D L Crowe

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 29:2789-94. 2001
  2. pmc Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Neoplasia 1:368-72. 1999
  3. pmc Jun N-terminal kinase 1 mediates transcriptional induction of matrix metalloproteinase 9 expression
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Neoplasia 3:27-32. 2001
  4. ncbi request reprint Receptor selective synthetic retinoids as potential cancer chemotherapy agents
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Curr Cancer Drug Targets 2:77-86. 2002
  5. ncbi request reprint Molecular pathology of head and neck cancer
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Histol Histopathol 17:909-14. 2002
  6. ncbi request reprint Retinoic acid and extracellular matrix inhibition of matrix metalloproteinase 9 expression is mediated by the mitogen activated protein kinase pathway
    K J Tsang
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Int J Oncol 18:369-74. 2001
  7. ncbi request reprint Rb and E2F-1 regulate telomerase activity in human cancer cells
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA
    Biochim Biophys Acta 1518:1-6. 2001
  8. ncbi request reprint Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: rescue by retinoic acid treatment
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Mol Carcinog 32:187-94. 2001
  9. ncbi request reprint Relationships between stem cells and cancer stem cells
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histol Histopathol 19:505-9. 2004
  10. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000

Detail Information

Publications12

  1. pmc E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 29:2789-94. 2001
    ..Human cancer cell lines stably overexpressing E2F-1 exhibited decreased hTERT mRNA expression and telomerase activity. We conclude that E2F-1 has an atypical function as a transcriptional repressor of the hTERT gene in human cells...
  2. pmc Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Neoplasia 1:368-72. 1999
    ..We concluded that the proximal AP-1 site mediated the transcriptional downregulation of the MMP-9 promoter by a conditionally activated c-fos fusion protein...
  3. pmc Jun N-terminal kinase 1 mediates transcriptional induction of matrix metalloproteinase 9 expression
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Neoplasia 3:27-32. 2001
    ..These results suggest that elevated JNK1 expression may contribute to increased MMP-9 activity and ECM invasion by tumor cells...
  4. ncbi request reprint Receptor selective synthetic retinoids as potential cancer chemotherapy agents
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Curr Cancer Drug Targets 2:77-86. 2002
    ..This review will examine the development of receptor selective retinoids, their uses to date, and future potential...
  5. ncbi request reprint Molecular pathology of head and neck cancer
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Histol Histopathol 17:909-14. 2002
    ..This review will focus on the molecular changes which occur in these pathways and how they contribute to the pathogenesis of HNSCC...
  6. ncbi request reprint Retinoic acid and extracellular matrix inhibition of matrix metalloproteinase 9 expression is mediated by the mitogen activated protein kinase pathway
    K J Tsang
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Int J Oncol 18:369-74. 2001
    ..The results of these experiments indicate that induction of hypophosphorylated ets-1 as the result of RA and ECM mediated decreases in ERK1 activity represents a novel mechanism by which RA regulates MMP-9 gene expression...
  7. ncbi request reprint Rb and E2F-1 regulate telomerase activity in human cancer cells
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA
    Biochim Biophys Acta 1518:1-6. 2001
    ..Tumor tissue from E2F-1 -/- mice was negative for telomerase activity, indicating a key regulatory role for this transcription factor...
  8. ncbi request reprint Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: rescue by retinoic acid treatment
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Mol Carcinog 32:187-94. 2001
    ..In support of this hypothesis, overexpression of the EGFR adaptor protein Grb2 increased cell proliferation and restored EGF-induced mitosis...
  9. ncbi request reprint Relationships between stem cells and cancer stem cells
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histol Histopathol 19:505-9. 2004
    ..If cancer stem cells can be prospectively identified and isolated, it should be possible to identify therapies that will selectively target these cells...
  10. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
    ..The optimization of TGF-beta signaling during early lung development therefore requires a finely-regulated competitive balance between both permissive and inhibitory members of the Smad family...
  11. ncbi request reprint Immunohistochemical localization of TGF-beta type II receptor and TGF-beta3 during palatogenesis in vivo and in vitro
    X M Cui
    The University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles 90033, USA
    Int J Dev Biol 42:817-20. 1998
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