Research Topics
Species | Fulton Timm CrewsSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Adolescent cortical development: a critical period of vulnerability for addictionFulton Crews
Bowles Center for Alcohol Studies, School of Medecine, University of North Carolina at Chapel Hill, NC 27599, USA
Pharmacol Biochem Behav 86:189-99. 2007..This review presents findings supporting adolescence as a critical period of cortical development important for establishing life long adult characteristics that are disrupted by alcohol and drug use...
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatmentLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
J Neuroinflammation 5:10. 2008..The purpose of this study was to investigate the interaction of liver, serum and brain cytokines as well as whether ethanol would potentiate endotoxin (Lipopolysaccharide, LPS) responses once ethanol had cleared...- Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factorF T Crews
Center for Alcohol Studies, University of North Carolina, Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 23:1834-42. 1999..Because chronic ethanol is known to cause supersensitivity to NMDA excitotoxicity in cortical neurons, this study sought to determine the effect of ethanol treatment on biogenic amine neurons... - Impulsivity, frontal lobes and risk for addictionFulton Timm Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Pharmacol Biochem Behav 93:237-47. 2009..This review will examine the relationships between impulsivity and executive function behaviors to changes in cortical structure during alcohol dependence and recovery... - Alcoholic neurobiology: changes in dependence and recoveryFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 29:1504-13. 2005.... - Neurogenesis in adolescent brain is potently inhibited by ethanolF T Crews
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
Neuroscience 137:437-45. 2006..These studies indicate that the adolescent brain is very sensitive to acute ethanol inhibition of neurogenesis... - Cytokines and alcoholFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 30:720-30. 2006..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies... - BHT blocks NF-kappaB activation and ethanol-induced brain damageFulton Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599, USA
Alcohol Clin Exp Res 30:1938-49. 2006..g., butylated hydroxytoluene (BHT), ebselen (Eb), vitamin E (VE), and blueberry (BB) extract, during binge ethanol treatment and assessed various measures of neurodegeneration... - Mechanisms of neurodegeneration and regeneration in alcoholismFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
Alcohol Alcohol 44:115-27. 2009..g. brain regeneration. Efforts are made to relate preclinical studies to human studies... - Exercise reverses ethanol inhibition of neural stem cell proliferationFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
Alcohol 33:63-71. 2004..The opposing effects of ethanol consumption and exercise on neurogenesis could contribute to the CNS pathology and health benefits, respectively, of these two behaviors... - Interaction of nutrition and binge ethanol treatment on brain damage and withdrawalF T Crews
Bowles Center for Alcohol Studies, CB 7178, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
J Biomed Sci 8:134-42. 2001..This study suggests that nutritional components and total caloric intake do not effect behavior during ethanol withdrawal and that a nutritionally complete diet may increase ethanol-induced brain damage... - Alcohol-induced neurodegeneration: when, where and why?Fulton T Crews
University at Buffalo, SUNY, NY, USA
Alcohol Clin Exp Res 28:350-64. 2004..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal... - Summary report of a symposium: genes and gene delivery for diseases of alcoholismF T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 25:1778-800. 2001..Three main pathologies associated with alcoholism--addiction, liver disease, and birth defects--were discussed. This summary of the meeting is grouped into sections on the brain, liver, and fetus... - Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult ratsF T Crews
The Bowles Center For Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
Alcohol Clin Exp Res 24:1712-23. 2000..Adolescents respond differently to alcohol than adults. Furthermore, binge drinking in young adolescents is becoming increasingly common... - Neural stem cells and alcoholF T Crews
University of North Carolina and Chapel Hill, NC 27599, USA
Alcohol Clin Exp Res 27:324-35. 2003..Dr. W. Michael Zawada described studies directed at dopamine neuron cell transplants into mammalian central nervous system. These studies clearly establish that ethanol has significant effects on stem cells... - Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP ratsFulton T Crews
Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 27:1075-82. 2003..To investigate the role of genetics in binge-drinking-induced brain damage, we studied bidirectionally selected rat lines, the alcohol-preferring P and the alcohol-nonpreferring NP rat lines... - Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease... - Alcohol, neural stem cells, and adult neurogenesisFulton T Crews
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, University of North Carolina, Chapel Hill, USA
Alcohol Res Health 27:197-204. 2003.... - Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in miceJennie R Stevenson
Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Neuropsychopharmacology 34:1209-22. 2009..e. behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations... - Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcoholKimberly Nixon
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurosci 24:9714-22. 2004..For the first time, these data provide a neurobiological mechanism that may underlie the return of human cognitive function and brain volume associated with recovery from addiction... - Neurogenesis decreases during brain maturation from adolescence to adulthoodJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Pharmacol Biochem Behav 86:327-33. 2007..However, the role of IGF-1 during adolescent development is still unclear... 
Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P ratsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Alcohol Clin Exp Res 33:129-38. 2009..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)...- Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neuronsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Eur J Neurosci 21:2711-20. 2005..These data implicate impaired hippocampal neurogenesis with the cognitive and affective dysfunction associated with chronic alcoholism... - Binge ethanol exposure decreases neurogenesis in adult rat hippocampusKimberly Nixon
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurochem 83:1087-93. 2002..These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction... - 1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in ratsPeter C Nicholas
Bowles Center for Alcohol Studies, Department of Biomedical Engineering, and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Chem Res Toxicol 21:408-20. 2008..Reduction of EtG by pretreatment with BHT suggests that BHT and perhaps other compounds may alter the pharmacokinetics of EtG so that EtG may not always be a sensitive marker for ethanol abuse... - Increased MCP-1 and microglia in various regions of the human alcoholic brainJun He
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Exp Neurol 210:349-58. 2008..In VTA and midbrain, only GluT5, but not Iba-1 was increased in alcoholic brains. These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis... - TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibitionJian Y Zou
Bowles Center for Alcohol Studies, CB 7178 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Brain Res 1034:11-24. 2005..TNF alpha potentiation of glutamate neurotoxicity through the blockade of glutamate transporter activity may represent an important mechanism of neurodegeneration associated with neuroinflammation... - Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatmentLeon G Coleman
Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
Pharmacol Biochem Behav 93:322-30. 2009..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction... - Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in ratsJennifer A Obernier
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599-7178, USA
Pharmacol Biochem Behav 72:521-32. 2002..The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process... - Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liverPeter C Nicholas
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Anal Biochem 358:185-91. 2006..24 ppm. This study demonstrates that proton NMR spectroscopy is capable of detecting EtG and that future NMR-based metabolomic studies may encounter this metabolite of ethanol... - Adolescence: booze, brains, and behaviorPeter M Monti
Veterans Affairs Medical Center, Brown University, Providence, Rhode Island 02912, USA
Alcohol Clin Exp Res 29:207-20. 2005..5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher... - CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addictionSubhash C Pandey
Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
Alcohol Clin Exp Res 29:176-84. 2005..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy... - Consequences of multiple withdrawals from alcoholTheodora Duka
Psychology Department, School of Life Sciences, University of Sussex, Sussex, Brighton, United Kingdom
Alcohol Clin Exp Res 28:233-46. 2004....
Research Grants
- MOLECULAR AND CELLULAR ALCOHOL RESEARCH TRAININGFulton Crews; Fiscal Year: 2007....
- MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMFulton Crews; Fiscal Year: 2007..Studies in multiple cellular and tissue systems strengthen the ability of investigators to explore new avenues to uncover the molecular mechanisms of alcohol pathogenesis. ..
- ETHANOL EFFECTS ON NEUROTRANSMISSIONFulton Crews; Fiscal Year: 2009..abstract_text> ..