Stephen J Crozier

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Molecular mechanisms of pancreatic dysfunction induced by protein malnutrition
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Gastroenterology 137:1093-101, 1101.e1-3. 2009
  2. doi request reprint CCK-induced pancreatic growth is not limited by mitogenic capacity in mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1148-57. 2008
  3. pmc Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Physiol 573:775-86. 2006
  4. pmc Regulator of calcineurin 1 controls growth plasticity of adult pancreas
    Grzegorz T Gurda
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Gastroenterology 139:609-19, 619.e1-6. 2010
  5. pmc CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth
    Stephen J Crozier
    Department of 1Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1154-63. 2010
  6. pmc AMPK represses TOP mRNA translation but not global protein synthesis in liver
    Ali K Reiter
    Department of Cellular and Molecular Physiology, The Pennsylvania State College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 374:345-50. 2008
  7. pmc Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion
    Stephen J Crozier
    Dept of Cellular and Molecular Physiology, The Pennsylvania State Univ College of Medicine, PO Box 850, Hershey, PA 17033, USA
    J Appl Physiol 101:576-82. 2006
  8. ncbi request reprint Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes 51:928-36. 2002
  9. ncbi request reprint Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E1092-101. 2002
  10. ncbi request reprint Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Am J Physiol Endocrinol Metab 287:E772-80. 2004

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Molecular mechanisms of pancreatic dysfunction induced by protein malnutrition
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    Gastroenterology 137:1093-101, 1101.e1-3. 2009
    ..The purpose of this study was to elucidate the role of mTOR in protein deficiency-induced pancreatic dysfunction...
  2. doi request reprint CCK-induced pancreatic growth is not limited by mitogenic capacity in mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1148-57. 2008
    ..These results indicate that CCK-stimulated growth of the pancreas is not limited by acinar cell mitogenic capacity but is due, at least in part, to inhibition of promitogenic Akt signaling...
  3. pmc Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Physiol 573:775-86. 2006
    ..We conclude that the mTOR signalling pathway is required for CCK-induced cell division and pancreatic growth...
  4. pmc Regulator of calcineurin 1 controls growth plasticity of adult pancreas
    Grzegorz T Gurda
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Gastroenterology 139:609-19, 619.e1-6. 2010
    ..CCK-driven pancreatic growth requires calcineurin (CN), which activates Nuclear Factor of Activated T cells (NFATs), but the genetic underpinnings and feedback mechanisms that regulate this response are not known...
  5. pmc CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth
    Stephen J Crozier
    Department of 1Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1154-63. 2010
    ..Prolonged mTORC1 activation is thus required for dietary protein-induced pancreatic growth in the absence of CCK...
  6. pmc AMPK represses TOP mRNA translation but not global protein synthesis in liver
    Ali K Reiter
    Department of Cellular and Molecular Physiology, The Pennsylvania State College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 374:345-50. 2008
    ..Thus, in liver, AMPK activation repressed translation of TOP mRNAs through a mechanism distinct from downregulated phosphorylation of S6K1 or rpS6...
  7. pmc Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion
    Stephen J Crozier
    Dept of Cellular and Molecular Physiology, The Pennsylvania State Univ College of Medicine, PO Box 850, Hershey, PA 17033, USA
    J Appl Physiol 101:576-82. 2006
    ..These changes in protein phosphorylation suggest that control of mRNA translation following ischemia and reperfusion is modulated through a number of signaling pathways and regulatory mechanisms...
  8. ncbi request reprint Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes 51:928-36. 2002
    ..The insulin-dependent mechanism is associated with increased phosphorylation of 4E-BP1 and S6K1. In contrast, the insulin-independent effect on protein synthesis is mediated by an unknown mechanism...
  9. ncbi request reprint Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
    Joshua C Anthony
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E1092-101. 2002
    ..In contrast, assembly of the mRNA cap-binding complex occurs independently of increases in insulin and, by itself, is insufficient to stimulate rates of protein synthesis in skeletal muscle after leucine administration...
  10. ncbi request reprint Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Am J Physiol Endocrinol Metab 287:E772-80. 2004
    ..The results are consistent with a model wherein protein synthesis is enhanced during aging in a futile attempt to maintain muscle mass...
  11. pmc Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle
    Douglas R Bolster
    The Pennsylvania State University College of Medicine, Department of Cellular and Molecular Physiology, Hershey, PA 17033, USA
    J Physiol 553:213-20. 2003
    ....
  12. ncbi request reprint Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart
    Stephen J Crozier
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E1144-50. 2002
    ..Therefore, the activation state of signal transduction pathways that are responsive to cellular energy stress represents one mechanism whereby translation initiation may be regulated in cardiac muscle...
  13. ncbi request reprint Meal feeding alters translational control of gene expression in rat liver
    Ali K Reiter
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 135:367-75. 2005
    ....
  14. ncbi request reprint AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    Douglas R Bolster
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:23977-80. 2002
    ..This is the first investigation to demonstrate changes in translation initiation and skeletal muscle protein synthesis in response to AMPK activation...
  15. ncbi request reprint Tissue-specific regulation of protein synthesis by insulin and free fatty acids
    Stephen J Crozier
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 285:E754-62. 2003
    ..Thus FFAs may contribute to the translational control of protein synthesis in the heart but not in the gastrocnemius. In contrast, insulin, but not FFAs, is required for the maintenance of protein synthesis in the gastrocnemius...
  16. ncbi request reprint Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts
    Stephen J Crozier
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Am J Physiol Heart Circ Physiol 289:H1242-50. 2005
    ....
  17. ncbi request reprint Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside
    Ali K Reiter
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 288:E980-8. 2005
    ..Overall, however, the results from both experimental models support a scenario in which AICAR directly represses protein synthesis and mTOR signaling in the liver through an AMPK-dependent mechanism...
  18. ncbi request reprint Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    Stephen J Crozier
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 135:376-82. 2005
    ..The ability of small doses of leucine to stimulate skeletal muscle protein synthesis suggests that future research on the regulation of skeletal muscle protein synthesis by orally administered leucine will be feasible in humans...

Research Grants2

  1. Mechanisms of Protein Malnutrition-Induced Exocrine Pancreas Dysfunction
    STEPHEN CROZIER; Fiscal Year: 2007
    ..Individuals lacking protein in their diet often have pancreatic dysfunction and are unable to properly digest food. It is the purpose of this research is to understand how dietary protein maintains pancreatic health. ..