L A Criswell

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3,240 rheumatoid arthritis patients
    Jennifer D Gorman
    University of California, San Francisco, CA 94143 0500, USA
    Arthritis Rheum 50:400-12. 2004
  2. ncbi request reprint Differences in the use of second-line agents and prednisone for treatment of rheumatoid arthritis by rheumatologists and non-rheumatologists
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, USA
    J Rheumatol 24:2283-90. 1997
  3. ncbi request reprint Inheritance of the shared epitope and long-term outcomes of rheumatoid arthritis among community-based Caucasian females
    L A Criswell
    Rosalind Russell Medical Research Center Arthritis, Department of Medicine, University of California, San Francisco, USA
    Genet Epidemiol 15:61-72. 1998
  4. ncbi request reprint Update on genetic risk factors for systemic lupus erythematosus and rheumatoid arthritis
    L A Criswell
    The Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, Division of Rheumatology, 94143 0500, USA
    Curr Opin Rheumatol 12:85-90. 2000
  5. pmc Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA
    Ann Rheum Dis 65:1163-7. 2006
  6. pmc CIITA is not associated with risk of developing rheumatoid arthritis
    P G Bronson
    Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 12:235-8. 2011
  7. pmc Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis
    F B S Briggs
    University of California, Berkeley, 94720, USA
    Genes Immun 11:199-208. 2010
  8. pmc A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis
    P G Bronson
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 11:504-8. 2010
  9. pmc Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    S L Musone
    Cardiovascular Research Institute and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA
    Genes Immun 12:176-82. 2011
  10. pmc Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort
    C M Thorburn
    Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
    Genes Immun 8:279-87. 2007

Detail Information

Publications95

  1. ncbi request reprint Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3,240 rheumatoid arthritis patients
    Jennifer D Gorman
    University of California, San Francisco, CA 94143 0500, USA
    Arthritis Rheum 50:400-12. 2004
    ..The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-analysis...
  2. ncbi request reprint Differences in the use of second-line agents and prednisone for treatment of rheumatoid arthritis by rheumatologists and non-rheumatologists
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, USA
    J Rheumatol 24:2283-90. 1997
    ..To compare the use of methotrexate (MTX), intramuscular (i.m.) gold, hydroxychloroquine, and prednisone for rheumatoid arthritis (RA) treatment among patients managed by rheumatologists and nonrheumatologists...
  3. ncbi request reprint Inheritance of the shared epitope and long-term outcomes of rheumatoid arthritis among community-based Caucasian females
    L A Criswell
    Rosalind Russell Medical Research Center Arthritis, Department of Medicine, University of California, San Francisco, USA
    Genet Epidemiol 15:61-72. 1998
    ..16) reflects an average of 2 very different ORs when patients are further categorized according to genotype groups 4 and 5 (OR = 1.3 and 11.9, respectively)...
  4. ncbi request reprint Update on genetic risk factors for systemic lupus erythematosus and rheumatoid arthritis
    L A Criswell
    The Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, Division of Rheumatology, 94143 0500, USA
    Curr Opin Rheumatol 12:85-90. 2000
    ..In addition, the results of these studies, in conjunction with progress in other complex human diseases, suggest several important considerations for future studies...
  5. pmc Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA
    Ann Rheum Dis 65:1163-7. 2006
    ..To determine whether the impact of tobacco exposure on rheumatoid arthritis (RA) risk is influenced by polymorphisms at the HLA-DRB1 and glutathione S-transferase M1 (GSTM1) loci...
  6. pmc CIITA is not associated with risk of developing rheumatoid arthritis
    P G Bronson
    Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 12:235-8. 2011
    ..This is the largest study to fully characterize common genetic variation in CIITA, including an assessment of haplotypes. Results exclude even a modest role for common CIITA polymorphisms in susceptibility to RA...
  7. pmc Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis
    F B S Briggs
    University of California, Berkeley, 94720, USA
    Genes Immun 11:199-208. 2010
    ..A total of seven replicating epistatic interactions were identified. SNP variants within CDH13, MYO3A, CEP72 and near WFDC1 showed significant evidence for interaction with PTPN22, affecting susceptibility to RA...
  8. pmc A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis
    P G Bronson
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 11:504-8. 2010
    ..The previously reported association between RA and rs6498169 was not replicated. Results show that CLEC16A does not have a prominent function in susceptibility to anti-CCP-positive RA...
  9. pmc Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    S L Musone
    Cardiovascular Research Institute and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA
    Genes Immun 12:176-82. 2011
    ..04), but not specifically for common (>2% minor allele frequency), rare, exonic, intronic, non-synonymous or synonymous variants...
  10. pmc Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort
    C M Thorburn
    Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
    Genes Immun 8:279-87. 2007
    ..These results suggest that PDCD1 genetic variation influences the risk and expression of SLE and that these associations vary according to ethnic background...
  11. pmc Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort
    R Kaiser
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA
    Ann Rheum Dis 68:238-41. 2009
    ..Few studies have examined thrombosis in systemic lupus erythematosus (SLE), none have included Asian-Americans, and most have had small sample sizes. We analysed risk factors for thrombosis in a large, multi-ethnic SLE cohort...
  12. pmc The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus
    P G Bronson
    Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Genes Immun 12:667-71. 2011
    ..9 × 10(-3)). Results support a role for CIITA in SLE, which appears to be stronger in the presence of DRB1*03:01...
  13. ncbi request reprint Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis
    A Parsa
    Division of Nephrology, University of California, San Francisco, CA 94143 0500, USA
    Genes Immun 6:217-24. 2005
    ..005) and Atg M235T (P=0.04) polymorphisms, and GFR analyzed as a continuous variable among Asians. These findings suggest a significant role for ACE and Atg gene sequence variation and severity of LN among Asians with SLE...
  14. ncbi request reprint Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families
    A Parsa
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Genes Immun 3:S42-6. 2002
    ..010). Due to the choice of study design and analytic method these results are unlikely to be due to population admixture. Our findings suggest that DNA sequence variation in the ACE gene influences the risk of developing SLE and LN...
  15. ncbi request reprint The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  16. ncbi request reprint Influence of male sex on disease phenotype in familial rheumatoid arthritis
    Damini Jawaheer
    University of California, Los Angeles, USA
    Arthritis Rheum 54:3087-94. 2006
    ..To examine sex differences in clinical, demographic, and genetic characteristics among a large cohort of patients with familial rheumatoid arthritis (RA)...
  17. pmc Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus
    Brent W Kinder
    Division of Rheumatology, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143, USA
    Arthritis Rheum 56:2679-86. 2007
    ....
  18. ncbi request reprint Health care utilization and outcomes among persons with rheumatoid arthritis in fee-for-service and prepaid group practice settings
    E H Yelin
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco 94143 0920, USA
    JAMA 276:1048-53. 1996
    ..To compare health care utilization and outcomes over an 11-year period among persons with rheumatoid arthritis (RA) in fee-for-service and prepaid group practice settings...
  19. pmc The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association
    P G Bronson
    Division of Epidemiology, School of Public Health, University of California, 209 Hildebrand Hall, Berkeley, CA 94720, USA
    Ann Rheum Dis 67:933-6. 2008
    ..Previous studies of a promoter region polymorphism (-168A/G, rs3087456) in the MHC2TA gene and RA have yielded conflicting results...
  20. ncbi request reprint Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis
    Jennifer D Gorman
    Division of Rheumatology, University of California San Francisco, 374 Parnassus Avenue, San Francisco, CA 94143 0500, USA
    Arthritis Rheum 50:3476-84. 2004
    ..To examine the relationship of the HLA-DRB1 shared epitope (SE) to rheumatoid vasculitis, using individual patient data (IPD) meta-analytic methods...
  21. pmc Medicaid and access to care among persons with systemic lupus erythematosus
    JoAnn Zell Gillis
    University of California, San Francisco, CA 94143 0920, USA
    Arthritis Rheum 57:601-7. 2007
    ..To evaluate the associations between Medicaid insurance and distance traveled by patients to treating physicians and health care utilization for patients with systemic lupus erythematosus (SLE)...
  22. pmc Association of socioeconomic and demographic factors with utilization of rheumatology subspecialty care in systemic lupus erythematosus
    Jinoos Yazdany
    University of California, San Francisco, CA 94143 0920, USA
    Arthritis Rheum 57:593-600. 2007
    ....
  23. pmc Impact of memory impairment on employment status in persons with systemic lupus erythematosus
    Pantelis Panopalis
    Rosalind Russel Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA 94143 0920, USA
    Arthritis Rheum 57:1453-60. 2007
    ..To assess the specific contribution of memory impairment to employment status in persons with systemic lupus erythematosus (SLE)...
  24. pmc Impact of health maintenance organizations and fee-for-service on health care utilization among people with systemic lupus erythematosus
    Edward Yelin
    University of California, San Francisco, CA, USA
    Arthritis Rheum 57:508-15. 2007
    ..To compare health care utilization in people with systemic lupus erythematosus (SLE) in health maintenance organizations (HMOs) and fee-for-service (FFS)...
  25. ncbi request reprint Dissecting the heterogeneity of rheumatoid arthritis through linkage analysis of quantitative traits
    Lindsey A Criswell
    University of California, San Francisco, CA 94143, USA
    Arthritis Rheum 56:58-68. 2007
    ..To dissect the heterogeneity of rheumatoid arthritis (RA) through linkage analysis of quantitative traits, specifically, IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide (anti-CCP) autoantibody titers...
  26. pmc Genome-wide single-nucleotide polymorphism linkage analyses of quantitative rheumatoid arthritis phenotypes in Caucasian NARAC families
    Kimberly E Taylor
    University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, 374 Parnassus Avenue, Box 0500, San Francisco, California 94143, USA
    BMC Proc 1:S105. 2007
    ....
  27. pmc The role of neighborhood and individual socioeconomic status in outcomes of systemic lupus erythematosus
    Laura Trupin
    Department of Medicine, Institute for Health Policy Studies, University of California, San Francisco, CA 94143 0920, USA
    J Rheumatol 35:1782-8. 2008
    ..To determine if neighborhood socioeconomic status (SES) is independently related to physical and mental health outcomes in systemic lupus erythematosus (SLE)...
  28. pmc European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus
    Sharon A Chung
    Division of Rheumatology, University of California, San Francisco, CA 94143 0500, USA
    Arthritis Rheum 60:2448-56. 2009
    ..To determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease...
  29. doi request reprint Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 233:55-61. 2010
    ..These genetic discoveries shed light on underlying disease mechanisms in RA and provide targets for the development of novel diagnostic and therapeutic tools for future use in this chronic inflammatory disorder...
  30. pmc Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus
    Paola G Bronson
    University of California, Berkeley, California 94720 7356, USA
    Arthritis Rheum 62:1712-7. 2010
    ..Thus, we investigated maternal-offspring HLA compatibility, parent-of-origin effects, and NIMA effects at DRB1 in SLE...
  31. pmc Conditional analysis of the major histocompatibility complex in rheumatoid arthritis
    Kimberly E Taylor
    The Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 374 Parnassus Ave, San Francisco, California 94143 USA
    BMC Proc 3:S36. 2009
    ..001). This supports the presence of significant effects on RA susceptibility in the MHC in addition to the shared epitope...
  32. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  33. pmc Work loss and work entry among persons with systemic lupus erythematosus: comparisons with a national matched sample
    Edward Yelin
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA 94143, USA
    Arthritis Rheum 61:247-58. 2009
    ....
  34. pmc Depression, medication adherence, and service utilization in systemic lupus erythematosus
    Laura J Julian
    University of California, San Francisco, CA 94143 0920, USA
    Arthritis Rheum 61:240-6. 2009
    ..Relationships among adherence problems and service utilization (outpatient visits, emergency department visits, and hospitalizations) were also evaluated...
  35. pmc Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus
    Aimee O Hersh
    University of California, San Francisco, CA, USA
    Arthritis Rheum 61:13-20. 2009
    ..To compare differences in long-term outcome between adults with childhood-onset (age at diagnosis <18 years) systemic lupus erythematosus (SLE) and with adult-onset SLE...
  36. ncbi request reprint The genetic contribution to systemic lupus erythematosus
    Lindsey A Criswell
    Department of Medicine, University of California, San Francisco, CA, USA
    Bull NYU Hosp Jt Dis 66:176-83. 2008
    ....
  37. pmc Provision of preventive health care in systemic lupus erythematosus: data from a large observational cohort study
    Jinoos Yazdany
    Division of Rheumatology, University of California, San Francisco, and General Clinical Research Center, Moffit Hospital, UCSF Box 0920, San Francisco, CA 94143 0920, USA
    Arthritis Res Ther 12:R84. 2010
    ..We compared the receipt of these services in SLE to the general population, and identified subgroups of patients who were less likely to receive these services...
  38. pmc Childhood-onset disease as a predictor of mortality in an adult cohort of patients with systemic lupus erythematosus
    Aimee O Hersh
    University of California, San Francisco, 94143, USA
    Arthritis Care Res (Hoboken) 62:1152-9. 2010
    ..To examine childhood-onset disease as a predictor of mortality in a cohort of adult patients with systemic lupus erythematosus (SLE)...
  39. ncbi request reprint The shared epitope and severity of rheumatoid arthritis
    Jennifer D Gorman
    Division of Rheumatology, University of California San Francisco, San Francisco, California, USA
    Rheum Dis Clin North Am 28:59-78. 2002
    ..Ultimately, clarification of the role of the SE may be valuable for the development of specific therapies directed toward DRB1 and related targets...
  40. pmc Frequent use of the emergency department among persons with systemic lupus erythematosus
    Pantelis Panopalis
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA 94143 0920, USA
    Arthritis Care Res (Hoboken) 62:401-8. 2010
    ..To describe characteristics of systemic lupus erythematosus (SLE) patients who are frequent users of the emergency department and to identify predictors of frequent emergency department use...
  41. pmc Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus
    Kimberly E Taylor
    Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, California, USA
    PLoS Genet 4:e1000084. 2008
    ..We conclude that this common polymorphism of STAT4 contributes to the phenotypic heterogeneity of SLE, predisposing specifically to more severe disease...
  42. pmc Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Am J Hum Genet 76:561-71. 2005
    ..DNA and clinical data for the MADGC families are available to the scientific community; these data will provide a valuable resource for the dissection of the complex genetic factors that underlie the various autoimmune phenotypes...
  43. ncbi request reprint Lack of association of the HLA-DRB1 shared epitope with rheumatoid nodules: an individual patient data meta-analysis of 3,272 Caucasian patients with rheumatoid arthritis
    Jennifer D Gorman
    University of California, San Francisco, and School of Public Health, University of California, Berkeley
    Arthritis Rheum 50:753-62. 2004
    ..The objective of this individual patient data (IPD) meta-analysis was to examine the relationship of rheumatoid nodules to the HLA-DRB1 shared epitope (SE) and to individual SE genotypes...
  44. pmc The influence of polygenic risk scores on heritability of anti-CCP level in RA
    J Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Genes Immun 15:107-14. 2014
    ..In summary, anti-CCP level is a heritable trait, and HLA-DR3 and GP2 are associated with lower anti-CCP levels. ..
  45. ncbi request reprint Antiphospholipid antibody syndrome in renal transplantation: occurrence of clinical events in 96 consecutive patients with systemic lupus erythematosus
    J H Stone
    Rosalind Russell Medical Research Center For Arthritis at the University of California, San Francisco, CA, USA
    Am J Kidney Dis 34:1040-7. 1999
    ..Further investigation of aPLs in SLE patients with end-stage renal disease is required to clarify the risks, benefits, and optimal clinical management of renal transplantation for these patients...
  46. ncbi request reprint The Fcgamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non-Caucasians
    V A Seligman
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA
    Arthritis Rheum 44:618-25. 2001
    ..To determine whether inheritance of Fcgamma receptor (FcgammaR) alleles conferring lower affinity for IgG binding increases the risk of developing lupus nephritis...
  47. pmc Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis
    R Kaiser
    Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, University of California, San Francisco UCSF, San Francisco, CA 94143, USA
    Genes Immun 10:495-502. 2009
    ..SLE and/or aPL-positive patients with the FVL variant have more than two times the odds of thrombosis compared to those without this polymorphism...
  48. ncbi request reprint Current understanding of the genetic aetiology of rheumatoid arthritis and likely future developments
    L A Criswell
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA 94143 0500, USA
    Rheumatology (Oxford) 44:iv9-iv13. 2005
    ..We conclude by briefly summarizing our future plans to elucidate the genetic aetiology of RA...
  49. pmc European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent
    I B Richman
    Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Genes Immun 11:515-21. 2010
    ..Genetic ancestry may contribute to the development of SLE endophenotypes and should be accounted for in genetic studies of disease characteristics...
  50. ncbi request reprint Recent advances in the genetics of rheumatoid arthritis
    Chris Deighton
    Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, 374 Parnassus Avenue, Box 0500, San Francisco, CA 94143 0500, USA
    Curr Rheumatol Rep 8:394-400. 2006
    ..Lastly, a recent single nucleotide polymorphism-based genome-wide linkage analysis of multicase RA families revealed novel genomic regions that likely contain genes that predispose to RA or more specific phenotypes...
  51. pmc PTPN22: its role in SLE and autoimmunity
    Sharon A Chung
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA
    Autoimmunity 40:582-90. 2007
    ..In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases...
  52. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  53. pmc Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    Stacy L Musone
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 40:1062-4. 2008
    ..These findings provide critical links between A20 and the etiology of SLE...
  54. pmc Mortality risk associated with rheumatoid arthritis in a prospective cohort of older women: results from the Iowa Women's Health Study
    T R Mikuls
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Ann Rheum Dis 61:994-9. 2002
    ..To determine whether rheumatoid arthritis (RA) is associated with excess mortality among older women...
  55. pmc Association of smoking with dsDNA autoantibody production in systemic lupus erythematosus
    M M Freemer
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143 0500, USA
    Ann Rheum Dis 65:581-4. 2006
    ..To determine whether exposure to tobacco smoke is associated with double stranded DNA (dsDNA) seropositivity in patients with systemic lupus erythematosus (SLE)...
  56. pmc Systematic review and metaanalysis of patient self-report versus trained assessor joint counts in rheumatoid arthritis
    Jennifer L Barton
    Division of Rheumatology, University of California, San Francisco, California 94143, USA
    J Rheumatol 36:2635-41. 2009
    ..This metaanalysis examines the degree of concordance in joint counts between trained assessors and patients with rheumatoid arthritis (RA)...
  57. ncbi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  58. doi request reprint Genetics research in systemic lupus erythematosus for clinicians: methodology, progress, and controversies
    Rachel Kaiser
    Division of Rheumatology, UCSF Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, San Francisco, California 94143, USA
    Curr Opin Rheumatol 22:119-25. 2010
    ..In this review, we discuss basic issues important to understanding and contextualizing new genetic association studies. We, therefore, highlight literature related to methodology as well as recent genetic discoveries in SLE...
  59. ncbi request reprint Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis LAC, University of California, San Francisco, USA
    Am J Med 112:465-71. 2002
    ..To determine whether cigarette smoking increases the risk of rheumatoid arthritis among postmenopausal women...
  60. doi request reprint Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions
    Robert M Plenge
    Division of Rheumatology, Immunology and Allergy, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Curr Opin Rheumatol 20:145-52. 2008
    ..Here we review genetic association studies conducted to search for DNA biomarkers of response to anti-TNF therapy...
  61. ncbi request reprint Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine
    Nan Yang
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California, One Shields Avenue, Davis, CA, 95616 8669, USA
    Hum Genet 118:382-92. 2005
    ..99). Overall, the study demonstrates that AIMs can provide a useful adjunct to forensic medicine, pharmacogenomics and disease studies in which major ancestry or ethnic affiliation might be linked to specific outcomes...
  62. pmc Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus
    Pantelis Panopalis
    University of California, San Francisco, CA, USA
    Arthritis Rheum 59:1788-95. 2008
    ..To estimate health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus (SLE) in the US...
  63. ncbi request reprint Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile
    A Cecile J W Janssens
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Rheumatol 33:2383-9. 2006
    ..To investigate the influence of individual patient risk profiles on the value of the HLA-DRB1 shared epitope (SE) as a predictor of severe erosive damage in rheumatoid arthritis (RA)...
  64. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  65. pmc TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
    Robert M Plenge
    Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
    N Engl J Med 357:1199-209. 2007
    ..We carried out a genomewide association analysis to identify additional genetic loci associated with an increased risk of rheumatoid arthritis...
  66. pmc Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, United States of America
    Mol Med 14:293-300. 2008
    ..These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles...
  67. ncbi request reprint Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE
    Robert R Graham
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Hum Genet 15:823-30. 2007
    ..These data provide convincing evidence that particular combinations of HLA Class II DR2 and DR3 haplotypes are key determinants of autoantibody production and disease susceptibility in human SLE...
  68. ncbi request reprint Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts
    Hye Soon Lee
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Arthritis Rheum 56:1745-53. 2007
    ..In an effort to confirm this interaction between smoking and shared epitope alleles, we performed a case-only analysis of 3 North American RA cohorts...
  69. ncbi request reprint Clinical usefulness of genetic information for predicting radiographic damage in rheumatoid arthritis
    John J Chen
    Department of Preventive Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA
    J Rheumatol 29:2068-73. 2002
    ....
  70. pmc Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis
    Damini Jawaheer
    Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, Manhasset, NY, 11030, USA
    Am J Hum Genet 71:585-94. 2002
    ....
  71. ncbi request reprint Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles
    Patricia Irigoyen
    North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 52:3813-8. 2005
    ..To examine the association between HLA-DRB1 alleles and the production of anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) autoantibodies in patients with rheumatoid arthritis (RA)...
  72. ncbi request reprint Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Tom W J Huizinga
    Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3433-8. 2005
    ..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies...
  73. pmc A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2
    Monica Chang
    Celera, Alameda, California, United States of America
    PLoS Genet 4:e1000107. 2008
    ..Lastly, in combination with the other two known genetic risk factors, HLA-DRB1 and PTPN22, the variants reported here generate more than a 45-fold RA-risk differential...
  74. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  75. ncbi request reprint Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families
    Damini Jawaheer
    Center for Genomics and Human Genetics, Manhasset, New York 11030, USA
    Arthritis Rheum 48:906-16. 2003
    ..A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) have been previously identified. The present study attempts to confirm these findings...
  76. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  77. ncbi request reprint Mexican American ancestry-informative markers: examination of population structure and marker characteristics in European Americans, Mexican Americans, Amerindians and Asians
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 114:263-71. 2004
    ..Together, these data provide additional support for the practical application of admixture mapping in the Mexican American population...
  78. pmc A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    Ann B Begovich
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 75:330-7. 2004
    ..The minor allele of this SNP recently was implicated in type 1 diabetes, suggesting that the variant phosphatase may increase overall reactivity of the immune system and may heighten an individual carrier's risk for autoimmune disease...
  79. ncbi request reprint The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis
    Ludmila Prokunina
    Uppsala University Uppsala, Sweden
    Arthritis Rheum 50:327-8. 2004
  80. pmc Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:6758-63. 2007
    ....
  81. ncbi request reprint Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women
    James R Cerhan
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Rheumatol 29:246-54. 2002
    ..To evaluate whether blood transfusion, alcohol use, or anthropometric characteristics are risk factors for rheumatoid arthritis (RA) in older women...
  82. ncbi request reprint Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study
    Ted R Mikuls
    University of Alabama at Birmingham, 35294 3296, USA
    Arthritis Rheum 46:83-91. 2002
    ..To evaluate whether coffee, tea, and caffeine consumption are risk factors for rheumatoid arthritis (RA) onset among older women...
  83. ncbi request reprint The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans
    Xiaolan Hu
    Celera Diagnostics, Alameda, CA
    Arthritis Rheum 54:1022-5. 2006
  84. ncbi request reprint Familial clustering of disease features: implications for the etiology and investigation of systemic autoimmune disease
    Lindsey A Criswell
    Arthritis Rheum 50:1707-8. 2004
  85. ncbi request reprint Markers that discriminate between European and African ancestry show limited variation within Africa
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 111:566-9. 2002
    ....
  86. pmc Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping
    Michael F Seldin
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616 8669, USA
    Genome Res 14:1076-84. 2004
    ..These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes...
  87. ncbi request reprint Estrogen and other female reproductive risk factors are not strongly associated with the development of rheumatoid arthritis in elderly women
    Linda A Merlino
    College of Public Health, University of Iowa, Iowa City, IA, USA
    Semin Arthritis Rheum 33:72-82. 2003
    ..Endogenous and exogenous reproductive hormones have been associated with rheumatoid arthritis (RA) in women, but data are inconsistent and no studies have assessed RA risk factors exclusively in elderly women...
  88. ncbi request reprint Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population
    Heather E Collins-Schramm
    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616 8669, USA
    Hum Genet 113:211-9. 2003
    ..This examination of several genomic segments provides strong evidence that appropriate selection of informative markers is a crucial prerequisite for the application of admixture mapping to the AA population...
  89. pmc The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis
    Monica Chang
    Celera, Alameda, CA, USA
    Arthritis Rheum 58:1877-81. 2008
  90. ncbi request reprint Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study
    Linda A Merlino
    College of Public Health, University of Iowa, Iowa City
    Arthritis Rheum 50:72-7. 2004
    ..The influence of vitamin D on human autoimmune disease has not been well defined. The purpose of this study was to evaluate the association of dietary and supplemental vitamin D intake with rheumatoid arthritis (RA) incidence...
  91. doi request reprint Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  92. pmc PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis
    Victoria E H Carlton
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 77:567-81. 2005
    ..Additional analyses identified two SNPs on a single common haplotype that are associated with RA independent of R620W, suggesting that R620W and at least one additional variant in the PTPN22 gene region influence RA susceptibility...
  93. ncbi request reprint Clustering of disease features within 512 multicase rheumatoid arthritis families
    Damini Jawaheer
    North Shore LIJ Research Institute, Manhasset, New York
    Arthritis Rheum 50:736-41. 2004
    ..To determine whether specific rheumatoid arthritis (RA) disease features demonstrate the presence of significant familial clustering...
  94. ncbi request reprint Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women
    James R Cerhan
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Am J Epidemiol 157:345-54. 2003
    ..Intake of certain antioxidant micronutrients, particularly beta-cryptoxanthin and supplemental zinc, and possibly diets high in fruits and cruciferous vegetables, may be protective against the development of rheumatoid arthritis...
  95. ncbi request reprint Gender and racial differences in rates of total hip replacement
    Franklin T Hoaglund
    J Bone Joint Surg Am 85:569-70; author reply 570-1. 2003