Leslie Crofford

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
    Annaleise V Sampey
    University of Michigan, Ann Arbor, MI, USA
    Arthritis Res Ther 7:114-7. 2005
  2. ncbi request reprint Violence, stress, and somatic syndromes
    Leslie J Crofford
    Center for the Advancement of Women s Health, University of Kentucky, USA
    Trauma Violence Abuse 8:299-313. 2007
  3. doi request reprint Pain management in fibromyalgia
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    Curr Opin Rheumatol 20:246-50. 2008
  4. doi request reprint Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin
    Leslie J Crofford
    University of Kentucky, Internal Medicine, Room J 503 Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536 0284, USA
    Pain 136:419-31. 2008
  5. ncbi request reprint The relationship of fibromyalgia to neuropathic pain syndromes
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    J Rheumatol Suppl 75:41-5. 2005
  6. ncbi request reprint Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial
    Leslie J Crofford
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 52:1264-73. 2005
  7. ncbi request reprint Immunomodulatory therapy for SSc: will high-intensity immunosuppression with stem cell rescue improve outcome?
    Leslie J Crofford
    Women s Health Program, Chief Division of Rheumatology, Room J 503, Kentucky Clinic, 740 S Limestone St, Lexington, KY 40536, USA
    Curr Rheumatol Rep 7:142-9. 2005
  8. ncbi request reprint Adverse effects of chronic opioid therapy for chronic musculoskeletal pain
    Leslie J Crofford
    Division of Rheumatology and Women s Health, University of Kentucky, Room J 503, Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536, USA
    Nat Rev Rheumatol 6:191-7. 2010
  9. ncbi request reprint A pilot study: pain, fatigue and stress in maternal relatives of adolescent female psychiatric inpatients assessed for juvenile primary fibromyalgia syndrome
    Karen Lommel
    Division of Rheumatology and College of Public Health, Department of Psychiatry, University of Kentucky, Lexington, KY 40509, USA
    Int J Adolesc Med Health 23:59-63. 2011
  10. ncbi request reprint A pilot study of a combined intervention for management of juvenile primary fibromyalgia symptoms in adolescents in an inpatient psychiatric unit
    Karen Lommel
    Department of Psychiatry, Division of Rheumatology, 3470 Blazer Parkway, University of Kentucky, Lexington, KY 40509, USA
    Int J Adolesc Med Health 23:193-7. 2011

Research Grants

  1. SYNOVIOCYTE RHO-TYPE GTPASES IN CARTILAGE DESTRUCTION
    Leslie Crofford; Fiscal Year: 2002
  2. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2004
  3. NEUROENDOCRINE FUNCTION IN FIBROMYALGIA
    Leslie Crofford; Fiscal Year: 2004
  4. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2006
  5. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2007
  6. Microsomal Prostaglandin E Synthase in Rheumatoid Arthritis
    Leslie J Crofford; Fiscal Year: 2010

Detail Information

Publications40

  1. pmc Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
    Annaleise V Sampey
    University of Michigan, Ann Arbor, MI, USA
    Arthritis Res Ther 7:114-7. 2005
    ..The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis...
  2. ncbi request reprint Violence, stress, and somatic syndromes
    Leslie J Crofford
    Center for the Advancement of Women s Health, University of Kentucky, USA
    Trauma Violence Abuse 8:299-313. 2007
    ..Understanding the relationship between violence, stress, and somatic syndromes will help in clarifying the consequences of violence exposure to long-term health and health-related quality of life...
  3. doi request reprint Pain management in fibromyalgia
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    Curr Opin Rheumatol 20:246-50. 2008
    ..This review addresses newer strategies for the treatment of pain in patients with fibromyalgia that may be also useful in patients with other rheumatic diseases...
  4. doi request reprint Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin
    Leslie J Crofford
    University of Kentucky, Internal Medicine, Room J 503 Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536 0284, USA
    Pain 136:419-31. 2008
    ..In those who respond, pregabalin demonstrated durability of effect for relieving FM pain...
  5. ncbi request reprint The relationship of fibromyalgia to neuropathic pain syndromes
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    J Rheumatol Suppl 75:41-5. 2005
    ..In this afterword, a synthesis of the information presented in these proceedings and opinion as to how FM relates to classical neuropathic pain syndromes is provided...
  6. ncbi request reprint Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial
    Leslie J Crofford
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 52:1264-73. 2005
    ..FMS affects an estimated 2% of the population, predominantly women. This trial was designed to evaluate the efficacy and safety of pregabalin, a novel alpha(2)-delta ligand, for treatment of symptoms associated with FMS...
  7. ncbi request reprint Immunomodulatory therapy for SSc: will high-intensity immunosuppression with stem cell rescue improve outcome?
    Leslie J Crofford
    Women s Health Program, Chief Division of Rheumatology, Room J 503, Kentucky Clinic, 740 S Limestone St, Lexington, KY 40536, USA
    Curr Rheumatol Rep 7:142-9. 2005
    ..New studies to compare these approaches with conventional immunomodulatory therapy are underway...
  8. ncbi request reprint Adverse effects of chronic opioid therapy for chronic musculoskeletal pain
    Leslie J Crofford
    Division of Rheumatology and Women s Health, University of Kentucky, Room J 503, Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536, USA
    Nat Rev Rheumatol 6:191-7. 2010
    ..Patients with chronic musculoskeletal pain should avoid the long-term use of opioids unless the benefits are determined to outweigh risks, in which case, the use of chronic opioids should be regularly re-evaluated...
  9. ncbi request reprint A pilot study: pain, fatigue and stress in maternal relatives of adolescent female psychiatric inpatients assessed for juvenile primary fibromyalgia syndrome
    Karen Lommel
    Division of Rheumatology and College of Public Health, Department of Psychiatry, University of Kentucky, Lexington, KY 40509, USA
    Int J Adolesc Med Health 23:59-63. 2011
    ..We compared the relatives of adolescents who met the criteria for juvenile primary fibromyalgia syndrome (JPFS) to relatives of adolescents who did not meet the criteria for JPFS...
  10. ncbi request reprint A pilot study of a combined intervention for management of juvenile primary fibromyalgia symptoms in adolescents in an inpatient psychiatric unit
    Karen Lommel
    Department of Psychiatry, Division of Rheumatology, 3470 Blazer Parkway, University of Kentucky, Lexington, KY 40509, USA
    Int J Adolesc Med Health 23:193-7. 2011
    ..Very little is known about the prevalence and treatment on inpatient psychiatric units...
  11. ncbi request reprint Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targets
    Mohit Kapoor
    Department of Internal Medicine, Rheumatology Division, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
    Curr Opin Investig Drugs 7:418-22. 2006
    ..The major therapeutic targets within these processes will also be highlighted...
  12. doi request reprint Violence against women and postpartum depression
    Matthew J Garabedian
    Department of Obstetrics and Gynecology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0293, USA
    J Womens Health (Larchmt) 20:447-53. 2011
    ..We examined the association between these violence exposures and self-reported history of postpartum depression (PPD)...
  13. ncbi request reprint Pharmaceutical treatment options for fibromyalgia
    Leslie J Crofford
    Division of Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
    Curr Rheumatol Rep 6:274-80. 2004
    ..This paper will review the rationale for the different types of pharmaceutical treatments that may be useful for the treatment of FMS and issues regarding new drug development for this indication...
  14. ncbi request reprint Juvenile primary fibromyalgia syndrome in an inpatient adolescent psychiatric population
    Karen Lommel
    University of Kentucky College of Medicine, Department of Psychiatry, 3470 Blazer Parkway, Lexington, Kentucky 40509, USA
    Int J Adolesc Med Health 21:571-9. 2009
    ..The purpose of this study was to identify the clinical and demographic characteristics of adolescent females admitted to a psychiatric hospital who meet the criteria for Juvenile Primary Fibromyalgia Syndrome (JPFS)...
  15. pmc Objective measures of disordered sleep in fibromyalgia
    Ronald D Chervin
    Michael S Aldrich Sleep Disorders Laboratory, Ann Arbor, MI 48109 5845, USA
    J Rheumatol 36:2009-16. 2009
    ..However, measures that consistently and objectively distinguish FM patients remain elusive...
  16. ncbi request reprint Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia
    Samuel A McLean
    Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
    Arthritis Rheum 52:3660-9. 2005
    ....
  17. ncbi request reprint Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing
    Michael E Geisser
    Department of Physical Medicine and Rehabilitation, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Pain 102:243-50. 2003
    ..They also suggest that catastrophic thoughts about pain may play a role in increased pain perception in this population...
  18. doi request reprint Violence against Women Raises Risk of Cervical Cancer
    Ann L Coker
    Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY 40536 0293, USA
    J Womens Health (Larchmt) 18:1179-85. 2009
    ..The purpose of this cross-sectional analysis was to determine if women who had experienced violence had higher prevalence rates of invasive cervical cancer...
  19. ncbi request reprint Sleep stage dynamics in fibromyalgia patients and controls
    Joseph W Burns
    Michigan Tech Research Institute, Michigan Technological University, 3600 Green Court, Suite 100, Ann Arbor, MI 48105, USA
    Sleep Med 9:689-96. 2008
    ..To determine whether previously described sleep stage dynamics, reflecting the mean duration of specific sleep stages, may have clinical utility in a sample of patients with fibromyalgia syndrome (FMS) and controls...
  20. pmc Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice
    Fumiaki Kojima
    Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 180:8361-8. 2008
    ..Pharmacologic inhibition of mPGES-1 may therefore impact both the inflammation and the autoimmunity associated with human diseases such as rheumatoid arthritis...
  21. ncbi request reprint Self-regulatory deficits in fibromyalgia and temporomandibular disorders
    Lise Solberg Nes
    Department of Psychology, University of Kentucky, Lexington, KY, USA
    Pain 151:37-44. 2010
    ....
  22. ncbi request reprint Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome
    Leslie J Crofford
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Brain Behav Immun 18:314-25. 2004
    ..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency...
  23. ncbi request reprint Chronic widespread pain and fibromyalgia: what we know, and what we need to know
    Daniel J Clauw
    Division of Rheumatology, Department of Medicine, University of Michigan Medical School, 101 Simpson, Ann Arbor, MI 48109 0723, USA
    Best Pract Res Clin Rheumatol 17:685-701. 2003
    ..g. NSAIDs, corticosteroids), neuroactive compounds [especially those that raise central levels of noradrenaline (norepinephrine) or serotonin] are most effective for treating central pain...
  24. pmc COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease
    Leslie J Crofford
    Associate Professor of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Arthritis Res Ther 5:25-7. 2003
    ..Clinical data suggest that protective PGs are derived from cyclooxygenase (COX)-1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not cross-reactive with aspirin in patients with AERD...
  25. ncbi request reprint The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases
    Leslie J Crofford
    Department of Internal Medicine and Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, An Arbor, MI 48109 0680, USA
    Endocrinol Metab Clin North Am 31:1-13. 2002
    ..Availability of technology to study better central components of the HPA axis may shed further light on its role in the pathogenesis of inflammatory autoimmune rheumatic diseases and musculoskeletal pain syndromes...
  26. ncbi request reprint Memory beliefs and function in fibromyalgia patients
    Jennifer M Glass
    Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, MI 48106, United States
    J Psychosom Res 58:263-9. 2005
    ..The aim of this study was to investigate memory beliefs and their relationship to actual memory function in fibromyalgia (FM) patients...
  27. pmc Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course study
    Mohit Kapoor
    Department of Internal Medicine, Division of Rheumatology, Room J 509, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
    Prostaglandins Leukot Essent Fatty Acids 76:103-12. 2007
    ..In this study, we show that PPARgamma is upregulated during the resolution phase of wound repair concomitant with the shift to PGD2, and may be responsible for initiating endogenous mechanism resulting in healing/resolution...
  28. ncbi request reprint Growth factor receptors: implications in tumor biology
    Divya Mani Srinivasan
    University of Kentucky, Department of Molecular and Biomedical Pharmacology, 800 Rose Street, Lexington, KY 40536 0284, USA
    Curr Opin Investig Drugs 6:1246-9. 2005
    ..This review discusses the involvement of growth factor receptors in solid tumor formation and their value as potential anticancer drug targets...
  29. doi request reprint Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises
    Phillip J Mease
    Seattle Rheumatology Associates, Seattle, Washington 98104, USA
    Arthritis Rheum 59:952-60. 2008
    ....
  30. ncbi request reprint Why is the management of fibromyalgia syndrome so difficult for rheumatologists?
    Elizabeth Scarbrough
    University of Kentucky in Lexington, KY 40502, USA
    Nat Clin Pract Rheumatol 3:480-1. 2007
  31. pmc High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 110:1388-96. 2007
    ..Sustained responses including a decrease in dermal fibrosis were observed exceeding those previously reported with other therapies. HDIT and autologous HCT for SSc should be evaluated in a randomized clinical trial...
  32. ncbi request reprint The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia
    Lesley M Arnold
    Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Pain Med 8:633-8. 2007
    ..To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment...
  33. ncbi request reprint Controversies in COX-2 selective inhibition
    Lee S Simon
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Rheumatol 29:1501-10. 2002
  34. pmc High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes
    Peter A McSweeney
    University of Colorado Health Sciences Center, Denver 80262, USA
    Blood 100:1602-10. 2002
    ..Responses in skin and mHAQ-DI scores exceed those reported with other therapies, suggesting that HDIT is a promising new therapy for SSc that should be evaluated in prospective randomized studies...
  35. ncbi request reprint Fibromyalgia: where are we a decade after the American College of Rheumatology classification criteria were developed?
    Leslie J Crofford
    Arthritis Rheum 46:1136-8. 2002
  36. ncbi request reprint A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
    Arthritis Rheum 50:2974-84. 2004
    ..To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder...
  37. ncbi request reprint Fibromyalgia syndrome
    Philip J Mease
    Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
    J Rheumatol 32:2270-7. 2005
    ..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached...
  38. ncbi request reprint Fibromyalgia: combining pharmacological and nonpharmacological approaches to treating the person, not just the pain
    Dennis C Turk
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pain 9:99-104. 2008
  39. ncbi request reprint Is there a place for non-selective NSAIDs in the treatment of arthritis?
    Leslie J Crofford
    Joint Bone Spine 69:4-7. 2002

Research Grants7

  1. SYNOVIOCYTE RHO-TYPE GTPASES IN CARTILAGE DESTRUCTION
    Leslie Crofford; Fiscal Year: 2002
    ..Ultimately, we will determine the effects of the Rho-type GTPases on synoviocyte adherence to and migration over articular cartilage, production of MMPs, and destruction of the cartilage matrix. ..
  2. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2004
    ..These data will provide the scientific basis by which to determine if mPGES-1 is an appropriate target for therapeutic intervention in arthritis. ..
  3. NEUROENDOCRINE FUNCTION IN FIBROMYALGIA
    Leslie Crofford; Fiscal Year: 2004
    ..This award will allow for continuing high quality patient-oriented research in central and peripheral neuroendocrine function in FM and other syndromes of chronic musculoskeletal pain. ..
  4. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2006
    ..These data will provide the scientific basis by which to determine if mPGES-1 is an appropriate target for therapeutic intervention in arthritis. ..
  5. Prostaglandin E synthase in rheumatoid arthritis
    Leslie Crofford; Fiscal Year: 2007
    ..These data will provide the scientific basis by which to determine if mPGES-1 is an appropriate target for therapeutic intervention in arthritis. ..
  6. Microsomal Prostaglandin E Synthase in Rheumatoid Arthritis
    Leslie J Crofford; Fiscal Year: 2010
    ..It is our expectation that our work will yield new insights into the role of PGs in the functioning of eicosanoids during initiation and resolution of inflammation and the transition from the innate to the acquired immune response. ..