Timothy R Crother

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin
    Timothy R Crother
    Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles, 37 121 Center for Health Sciences, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Infect Immun 72:5063-72. 2004
  2. pmc Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
    J Immunol 181:7186-93. 2008
  3. pmc Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses
    Rosalinda Sorrentino
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Am J Respir Cell Mol Biol 43:422-31. 2010
  4. pmc IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 185:5619-27. 2010
  5. pmc Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease
    Shuang Chen
    David Geffen School of Medicine at the University of California, Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:e60-71. 2012
  6. pmc Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease
    Youngho Lee
    Los Angeles, Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Circulation 125:1542-50. 2012
  7. pmc TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis
    Yoshikazu Naiki
    Division of Pediatric Infectious Diseases, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
    J Immunol 181:7176-85. 2008
  8. pmc Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease
    Danica J Schulte
    Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA 90048, USA
    J Immunol 183:5311-8. 2009
  9. pmc Antigenic composition of Borrelia burgdorferi during infection of SCID mice
    Timothy R Crother
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Infect Immun 71:3419-28. 2003
  10. pmc Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling
    Pearl Gray
    Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90048, USA
    J Immunol 184:6359-66. 2010

Collaborators

Detail Information

Publications17

  1. pmc Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin
    Timothy R Crother
    Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles, 37 121 Center for Health Sciences, 10833 LeConte Ave, Los Angeles, CA 90095, USA
    Infect Immun 72:5063-72. 2004
    ..This marked diminution in VlsE lower forms paralleled the clearance of the spirochete from skin...
  2. pmc Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
    J Immunol 181:7186-93. 2008
    ..pneumoniae accelerates the development of atherosclerotic plaque and lends support to the proposal that LXR agonists might prove clinically useful in suppressing atherogenesis...
  3. pmc Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses
    Rosalinda Sorrentino
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Am J Respir Cell Mol Biol 43:422-31. 2010
    ..pneumoniae-induced mDCs responses toward a Th2 bias in the lung, which is prevented by pDCs. We propose that pDCs may play a major role in the immunosuppressive lung environment in smokers with C. pneumoniae infection...
  4. pmc IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 185:5619-27. 2010
    ..pneumoniae infection-mediated acceleration of atherosclerotic lesions in the presence of HFD...
  5. pmc Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease
    Shuang Chen
    David Geffen School of Medicine at the University of California, Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:e60-71. 2012
    ..Furthermore, daily injections of the interleukin-1Ra, which inhibits Lactobacillus casei cell wall extract-induced KD vasculitis, prevented the acceleration of atherosclerosis...
  6. pmc Interleukin-1β is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease
    Youngho Lee
    Los Angeles, Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Circulation 125:1542-50. 2012
    ..Genetic studies have indicated a possible role for interleukin (IL)-1β in KD. We therefore explored the role of IL-1β in a murine model of KD...
  7. pmc TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis
    Yoshikazu Naiki
    Division of Pediatric Infectious Diseases, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, CA 90048, USA
    J Immunol 181:7176-85. 2008
    ..pneumoniae infection...
  8. pmc Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease
    Danica J Schulte
    Pediatric Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, CA 90048, USA
    J Immunol 183:5311-8. 2009
    ..These studies are consistent with the interpretation that macrophages and DCs may collaborate with T cells in the pathological mechanisms of coronary arteritis...
  9. pmc Antigenic composition of Borrelia burgdorferi during infection of SCID mice
    Timothy R Crother
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Infect Immun 71:3419-28. 2003
    ..Extraction of hydrophobic B. burgdorferi antigens from tissue provides a powerful tool for determining the antigenic composition of HAB...
  10. pmc Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling
    Pearl Gray
    Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90048, USA
    J Immunol 184:6359-66. 2010
    ....
  11. pmc Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway
    Pearl Gray
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 187:4331-7. 2011
    ..Our study demonstrated that tyrosine phosphorylation of MD-2 is important for signaling following exposure to LPS and underscores the importance of this event in mediating an efficient and prompt immune response...
  12. pmc Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway
    Yonca Bulut
    Cedars Sinai Medical Center, Division of Pediatrics Infectious Diseases and Immunology, Los Angeles, CA 90048, USA
    Infect Immun 77:2683-90. 2009
    ..These data suggest that cHSP60 promotes lung inflammation and DC activation via TLR4 and MyD88 and therefore may play a significant role in the pathogenesis of C. pneumoniae-induced chronic inflammatory lung diseases...
  13. pmc Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA
    Immunity 36:401-14. 2012
    ..These results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtDNA to the NLRP3 inflammasome...
  14. pmc Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome
    Kenichi Shimada
    Division of Pediatric Infectious Diseases and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Microbes Infect 14:1301-7. 2012
    ..In this review article we highlight how recent studies have increased our knowledge of Chlamydia pneumoniae pathogenesis and mechanisms of innate immunity directed host defense against C. pneumoniae infection...
  15. doi request reprint Analysis of bacterial membrane proteins produced during mammalian infection using hydrophobic antigen tissue triton extraction (HATTREX)
    Timothy R Crother
    Pediatrics Infectious Diseases, Cedars Sinai Medical Center, University of California, Los Angeles, California, USA
    Curr Protoc Microbiol . 2008
    ..Characterization of the detergent phase sample provides insights into the proteome of bacterial membranes during infection...
  16. pmc Emerging role of IL-17 in atherosclerosis
    Shuang Chen
    Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Innate Immun 2:325-33. 2010
    ..In this review, we will highlight all the latest studies involving IL-17 and atherosclerosis, including both clinical and experimental research...
  17. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
    ..pneumoniae from the lungs and survival of the infectious challenge...