Research Topics
Genomes and GenesSpecies | Thomas J CrowleySummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Risky decisions and their consequences: neural processing by boys with Antisocial Substance DisorderThomas J Crowley
Substance Dependence Division, Psychiatry Department, University of Colorado Denver, Denver, Colorado, USA
PLoS ONE 5:e12835. 2010..We hypothesized that, during processing of risky decisions and resulting rewards and punishments, brain activation would differ between abstinent ASD boys and comparison boys...
The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibitionIsabel R Schlaepfer
Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Addict Biol 12:200-9. 2007..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples...
Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problemsJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
Drug Alcohol Depend 88:130-7. 2007....
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescentsChristie A Hartman
School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 47:165-73. 2008..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?..
A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9Christian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
Drug Alcohol Depend 89:34-41. 2007..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci...
Case-control and within-family tests for an association between conduct disorder and 5HTTLPRJoseph T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Am J Med Genet B Neuropsychiatr Genet 141:825-32. 2006..61; P = 0.20). These data suggest that the s-allele may confer some risk for aggressive behavior or may be in linkage disequilibrium with such an allele...
A behavioral test of accepting benefits that cost others: associations with conduct problems and callous-unemotionalityJoseph T Sakai
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
PLoS ONE 7:e36158. 2012..Such behavioral tendencies are generally measured using self- or observer-report. We are unaware of attempts to measure this tendency with a behavioral paradigm...
Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorderJoseph T Sakai
Division of Substance Dependence, School of Medicine, University of Colorado Denver, 12469 East 17th Place, Aurora, CO 80045, USA
Psychiatr Genet 22:99-102. 2012..004). We concluded that in this sample, 10 SNPs in the OXTR gene were not significantly associated with CD...
DSM-IV conduct disorder criteria as predictors of antisocial personality disorderHeather L Gelhorn
Department of Psychiatry, University of Colorado Health Sciences Center, Box C 268 35, Denver, CO 80262, USA
Compr Psychiatry 48:529-38. 2007..Relationships between individual DSM-IV CD symptom criteria and persistent antisocial outcomes are discussed. These findings may be relevant to the development of DSM-V...
Reduced cortical gray matter volume in male adolescents with substance and conduct problemsManish Dalwani
Department of Psychiatry, University of Colorado Denver School of Medicine, 12469 E 17th Place, Aurora, CO 80045, USA
Drug Alcohol Depend 118:295-305. 2011..Because prefrontal cortex (PFC) is involved in planning behavior in accord with prior rewards and punishments, structural abnormalities in PFC could contribute to a person's propensity to make risky decisions...
Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relativesJoseph T Sakai
Division of Substance Dependence, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Drug Alcohol Depend 106:199-203. 2010..We sought to replicate previous findings and test for an association between a single nucleotide polymorphism (SNP) in the GABRA2 gene (rs279871) and CD among adolescents...
Adolescents and substance-related disorders: research agenda to guide decisions on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V)Thomas J Crowley
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Addiction 101:115-24. 2006..Based on that adolescent literature, this paper suggests further research to help guide decisions about revising for DSM-V the SUD criteria in DSM-IV...
Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescentsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis...
A risk-taking "set" in a novel task among adolescents with serious conduct and substance problemsThomas J Crowley
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 45:175-83. 2006..The authors asked whether such youths also take excessive risks in new situations without prior learning, peer pressure, or intoxication...
Inhalant use, abuse, and dependence among adolescent patients: commonly comorbid problemsJoseph T Sakai
Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 43:1080-8. 2004....
Validity of transdermal alcohol monitoring: fixed and self-regulated dosingJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Alcohol Clin Exp Res 30:26-33. 2006..To study the validity of transdermal assessment of alcohol concentration measured by a lightweight, noninvasive device...
The family transmission of adolescent alcohol abuse and dependenceChristie A Hartman
University of Colorado Health Sciences Center, Division of Substance Dependence, 4200 East 9th Avenue, Box C 268 35, Denver, Colorado 80262, USA
J Stud Alcohol 67:657-64. 2006..This study examines the familial transmission of alcohol abuse and dependence to adolescents...
Review of twin and adoption studies of adolescent substance useChristian J Hopfer
Division of Substance Dependence, Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
J Am Acad Child Adolesc Psychiatry 42:710-9. 2003..To review studies of adolescent substance use and abuse with genetically informative designs...
Treating adolescent heroin useChristian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, UC Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 42:609-11. 2003
