Research Topics
Genomes and Genes | Fulton T CrewsSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Binge ethanol exposure decreases neurogenesis in adult rat hippocampusKimberly Nixon
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurochem 83:1087-93. 2002..These studies are the first to show EtOH inhibition of neural progenitor cell proliferation and survival in the adult, a possible new mechanism underlying alcoholic cognitive dysfunction...
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatmentLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
J Neuroinflammation 5:10. 2008..The purpose of this study was to investigate the interaction of liver, serum and brain cytokines as well as whether ethanol would potentiate endotoxin (Lipopolysaccharide, LPS) responses once ethanol had cleared...- Neurogenesis decreases during brain maturation from adolescence to adulthoodJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Pharmacol Biochem Behav 86:327-33. 2007..However, the role of IGF-1 during adolescent development is still unclear... - 1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in ratsPeter C Nicholas
Bowles Center for Alcohol Studies, Department of Biomedical Engineering, and Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Chem Res Toxicol 21:408-20. 2008..Reduction of EtG by pretreatment with BHT suggests that BHT and perhaps other compounds may alter the pharmacokinetics of EtG so that EtG may not always be a sensitive marker for ethanol abuse... - Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in miceJennie R Stevenson
Department of Psychiatry, Bowles Center for Alcohol Studies, Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Neuropsychopharmacology 34:1209-22. 2009..e. behavioral) and structural changes occur during abstinence from alcohol use and suggest that antidepressant treatment may alleviate some of these pathological neurobehavioral adaptations... - Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesisLeon G Coleman
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill CB 7178, Chapel Hill, NC 27599 7178, USA
Alcohol 46:603-12. 2012..Increased adult neurogenesis in males, but not females, is consistent with differential adaptive responses to P7 ethanol toxicity between the sexes. One day of ethanol exposure, e.g. P7, causes persistent adult brain dysmorphology... - NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
J Neuroinflammation 9:5. 2012..In the present study, we investigate the effects of chronic ethanol on activation of NOX and release of ROS, and their contribution to ethanol neurotoxicity... - Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in miceLeon G Coleman
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Alcohol Clin Exp Res 35:671-88. 2011..Therefore, adolescent binge ethanol may have long-term effects on the adult brain that alter brain structure and behaviors that are relevant to alcohol-use disorders... - Alcoholic neurobiology: changes in dependence and recoveryFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 29:1504-13. 2005.... 
Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P ratsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Alcohol Clin Exp Res 33:129-38. 2009..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)...- ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferationJian Zou
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Glia 60:661-73. 2012..Taken together, these novel findings demonstrate the importance of ATP-P2X(7) signaling in controlling proliferation of glial progenitors under the pathological conditions associated with increased TNFα... - Systemic LPS causes chronic neuroinflammation and progressive neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Glia 55:453-62. 2007..These findings provide valuable insight into the potential pathogenesis and self-propelling nature of Parkinson's disease... - Mechanisms of neurodegeneration and regeneration in alcoholismFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599, USA
Alcohol Alcohol 44:115-27. 2009..g. brain regeneration. Efforts are made to relate preclinical studies to human studies... - Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neuronsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Eur J Neurosci 21:2711-20. 2005..These data implicate impaired hippocampal neurogenesis with the cognitive and affective dysfunction associated with chronic alcoholism... - Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatmentLeon G Coleman
Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
Pharmacol Biochem Behav 93:322-30. 2009..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction... - Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcoholKimberly Nixon
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurosci 24:9714-22. 2004..For the first time, these data provide a neurobiological mechanism that may underlie the return of human cognitive function and brain volume associated with recovery from addiction... - Exercise reverses ethanol inhibition of neural stem cell proliferationFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
Alcohol 33:63-71. 2004..The opposing effects of ethanol consumption and exercise on neurogenesis could contribute to the CNS pathology and health benefits, respectively, of these two behaviors... - Increased MCP-1 and microglia in various regions of the human alcoholic brainJun He
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Exp Neurol 210:349-58. 2008..In VTA and midbrain, only GluT5, but not Iba-1 was increased in alcoholic brains. These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis... - Alcohol, neural stem cells, and adult neurogenesisFulton T Crews
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, University of North Carolina, Chapel Hill, USA
Alcohol Res Health 27:197-204. 2003.... - Alcohol-induced neurodegeneration: when, where and why?Fulton T Crews
University at Buffalo, SUNY, NY, USA
Alcohol Clin Exp Res 28:350-64. 2004..Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal... - Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP ratsFulton T Crews
Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 27:1075-82. 2003..To investigate the role of genetics in binge-drinking-induced brain damage, we studied bidirectionally selected rat lines, the alcohol-preferring P and the alcohol-nonpreferring NP rat lines... - High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependenceFulton T Crews
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
Biol Psychiatry 73:602-12. 2013.... - Cytokines and alcoholFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
Alcohol Clin Exp Res 30:720-30. 2006..Together these studies suggest that ethanol disruption of cytokines and inflammation contribute in multiple ways to a diversity of alcoholic pathologies... - Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in ratsJennifer A Obernier
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599-7178, USA
Pharmacol Biochem Behav 72:521-32. 2002..The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process... - Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal NeurogenesisJian Zou
Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
Front Neurosci 6:77. 2012.... - Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegenerationLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
J Neuroinflammation 9:130. 2012..Here, we investigate the effects of chronic ethanol on neuroinflammation and neurodegeneration triggered by toll-like receptor 3 (TLR3) agonist poly I:C... - Proton nuclear magnetic resonance spectroscopic determination of ethanol-induced formation of ethyl glucuronide in liverPeter C Nicholas
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Anal Biochem 358:185-91. 2006..24 ppm. This study demonstrates that proton NMR spectroscopy is capable of detecting EtG and that future NMR-based metabolomic studies may encounter this metabolite of ethanol... - TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibitionJian Y Zou
Bowles Center for Alcohol Studies, CB 7178 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Brain Res 1034:11-24. 2005..TNF alpha potentiation of glutamate neurotoxicity through the blockade of glutamate transporter activity may represent an important mechanism of neurodegeneration associated with neuroinflammation... - Consequences of multiple withdrawals from alcoholTheodora Duka
Psychology Department, School of Life Sciences, University of Sussex, Sussex, Brighton, United Kingdom
Alcohol Clin Exp Res 28:233-46. 2004.... - Adolescence: booze, brains, and behaviorPeter M Monti
Veterans Affairs Medical Center, Brown University, Providence, Rhode Island 02912, USA
Alcohol Clin Exp Res 29:207-20. 2005..5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher... - CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addictionSubhash C Pandey
Department of Psychiatry, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
Alcohol Clin Exp Res 29:176-84. 2005..Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy...