Peter B Crino

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Gene expression, genetics, and genomics in epilepsy: some answers, more questions
    Peter B Crino
    Department of Neurology and PENN Epilepsy Center, University of Pennsylvania, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Epilepsia 48:42-50. 2007
  2. ncbi request reprint The tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    N Engl J Med 355:1345-56. 2006
  3. pmc Biallelic TSC gene inactivation in tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 74:1716-23. 2010
  4. doi request reprint Focal brain malformations: seizures, signaling, sequencing
    Peter B Crino
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 50:3-8. 2009
  5. doi request reprint mTOR: A pathogenic signaling pathway in developmental brain malformations
    Peter B Crino
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Trends Mol Med 17:734-42. 2011
  6. pmc Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias
    Ksenia A Orlova
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 69:850-63. 2010
  7. ncbi request reprint Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling
    Jia Yu
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Brain Pathol 15:179-86. 2005
  8. ncbi request reprint Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
  9. pmc Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex
    Whitney E Parker
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 178:296-305. 2011
  10. ncbi request reprint Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology
    Kevin C Ess
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 46:28-40. 2004

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Gene expression, genetics, and genomics in epilepsy: some answers, more questions
    Peter B Crino
    Department of Neurology and PENN Epilepsy Center, University of Pennsylvania, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Epilepsia 48:42-50. 2007
    ..Identifying the contribution that each plays in epileptogenesis may help define new therapeutic targets...
  2. ncbi request reprint The tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    N Engl J Med 355:1345-56. 2006
  3. pmc Biallelic TSC gene inactivation in tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 74:1716-23. 2010
    ..Loss of TSC1 or TSC2 in vitro and in vivo leads to mTORC1 cascade activation and ribosomal protein S6 phosphorylation (P-S6). Giant cells (GCs) in tubers exhibit S6 phosphorylation, suggesting cell-specific loss of TSC gene function...
  4. doi request reprint Focal brain malformations: seizures, signaling, sequencing
    Peter B Crino
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 50:3-8. 2009
    ..Most importantly, however, if select focal cortical malformations result from enhanced mTOR signaling, new therapeutic antiepileptic compounds, such as rapamycin, can be designed and tested that specifically target mTOR signaling...
  5. doi request reprint mTOR: A pathogenic signaling pathway in developmental brain malformations
    Peter B Crino
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Trends Mol Med 17:734-42. 2011
    ..As we learn more about mTOR and its activity in the developing brain, many challenges will arise that must be overcome before widespread clinical therapeutics can be implemented...
  6. pmc Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias
    Ksenia A Orlova
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 69:850-63. 2010
    ..Our results demonstrate new potential pathogenic pathways in type II FCDs and suggest biomarkers for diagnostic pathology in resected epilepsy specimens...
  7. ncbi request reprint Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling
    Jia Yu
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Brain Pathol 15:179-86. 2005
    ..Enhanced cyclin D1 and c-myc transcription likely reflects increased transcriptionally active beta-catenin due to decreased Ser33/Ser37/Thr41 phospho-beta-catenin and suggests activation of the Wnt-1/beta-catenin cascade in HMEG...
  8. ncbi request reprint Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
    ..Here, we investigated the hypothesis that impairment of potassium uptake through astrocyte inward rectifier potassium (Kir) channels may contribute to epileptogenesis in Tsc1(GFAP)CKO mice...
  9. pmc Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex
    Whitney E Parker
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 178:296-305. 2011
    ....
  10. ncbi request reprint Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology
    Kevin C Ess
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 46:28-40. 2004
    ....
  11. ncbi request reprint mTOR cascade activation distinguishes tubers from focal cortical dysplasia
    Marianna Baybis
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 56:478-87. 2004
    ..Phospho-S6 expression alone in BCs does not support mTOR cascade activation in FCD. Differential gene expression profiles in BCs and GCs supports the hypothesis that these cell types derive by distinct pathogenic mechanisms...
  12. ncbi request reprint Differential cellular gene expression in ganglioglioma
    Uzma Samadani
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:646-53. 2007
    ....
  13. ncbi request reprint Developmental lineage of cell types in cortical dysplasia with balloon cells
    Phillip Lamparello
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Brain 130:2267-76. 2007
    ..These findings provide a developmental lineage model in which balloon cells and dysplastic neurons are derived from radial glial progenitor cells...
  14. ncbi request reprint Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly
    Marianna Baybis
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:1517-24. 2004
    ..We hypothesize that a differential expression of excitatory amino acid and gamma-aminobutyric acid (GABA)A-receptor subunit messenger RNAs (mRNAs) exists in HMEG...
  15. pmc STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
    Ksenia A Orlova
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:1591-602. 2010
    ....
  16. ncbi request reprint Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex
    Michelle Maldonado
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurobiol Dis 14:279-90. 2003
    ....
  17. doi request reprint Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex
    Leah Marcotte
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Acta Neuropathol 123:685-93. 2012
    ..Tubers may represent the most dramatic developmental abnormality in TSC; however, more regionally pervasive yet subtle abnormalities may contribute to neurological disability in TSC...
  18. ncbi request reprint Molecular pathogenesis of tuber formation in tuberous sclerosis complex
    Peter B Crino
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 19:716-25. 2004
    ..These findings support impaired hamartin- and tuberin-mediated mTOR pathway regulation. Tubers likely form by constitutive activation of the mTOR cascade during brain development as a consequence of impaired hamartin or tuberin function...
  19. ncbi request reprint Detection of human papillomavirus in human focal cortical dysplasia type IIB
    Julie Chen
    PENN Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140, USA
    Ann Neurol 72:881-92. 2012
    ..Recently, the high-risk human papillomavirus type 16 oncoprotein E6 was identified as a potent activator of mTORC1 signaling. Here, we test the hypothesis that HPV16 E6 is present in human FCDIIB specimens...
  20. pmc Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder
    Whitney E Parker
    PENN Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Transl Med 5:182ra53. 2013
    ..Our findings demonstrate a mechanistic link between STRADA loss and mTORC1 hyperactivity in PMSE, and suggest that mTORC1 inhibition may be a potential treatment for PMSE as well as other mTOR-associated neurodevelopmental disorders...
  21. ncbi request reprint Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 20:330-6. 2005
    ..Enhanced activation of phospho-S6 and beta-catenin suggests two converging cell pathways that can be pivotal in the pathogenesis of focal cortical dysplasia and hemimegalencephaly...
  22. pmc Fetal brain mTOR signaling activation in tuberous sclerosis complex
    Victoria Tsai
    PENN Epilepsy Center, Department of Neurology and University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Cereb Cortex 24:315-27. 2014
    ..These results suggest that inhibition of mTOR pathway signaling during embryogenesis could prevent abnormal brain development in TSC...
  23. doi request reprint Tuberous sclerosis and epilepsy: role of astrocytes
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Glia 60:1244-50. 2012
    ..Targeting these defects in astrocytes may represent a novel therapeutic strategy for epilepsy in patients with TSC...
  24. ncbi request reprint Focal brain malformations: a spectrum of disorders along the mTOR cascade
    Peter B Crino
    PENN Epilepy Center, Department of Neurology, University of Pennsylvania Medical Center, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Novartis Found Symp 288:260-72; discussion 272-81. 2007
    ..Second, we are using gene and protein expression profile techniques to understand how mTOR activation affects the developing cortex...
  25. ncbi request reprint The neurobiology of the tuberous sclerosis complex
    Leah Marcotte
    Department of Neurology and PENN Epilepsy Center, 3 West Gates Bldg 3400 Spruce St, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neuromolecular Med 8:531-46. 2006
    ..This review will provide an overview of the neurobiological aspects of TSC...
  26. ncbi request reprint Markers of cellular proliferation are expressed in cortical tubers
    Allana Lee
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 53:668-73. 2003
    ..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells...
  27. ncbi request reprint Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 54:251-6. 2003
    ..These findings suggest that Tsc1 inactivation in astrocytes causes dysfunctional glutamate homeostasis, leading to seizure development in TSC...
  28. ncbi request reprint Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1608-16. 2006
  29. pmc The tuberous sclerosis complex
    Ksenia A Orlova
    Departments of Neurology and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1184:87-105. 2010
    ..Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients...
  30. ncbi request reprint Gene expression in TUNEL-positive neurons in human immunodeficiency virus-infected brain
    Dennis L Kolson
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neurovirol 10:102-7. 2004
    ....
  31. ncbi request reprint Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Brain Pathol 12:212-33. 2002
    ..Finally, novel techniques allowing for analysis of patterns of gene expression within single cells, including neurons, is likely to provide answers to the most vexing and important question about these lesions: Why are they epileptogenic?..
  32. ncbi request reprint Evolving neurobiology of tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, 6th Floor Medical Education and Research Building, 3500N Broad Street, Philadelphia, PA 19140 4106, USA
    Acta Neuropathol 125:317-32. 2013
    ..The study of TSC has in many ways reflected a paradigm "bench-to-bedside" success story that serves as a model of many other neurological disorders...
  33. ncbi request reprint Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons
    Albert E Telfeian
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, U S A
    Epilepsia 44:143-9. 2003
    ..Our hypothesis was that differences in gene expression between inhibitory and excitatory neurons in the rat hippocampus might point to specific new targets for seizure pharmacotherapy...
  34. ncbi request reprint Gene expression analysis as a strategy to understand the molecular pathogenesis of infantile spasms
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int Rev Neurobiol 49:367-89. 2002
  35. ncbi request reprint Malformations of cortical development: molecular pathogenesis and experimental strategies
    Peter B Crino
    Penn Epilespsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Adv Exp Med Biol 548:175-91. 2004
    ..The pathogenesis of MCD such as focal cortical dysplasia, hemimegalencephaly, and polymicrogyria, remains unknown. A variety of new techniques including cDNA array analysis now allow for analysis of gene expression within MCD...
  36. pmc Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 43:211-8. 2002
    ..To define the changes in gene and protein expression of the neuronal glutamate transporter (EAAT3/EAAC1) in a rat model of temporal lobe epilepsy as well as in human hippocampal and neocortical epilepsy...
  37. ncbi request reprint Single cell lineage analysis in human focal cortical dysplasia
    Yue Hua
    Department of Neurology and PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Cereb Cortex 13:693-9. 2003
    ..These results support a random X-inactivation pattern in FCD. We propose that dysplastic, 'balloon' and heterotopic neurons in FCD derive from a population of progenitor cells or post-mitotic neurons during cortical development...
  38. doi request reprint Tuberous sclerosis complex: a tale of two genes
    Ruth Nass
    Neurology 70:904-5. 2008
  39. ncbi request reprint A multilayered approach to studying cortical malformations: EEG-fMRI
    John A Detre
    Neurology 64:1108-10. 2005
  40. ncbi request reprint Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway
    Hiroaki Onda
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Neurosci 21:561-74. 2002
    ..We conclude that giant cells in human tubers likely result from a complete loss of TSC2 expression and activation of an mTOR pathway during cortical development...
  41. pmc Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    Stephan Ruegg
    Division of Clinical Neurophysiology, Department of Neurology, University Hospital Basel, Switzerland
    Epilepsy Res 77:85-92. 2007
    ....
  42. ncbi request reprint Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5
    Erik G Puffenberger
    Clinic for Special Children, 535 Bunker Hill Road, Strasburg, PA 17579, USA
    Brain 130:1929-41. 2007
    ....
  43. ncbi request reprint Genetics of epilepsy: epilepsy research foundation workshop report
    Sanjay Sisodiya
    Epilepsy Research Foundation, United Kingdom
    Epileptic Disord 9:194-236. 2007
    ..Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy...
  44. ncbi request reprint Renal angiomyolipoma: long-term results after arterial embolization
    Nishita Kothary
    Department of Radiology, New York Presbyterian Columbia Hospital, 177 Fort Washington Avenue, MHB 4 100, New York, New York, USA
    J Vasc Interv Radiol 16:45-50. 2005
    ..Selective arterial embolization of renal angiomyolipomas (AMLs) was performed to prevent hemorrhage in patients with AMLs larger than 4 cm. This study was conducted to evaluate the long-term efficacy of AML embolization...
  45. doi request reprint Rapamycin and tuberous sclerosis complex: from Easter Island to epilepsy
    Peter B Crino
    Ann Neurol 63:415-7. 2008
  46. ncbi request reprint Bourneville and Taylor: a developing story?
    Peter B Crino
    Ann Neurol 52:6-9. 2002