James J Crowley

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Brain levels of the neurotoxic pyridinium metabolite HPP+ and extrapyramidal symptoms in haloperidol-treated mice
    James J Crowley
    Center for Psychiatric Genomics, Department of Genetics, University of North Carolina at Chapel Hill, NC, USA Electronic address
    Neurotoxicology 39:153-7. 2013
  2. pmc Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
    James J Crowley
    Department of Genetics, University of North Carolina, Genomic Medicine Building, CB 7264, Chapel Hill, NC 27599 7264, USA
    Mamm Genome 23:322-35. 2012
  3. pmc Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice
    J J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Pharmacogenomics J 12:147-55. 2012
  4. pmc The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
  5. pmc No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition
    Thomas I Konneker
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010
  6. pmc Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis
    James J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264
    Genetics 196:321-47. 2014
  7. pmc Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa
    Yunjung Kim
    Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
    Psychiatry Res 210:287-93. 2013
  8. pmc A novel statistical approach for jointly analyzing RNA-Seq data from F1 reciprocal crosses and inbred lines
    Fei Zou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599
    Genetics 197:389-99. 2014
  9. ncbi A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
  10. ncbi Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 183:257-64. 2005

Detail Information

Publications11

  1. pmc Brain levels of the neurotoxic pyridinium metabolite HPP+ and extrapyramidal symptoms in haloperidol-treated mice
    James J Crowley
    Center for Psychiatric Genomics, Department of Genetics, University of North Carolina at Chapel Hill, NC, USA Electronic address
    Neurotoxicology 39:153-7. 2013
    ..The results suggest that strain differences in steady-state HPP+ levels do not explain sensitivity to haloperidol-induced EPS in the mice we studied. ..
  2. pmc Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in mice
    James J Crowley
    Department of Genetics, University of North Carolina, Genomic Medicine Building, CB 7264, Chapel Hill, NC 27599 7264, USA
    Mamm Genome 23:322-35. 2012
    ....
  3. pmc Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in mice
    J J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Pharmacogenomics J 12:147-55. 2012
    ..Murine VCMs are a face valid animal model of antipsychotic-induced TD, and heritability estimates from this study support the feasibility of mapping of susceptibility loci for VCMs...
  4. pmc The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    ..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
  5. pmc No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition
    Thomas I Konneker
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010
    ..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons...
  6. pmc Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis
    James J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264
    Genetics 196:321-47. 2014
    ....
  7. pmc Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa
    Yunjung Kim
    Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
    Psychiatry Res 210:287-93. 2013
    ..Although results are preliminary secondary to a small sample size, these data provide initial evidence of transcriptional alterations during weight restoration in AN. ..
  8. pmc A novel statistical approach for jointly analyzing RNA-Seq data from F1 reciprocal crosses and inbred lines
    Fei Zou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599
    Genetics 197:389-99. 2014
    ..Unless sample recruiting is too expensive to conduct, we recommend sequencing more samples with lower coverage. ..
  9. ncbi A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  10. ncbi Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 183:257-64. 2005
    ..Variations in the effects of antidepressant drugs between different mouse strains are important for drug discovery and could lead to the identification of genes that predict differences in drug efficacy...
  11. ncbi Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...