Research Topics

Sean Crosson


Affiliation: University of Chicago
Country: USA


  1. Fiebig A, Herrou J, Willett J, Crosson S. General Stress Signaling in the Alphaproteobacteria. Annu Rev Genet. 2015;49:603-25 pubmed publisher
    ..This review synthesizes our structural and functional understanding of the core GSR regulatory proteins and highlights emerging data that are defining the systems that regulate GSR transcription in a variety of species. ..
  2. Herrou J, Willett J, Fiebig A, Czyz D, Cheng J, Ultee E, et al. Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence. J Bacteriol. 2019;: pubmed publisher
    ..i>eipB genetically interacts with ttpA, which also encodes a periplasmic protein. We propose that EipB and TtpA function as part of a system required for cell envelope homeostasis in select Alphaproteobacteria. ..
  3. Hershey D, Fiebig A, Crosson S. A Genome-Wide Analysis of Adhesion in Caulobacter crescentus Identifies New Regulatory and Biosynthetic Components for Holdfast Assembly. MBio. 2019;10: pubmed publisher
    ..Our genetic selection identified what likely represents a comprehensive set of genes required to generate a holdfast, laying the groundwork for a detailed characterization of the enzymes that build this specialized adhesin. ..
  4. Hentchel K, Reyes Ruiz L, Curtis P, Fiebig A, Coleman M, Crosson S. Genome-scale fitness profile of Caulobacter crescentus grown in natural freshwater. ISME J. 2019;13:523-536 pubmed publisher
    ..This study reveals genetic interactions between Caulobacter and a natural freshwater environment, and provides a new avenue to study gene function in complex ecosystems. ..
  5. Willett J, Herrou J, Briegel A, Rotskoff G, Crosson S. Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. Proc Natl Acad Sci U S A. 2015;112:E3709-18 pubmed publisher
    ..abortus. More generally, our results provide insight into the structural basis of two-component signal transduction, which is broadly conserved in bacteria, plants, and fungi. ..
  6. Herrou J, Willett J, Crosson S. Structured and Dynamic Disordered Domains Regulate the Activity of a Multifunctional Anti-σ Factor. MBio. 2015;6:e00910 pubmed publisher
    ..Our results provide evidence for a new layer of GSR regulatory control in which NepR directly modulates PhyR phosphorylation and, hence, activation of the GSR. ..
  7. Herrou J, Czyz D, Fiebig A, Willett J, Kim Y, Wu R, et al. Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor. J Biol Chem. 2018;293:7437-7456 pubmed publisher
    ..Our study provides molecular-level understanding of a gene expression program in B. abortus that is downstream of σE1. ..
  8. Tien M, Stein B, Crosson S. Coherent Feedforward Regulation of Gene Expression by Caulobacter σT and GsrN during Hyperosmotic Stress. J Bacteriol. 2018;200: pubmed publisher
    ..We further provide evidence that a coherent feedforward motif influences the system properties of the Caulobacter GSR pathway. ..
  9. Baric R, Crosson S, Damania B, Miller S, Rubin E. Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio. 2016;7: pubmed publisher

More Information


  1. Herrou J, Willett J, Czyz D, Babnigg G, Kim Y, Crosson S. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. J Bacteriol. 2017;199: pubmed publisher
    ..abortus YehZ provides molecular insight into differences between bona fide quaternary ammonium osmolyte importers and YehZ-related proteins, which form a distinct phylogenetic and functional group of PBPs. ..
  2. Herrou J, Czyż D, Willett J, Kim H, Chhor G, Babnigg G, et al. WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. J Bacteriol. 2016;198:1281-93 pubmed publisher
    ..However, WrpA does affect spleen inflammation in a murine infection model. Our data provide evidence that WrpA forms a new functional class of WrbA/flavodoxin family proteins. ..
  3. Czyż D, Willett J, Crosson S. Brucella abortus Induces a Warburg Shift in Host Metabolism That Is Linked to Enhanced Intracellular Survival of the Pathogen. J Bacteriol. 2017;199: pubmed publisher
    ..abortus in an in vitro infection model; these drugs may be broadly useful therapeutics for intracellular infections. ..