Hugh E Criswell

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol
    Hugh E Criswell
    Bowles Center for Alcohol Studies, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 304:192-9. 2003
  2. ncbi request reprint Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers
    Hugh E Criswell
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1015:107-13. 2004
  3. pmc Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals
    Hugh E Criswell
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    J Pharmacol Exp Ther 326:596-603. 2008
  4. ncbi request reprint A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary
    Hugh E Criswell
    Center for Alcohol Studies, UNC Neuroscience Center, Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1407-25. 2005
  5. ncbi request reprint Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity
    Zhen Ming
    Anesthesiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Anesthesiology 97:856-67. 2002
  6. pmc The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons
    M Katherine Kelm
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Neurophysiol 100:3417-28. 2008
  7. pmc The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release
    M Katherine Kelm
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    Neuropharmacology 58:1179-86. 2010
  8. pmc Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons
    M Katherine Kelm
    Bowles Center for Alcohol Studies, CB 7178, Thurston Bowles Building, Chapel Hill, NC 27599 7178, USA
    J Pharmacol Exp Ther 323:356-64. 2007
  9. pmc Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons
    Zhen Ming
    Department of Psychiatry, Center for Alcohol Studies, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:1400-7. 2006
  10. pmc Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice
    Jason E Kralic
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Clin Invest 115:774-9. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol
    Hugh E Criswell
    Bowles Center for Alcohol Studies, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 304:192-9. 2003
    ..These data suggest that the regional differences in the effect of ethanol observed in vivo are not due to a differential action of ethanol at the postsynaptic NMDA or GABAA receptor subtypes...
  2. ncbi request reprint Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers
    Hugh E Criswell
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1015:107-13. 2004
    ..These data indicate that a wide variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated currents and that the kinetics for these agents are inconsistent with an open channel block...
  3. pmc Brain regional differences in the effect of ethanol on GABA release from presynaptic terminals
    Hugh E Criswell
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    J Pharmacol Exp Ther 326:596-603. 2008
    ..This regional difference is consistent with earlier in vivo studies in which ethanol affected neural activity and sensitivity to GABA in some, but not all, brain sites...
  4. ncbi request reprint A conceptualization of integrated actions of ethanol contributing to its GABAmimetic profile: a commentary
    Hugh E Criswell
    Center for Alcohol Studies, UNC Neuroscience Center, Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1407-25. 2005
    ..Thus, an integration of these consequences induced by ethanol is proposed to provide a logical basis for its in vivo GABAmimetic profile...
  5. ncbi request reprint Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity
    Zhen Ming
    Anesthesiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Anesthesiology 97:856-67. 2002
    ..The authors have investigated changes in the effect of isoflurane on NMDA-gated currents from cultured cortical neurons with time in culture and related these changes to the subunit composition of the NMDA receptors...
  6. pmc The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons
    M Katherine Kelm
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Neurophysiol 100:3417-28. 2008
    ..Overall, these results suggest that PKA activation is necessary for ethanol to increase spontaneous GABA release...
  7. pmc The PLC/IP 3 R/PKC pathway is required for ethanol-enhanced GABA release
    M Katherine Kelm
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7365, USA
    Neuropharmacology 58:1179-86. 2010
    ..Overall, these results suggest that activation of the PLC/IP(3)R/PKC pathway is necessary for ethanol to increase spontaneous GABA release from presynaptic terminals onto Purkinje cells...
  8. pmc Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons
    M Katherine Kelm
    Bowles Center for Alcohol Studies, CB 7178, Thurston Bowles Building, Chapel Hill, NC 27599 7178, USA
    J Pharmacol Exp Ther 323:356-64. 2007
    ..Overall, these data suggest that calcium release from presynaptic internal stores plays a vital role in the mechanism of ethanol-enhanced spontaneous GABA release at the interneuron-Purkinje cell synapse...
  9. pmc Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons
    Zhen Ming
    Department of Psychiatry, Center for Alcohol Studies, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:1400-7. 2006
    ..The present study examines the interplay of presynaptic and postsynaptic mechanisms to determine the net effect of ethanol on the neuronal firing rate of cerebellar Purkinje neurons...
  10. pmc Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice
    Jason E Kralic
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7178, USA
    J Clin Invest 115:774-9. 2005
    ..This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor...
  11. pmc Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Brain Behav Immun 25:S146-54. 2011
    ..Interrupting this potential glial-neuronal interaction could provide a novel means by which to alter the development of emotional states induced by stress that predict relapse in the alcoholic...
  12. pmc PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons
    David F Werner
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Neurochem 116:554-63. 2011
    ..We conclude that PKCγ regulates ethanol-induced alterations in α4-containing GABA(A) receptors...
  13. ncbi request reprint The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles
    George R Breese
    Department of Psychiatry, UNC School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 48:57-73. 2005
    ..Despite an extraordinary legacy from studies of the neurobiology of this treatment, a host of unknowns remain that will inspire future investigations...
  14. pmc Ethanol-enhanced GABA release: a focus on G protein-coupled receptors
    M Katherine Kelm
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7178, USA
    Brain Res Rev 65:113-23. 2011
    ....
  15. pmc Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    Steven J Gray
    UNC Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Ther 18:570-8. 2010
    ..Thus, novel AAV vectors have been created that can selectively cross the seizure-compromised BBB and transduce cells...
  16. pmc Evidence for TNFα action on excitatory and inhibitory neurotransmission in the central amygdala: A brain site influenced by stress
    Zhen Ming
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Brain Behav Immun 33:102-11. 2013
    ..Nonetheless, these data provide convincing evidence that release of TNFα by stress could alter neural activity of CeA-neurons by influencing GABA-and glutamate function. ..
  17. ncbi request reprint Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury
    Xiang Ji
    Department of Anesthesiology, CB 7010, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Life Sci 74:3043-52. 2004
    ..These results indicate a possible correlation between the inhibition of sodium current and cardioprotection against ischemia-reperfusion injury...