Research Topics
Species | Thomas CrowleySummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Validity of structured clinical evaluations in adolescents with conduct and substance problemsT J Crowley
Psychiatry Department, University of Colorado Medical School, Denver 80262, USA
J Am Acad Child Adolesc Psychiatry 40:265-73. 2001..To determine discriminative and convergent validity for certain structured diagnostic assessments among adolescents with conduct and substance problems...- Adolescents and substance-related disorders: research agenda to guide decisions on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V)Thomas J Crowley
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Addiction 101:115-24. 2006..Based on that adolescent literature, this paper suggests further research to help guide decisions about revising for DSM-V the SUD criteria in DSM-IV... - Discriminative validity and clinical utility of an abuse-neglect interview for adolescents with conduct and substance use problemsThomas J Crowley
Division of Substance Dependence, Department of Psychiatry, Unviersity of Colorado School of Medicien, CO 80262, USA
Am J Psychiatry 160:1461-9. 2003.... - A risk-taking "set" in a novel task among adolescents with serious conduct and substance problemsThomas J Crowley
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 45:175-83. 2006..The authors asked whether such youths also take excessive risks in new situations without prior learning, peer pressure, or intoxication... 
Toward DSM-V: an item response theory analysis of the diagnostic process for DSM-IV alcohol abuse and dependence in adolescentsHeather Gelhorn
School of Medicine at the University of Colorado at Denver, CO, USA
J Am Acad Child Adolesc Psychiatry 47:1329-39. 2008..The present study extends prior research with a larger and more comprehensive sample and an examination of an alternative diagnostic algorithm for AUDs...- Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relativesJoseph T Sakai
Division of Substance Dependence, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Drug Alcohol Depend 106:199-203. 2010..We sought to replicate previous findings and test for an association between a single nucleotide polymorphism (SNP) in the GABRA2 gene (rs279871) and CD among adolescents... - The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibitionIsabel R Schlaepfer
Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Addict Biol 12:200-9. 2007..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples... - Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescentsChristie A Hartman
School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 47:165-73. 2008..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?.. - Negative reinforcement learning is affected in substance dependenceLaetitia L Thompson
University of Colorado School of Medicine, Department of Psychiatry, Aurora, CO 80045, USA
Drug Alcohol Depend 123:84-90. 2012..We hypothesized that SDI would show differences in negative reinforcement learning compared to controls and we investigated whether learning differed as a function of the relative magnitude or frequency of the reinforcer... - An item response theory analysis of DSM-IV conduct disorderHeather Gelhorn
School of Medicine at the University of Colorado, Denver, CO, USA
J Am Acad Child Adolesc Psychiatry 48:42-50. 2009.... - Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotineJody Tanabe
Department of Radiology, University of Colorado at Denver Health Sciences, Denver, CO 80262, USA
Neuropsychopharmacology 33:627-33. 2008..The lack of a main effect on withdrawal, but correlation of thalamic blood flow with withdrawal symptoms suggests that more complex mechanisms mediate the subjective features of the withdrawal state... - Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individualsJody Tanabe
Department of Radiology, University of Denver School of Medicine, Denver, CO, USA
Biol Psychiatry 65:160-4. 2009..We tested the hypothesis that medial OFC gray matter (GM) volume would be lower in SDI compared with control subjects... - DSM-IV conduct disorder criteria as predictors of antisocial personality disorderHeather L Gelhorn
Department of Psychiatry, University of Colorado Health Sciences Center, Box C 268 35, Denver, CO 80262, USA
Compr Psychiatry 48:529-38. 2007..Relationships between individual DSM-IV CD symptom criteria and persistent antisocial outcomes are discussed. These findings may be relevant to the development of DSM-V... - Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problemsJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
Drug Alcohol Depend 88:130-7. 2007.... - Family transmission of marijuana use, abuse, and dependenceChristian J Hopfer
University of Colorado Health Sciences Center, Denver 80262, USA
J Am Acad Child Adolesc Psychiatry 42:834-41. 2003..To examine the familial aggregation of marijuana use, abuse, and dependence... - Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescentsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis... - Review of twin and adoption studies of adolescent substance useChristian J Hopfer
Division of Substance Dependence, Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA
J Am Acad Child Adolesc Psychiatry 42:710-9. 2003..To review studies of adolescent substance use and abuse with genetically informative designs... - Treating adolescent heroin useChristian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, UC Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 42:609-11. 2003 - Adolescent inhalant use among male patients in treatment for substance and behavior problems: two-year outcomeJoseph T Sakai
Division of Substance Dependence, University of Colorado School of Medicine, Denver 80262, USA
Am J Drug Alcohol Abuse 32:29-40. 2006..Yet little has been published regarding treatment outcome for inhalant users... - Measuring impulsivity in adolescents with serious substance and conduct problemsLaetitia L Thompson
University of Colorado School of Medicine, Denver CO 80262, USA
Assessment 13:3-15. 2006..Furthermore, the IMT/DMT correlated significantly with self-reported impulsivity. In summary, the IMT/DMT may be an effective behavioral measure of impulsivity in adolescents... - Validity of transdermal alcohol monitoring: fixed and self-regulated dosingJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Alcohol Clin Exp Res 30:26-33. 2006..To study the validity of transdermal assessment of alcohol concentration measured by a lightweight, noninvasive device... - Comparing linear and nonlinear mixed model approaches to cosinor analysisSusan K Mikulich
Department of Psychiatry, University of Colorado Health Sciences Center UCHSC, Denver, Colorado 80262, U S A
Stat Med 22:3195-211. 2003..However, for some multiple-group analyses, the linear cosinor transformation should not be used and we clarify when the two methods are equivalent and when they differ... - Adolescent heroin use: a review of the descriptive and treatment literatureChristian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
J Subst Abuse Treat 23:231-37. 2002..Length of time in treatment, regardless of modality, was the best predictor of outcome. The rise of heroin use among adolescents and young adults calls for descriptive studies as well as controlled treatment studies... - Inhalant use, abuse, and dependence among adolescent patients: commonly comorbid problemsJoseph T Sakai
Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 43:1080-8. 2004.... - A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9Christian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
Drug Alcohol Depend 89:34-41. 2007..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci... - Case-control and within-family tests for an association between conduct disorder and 5HTTLPRJoseph T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Am J Med Genet B Neuropsychiatr Genet 141:825-32. 2006..61; P = 0.20). These data suggest that the s-allele may confer some risk for aggressive behavior or may be in linkage disequilibrium with such an allele... - The family transmission of adolescent alcohol abuse and dependenceChristie A Hartman
University of Colorado Health Sciences Center, Division of Substance Dependence, 4200 East 9th Avenue, Box C 268 35, Denver, Colorado 80262, USA
J Stud Alcohol 67:657-64. 2006..This study examines the familial transmission of alcohol abuse and dependence to adolescents... - Personality risk profile for conduct disorder and substance use disorders in youthKristen G Anderson
Department of Psychology, University of California, San Diego, United States
Addict Behav 32:2377-82. 2007..These findings support the role for personality in models of the etiology and persistence of conduct disorder and substance use disorders... - A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescenceMichael C Stallings
Institute for Behavioral Genetics and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309 0444, USA
Arch Gen Psychiatry 62:1042-51. 2005..Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence... - Comorbidity between alcohol dependence and illicit drug dependence in adolescents with antisocial behavior and matched controlsSoo Hyun Rhee
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
Drug Alcohol Depend 84:85-92. 2006..Discrepancies in results may reflect different analytical approaches or differences in the samples. Here, we examine the causes of comorbidity between alcohol dependence and illicit drug dependence in adolescents... 
Case-control and within-family tests for an association between conduct disorder and DAT1R Jay Schulz-Heik
Institute for Behavioral Genetics, Department of Psychology, University of Colorado, Boulder 80309, USA
Psychiatr Genet 18:17-24. 2008..Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children...- Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patientsSusan E Young
Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
Am J Psychiatry 163:1019-25. 2006.... - The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobaccoJoanna S Zeiger
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Hum Mol Genet 17:724-34. 2008..These results indicate that early subjective response to nicotine may be a valuable endophenotype for genetic studies aimed at uncovering genes contributing to nicotine use and addiction... - A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescenceMichael C Stallings
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309 0447, USA
Drug Alcohol Depend 70:295-307. 2003..2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838)... - Brain activation during the Stroop task in adolescents with severe substance and conduct problems: A pilot studyMarie T Banich
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0344, USA
Drug Alcohol Depend 90:175-82. 2007..This study investigated patterns of brain activation in adolescents with severe substance and conduct problems (SCP) compared to controls... - Errors in assessing DSM-IV substance use disordersBridget F Grant
Arch Gen Psychiatry 64:379-80; author reply 381-2. 2007 - Genetic and environmental influences on substance initiation, use, and problem use in adolescentsSoo Hyun Rhee
Department of Psychology and the Institute for Behavioral Genetics, University of Colorado at Boulder, 90309, USA
Arch Gen Psychiatry 60:1256-64. 2003..We conducted a sibling/twin/adoption study of substance initiation, use, and problem use, estimating the relative contribution of genetic and environmental influences on these phenotypes in adolescents... - Setting priorities for genomic researchWade Berrettini
Science 304:1445-7; author reply 1445-7. 2004 - Dopamine transporter polymorphism associated with externalizing behavior problems in childrenSusan E Young
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet 114:144-9. 2002..001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70)...
Research Grants
- Substance Dependent Adolescents: Imaging Risk-TakingThomas Crowley; Fiscal Year: 2009....
- Substance Dependent Adolescents: Imaging Risk-TakingThomas Crowley; Fiscal Year: 2007....
- GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCEThomas Crowley; Fiscal Year: 2005..5) To establish, for the use of qualified researchers, a data library, which will include posted genotype and phenotype information, together with lymphoblastoid cell lines, from subjects of this research. ..
- Substance Dependent Adolescents: Imaging Risk-TakingThomas J Crowley; Fiscal Year: 2010....