P B Crino

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1608-16. 2006
  2. ncbi request reprint Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia
    P B Crino
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 56:906-13. 2001
  3. ncbi request reprint Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 20:330-6. 2005
  4. ncbi request reprint Molecular pathogenesis of tuber formation in tuberous sclerosis complex
    Peter B Crino
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 19:716-25. 2004
  5. ncbi request reprint Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Brain Pathol 12:212-33. 2002
  6. ncbi request reprint Transcription of intermediate filament genes is enhanced in focal cortical dysplasia
    J P Taylor
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Acta Neuropathol 102:141-8. 2001
  7. ncbi request reprint mTOR cascade activation distinguishes tubers from focal cortical dysplasia
    Marianna Baybis
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 56:478-87. 2004
  8. ncbi request reprint Differential cellular gene expression in ganglioglioma
    Uzma Samadani
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:646-53. 2007
  9. pmc Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex
    R Kyin
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 159:1541-54. 2001
  10. ncbi request reprint Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers
    R White
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Neurol 49:67-78. 2001

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1608-16. 2006
  2. ncbi request reprint Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia
    P B Crino
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 56:906-13. 2001
    ....
  3. ncbi request reprint Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 20:330-6. 2005
    ..Enhanced activation of phospho-S6 and beta-catenin suggests two converging cell pathways that can be pivotal in the pathogenesis of focal cortical dysplasia and hemimegalencephaly...
  4. ncbi request reprint Molecular pathogenesis of tuber formation in tuberous sclerosis complex
    Peter B Crino
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Child Neurol 19:716-25. 2004
    ..These findings support impaired hamartin- and tuberin-mediated mTOR pathway regulation. Tubers likely form by constitutive activation of the mTOR cascade during brain development as a consequence of impaired hamartin or tuberin function...
  5. ncbi request reprint Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
    Brain Pathol 12:212-33. 2002
    ..Finally, novel techniques allowing for analysis of patterns of gene expression within single cells, including neurons, is likely to provide answers to the most vexing and important question about these lesions: Why are they epileptogenic?..
  6. ncbi request reprint Transcription of intermediate filament genes is enhanced in focal cortical dysplasia
    J P Taylor
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Acta Neuropathol 102:141-8. 2001
    ....
  7. ncbi request reprint mTOR cascade activation distinguishes tubers from focal cortical dysplasia
    Marianna Baybis
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 56:478-87. 2004
    ..Phospho-S6 expression alone in BCs does not support mTOR cascade activation in FCD. Differential gene expression profiles in BCs and GCs supports the hypothesis that these cell types derive by distinct pathogenic mechanisms...
  8. ncbi request reprint Differential cellular gene expression in ganglioglioma
    Uzma Samadani
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:646-53. 2007
    ....
  9. pmc Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex
    R Kyin
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 159:1541-54. 2001
    ..We conclude that alterations in NT4/trkB and NT3/trkC expression may contribute to tuber formation during brain development as downstream effects of the hamartin and tuberin pathway in TSC...
  10. ncbi request reprint Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers
    R White
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Ann Neurol 49:67-78. 2001
    ....
  11. ncbi request reprint Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling
    Jia Yu
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Brain Pathol 15:179-86. 2005
    ..Enhanced cyclin D1 and c-myc transcription likely reflects increased transcriptionally active beta-catenin due to decreased Ser33/Ser37/Thr41 phospho-beta-catenin and suggests activation of the Wnt-1/beta-catenin cascade in HMEG...
  12. ncbi request reprint Gene expression, genetics, and genomics in epilepsy: some answers, more questions
    Peter B Crino
    Department of Neurology and PENN Epilepsy Center, University of Pennsylvania, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Epilepsia 48:42-50. 2007
    ..Identifying the contribution that each plays in epileptogenesis may help define new therapeutic targets...
  13. pmc Biallelic TSC gene inactivation in tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurology 74:1716-23. 2010
    ..Loss of TSC1 or TSC2 in vitro and in vivo leads to mTORC1 cascade activation and ribosomal protein S6 phosphorylation (P-S6). Giant cells (GCs) in tubers exhibit S6 phosphorylation, suggesting cell-specific loss of TSC gene function...
  14. doi request reprint Focal brain malformations: seizures, signaling, sequencing
    Peter B Crino
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 50:3-8. 2009
    ..Most importantly, however, if select focal cortical malformations result from enhanced mTOR signaling, new therapeutic antiepileptic compounds, such as rapamycin, can be designed and tested that specifically target mTOR signaling...
  15. ncbi request reprint The tuberous sclerosis complex
    Peter B Crino
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    N Engl J Med 355:1345-56. 2006
  16. ncbi request reprint Gene expression in TUNEL-positive neurons in human immunodeficiency virus-infected brain
    Dennis L Kolson
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neurovirol 10:102-7. 2004
    ....
  17. ncbi request reprint Markers of cellular proliferation are expressed in cortical tubers
    Allana Lee
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Ann Neurol 53:668-73. 2003
    ..Tubers and SEGAs exhibit a heterogeneous profile of differentiation and may share a common cellular lineage. Tubers may contain a subpopulation of newly generated cells...
  18. ncbi request reprint Postoperative epilepsy in patients undergoing craniotomy for glioblastoma multiforme
    A E Telfeian
    Dept of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Exp Clin Cancer Res 20:5-10. 2001
    ....
  19. ncbi request reprint Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex
    Michelle Maldonado
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurobiol Dis 14:279-90. 2003
    ....
  20. ncbi request reprint Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
    ..Here, we investigated the hypothesis that impairment of potassium uptake through astrocyte inward rectifier potassium (Kir) channels may contribute to epileptogenesis in Tsc1(GFAP)CKO mice...
  21. ncbi request reprint The neurobiology of the tuberous sclerosis complex
    Leah Marcotte
    Department of Neurology and PENN Epilepsy Center, 3 West Gates Bldg 3400 Spruce St, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Neuromolecular Med 8:531-46. 2006
    ..This review will provide an overview of the neurobiological aspects of TSC...
  22. ncbi request reprint Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology
    Kevin C Ess
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 46:28-40. 2004
    ....
  23. ncbi request reprint Developmental lineage of cell types in cortical dysplasia with balloon cells
    Phillip Lamparello
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Brain 130:2267-76. 2007
    ..These findings provide a developmental lineage model in which balloon cells and dysplastic neurons are derived from radial glial progenitor cells...
  24. ncbi request reprint Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 54:251-6. 2003
    ..These findings suggest that Tsc1 inactivation in astrocytes causes dysfunctional glutamate homeostasis, leading to seizure development in TSC...
  25. ncbi request reprint Single cell lineage analysis in human focal cortical dysplasia
    Yue Hua
    Department of Neurology and PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Cereb Cortex 13:693-9. 2003
    ..These results support a random X-inactivation pattern in FCD. We propose that dysplastic, 'balloon' and heterotopic neurons in FCD derive from a population of progenitor cells or post-mitotic neurons during cortical development...
  26. pmc The tuberous sclerosis complex
    Ksenia A Orlova
    Departments of Neurology and Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1184:87-105. 2010
    ..Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients...
  27. pmc Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Epilepsia 43:211-8. 2002
    ..To define the changes in gene and protein expression of the neuronal glutamate transporter (EAAT3/EAAC1) in a rat model of temporal lobe epilepsy as well as in human hippocampal and neocortical epilepsy...
  28. ncbi request reprint Focal brain malformations: a spectrum of disorders along the mTOR cascade
    Peter B Crino
    PENN Epilepy Center, Department of Neurology, University of Pennsylvania Medical Center, 3 West Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Novartis Found Symp 288:260-72; discussion 272-81. 2007
    ..Second, we are using gene and protein expression profile techniques to understand how mTOR activation affects the developing cortex...
  29. ncbi request reprint Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons
    Albert E Telfeian
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, U S A
    Epilepsia 44:143-9. 2003
    ..Our hypothesis was that differences in gene expression between inhibitory and excitatory neurons in the rat hippocampus might point to specific new targets for seizure pharmacotherapy...
  30. ncbi request reprint Gene expression analysis as a strategy to understand the molecular pathogenesis of infantile spasms
    Peter B Crino
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int Rev Neurobiol 49:367-89. 2002
  31. ncbi request reprint Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain
    H L Paulson
    Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA
    Ann Neurol 41:453-62. 1997
    ..The restricted expression of ataxin-3 in certain regions, however, may influence the pattern of neurodegeneration and provide clues to the protein's function...
  32. pmc Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias
    Ksenia A Orlova
    PENN Epilepsy Center and Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 69:850-63. 2010
    ..Our results demonstrate new potential pathogenic pathways in type II FCDs and suggest biomarkers for diagnostic pathology in resected epilepsy specimens...
  33. pmc STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
    Ksenia A Orlova
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:1591-602. 2010
    ....
  34. ncbi request reprint Malformations of cortical development: molecular pathogenesis and experimental strategies
    Peter B Crino
    Penn Epilespsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, USA
    Adv Exp Med Biol 548:175-91. 2004
    ..The pathogenesis of MCD such as focal cortical dysplasia, hemimegalencephaly, and polymicrogyria, remains unknown. A variety of new techniques including cDNA array analysis now allow for analysis of gene expression within MCD...
  35. ncbi request reprint Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly
    Marianna Baybis
    PENN Epilepsy Center, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:1517-24. 2004
    ..We hypothesize that a differential expression of excitatory amino acid and gamma-aminobutyric acid (GABA)A-receptor subunit messenger RNAs (mRNAs) exists in HMEG...
  36. doi request reprint Tuberous sclerosis complex: a tale of two genes
    Ruth Nass
    Neurology 70:904-5. 2008
  37. pmc Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    Stephan Ruegg
    Division of Clinical Neurophysiology, Department of Neurology, University Hospital Basel, Switzerland
    Epilepsy Res 77:85-92. 2007
    ....
  38. ncbi request reprint Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway
    Hiroaki Onda
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Neurosci 21:561-74. 2002
    ..We conclude that giant cells in human tubers likely result from a complete loss of TSC2 expression and activation of an mTOR pathway during cortical development...
  39. ncbi request reprint A multilayered approach to studying cortical malformations: EEG-fMRI
    John A Detre
    Neurology 64:1108-10. 2005
  40. doi request reprint Rapamycin and tuberous sclerosis complex: from Easter Island to epilepsy
    Peter B Crino
    Ann Neurol 63:415-7. 2008
  41. ncbi request reprint Bourneville and Taylor: a developing story?
    Peter B Crino
    Ann Neurol 52:6-9. 2002
  42. ncbi request reprint Genetics of epilepsy: epilepsy research foundation workshop report
    Sanjay Sisodiya
    Epilepsy Research Foundation, United Kingdom
    Epileptic Disord 9:194-236. 2007
    ..Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy...
  43. ncbi request reprint Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5
    Erik G Puffenberger
    Clinic for Special Children, 535 Bunker Hill Road, Strasburg, PA 17579, USA
    Brain 130:1929-41. 2007
    ....
  44. ncbi request reprint Renal angiomyolipoma: long-term results after arterial embolization
    Nishita Kothary
    Department of Radiology, New York Presbyterian Columbia Hospital, 177 Fort Washington Avenue, MHB 4 100, New York, New York, USA
    J Vasc Interv Radiol 16:45-50. 2005
    ..Selective arterial embolization of renal angiomyolipomas (AMLs) was performed to prevent hemorrhage in patients with AMLs larger than 4 cm. This study was conducted to evaluate the long-term efficacy of AML embolization...

Research Grants17

  1. GENE EXPRESSION AND CLONALITY IN DYSPLASTIC CORTICAL NEU
    Peter Crino; Fiscal Year: 2002
    ..Furthermore, by identifying altered expression of select genes, the relationship between FCD and various mental disorders can be discerned. These analyses may point toward new avenues for therapy. ..
  2. Molecular pathogenesis of focal cortical dysplasias
    Peter B Crino; Fiscal Year: 2010
    ..These studies provide a targeted, pathway directed strategy to identify altered protein expression, gene transcription, and gene sequence that lead to the formation of FCD and HMEG during brain development. ..
  3. Structural consequences of TSC gene mutations in brain
    Peter B Crino; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms leading to epilepsy, autism, and cognitive impairment in TSC. ..
  4. Molecular pathogenesis of focal cortical dysplasias
    Peter Crino; Fiscal Year: 2007
    ..These studies provide a targeted, pathway directed strategy to identify altered protein expression, gene transcription, and gene sequence that lead to the formation of FCD and HMEG during brain development. ..
  5. Gene Expression Analysis in Tuberous Sclerosis
    Peter Crino; Fiscal Year: 2006
    ..abstract_text> ..
  6. Cellular Proliferation and Epileptogenesis
    Peter Crino; Fiscal Year: 2004
    ..abstract_text> ..
  7. DEVELOPMENTAL PATHOGENESIS OF HUMAN CORTICAL DYSPLASIA
    Peter Crino; Fiscal Year: 2003
    ..Furthermore, in identifying alterations in specific genes, the relationship between FCD and mental disorders can be rendered. These analyses may point toward new avenues for therapy. ..
  8. Structural consequences of TSC gene mutations in brain
    Peter Crino; Fiscal Year: 2009
    ..These studies will provide new insights into the mechanisms leading to epilepsy, autism, and cognitive impairment in TSC. ..