John D Crispino

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome
    Alice Norton
    Blood 110:1077-9. 2007
  2. ncbi request reprint GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia
    John D Crispino
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Blood Cancer 44:40-4. 2005
  3. ncbi request reprint GATA1 in normal and malignant hematopoiesis
    John D Crispino
    Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Semin Cell Dev Biol 16:137-47. 2005
  4. pmc ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    Monika J Stankiewicz
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 113:3337-47. 2009
  5. ncbi request reprint Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome
    Marianne E Greene
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, USA
    Blood Cells Mol Dis 31:351-6. 2003
  6. pmc Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells
    Cindy G Leung
    Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:1603-11. 2007
  7. pmc Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling
    Sebastien Malinge
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 121:2440-51. 2013
  8. pmc Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression
    Timothy M Chlon
    Northwestern University, Division of Hematology Oncology, Chicago, IL 60611, USA
    Mol Cell 47:608-21. 2012
  9. pmc Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
    Louis C Dore
    Division of Hematology Oncology, Northwestern University, Chicago, IL, USA
    Blood 119:3724-33. 2012
  10. pmc GATA-2 reinforces megakaryocyte development in the absence of GATA-1
    Zan Huang
    Division of Hematology and Oncology, Northwestern University, Lurie Research Building 5 113, Chicago, IL 60611, USA
    Mol Cell Biol 29:5168-80. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome
    Alice Norton
    Blood 110:1077-9. 2007
  2. ncbi request reprint GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia
    John D Crispino
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Pediatr Blood Cancer 44:40-4. 2005
    ..Future research aimed at defining the activity of mutant GATA-1 protein and identifying interacting factors encoded by chromosome 21 will likely lead to an even greater understanding of this intriguing leukemia...
  3. ncbi request reprint GATA1 in normal and malignant hematopoiesis
    John D Crispino
    Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Semin Cell Dev Biol 16:137-47. 2005
    ..In this review, I will summarize our current knowledge of the role of GATA-1 in normal development, and discuss how mutations in GATA1 lead to abnormal and malignant hematopoiesis...
  4. pmc ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    Monika J Stankiewicz
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 113:3337-47. 2009
    ..These findings provide evidence for synergy between alterations in GATA-1 and overexpression of ETS proteins in aberrant megakaryopoiesis...
  5. ncbi request reprint Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome
    Marianne E Greene
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, USA
    Blood Cells Mol Dis 31:351-6. 2003
    ..We hypothesize that disruption of normal GATA-1 function is an essential step in the initiation of megakaryoblastic leukemia in DS...
  6. pmc Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells
    Cindy G Leung
    Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 204:1603-11. 2007
    ..Our studies demonstrate that survivin is essential for steady-state hematopoiesis and survival of the adult, and further, that a high level of survivin expression is critical for proper erythroid differentiation...
  7. pmc Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling
    Sebastien Malinge
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 121:2440-51. 2013
    ..Taken together, our observations demonstrate an important functional interplay between Ikaros, GATA factors, and the NOTCH signaling pathway in specification and homeostasis of the megakaryocyte lineage...
  8. pmc Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression
    Timothy M Chlon
    Northwestern University, Division of Hematology Oncology, Chicago, IL 60611, USA
    Mol Cell 47:608-21. 2012
    ..Together these findings establish a mechanism of gene regulation whereby a non-DNA binding cofactor directly modulates the occupancy of a transcription factor to control lineage specification...
  9. pmc Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
    Louis C Dore
    Division of Hematology Oncology, Northwestern University, Chicago, IL, USA
    Blood 119:3724-33. 2012
    ..Finally, by comparing GATA1 occupancy in erythroid cells and megakaryocytes, we find that the presence of ETS factor motifs is a major discriminator of megakaryocyte versus red cell specification...
  10. pmc GATA-2 reinforces megakaryocyte development in the absence of GATA-1
    Zan Huang
    Division of Hematology and Oncology, Northwestern University, Lurie Research Building 5 113, Chicago, IL 60611, USA
    Mol Cell Biol 29:5168-80. 2009
    ..Moreover, our data reveal that overexpression of GATA-2 facilitates aberrant megakaryopoiesis...
  11. pmc Survivin is not required for the endomitotic cell cycle of megakaryocytes
    Qiang Wen
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 114:153-6. 2009
    ..These results demonstrate that survivin is necessary for survival of megakaryocyte progenitors, but is not required for polyploidization of committed megakaryocytes...
  12. pmc Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
    Andrew G Muntean
    Ben May Institute for Cancer Research, Univeristy of Chicago, IL, USA
    Blood 106:1223-31. 2005
    ..These studies show that GATA-1 is required for both normal regulation of proliferation and terminal maturation of megakaryocytes, and further, that these functions can be uncoupled by mutations in GATA1...
  13. pmc Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders
    John M Joslin
    Section of Hematology Oncology and the Cancer Research Center, University of Chicago, IL 60637, USA
    Blood 110:719-26. 2007
    ..Our data suggest that haploinsufficiency for Egr1 plays a role in murine leukemogenesis, and in the development of AML/MDS characterized by abnormalities of chromosome 5...
  14. pmc Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
    Sebastien Malinge
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 113:2619-28. 2009
    ....
  15. pmc Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome
    Sebastien Malinge
    Division of Hematology Oncology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Invest 122:948-62. 2012
    ..Given that calcineurin/NFAT pathway inhibition has been implicated in the decreased tumor incidence in adults with DS, our results show that the same pathway can be both proleukemic in children and antitumorigenic in adults...
  16. ncbi request reprint Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    Joshua Wechsler
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 32:148-52. 2002
    ..Together, these findings indicate that loss of wildtype GATA1 constitutes one step in the pathogenesis of AMKL in Down syndrome...
  17. pmc FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis
    Zhiguang Gao
    Department of Medicine, The University of Chicago, Chicago, IL, USA
    EMBO J 29:457-68. 2010
    ..Taken together, these results underscore the importance of the FOG-1/NuRD interaction for the re-enforcement of lineage commitment during erythropoiesis and megakaryopoiesis in vivo...
  18. ncbi request reprint Transcription factor GATA-1 and Down syndrome leukemogenesis
    Andrew G Muntean
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Leuk Lymphoma 47:986-97. 2006
    ..Future studies to define the entire class of genes dysregulated by mutations in GATA1 will provide important insights into the etiology of these malignancies...
  19. pmc Vesicle trafficking plays a novel role in erythroblast enucleation
    Ganesan Keerthivasan
    Division of Hematology Oncology, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Blood 116:3331-40. 2010
    ....
  20. pmc Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL
    Qiang Wen
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Cell 150:575-89. 2012
    ..Our findings provide a rationale to support clinical trials of MLN8237 and other inducers of polyploidization and differentiation in AMKL...
  21. doi request reprint Normal and malignant megakaryopoiesis
    Qiang Wen
    Division of Hematology Oncology, Northwestern University, Chicago, IL, USA
    Expert Rev Mol Med 13:e32. 2011
    ..We anticipate that an increased understanding of normal MK differentiation will provide new insights into novel therapeutic approaches that will directly benefit patients...
  22. pmc Transcription factor networks in erythroid cell and megakaryocyte development
    Louis C Dore
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Blood 118:231-9. 2011
    ....
  23. pmc Differential requirements for survivin in hematopoietic cell development
    Sandeep Gurbuxani
    The Ben May Institute for Cancer Research and Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 102:11480-5. 2005
    ..Together, these studies show that whereas survivin expression is essential for megakaryocyte and erythroid progenitors, its down-regulation is required for terminal differentiation of megakaryocytes...
  24. pmc FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis
    Qi Quan Huang
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Blood 116:4968-77. 2010
    ..These observations demonstrate that FLIP is necessary for macrophage differentiation and the homeostatic regulation of granulopoiesis...
  25. ncbi request reprint Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis
    Gina Mundschau
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Blood 101:4298-300. 2003
    ..These results demonstrate that GATA1 is likely to play a critical role in the etiology of TMD, and mutagenesis of GATA1 represents a very early event in DS myeloid leukemogenesis...
  26. pmc Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
    Gina Kirsammer
    Ben May Department for Cancer Research, University of Chicago, IL 60611, USA
    Blood 111:767-75. 2008
    ..Our studies demonstrate the potential of DS mouse models to improve our understanding of chromosome 21 gene dosage effects in human hematologic malignancies...
  27. pmc Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization
    Andrew G Muntean
    Graduate Program in Molecular Genetics and Cell Biology, University of Chicago, IL, USA
    Blood 109:5199-207. 2007
    ..Together, these data show that GATA-1 controls growth and polyploidization by regulating cyclin D-Cdk4 kinase activity...
  28. ncbi request reprint Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
    Sandeep Gurbuxani
    University of Chicago, 924 E 57th St, Rm R116, Chicago, IL 60637, USA
    Blood 103:399-406. 2004
    ....
  29. pmc STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice
    Zan Huang
    Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 117:3890-9. 2007
    ..Our studies elucidate potential mechanisms by which various inflammatory disorders can cause elevated platelet counts...
  30. ncbi request reprint Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo
    Robyn Karnauskas
    Department of Medicine, University of Chicago, IL 60637, USA
    Oncogene 22:688-98. 2003
    ..These results implicate activated Akt and growth-factor independence in leukemogenic transformation, and demonstrate the potential for in vivo analysis of genetic determinants of leukemogenesis...
  31. pmc Combinatorial regulation of tissue specification by GATA and FOG factors
    Timothy M Chlon
    Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Development 139:3905-16. 2012
    ....
  32. pmc A model of early human embryonic stem cell differentiation reveals inter- and intracellular changes on transition to squamous epithelium
    Vasiliy Galat
    Developmental Biology Program, iPS and Human Stem Cell Core Facility, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Stem Cells Dev 21:1250-63. 2012
    ..Moreover, we hypothesize that these events may be common during the primary steps of hESC commitment to functionally varied epithelial tissue derivatives of different embryological origins...
  33. pmc More than blood, a novel gene required for mammalian postimplantation development
    Erica D Smith
    The Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 24:1168-73. 2004
    ..Furthermore, Mtb(-/-) blastocysts exhibited a higher frequency of apoptotic cells than wild-type or heterozygous blastocysts. These findings demonstrate that Mtb is a novel gene that is essential for early embryonic development...
  34. pmc Erythroblast enucleation
    Ganesan Keerthivasan
    Division of Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Stem Cells Int 2011:139851. 2011
    ..This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells...
  35. pmc BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia
    John D Crispino
    Division of Hematology Oncology, Northwestern University, University of Chicago, Chicago, IL 60637, USA Electronic address
    Cancer Cell 22:567-8. 2012
    ..This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia...
  36. ncbi request reprint The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes
    John D Crispino
    Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Methods 26:84-92. 2002
    ..Once altered specificity factors are obtained, a researcher can then proceed to functional assays that address the role of a specific protein-protein interaction...
  37. doi request reprint Janus kinase inhibitors: an update on the progress and promise of targeted therapy in the myeloproliferative neoplasms
    Brady L Stein
    Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Curr Opin Oncol 23:609-16. 2011
    ..Alongside this period of discovery has been the rapid development of targeted therapy and, here, we summarize results from clinical trials involving these small molecule Janus family of tyrosine kinase (JAK) inhibitors...
  38. pmc Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors
    Xun Wang
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    EMBO J 21:5225-34. 2002
    ..Our studies define a molecular context for transcriptional activation by GATA-1 and FOG-1, and may explain the occurrence of tandem GATA and Ets elements in the promoters of numerous megakaryocyte-expressed genes...
  39. ncbi request reprint Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
    Sergei G Tevosian
    Division of Hematology and Oncology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Development 129:4627-34. 2002
    ..These results indicate that GATA4 and FOG2 and their physical interaction are required for normal gonadal development...
  40. pmc GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis
    Aaron N Chang
    Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9237-42. 2002
    ..On the basis of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG protein function...
  41. ncbi request reprint Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome
    Jeffrey W Taub
    Blood 104:1588-9. 2004
  42. ncbi request reprint Molecular insights into Down syndrome-associated leukemia
    Paresh Vyas
    Department of Haematology, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Curr Opin Pediatr 19:9-14. 2007
    ..Studies within the past year, described within this review, have provided tremendous insights into the role of GATA1 mutations in these malignancies...
  43. pmc Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice
    Donald J McCrann
    Department of Biochemistry, 15 Stoughton St, K225, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 111:4092-5. 2008
    ..We conclude that elevated survivin expression does not alter MK/erythroid lineage development and that elevated survivin, alone, does not interfere with MK ploidy in vivo...