 595 LaSalle St, Durham, NC 27710, USA
    Am J Psychiatry 163:929-31. 2006
    ..This study aimed to test for association in SLC25A12 in an independent data set of 327 families with autistic offspring...
  4. doi request reprint Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Autism Res 2:258-66. 2009
    ..The chromosomal abnormality in this family strengthens the case for an autism susceptibility gene in the chromosome 7q22-31 region and targets a candidate region for further investigation...
  5. pmc Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
    Ann L Collins
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:167-74. 2006
    ..0253). These results confirmed our earlier findings, indicating GABRA4 and GABRB1 as genes contributing to autism susceptibility, extending the effect to multiple ethnic groups and suggesting seizures as a stratifying phenotype...
  6. pmc Novel variants identified in methyl-CpG-binding domain genes in autistic individuals
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33136, USA
    Neurogenetics 11:291-303. 2010
    ..These results suggest that rare cases of autism may be influenced by mutations in members of the dynamic MBD protein family...
  7. pmc A de novo 1.5 Mb microdeletion on chromosome 14q23.2-23.3 in a patient with autism and spherocytosis
    Anthony J Griswold
    John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
    Autism Res 4:221-7. 2011
    ..2-23.3 in the etiology of autism and points to MTHFD1, PLEKHG3, and CHURC1 as potential candidate genes contributing to autism risk...
  8. pmc Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
    Anthony J Griswold
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Mol Genet 21:3513-23. 2012
    ..Taken together, these CNVs may be a few of the missing pieces of ASD heritability and lead to discovering novel etiological mechanisms...
  9. ncbi request reprint Factor analysis of the aberrant behavior checklist in individuals with autism spectrum disorders
    Jason Brinkley
    Center for Human Genetics, Duke University Medical Center, DUMC Box 3445, Durham, NC 27710, USA
    J Autism Dev Disord 37:1949-59. 2007
    ..The emergence of a self-injury factor, while not suggestive of a new subscale, warrants further exploration as a tool that could help dissect relevant neurobiobehavioral groups in ASD...
  10. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011
    ..abstract:..
  11. ncbi request reprint Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R
    Michael L Cuccaro
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Child Psychiatry Hum Dev 34:3-17. 2003
    ..Defining subgroups within autism will allow for reduction of clinical heterogeneity and enhance our ability to dissect the genetic etiology of this complex disorder...
  12. pmc Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder
    Yujun Shao
    Center for Human Genetics, CARL Building, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:1058-61. 2002
    ..86 and HLOD 2.12 for marker D2S116). These data support evidence for a gene on chromosome 2 contributing to risk of AutD, and they suggest that phenotypic homogeneity increases the power to find susceptibility genes for AutD...
  13. pmc The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Autism Res 5:385-97. 2012
    ....
  14. pmc A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
    Deqiong Ma
    Miami Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA
    Ann Hum Genet 73:263-73. 2009
    ..24E-04 to 3.40E-06) than in either dataset alone. Our findings demonstrate that in addition to multiple rare variations, part of the complex genetic architecture of autism involves common variation...
  15. pmc A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
    John P Hussman
    John P, Hussman Institute for Human Genomics, University of Miami, 1501 NW 10th Avenue, Miami, FL 33136, USA
    Mol Autism 2:1. 2011
    ..abstract:..
  16. ncbi request reprint A comparison of repetitive behaviors in Aspergers Disorder and high functioning autism
    Michael L Cuccaro
    Duke University Medical Center, Durham, NC, USA
    Child Psychiatry Hum Dev 37:347-60. 2007
    ..These findings add to the body of literature showing that HFA and ASP fail to differ with respect to repetitive behaviors. The implications of the findings for neurobiologic and genetic studies are discussed...
  17. ncbi request reprint Accelerated head growth in early development of individuals with autism
    Yulia A Dementieva
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Neurol 32:102-8. 2005
    ..This study confirms the presence of abnormal acceleration in head growth during the first and second months of life in a subgroup of autistic individuals...
  18. ncbi request reprint Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes
    Raquel Rabionet
    Department of Medicine, Center for Human Genetics, 595 LaSalle St, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 372:209-14. 2004
    ....
  19. pmc Evaluating mitochondrial DNA variation in autism spectrum disorders
    Athena Hadjixenofontos
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 77:9-21. 2013
    ..Accordingly, while there may be attractive biological hints suggesting the role of mitochondria in ASD our data indicate that mtDNA variation is not a major contributing factor to the development of ASD...
  20. ncbi request reprint Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk
    Allison E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Snyderman Genomic Sciences Building, Durham, NC 27710, USA
    Psychiatr Genet 17:221-6. 2007
    ..RELN shares a common biological pathway with APOE, and Persico et al. have observed transmission distortion of the APOE-2 allele in autism families...
  21. pmc Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
    Dale J Hedges
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, M 860, Miami, FL 33136, USA
    Mol Autism 3:2. 2012
    ..abstract:..
  22. ncbi request reprint Identification of MeCP2 mutations in a series of females with autistic disorder
    Regina M Carney
    Department of Medicine and the Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatr Neurol 28:205-11. 2003
    ..These data provide additional evidence of variable expression in the Rett disorder phenotype and suggest MeCP2 testing may be warranted for females presenting with autistic disorder...
  23. ncbi request reprint Ordered-subset analysis of savant skills in autism for 15q11-q13
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 135:38-41. 2005
    ..In addition, ordered subset analysis (OSA) using SSF as a covariate also failed to show evidence for linkage. Our findings do not support savant skills as an informative phenotypic subset for linkage in our sample...
  24. doi request reprint Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis
    Charles S Carver
    Department of Psychology, University of Miami, Coral Gables FL 33124, United States
    J Affect Disord 132:89-93. 2011
    ..BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model...
  25. ncbi request reprint Genomic screen and follow-up analysis for autistic disorder
    Yujun Shao
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet 114:99-105. 2002
    ..0) in stage two analysis. The peak lod score regions on chromosomes 2, 7, 15, 19, and X overlap previously reported peak linkage areas. The region on chromosome 3 is unique...
  26. ncbi request reprint No association between the WNT2 gene and autistic disorder
    Pinky A McCoy
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet 114:106-9. 2002
    ..We did not identify any activating mutation in the coding region of the WNT2 gene. Thus, we conclude that activating mutations of the WNT2 gene are not a major contributor to the development of autistic disorder in these data...
  27. doi request reprint Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells
    Brooke A Derosa
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB 509, Miami, FL 33146, USA
    Neurosci Lett 516:9-14. 2012
    ..In this article we describe, for the first time, the derivation of iPSC lines from PBMCs isolated from the whole blood of autistic children, and their subsequent differentiation in GABAergic neurons...
  28. pmc Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    Simon G Gregory
    Duke Center for Human Genetics, DUMC, Durham, NC, USA
    BMC Med 7:62. 2009
    ..Although numerous approaches have been used to identify genes implicated in the development of autism, less than 10% of autism cases have been attributed to single gene disorders...
  29. ncbi request reprint Repetitive behaviors in autism: relationships with associated clinical features
    Robin L Gabriels
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Res Dev Disabil 26:169-81. 2005
    ..The relationship between RBs and associated clinical features in autism is complex and future studies should control for cognitive ability when examining the direct and indirect relationships of these variables with RBs...
  30. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  31. ncbi request reprint Behavioral comparisons in autistic individuals from multiplex and singleton families
    Michael L Cuccaro
    W S Hall Psychiatric Institute, Department of Neuropsychiatry, University of South Carolina, Columbia, South Carolina, USA
    J Autism Dev Disord 33:87-91. 2003
    ..These results suggests the possibility that common etiologic mechanisms, either genetic and/or environmental, could underlie all of AD...