L J Crofford
Affiliation: University of Michigan
- The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndromeL J Crofford
Division of Rheumatology, University of Michigan, Ann Arbor 48109 0680, USA
Z Rheumatol 57:67-71. 1998....
- The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseasesLeslie J Crofford
Department of Internal Medicine and Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, An Arbor, MI 48109 0680, USA
Endocrinol Metab Clin North Am 31:1-13. 2002..Availability of technology to study better central components of the HPA axis may shed further light on its role in the pathogenesis of inflammatory autoimmune rheumatic diseases and musculoskeletal pain syndromes...
- Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndromeLeslie J Crofford
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
Brain Behav Immun 18:314-25. 2004..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency...
- Pharmaceutical treatment options for fibromyalgiaLeslie J Crofford
Division of Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
Curr Rheumatol Rep 6:274-80. 2004..This paper will review the rationale for the different types of pharmaceutical treatments that may be useful for the treatment of FMS and issues regarding new drug development for this indication...
- Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use?Leslie J Crofford
University of Michigan, Ann Arbor, Michigan 48109 0680, USA
Curr Opin Rheumatol 14:225-30. 2002..It remains important to increase our understanding of the place of these agents in clinical practice from the perspective of efficacy, toxicity, and cost...
- Adenovirus binding to cultured synoviocytes triggers signaling through MAPK pathways and induces expression of cyclooxygenase-2Leslie J Crofford
Division of Rheumatology, Department of Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
J Gene Med 7:288-96. 2005..coli beta-galactosidase gene...
- Prostaglandin biologyL J Crofford
Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
Gastroenterol Clin North Am 30:863-76. 2001..Dissecting these biochemical and molecular pathways allows development of therapeutic agents that can be [figure: see text] applied to specific clinical situations, while preserving PGs that play a role in normal physiology...
- Complementary and alternative therapies for fibromyalgiaL J Crofford
University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI, 48109 0680, USA
Curr Rheumatol Rep 3:147-56. 2001..However, because of widespread and growing use of alternative medicine, especially by persons with chronic illnesses, it is essential to review efficacy and adverse effects of complementary and alternative therapies...
- Clinical experience with specific COX-2 inhibitors in arthritisL J Crofford
Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48019, USA
Curr Pharm Des 6:1725-36. 2000..In patients with arthritis at risk for gastrointestinal complications of NSAIDs, specific inhibitors of COX-2 provide an effective and apparently safer form of anti-inflammatory agent...
- COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory diseaseLeslie J Crofford
Associate Professor of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
Arthritis Res Ther 5:25-7. 2003..Clinical data suggest that protective PGs are derived from cyclooxygenase (COX)-1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not cross-reactive with aspirin in patients with AERD...
- Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cellsD O Stichtenoth
Divisions of. Rheumatology and Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 167:469-74. 2001..In summary, these data demonstrate an induction of mPGES in rheumatoid synoviocytes by proinflammatory cytokines. This novel pathway may be a target for therapeutic intervention for patients with arthritis...
- Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndromeA Korszun
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK
J Rheumatol 27:1526-30. 2000..We tested the hypothesis that women with FM and CFS manifest abnormalities of the hypothalamic-pituitary-gonadal (HPG) hormonal axis...
- Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migrationS U Monrad
Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, USA
Prostaglandins Leukot Essent Fatty Acids 84:113-21. 2011..These findings provide useful information on the effects of inducible PGE2 on the innate immune system, and have important implications regarding potential consequences of pharmacologic mPGES-1 inhibition...
- Cognitive function in fibromyalgia patientsD C Park
Department of Psychology, University of Michigan, Ann Arbor 48109, USA
Arthritis Rheum 44:2125-33. 2001..FM patients' complaints about their memory are likely to be legitimate, since their memory function is not age appropriate...
- Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumoniaS V Kocheril
University of Michigan, Ann Arbor, MI 48109, USA
Arthritis Rheum 53:549-57. 2005....
- Violence, stress, and somatic syndromesLeslie J Crofford
Center for the Advancement of Women s Health, University of Kentucky, USA
Trauma Violence Abuse 8:299-313. 2007..Understanding the relationship between violence, stress, and somatic syndromes will help in clarifying the consequences of violence exposure to long-term health and health-related quality of life...
- Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgiaSamuel A McLean
Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
Arthritis Rheum 52:3660-9. 2005....
- Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercisesPhillip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Arthritis Rheum 59:952-60. 2008....
- Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study GroupLeslie J Crofford
Center for the Advancement of Women s Health, University of Kentucky, Lexington, Kentucky, USA
J Rheumatol 33:1403-8. 2006....
- Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalinLeslie J Crofford
University of Kentucky, Internal Medicine, Room J 503 Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536 0284, USA
Pain 136:419-31. 2008..In those who respond, pregabalin demonstrated durability of effect for relieving FM pain...
- Pain management in fibromyalgiaLeslie J Crofford
University of Kentucky, Lexington, Kentucky 40536, USA
Curr Opin Rheumatol 20:246-50. 2008..This review addresses newer strategies for the treatment of pain in patients with fibromyalgia that may be also useful in patients with other rheumatic diseases...
- Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathwayMohit Kapoor
Department of Internal Medicine, Rheumatology Division, University of Kentucky, Lexington, Kentucky 40536
J Biol Chem 282:5356-66. 2007..Thus, mPGES-1 inhibition may limit inflammation by multiple mechanisms and is a potential therapeutic target...
- Why is the management of fibromyalgia syndrome so difficult for rheumatologists?Elizabeth Scarbrough
University of Kentucky in Lexington, KY 40502, USA
Nat Clin Pract Rheumatol 3:480-1. 2007
- The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgiaLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Pain Med 8:633-8. 2007..To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment...
- Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizingMichael E Geisser
Department of Physical Medicine and Rehabilitation, University of Michigan Health System, Ann Arbor, MI 48109, USA
Pain 102:243-50. 2003..They also suggest that catastrophic thoughts about pain may play a role in increased pain perception in this population...
- Nephrogenic fibrosing dermopathy: a novel cutaneous fibrosing disorder in patients with renal failureRichard D Swartz
Division of Nephrology, University of Michigan Health Systems, Ann Arbor 48109 0364, USA
Am J Med 114:563-72. 2003..Presently, there is no effective treatment, and the condition persists in most patients...
- Regulation and function of COX-2 gene expression in isolated gastric parietal cellsNonthalee Pausawasdi
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 47109 0682, USA
Am J Physiol Gastrointest Liver Physiol 282:G1069-78. 2002..The functional significance of these effects seems to be stimulation of PGE(2) release...
- Chronic widespread pain and fibromyalgia: what we know, and what we need to knowDaniel J Clauw
Division of Rheumatology, Department of Medicine, University of Michigan Medical School, 101 Simpson, Ann Arbor, MI 48109 0723, USA
Best Pract Res Clin Rheumatol 17:685-701. 2003..g. NSAIDs, corticosteroids), neuroactive compounds [especially those that raise central levels of noradrenaline (norepinephrine) or serotonin] are most effective for treating central pain...
- Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatantJianmin Yang
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0640, USA
Arthritis Res 4:215-9. 2002..This protocol will be useful for investigators with applications that require efficient, stable, high level transgene expression in primary FLS...
- Is there a place for non-selective NSAIDs in the treatment of arthritis?Leslie J Crofford
Joint Bone Spine 69:4-7. 2002
- Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trialLeslie J Crofford
University of Michigan, Ann Arbor, USA
Arthritis Rheum 52:1264-73. 2005..FMS affects an estimated 2% of the population, predominantly women. This trial was designed to evaluate the efficacy and safety of pregabalin, a novel alpha(2)-delta ligand, for treatment of symptoms associated with FMS...
- Memory beliefs and function in fibromyalgia patientsJennifer M Glass
Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, MI 48106, United States
J Psychosom Res 58:263-9. 2005..The aim of this study was to investigate memory beliefs and their relationship to actual memory function in fibromyalgia (FM) patients...
- Controversies in COX-2 selective inhibitionLee S Simon
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Rheumatol 29:1501-10. 2002
- Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null miceFumiaki Kojima
Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
J Immunol 180:8361-8. 2008..Pharmacologic inhibition of mPGES-1 may therefore impact both the inflammation and the autoimmunity associated with human diseases such as rheumatoid arthritis...
- Fibromyalgia: where are we a decade after the American College of Rheumatology classification criteria were developed?Leslie J Crofford
Arthritis Rheum 46:1136-8. 2002
- Fibromyalgia: combining pharmacological and nonpharmacological approaches to treating the person, not just the painDennis C Turk
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Pain 9:99-104. 2008
- The relationship of fibromyalgia to neuropathic pain syndromesLeslie J Crofford
University of Kentucky, Lexington, Kentucky 40536, USA
J Rheumatol Suppl 75:41-5. 2005..In this afterword, a synthesis of the information presented in these proceedings and opinion as to how FM relates to classical neuropathic pain syndromes is provided...
- Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course studyMohit Kapoor
Department of Internal Medicine, Division of Rheumatology, Room J 509, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
Prostaglandins Leukot Essent Fatty Acids 76:103-12. 2007..In this study, we show that PPARgamma is upregulated during the resolution phase of wound repair concomitant with the shift to PGD2, and may be responsible for initiating endogenous mechanism resulting in healing/resolution...
- Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targetsMohit Kapoor
Department of Internal Medicine, Rheumatology Division, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
Curr Opin Investig Drugs 7:418-22. 2006..The major therapeutic targets within these processes will also be highlighted...
- A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorderLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Arthritis Rheum 50:2974-84. 2004..To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder...
- Growth factor receptors: implications in tumor biologyDivya Mani Srinivasan
University of Kentucky, Department of Molecular and Biomedical Pharmacology, 800 Rose Street, Lexington, KY 40536 0284, USA
Curr Opin Investig Drugs 6:1246-9. 2005..This review discusses the involvement of growth factor receptors in solid tumor formation and their value as potential anticancer drug targets...
- Fibromyalgia syndromePhilip J Mease
Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
J Rheumatol 32:2270-7. 2005..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached...
- High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot studyRichard A Nash
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Blood 110:1388-96. 2007..Sustained responses including a decrease in dermal fibrosis were observed exceeding those previously reported with other therapies. HDIT and autologous HCT for SSc should be evaluated in a randomized clinical trial...