James J Crowley
Affiliation: University of North Carolina
- Brain levels of the neurotoxic pyridinium metabolite HPP+ and extrapyramidal symptoms in haloperidol-treated miceJames J Crowley
Center for Psychiatric Genomics, Department of Genetics, University of North Carolina at Chapel Hill, NC, USA Electronic address
Neurotoxicology 39:153-7. 2013..The results suggest that strain differences in steady-state HPP+ levels do not explain sensitivity to haloperidol-induced EPS in the mice we studied. ..
- Genome-wide association mapping of loci for antipsychotic-induced extrapyramidal symptoms in miceJames J Crowley
Department of Genetics, University of North Carolina, Genomic Medicine Building, CB 7264, Chapel Hill, NC 27599 7264, USA
Mamm Genome 23:322-35. 2012....
- Antipsychotic-induced vacuous chewing movements and extrapyramidal side effects are highly heritable in miceJ J Crowley
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Pharmacogenomics J 12:147-55. 2012..Murine VCMs are a face valid animal model of antipsychotic-induced TD, and heritability estimates from this study support the feasibility of mapping of susceptibility loci for VCMs...
- The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognitionJames J Crowley
Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition...
- No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognitionThomas I Konneker
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons...
- Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysisJames J Crowley
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264
Genetics 196:321-47. 2014....
- Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosaYunjung Kim
Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
Psychiatry Res 210:287-93. 2013..Although results are preliminary secondary to a small sample size, these data provide initial evidence of transcriptional alterations during weight restoration in AN. ..
- A novel statistical approach for jointly analyzing RNA-Seq data from F1 reciprocal crosses and inbred linesFei Zou
Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599
Genetics 197:389-99. 2014..Unless sample recruiting is too expensive to conduct, we recommend sequencing more samples with lower coverage. ..
- A functional prodynorphin promoter polymorphism and opioid dependenceRiju Ray
Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
Psychiatr Genet 15:295-8. 2005..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
- Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension testJames J Crowley
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 183:257-64. 2005..Variations in the effects of antidepressant drugs between different mouse strains are important for drug discovery and could lead to the identification of genes that predict differences in drug efficacy...
- Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependenceRachel J Smith
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...