D L Crowe

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Mechanism of telomerase repression during terminal differentiation of normal epithelial cells and squamous carcinoma lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Oncol 27:847-54. 2005
  2. ncbi request reprint Induction of p97MAPK expression regulates collagen mediated inhibition of proliferation and migration in human squamous cell carcinoma lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Oncol 24:1159-63. 2004
  3. ncbi request reprint Relationships between stem cells and cancer stem cells
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histol Histopathol 19:505-9. 2004
  4. ncbi request reprint A common pathway for chemotherapy-induced apoptosis in human squamous cell carcinoma lines distinct from that of receptor-mediated cell death
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Anticancer Res 23:2321-8. 2003
  5. pmc Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    BMC Cancer 4:18. 2004
  6. pmc A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA
    Breast Cancer Res 6:R546-55. 2004
  7. pmc New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Breast Cancer Res 8:R1. 2006
  8. pmc E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 29:2789-94. 2001
  9. pmc Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Neoplasia 1:368-72. 1999
  10. pmc Jun N-terminal kinase 1 mediates transcriptional induction of matrix metalloproteinase 9 expression
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Neoplasia 3:27-32. 2001

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Mechanism of telomerase repression during terminal differentiation of normal epithelial cells and squamous carcinoma lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Oncol 27:847-54. 2005
    ..We propose a mechanism by which anchorage deprivation inhibits telomerase activity in stratified squamous epithelial cells and squamous cell carcinoma lines...
  2. ncbi request reprint Induction of p97MAPK expression regulates collagen mediated inhibition of proliferation and migration in human squamous cell carcinoma lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Oncol 24:1159-63. 2004
    ..These data represent the first reported function of p97MAPK in human cancer cells...
  3. ncbi request reprint Relationships between stem cells and cancer stem cells
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Histol Histopathol 19:505-9. 2004
    ..If cancer stem cells can be prospectively identified and isolated, it should be possible to identify therapies that will selectively target these cells...
  4. ncbi request reprint A common pathway for chemotherapy-induced apoptosis in human squamous cell carcinoma lines distinct from that of receptor-mediated cell death
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Anticancer Res 23:2321-8. 2003
    ..These two proteins exhibit distinct patterns of intracellular localization during chemotherapy-induced apoptosis...
  5. pmc Recruitment of focal adhesion kinase and paxillin to beta1 integrin promotes cancer cell migration via mitogen activated protein kinase activation
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    BMC Cancer 4:18. 2004
    ..We previously demonstrated that MAPK activation was required for growth factor induced in vitro migration and invasion by human squamous cell carcinoma (SCC) lines...
  6. pmc A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California, USA
    Breast Cancer Res 6:R546-55. 2004
    ..There are few published studies on the efficacy of combined therapy using PPAR and RXR ligands for breast cancer prevention or treatment...
  7. pmc New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Breast Cancer Res 8:R1. 2006
    ..Estrogen and retinoic acid receptors (ER and RAR) also require coactivator proteins for their ligand-dependent functions. Few studies have suggested a role for nuclear hormone receptors in DNA repair...
  8. pmc E2F-1 represses transcription of the human telomerase reverse transcriptase gene
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 29:2789-94. 2001
    ..Human cancer cell lines stably overexpressing E2F-1 exhibited decreased hTERT mRNA expression and telomerase activity. We conclude that E2F-1 has an atypical function as a transcriptional repressor of the hTERT gene in human cells...
  9. pmc Transcriptional inhibition of matrix metalloproteinase 9 (MMP-9) activity by a c-fos/estrogen receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Neoplasia 1:368-72. 1999
    ..We concluded that the proximal AP-1 site mediated the transcriptional downregulation of the MMP-9 promoter by a conditionally activated c-fos fusion protein...
  10. pmc Jun N-terminal kinase 1 mediates transcriptional induction of matrix metalloproteinase 9 expression
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Neoplasia 3:27-32. 2001
    ..These results suggest that elevated JNK1 expression may contribute to increased MMP-9 activity and ECM invasion by tumor cells...
  11. ncbi request reprint Retinoic acid and extracellular matrix inhibition of matrix metalloproteinase 9 expression is mediated by the mitogen activated protein kinase pathway
    K J Tsang
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Int J Oncol 18:369-74. 2001
    ..The results of these experiments indicate that induction of hypophosphorylated ets-1 as the result of RA and ECM mediated decreases in ERK1 activity represents a novel mechanism by which RA regulates MMP-9 gene expression...
  12. ncbi request reprint Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: rescue by retinoic acid treatment
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Mol Carcinog 32:187-94. 2001
    ..In support of this hypothesis, overexpression of the EGFR adaptor protein Grb2 increased cell proliferation and restored EGF-induced mitosis...
  13. ncbi request reprint Rb and E2F-1 regulate telomerase activity in human cancer cells
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, 90033, Los Angeles, CA, USA
    Biochim Biophys Acta 1518:1-6. 2001
    ..Tumor tissue from E2F-1 -/- mice was negative for telomerase activity, indicating a key regulatory role for this transcription factor...
  14. ncbi request reprint Receptor selective synthetic retinoids as potential cancer chemotherapy agents
    D L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Curr Cancer Drug Targets 2:77-86. 2002
    ..This review will examine the development of receptor selective retinoids, their uses to date, and future potential...
  15. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
    ..The optimization of TGF-beta signaling during early lung development therefore requires a finely-regulated competitive balance between both permissive and inhibitory members of the Smad family...
  16. ncbi request reprint Molecular pathology of head and neck cancer
    D L Crowe
    Center for Craniofacial Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Histol Histopathol 17:909-14. 2002
    ..This review will focus on the molecular changes which occur in these pathways and how they contribute to the pathogenesis of HNSCC...
  17. ncbi request reprint Immunohistochemical localization of TGF-beta type II receptor and TGF-beta3 during palatogenesis in vivo and in vitro
    X M Cui
    The University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles 90033, USA
    Int J Dev Biol 42:817-20. 1998
    ....
  18. pmc Regulation of the human involucrin gene promoter by co-activator proteins
    Nhu Q Tran
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Biochem J 381:267-73. 2004
    ..Kinase-induced changes in involucrin promoter activity directly resulted from changes in AP-1 protein expression. We concluded that CBP and P/CAF are important regulators of involucrin expression in stratified squamous epithelial cells...
  19. pmc Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun
    Linh N Tsai
    University of Illinois Cancer Center, 801 S Paulina Street, Room 530C, MC860, Chicago, IL 60612, USA
    Mol Cell Biol 28:4240-50. 2008
    ..We also demonstrated novel interactions between coactivators and AP-1 proteins. We propose that extracellular signal-mediated coactivator exchange at AP-1 sites is mediated via protein kinase pathways...
  20. ncbi request reprint Coactivator-mediated estrogen response in human squamous cell carcinoma lines
    Tony K S Ku
    University of Illinois Cancer Center, Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, Chicago, Illinois 60612, USA
    J Endocrinol 193:147-55. 2007
    ..SRC-1 and CBP were recruited to the proximal ERK1 promoter region in E2 but not in TAM-treated cells. We concluded that SRC-1 was a key molecular determinant of estrogen-mediated proliferation in human SCC lines...
  21. ncbi request reprint Understanding genetic progression of squamous cell carcinoma to spindle cell carcinoma in a mouse model of head and neck cancer
    Rita Chuang
    University of Illinois Cancer Center, Chicago, IL 60612, USA
    Int J Oncol 30:1279-87. 2007
    ..These changes in gene expression clearly show loss of epithelial characteristics, acquisition of mesenchymal phenotypes, and increased propensity for invasion and metastasis by spindle cell carcinomas...
  22. ncbi request reprint EphB4 provides survival advantage to squamous cell carcinoma of the head and neck
    Rizwan Masood
    Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 119:1236-48. 2006
    ..Expression of EphB4 in HNSCC tumor cells confers survival and invasive properties, and thereby provides a strong rationale for targeting EphB4 as novel therapy for HNSCC...
  23. ncbi request reprint Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion
    William C Conway
    Department of Surgery, John D Dingell VA Medical Center and Wayne State University, Detroit, Michigan 48201 1932, USA
    J Cell Biochem 98:1507-16. 2006
    ..Targeting paxillin in patients with malignancy and minimal tumor manipulation during surgical resection may be important therapeutic adjuncts...
  24. ncbi request reprint beta1 integrins modulate p66ShcA expression and EGF-induced MAP kinase activation in fetal lung cells
    Susan M Smith
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA, USA
    Biochem Biophys Res Commun 342:909-18. 2006
    ..This paradox was resolved by demonstrating that Erk inhibition attenuates integrin-mediated p66ShcA induction. These results suggest that p66ShcA is up-regulated as inhibitory feedback on integrin-mediated Erk activation...
  25. ncbi request reprint Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases
    Babak Shemirani
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Oral Oncol 38:251-7. 2002
    ..Overexpression of JNK1 or p38 was sufficient to induce HIF-1alpha and VEGF expression. These results indicate that induction of SAPKs by hypoxia regulates HIF-1alpha and VEGF expression in head and neck carcinoma cell lines...
  26. ncbi request reprint p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines
    David L Crowe
    Center for Craniofacial Molecular Biology, Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA
    Head Neck 28:15-23. 2006
    ..If DNA damage is severe, p53 may trigger programmed cell death by means of proapoptotic genes such as bax. Studies have suggested that p53 target genes must be intact for proper functioning of the tumor suppressor...
  27. ncbi request reprint A novel dominant negative Smad2 mutation in a TGFbeta resistant human carcinoma cell line
    Kenneth J Tsang
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Anticancer Res 22:13-9. 2002
    ..These results indicate that this novel Smad2 mutant protein has dominant negative activity in cultured cells...
  28. pmc Regulation of ERK1 gene expression by coactivator proteins
    Beanca Y Chu
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Biochem J 392:589-99. 2005
    ..PCAF mediated inhibition of ERK1 expression was due to decreased stability of the kinase mRNA. We conclude that CBP and PCAF coactivators mediate ERK1 gene expression at both the transcriptional and post-transcriptional level...
  29. ncbi request reprint Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas
    Dan C Nguyen
    Center for Craniofacial Molecular Biology, Los Angeles, CA, USA
    Int J Oncol 22:1285-90. 2003
    ..These results indicate that overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in HNSCC...
  30. ncbi request reprint Overlapping functions of Ras and Rac GTPases in regulating cancer cell proliferation and invasion
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Anticancer Res 24:593-7. 2004
    ..Both dominant negative constructs inhibited basal and growth factor-induced levels of cellular migration. We concluded that Ras and Rac1 have overlapping functions in cancer cell proliferation and migration...
  31. ncbi request reprint Retinoic acid differentially regulates cancer cell proliferation via dose-dependent modulation of the mitogen-activated protein kinase pathway
    David L Crowe
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Mol Cancer Res 1:532-40. 2003
    ..We concluded that low-dose RA induced proliferation by increased EGF signaling while higher concentrations inhibited cell division by decreasing ERK1 activation...
  32. pmc Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 5:85-94. 2008
    ..Our results thus indicated that elevated SOD2 levels is associated with lymph node metastasis in OSCC and may provide predictive values for diagnosis of metastasis...
  33. ncbi request reprint Hunchback sequence binding protein suppresses mouse TGF-beta3 promoter in vitro
    Kiyomi Yamazaki
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA, USA
    Biochem Biophys Res Commun 346:802-9. 2006
    ..HbSBP may function as a TGF-beta3 gene transcriptional regulator and may be expressed in a cell type-specific manner...
  34. ncbi request reprint Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer
    Tony K S Ku
    Center for Craniofacial Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer Res 5:351-62. 2007
    ..Our results provide novel insights into the molecular genetics of tumor progression in head and neck cancer...