Fulton Timm Crews

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Binge ethanol exposure decreases neurogenesis in adult rat hippocampus
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 83:1087-93. 2002
  2. ncbi request reprint Adolescent cortical development: a critical period of vulnerability for addiction
    Fulton Crews
    Bowles Center for Alcohol Studies, School of Medecine, University of North Carolina at Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 86:189-99. 2007
  3. pmc Release of neuronal HMGB1 by Ethanol through decreased HDAC activity activates brain neuroimmune signaling
    Jian Y Zou
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e87915. 2014
  4. pmc Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis
    Jian Zou
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Neurosci 6:77. 2012
  5. pmc High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence
    Fulton T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Biol Psychiatry 73:602-12. 2013
  6. pmc Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
    J Neuroinflammation 5:10. 2008
  7. pmc Mechanisms of neurodegeneration and regeneration in alcoholism
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Alcohol Alcohol 44:115-27. 2009
  8. pmc Impulsivity, frontal lobes and risk for addiction
    Fulton Timm Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Pharmacol Biochem Behav 93:237-47. 2009
  9. ncbi request reprint BHT blocks NF-kappaB activation and ethanol-induced brain damage
    Fulton Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599, USA
    Alcohol Clin Exp Res 30:1938-49. 2006
  10. ncbi request reprint Cytokines and alcohol
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:720-30. 2006

Research Grants

  1. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2007
  2. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2004
  3. MOLECULAR AND CELLULAR ALCOHOL RESEARCH TRAINING
    Fulton Crews; Fiscal Year: 2007
  4. MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    Fulton Crews; Fiscal Year: 2007
  5. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2006
  6. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2005
  7. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009

Detail Information

Publications36

  1. ncbi request reprint Binge ethanol exposure decreases neurogenesis in adult rat hippocampus
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 83:1087-93. 2002
    ..These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction...
  2. ncbi request reprint Adolescent cortical development: a critical period of vulnerability for addiction
    Fulton Crews
    Bowles Center for Alcohol Studies, School of Medecine, University of North Carolina at Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 86:189-99. 2007
    ..This review presents findings supporting adolescence as a critical period of cortical development important for establishing life long adult characteristics that are disrupted by alcohol and drug use...
  3. pmc Release of neuronal HMGB1 by Ethanol through decreased HDAC activity activates brain neuroimmune signaling
    Jian Y Zou
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e87915. 2014
    ..These findings provide new therapeutic targets for brain neuroimmune activation and alcoholism. ..
  4. pmc Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis
    Jian Zou
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Neurosci 6:77. 2012
    ....
  5. pmc High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence
    Fulton T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Biol Psychiatry 73:602-12. 2013
    ....
  6. pmc Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
    J Neuroinflammation 5:10. 2008
    ..The purpose of this study was to investigate the interaction of liver, serum and brain cytokines as well as whether ethanol would potentiate endotoxin (Lipopolysaccharide, LPS) responses once ethanol had cleared...
  7. pmc Mechanisms of neurodegeneration and regeneration in alcoholism
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Alcohol Alcohol 44:115-27. 2009
    ..g. brain regeneration. Efforts are made to relate preclinical studies to human studies...
  8. pmc Impulsivity, frontal lobes and risk for addiction
    Fulton Timm Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Pharmacol Biochem Behav 93:237-47. 2009
    ..This review will examine the relationships between impulsivity and executive function behaviors to changes in cortical structure during alcohol dependence and recovery...
  9. ncbi request reprint BHT blocks NF-kappaB activation and ethanol-induced brain damage
    Fulton Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599, USA
    Alcohol Clin Exp Res 30:1938-49. 2006
    ..g., butylated hydroxytoluene (BHT), ebselen (Eb), vitamin E (VE), and blueberry (BB) extract, during binge ethanol treatment and assessed various measures of neurodegeneration...
  10. ncbi request reprint Cytokines and alcohol
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:720-30. 2006
    ..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies...
  11. ncbi request reprint Neurogenesis in adolescent brain is potently inhibited by ethanol
    F T Crews
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
    Neuroscience 137:437-45. 2006
    ..These studies indicate that the adolescent brain is very sensitive to acute ethanol inhibition of neurogenesis...
  12. ncbi request reprint Alcoholic neurobiology: changes in dependence and recovery
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 29:1504-13. 2005
    ....
  13. ncbi request reprint Exercise reverses ethanol inhibition of neural stem cell proliferation
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Alcohol 33:63-71. 2004
    ..The opposing effects of ethanol consumption and exercise on neurogenesis could contribute to the CNS pathology and health benefits, respectively, of these two behaviors...
  14. ncbi request reprint Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factor
    F T Crews
    Center for Alcohol Studies, University of North Carolina, Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 23:1834-42. 1999
    ..Because chronic ethanol is known to cause supersensitivity to NMDA excitotoxicity in cortical neurons, this study sought to determine the effect of ethanol treatment on biogenic amine neurons...
  15. ncbi request reprint Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats
    F T Crews
    The Bowles Center For Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Alcohol Clin Exp Res 24:1712-23. 2000
    ..Adolescents respond differently to alcohol than adults. Furthermore, binge drinking in young adolescents is becoming increasingly common...
  16. ncbi request reprint Interaction of nutrition and binge ethanol treatment on brain damage and withdrawal
    F T Crews
    Bowles Center for Alcohol Studies, CB 7178, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Biomed Sci 8:134-42. 2001
    ..This study suggests that nutritional components and total caloric intake do not effect behavior during ethanol withdrawal and that a nutritionally complete diet may increase ethanol-induced brain damage...
  17. ncbi request reprint Summary report of a symposium: genes and gene delivery for diseases of alcoholism
    F T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 25:1778-800. 2001
    ..Three main pathologies associated with alcoholism--addiction, liver disease, and birth defects--were discussed. This summary of the meeting is grouped into sections on the brain, liver, and fetus...
  18. ncbi request reprint Neural stem cells and alcohol
    F T Crews
    University of North Carolina and Chapel Hill, NC 27599, USA
    Alcohol Clin Exp Res 27:324-35. 2003
    ..Dr. W. Michael Zawada described studies directed at dopamine neuron cell transplants into mammalian central nervous system. These studies clearly establish that ethanol has significant effects on stem cells...
  19. ncbi request reprint Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats
    Fulton T Crews
    Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 27:1075-82. 2003
    ..To investigate the role of genetics in binge-drinking-induced brain damage, we studied bidirectionally selected rat lines, the alcohol-preferring P and the alcohol-nonpreferring NP rat lines...
  20. ncbi request reprint Alcohol-induced neurodegeneration: when, where and why?
    Fulton T Crews
    University at Buffalo, SUNY, NY, USA
    Alcohol Clin Exp Res 28:350-64. 2004
    ..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal...
  21. ncbi request reprint Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:9714-22. 2004
    ..For the first time, these data provide a neurobiological mechanism that may underlie the return of human cognitive function and brain volume associated with recovery from addiction...
  22. ncbi request reprint Alcohol, neural stem cells, and adult neurogenesis
    Fulton T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, University of North Carolina, Chapel Hill, USA
    Alcohol Res Health 27:197-204. 2003
    ....
  23. ncbi request reprint Neurogenesis decreases during brain maturation from adolescence to adulthood
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 86:327-33. 2007
    ..However, the role of IGF-1 during adolescent development is still unclear...
  24. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  25. pmc Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice
    Jennie R Stevenson
    Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 34:1209-22. 2009
    ..e. behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations...
  26. doi request reprint Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P rats
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 33:129-38. 2009
    ..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)...
  27. ncbi request reprint Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Eur J Neurosci 21:2711-20. 2005
    ..These data implicate impaired hippocampal neurogenesis with the cognitive and affective dysfunction associated with chronic alcoholism...
  28. pmc Increased MCP-1 and microglia in various regions of the human alcoholic brain
    Jun He
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Exp Neurol 210:349-58. 2008
    ..In VTA and midbrain, only GluT5, but not Iba-1 was increased in alcoholic brains. These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis...
  29. ncbi request reprint 1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats
    Peter C Nicholas
    Bowles Center for Alcohol Studies, Department of Biomedical Engineering, and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Chem Res Toxicol 21:408-20. 2008
    ..Reduction of EtG by pretreatment with BHT suggests that BHT and perhaps other compounds may alter the pharmacokinetics of EtG so that EtG may not always be a sensitive marker for ethanol abuse...
  30. ncbi request reprint TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition
    Jian Y Zou
    Bowles Center for Alcohol Studies, CB 7178 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1034:11-24. 2005
    ..TNF alpha potentiation of glutamate neurotoxicity through the blockade of glutamate transporter activity may represent an important mechanism of neurodegeneration associated with neuroinflammation...
  31. ncbi request reprint Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
    Jennifer A Obernier
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Pharmacol Biochem Behav 72:521-32. 2002
    ..The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process...
  32. pmc Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment
    Leon G Coleman
    Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 93:322-30. 2009
    ..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction...
  33. ncbi request reprint Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liver
    Peter C Nicholas
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Anal Biochem 358:185-91. 2006
    ..24 ppm. This study demonstrates that proton NMR spectroscopy is capable of detecting EtG and that future NMR-based metabolomic studies may encounter this metabolite of ethanol...
  34. ncbi request reprint Adolescence: booze, brains, and behavior
    Peter M Monti
    Veterans Affairs Medical Center, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 29:207-20. 2005
    ..5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher...
  35. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
    ..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...
  36. ncbi request reprint Consequences of multiple withdrawals from alcohol
    Theodora Duka
    Psychology Department, School of Life Sciences, University of Sussex, Sussex, Brighton, United Kingdom
    Alcohol Clin Exp Res 28:233-46. 2004
    ....

Research Grants10

  1. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2007
    ..abstract_text> ..
  2. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2004
    ..abstract_text> ..
  3. MOLECULAR AND CELLULAR ALCOHOL RESEARCH TRAINING
    Fulton Crews; Fiscal Year: 2007
    ....
  4. MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM
    Fulton Crews; Fiscal Year: 2007
    ..Studies in multiple cellular and tissue systems strengthen the ability of investigators to explore new avenues to uncover the molecular mechanisms of alcohol pathogenesis. ..
  5. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2006
    ..abstract_text> ..
  6. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2005
    ..abstract_text> ..
  7. ETHANOL EFFECTS ON NEUROTRANSMISSION
    Fulton Crews; Fiscal Year: 2009
    ..abstract_text> ..