Fulton T Crews

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Binge ethanol exposure decreases neurogenesis in adult rat hippocampus
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 83:1087-93. 2002
  2. pmc Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
    J Neuroinflammation 5:10. 2008
  3. pmc NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration
    Liya Qin
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Glia 61:855-68. 2013
  4. ncbi request reprint Neurogenesis decreases during brain maturation from adolescence to adulthood
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 86:327-33. 2007
  5. ncbi request reprint 1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats
    Peter C Nicholas
    Bowles Center for Alcohol Studies, Department of Biomedical Engineering, and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Chem Res Toxicol 21:408-20. 2008
  6. pmc Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice
    Jennie R Stevenson
    Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 34:1209-22. 2009
  7. pmc Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis
    Leon G Coleman
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill CB 7178, Chapel Hill, NC 27599 7178, USA
    Alcohol 46:603-12. 2012
  8. pmc NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:5. 2012
  9. pmc Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice
    Leon G Coleman
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Alcohol Clin Exp Res 35:671-88. 2011
  10. doi request reprint Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P rats
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 33:129-38. 2009

Detail Information

Publications39

  1. ncbi request reprint Binge ethanol exposure decreases neurogenesis in adult rat hippocampus
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurochem 83:1087-93. 2002
    ..These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction...
  2. pmc Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
    J Neuroinflammation 5:10. 2008
    ..The purpose of this study was to investigate the interaction of liver, serum and brain cytokines as well as whether ethanol would potentiate endotoxin (Lipopolysaccharide, LPS) responses once ethanol had cleared...
  3. pmc NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration
    Liya Qin
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Glia 61:855-68. 2013
    ..Together, these results suggest that NOX contributes to persistent microglial activation, ROS production, and dopaminergic neurodegeneration that persist and continue to increase with age...
  4. ncbi request reprint Neurogenesis decreases during brain maturation from adolescence to adulthood
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 86:327-33. 2007
    ..However, the role of IGF-1 during adolescent development is still unclear...
  5. ncbi request reprint 1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats
    Peter C Nicholas
    Bowles Center for Alcohol Studies, Department of Biomedical Engineering, and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Chem Res Toxicol 21:408-20. 2008
    ..Reduction of EtG by pretreatment with BHT suggests that BHT and perhaps other compounds may alter the pharmacokinetics of EtG so that EtG may not always be a sensitive marker for ethanol abuse...
  6. pmc Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice
    Jennie R Stevenson
    Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 34:1209-22. 2009
    ..e. behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations...
  7. pmc Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis
    Leon G Coleman
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill CB 7178, Chapel Hill, NC 27599 7178, USA
    Alcohol 46:603-12. 2012
    ..Increased adult neurogenesis in males, but not females, is consistent with differential adaptive responses to P7 ethanol toxicity between the sexes. One day of ethanol exposure, e.g. P7, causes persistent adult brain dysmorphology...
  8. pmc NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:5. 2012
    ..In the present study, we investigate the effects of chronic ethanol on activation of NOX and release of ROS, and their contribution to ethanol neurotoxicity...
  9. pmc Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice
    Leon G Coleman
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Alcohol Clin Exp Res 35:671-88. 2011
    ..Therefore, adolescent binge ethanol may have long-term effects on the adult brain that alter brain structure and behaviors that are relevant to alcohol-use disorders...
  10. doi request reprint Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P rats
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 33:129-38. 2009
    ..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)...
  11. ncbi request reprint Alcoholic neurobiology: changes in dependence and recovery
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 29:1504-13. 2005
    ....
  12. pmc Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking
    Ryan P Vetreno
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Neurobiol Dis 59:52-62. 2013
    ....
  13. pmc ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation
    Jian Zou
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Glia 60:661-73. 2012
    ..Taken together, these novel findings demonstrate the importance of ATP-P2X(7) signaling in controlling proliferation of glial progenitors under the pathological conditions associated with increased TNFα...
  14. ncbi request reprint Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Eur J Neurosci 21:2711-20. 2005
    ..These data implicate impaired hippocampal neurogenesis with the cognitive and affective dysfunction associated with chronic alcoholism...
  15. pmc Mechanisms of neurodegeneration and regeneration in alcoholism
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
    Alcohol Alcohol 44:115-27. 2009
    ..g. brain regeneration. Efforts are made to relate preclinical studies to human studies...
  16. pmc Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Glia 55:453-62. 2007
    ..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease...
  17. pmc The cytokine mRNA increase induced by withdrawal from chronic ethanol in the sterile environment of brain is mediated by CRF and HMGB1 release
    Buddy A Whitman
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Department of Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Alcohol Clin Exp Res 37:2086-97. 2013
    ....
  18. pmc Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:130. 2012
    ..Here, we investigate the effects of chronic ethanol on neuroinflammation and neurodegeneration triggered by toll-like receptor 3 (TLR3) agonist poly I:C...
  19. pmc High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence
    Fulton T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Biol Psychiatry 73:602-12. 2013
    ....
  20. pmc Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment
    Leon G Coleman
    Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 93:322-30. 2009
    ..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction...
  21. pmc Increased MCP-1 and microglia in various regions of the human alcoholic brain
    Jun He
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Exp Neurol 210:349-58. 2008
    ..In VTA and midbrain, only GluT5, but not Iba-1 was increased in alcoholic brains. These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis...
  22. ncbi request reprint Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol
    Kimberly Nixon
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:9714-22. 2004
    ..For the first time, these data provide a neurobiological mechanism that may underlie the return of human cognitive function and brain volume associated with recovery from addiction...
  23. ncbi request reprint Exercise reverses ethanol inhibition of neural stem cell proliferation
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Alcohol 33:63-71. 2004
    ..The opposing effects of ethanol consumption and exercise on neurogenesis could contribute to the CNS pathology and health benefits, respectively, of these two behaviors...
  24. ncbi request reprint Alcohol, neural stem cells, and adult neurogenesis
    Fulton T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, University of North Carolina, Chapel Hill, USA
    Alcohol Res Health 27:197-204. 2003
    ....
  25. ncbi request reprint Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats
    Fulton T Crews
    Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 27:1075-82. 2003
    ..To investigate the role of genetics in binge-drinking-induced brain damage, we studied bidirectionally selected rat lines, the alcohol-preferring P and the alcohol-nonpreferring NP rat lines...
  26. ncbi request reprint Alcohol-induced neurodegeneration: when, where and why?
    Fulton T Crews
    University at Buffalo, SUNY, NY, USA
    Alcohol Clin Exp Res 28:350-64. 2004
    ..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal...
  27. pmc Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility
    LEON GARLAND COLEMAN
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599 7178, United States Electronic address
    Pharmacol Biochem Behav 116:142-51. 2014
    ..These findings are consistent with AIE causing persistent changes in brain structure that could contribute to a lack of behavioral flexibility. ..
  28. ncbi request reprint Cytokines and alcohol
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 30:720-30. 2006
    ..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies...
  29. pmc Comparison of magnetic resonance imaging in live vs. post mortem rat brains
    Ipek Oguz
    University of North Carolina at Chapel Hill, Department of Psychiatry, Chapel Hill, North Carolina, USA
    PLoS ONE 8:e71027. 2013
    ..These findings illustrate the validity and utility of using post mortem scans in volumetric neurobiological studies. ..
  30. ncbi request reprint Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
    Jennifer A Obernier
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Pharmacol Biochem Behav 72:521-32. 2002
    ..The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process...
  31. pmc Persistent Loss of Hippocampal Neurogenesis and Increased Cell Death following Adolescent, but Not Adult, Chronic Ethanol Exposure
    Margaret A Broadwater
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, N C, USA
    Dev Neurosci 36:297-305. 2014
    ..2014 S. Karger AG, Basel. ..
  32. pmc Release of neuronal HMGB1 by Ethanol through decreased HDAC activity activates brain neuroimmune signaling
    Jian Y Zou
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e87915. 2014
    ..These findings provide new therapeutic targets for brain neuroimmune activation and alcoholism. ..
  33. pmc Focal thalamic degeneration from ethanol and thiamine deficiency is associated with neuroimmune gene induction, microglial activation, and lack of monocarboxylic acid transporters
    Liya Qin
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Alcohol Clin Exp Res 38:657-71. 2014
    ..Although TD alone can cause WE, the high incidence in alcoholism suggests that TD and ethanol (EtOH) interact...
  34. pmc Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis
    Jian Zou
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Neurosci 6:77. 2012
    ....
  35. ncbi request reprint Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liver
    Peter C Nicholas
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Anal Biochem 358:185-91. 2006
    ..24 ppm. This study demonstrates that proton NMR spectroscopy is capable of detecting EtG and that future NMR-based metabolomic studies may encounter this metabolite of ethanol...
  36. ncbi request reprint TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition
    Jian Y Zou
    Bowles Center for Alcohol Studies, CB 7178 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1034:11-24. 2005
    ..TNF alpha potentiation of glutamate neurotoxicity through the blockade of glutamate transporter activity may represent an important mechanism of neurodegeneration associated with neuroinflammation...
  37. ncbi request reprint Consequences of multiple withdrawals from alcohol
    Theodora Duka
    Psychology Department, School of Life Sciences, University of Sussex, Sussex, Brighton, United Kingdom
    Alcohol Clin Exp Res 28:233-46. 2004
    ....
  38. ncbi request reprint CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction
    Subhash C Pandey
    Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    Alcohol Clin Exp Res 29:176-84. 2005
    ..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...
  39. ncbi request reprint Adolescence: booze, brains, and behavior
    Peter M Monti
    Veterans Affairs Medical Center, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 29:207-20. 2005
    ..5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher...