L J Crofford

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome
    L J Crofford
    Division of Rheumatology, University of Michigan, Ann Arbor 48109 0680, USA
    Z Rheumatol 57:67-71. 1998
  2. ncbi request reprint The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases
    Leslie J Crofford
    Department of Internal Medicine and Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, An Arbor, MI 48109 0680, USA
    Endocrinol Metab Clin North Am 31:1-13. 2002
  3. ncbi request reprint Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome
    Leslie J Crofford
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Brain Behav Immun 18:314-25. 2004
  4. ncbi request reprint Pharmaceutical treatment options for fibromyalgia
    Leslie J Crofford
    Division of Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
    Curr Rheumatol Rep 6:274-80. 2004
  5. ncbi request reprint Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use?
    Leslie J Crofford
    University of Michigan, Ann Arbor, Michigan 48109 0680, USA
    Curr Opin Rheumatol 14:225-30. 2002
  6. ncbi request reprint Adenovirus binding to cultured synoviocytes triggers signaling through MAPK pathways and induces expression of cyclooxygenase-2
    Leslie J Crofford
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Gene Med 7:288-96. 2005
  7. ncbi request reprint Prostaglandin biology
    L J Crofford
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterol Clin North Am 30:863-76. 2001
  8. ncbi request reprint Complementary and alternative therapies for fibromyalgia
    L J Crofford
    University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI, 48109 0680, USA
    Curr Rheumatol Rep 3:147-56. 2001
  9. ncbi request reprint Clinical experience with specific COX-2 inhibitors in arthritis
    L J Crofford
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48019, USA
    Curr Pharm Des 6:1725-36. 2000
  10. pmc COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease
    Leslie J Crofford
    Associate Professor of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Arthritis Res Ther 5:25-7. 2003

Detail Information

Publications44

  1. ncbi request reprint The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome
    L J Crofford
    Division of Rheumatology, University of Michigan, Ann Arbor 48109 0680, USA
    Z Rheumatol 57:67-71. 1998
    ....
  2. ncbi request reprint The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases
    Leslie J Crofford
    Department of Internal Medicine and Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, An Arbor, MI 48109 0680, USA
    Endocrinol Metab Clin North Am 31:1-13. 2002
    ..Availability of technology to study better central components of the HPA axis may shed further light on its role in the pathogenesis of inflammatory autoimmune rheumatic diseases and musculoskeletal pain syndromes...
  3. ncbi request reprint Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome
    Leslie J Crofford
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Brain Behav Immun 18:314-25. 2004
    ..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency...
  4. ncbi request reprint Pharmaceutical treatment options for fibromyalgia
    Leslie J Crofford
    Division of Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
    Curr Rheumatol Rep 6:274-80. 2004
    ..This paper will review the rationale for the different types of pharmaceutical treatments that may be useful for the treatment of FMS and issues regarding new drug development for this indication...
  5. ncbi request reprint Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use?
    Leslie J Crofford
    University of Michigan, Ann Arbor, Michigan 48109 0680, USA
    Curr Opin Rheumatol 14:225-30. 2002
    ..It remains important to increase our understanding of the place of these agents in clinical practice from the perspective of efficacy, toxicity, and cost...
  6. ncbi request reprint Adenovirus binding to cultured synoviocytes triggers signaling through MAPK pathways and induces expression of cyclooxygenase-2
    Leslie J Crofford
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Gene Med 7:288-96. 2005
    ..coli beta-galactosidase gene...
  7. ncbi request reprint Prostaglandin biology
    L J Crofford
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterol Clin North Am 30:863-76. 2001
    ..Dissecting these biochemical and molecular pathways allows development of therapeutic agents that can be [figure: see text] applied to specific clinical situations, while preserving PGs that play a role in normal physiology...
  8. ncbi request reprint Complementary and alternative therapies for fibromyalgia
    L J Crofford
    University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI, 48109 0680, USA
    Curr Rheumatol Rep 3:147-56. 2001
    ..However, because of widespread and growing use of alternative medicine, especially by persons with chronic illnesses, it is essential to review efficacy and adverse effects of complementary and alternative therapies...
  9. ncbi request reprint Clinical experience with specific COX-2 inhibitors in arthritis
    L J Crofford
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48019, USA
    Curr Pharm Des 6:1725-36. 2000
    ..In patients with arthritis at risk for gastrointestinal complications of NSAIDs, specific inhibitors of COX-2 provide an effective and apparently safer form of anti-inflammatory agent...
  10. pmc COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease
    Leslie J Crofford
    Associate Professor of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
    Arthritis Res Ther 5:25-7. 2003
    ..Clinical data suggest that protective PGs are derived from cyclooxygenase (COX)-1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not cross-reactive with aspirin in patients with AERD...
  11. ncbi request reprint Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
    D O Stichtenoth
    Divisions of. Rheumatology and Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 167:469-74. 2001
    ..In summary, these data demonstrate an induction of mPGES in rheumatoid synoviocytes by proinflammatory cytokines. This novel pathway may be a target for therapeutic intervention for patients with arthritis...
  12. ncbi request reprint Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome
    A Korszun
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
    J Rheumatol 27:1526-30. 2000
    ..We tested the hypothesis that women with FM and CFS manifest abnormalities of the hypothalamic-pituitary-gonadal (HPG) hormonal axis...
  13. pmc Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration
    S U Monrad
    Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
    Prostaglandins Leukot Essent Fatty Acids 84:113-21. 2011
    ..These findings provide useful information on the effects of inducible PGE2 on the innate immune system, and have important implications regarding potential consequences of pharmacologic mPGES-1 inhibition...
  14. ncbi request reprint Cognitive function in fibromyalgia patients
    D C Park
    Department of Psychology, University of Michigan, Ann Arbor 48109, USA
    Arthritis Rheum 44:2125-33. 2001
    ..FM patients' complaints about their memory are likely to be legitimate, since their memory function is not age appropriate...
  15. ncbi request reprint Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia
    S V Kocheril
    University of Michigan, Ann Arbor, MI 48109, USA
    Arthritis Rheum 53:549-57. 2005
    ....
  16. ncbi request reprint Violence, stress, and somatic syndromes
    Leslie J Crofford
    Center for the Advancement of Women s Health, University of Kentucky, USA
    Trauma Violence Abuse 8:299-313. 2007
    ..Understanding the relationship between violence, stress, and somatic syndromes will help in clarifying the consequences of violence exposure to long-term health and health-related quality of life...
  17. ncbi request reprint Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia
    Samuel A McLean
    Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
    Arthritis Rheum 52:3660-9. 2005
    ....
  18. doi request reprint Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises
    Phillip J Mease
    Seattle Rheumatology Associates, Seattle, Washington 98104, USA
    Arthritis Rheum 59:952-60. 2008
    ....
  19. ncbi request reprint Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study Group
    Leslie J Crofford
    Center for the Advancement of Women s Health, University of Kentucky, Lexington, Kentucky, USA
    J Rheumatol 33:1403-8. 2006
    ....
  20. doi request reprint Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin
    Leslie J Crofford
    University of Kentucky, Internal Medicine, Room J 503 Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536 0284, USA
    Pain 136:419-31. 2008
    ..In those who respond, pregabalin demonstrated durability of effect for relieving FM pain...
  21. doi request reprint Pain management in fibromyalgia
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    Curr Opin Rheumatol 20:246-50. 2008
    ..This review addresses newer strategies for the treatment of pain in patients with fibromyalgia that may be also useful in patients with other rheumatic diseases...
  22. ncbi request reprint Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway
    Mohit Kapoor
    Department of Internal Medicine, Rheumatology Division, University of Kentucky, Lexington, Kentucky 40536
    J Biol Chem 282:5356-66. 2007
    ..Thus, mPGES-1 inhibition may limit inflammation by multiple mechanisms and is a potential therapeutic target...
  23. ncbi request reprint Why is the management of fibromyalgia syndrome so difficult for rheumatologists?
    Elizabeth Scarbrough
    University of Kentucky in Lexington, KY 40502, USA
    Nat Clin Pract Rheumatol 3:480-1. 2007
  24. ncbi request reprint The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia
    Lesley M Arnold
    Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Pain Med 8:633-8. 2007
    ..To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment...
  25. ncbi request reprint Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing
    Michael E Geisser
    Department of Physical Medicine and Rehabilitation, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Pain 102:243-50. 2003
    ..They also suggest that catastrophic thoughts about pain may play a role in increased pain perception in this population...
  26. ncbi request reprint Nephrogenic fibrosing dermopathy: a novel cutaneous fibrosing disorder in patients with renal failure
    Richard D Swartz
    Division of Nephrology, University of Michigan Health Systems, Ann Arbor 48109 0364, USA
    Am J Med 114:563-72. 2003
    ..Presently, there is no effective treatment, and the condition persists in most patients...
  27. ncbi request reprint Regulation and function of COX-2 gene expression in isolated gastric parietal cells
    Nonthalee Pausawasdi
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 47109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 282:G1069-78. 2002
    ..The functional significance of these effects seems to be stimulation of PGE(2) release...
  28. ncbi request reprint Chronic widespread pain and fibromyalgia: what we know, and what we need to know
    Daniel J Clauw
    Division of Rheumatology, Department of Medicine, University of Michigan Medical School, 101 Simpson, Ann Arbor, MI 48109 0723, USA
    Best Pract Res Clin Rheumatol 17:685-701. 2003
    ..g. NSAIDs, corticosteroids), neuroactive compounds [especially those that raise central levels of noradrenaline (norepinephrine) or serotonin] are most effective for treating central pain...
  29. pmc Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatant
    Jianmin Yang
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0640, USA
    Arthritis Res 4:215-9. 2002
    ..This protocol will be useful for investigators with applications that require efficient, stable, high level transgene expression in primary FLS...
  30. ncbi request reprint Is there a place for non-selective NSAIDs in the treatment of arthritis?
    Leslie J Crofford
    Joint Bone Spine 69:4-7. 2002
  31. ncbi request reprint Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial
    Leslie J Crofford
    University of Michigan, Ann Arbor, USA
    Arthritis Rheum 52:1264-73. 2005
    ..FMS affects an estimated 2% of the population, predominantly women. This trial was designed to evaluate the efficacy and safety of pregabalin, a novel alpha(2)-delta ligand, for treatment of symptoms associated with FMS...
  32. ncbi request reprint Memory beliefs and function in fibromyalgia patients
    Jennifer M Glass
    Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, MI 48106, United States
    J Psychosom Res 58:263-9. 2005
    ..The aim of this study was to investigate memory beliefs and their relationship to actual memory function in fibromyalgia (FM) patients...
  33. ncbi request reprint Controversies in COX-2 selective inhibition
    Lee S Simon
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Rheumatol 29:1501-10. 2002
  34. pmc Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice
    Fumiaki Kojima
    Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    J Immunol 180:8361-8. 2008
    ..Pharmacologic inhibition of mPGES-1 may therefore impact both the inflammation and the autoimmunity associated with human diseases such as rheumatoid arthritis...
  35. ncbi request reprint Fibromyalgia: where are we a decade after the American College of Rheumatology classification criteria were developed?
    Leslie J Crofford
    Arthritis Rheum 46:1136-8. 2002
  36. ncbi request reprint Fibromyalgia: combining pharmacological and nonpharmacological approaches to treating the person, not just the pain
    Dennis C Turk
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pain 9:99-104. 2008
  37. ncbi request reprint The relationship of fibromyalgia to neuropathic pain syndromes
    Leslie J Crofford
    University of Kentucky, Lexington, Kentucky 40536, USA
    J Rheumatol Suppl 75:41-5. 2005
    ..In this afterword, a synthesis of the information presented in these proceedings and opinion as to how FM relates to classical neuropathic pain syndromes is provided...
  38. pmc Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course study
    Mohit Kapoor
    Department of Internal Medicine, Division of Rheumatology, Room J 509, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
    Prostaglandins Leukot Essent Fatty Acids 76:103-12. 2007
    ..In this study, we show that PPARgamma is upregulated during the resolution phase of wound repair concomitant with the shift to PGD2, and may be responsible for initiating endogenous mechanism resulting in healing/resolution...
  39. ncbi request reprint Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targets
    Mohit Kapoor
    Department of Internal Medicine, Rheumatology Division, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
    Curr Opin Investig Drugs 7:418-22. 2006
    ..The major therapeutic targets within these processes will also be highlighted...
  40. ncbi request reprint A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
    Arthritis Rheum 50:2974-84. 2004
    ..To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder...
  41. ncbi request reprint Growth factor receptors: implications in tumor biology
    Divya Mani Srinivasan
    University of Kentucky, Department of Molecular and Biomedical Pharmacology, 800 Rose Street, Lexington, KY 40536 0284, USA
    Curr Opin Investig Drugs 6:1246-9. 2005
    ..This review discusses the involvement of growth factor receptors in solid tumor formation and their value as potential anticancer drug targets...
  42. ncbi request reprint Fibromyalgia syndrome
    Philip J Mease
    Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
    J Rheumatol 32:2270-7. 2005
    ..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached...
  43. pmc High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study
    Richard A Nash
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 110:1388-96. 2007
    ..Sustained responses including a decrease in dermal fibrosis were observed exceeding those previously reported with other therapies. HDIT and autologous HCT for SSc should be evaluated in a randomized clinical trial...