F T Crews

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Addiction, adolescence, and innate immune gene induction
    Fulton T Crews
    Department of Pharmacology, Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Psychiatry 2:19. 2011
  2. pmc Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:130. 2012
  3. pmc NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:5. 2012
  4. pmc Induction of innate immune genes in brain create the neurobiology of addiction
    F T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The School of Medicine, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Brain Behav Immun 25:S4-S12. 2011
  5. ncbi request reprint Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats
    F T Crews
    The Bowles Center For Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Alcohol Clin Exp Res 24:1712-23. 2000
  6. ncbi request reprint Neurogenesis in adolescent brain is potently inhibited by ethanol
    F T Crews
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
    Neuroscience 137:437-45. 2006
  7. ncbi request reprint Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates
    D H Overstreet
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine at Chapel Hill 27599 7178, USA
    Psychiatr Genet 6:107-17. 1996
  8. ncbi request reprint Interaction of nutrition and binge ethanol treatment on brain damage and withdrawal
    F T Crews
    Bowles Center for Alcohol Studies, CB 7178, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Biomed Sci 8:134-42. 2001
  9. ncbi request reprint Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factor
    F T Crews
    Center for Alcohol Studies, University of North Carolina, Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 23:1834-42. 1999
  10. ncbi request reprint Summary report of a symposium: genes and gene delivery for diseases of alcoholism
    F T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 25:1778-800. 2001

Detail Information

Publications16

  1. pmc Addiction, adolescence, and innate immune gene induction
    Fulton T Crews
    Department of Pharmacology, Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill Chapel Hill, NC, USA
    Front Psychiatry 2:19. 2011
    ..This review suggests that persistent and progressive changes in innate immune gene expression contribute to the development of addiction. Innate immune genes may represent a novel new target for addiction therapy...
  2. pmc Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:130. 2012
    ..Here, we investigate the effects of chronic ethanol on neuroinflammation and neurodegeneration triggered by toll-like receptor 3 (TLR3) agonist poly I:C...
  3. pmc NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:5. 2012
    ..In the present study, we investigate the effects of chronic ethanol on activation of NOX and release of ROS, and their contribution to ethanol neurotoxicity...
  4. pmc Induction of innate immune genes in brain create the neurobiology of addiction
    F T Crews
    Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, The School of Medicine, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Brain Behav Immun 25:S4-S12. 2011
    ..The hypothesis that innate immune gene induction underlies addiction and affective disorders creates new targets for therapy...
  5. ncbi request reprint Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats
    F T Crews
    The Bowles Center For Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Alcohol Clin Exp Res 24:1712-23. 2000
    ..Adolescents respond differently to alcohol than adults. Furthermore, binge drinking in young adolescents is becoming increasingly common...
  6. ncbi request reprint Neurogenesis in adolescent brain is potently inhibited by ethanol
    F T Crews
    Bowles Center for Alcohol Studies, The University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, 27599 7178, USA
    Neuroscience 137:437-45. 2006
    ..These studies indicate that the adolescent brain is very sensitive to acute ethanol inhibition of neurogenesis...
  7. ncbi request reprint Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates
    D H Overstreet
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine at Chapel Hill 27599 7178, USA
    Psychiatr Genet 6:107-17. 1996
    ..The pattern of binding results suggests that these behavioral correlates of 8-OH-DPAT selection may be related to changes in cortical 5-HT-1A receptors rather than raphe autoreceptors...
  8. ncbi request reprint Interaction of nutrition and binge ethanol treatment on brain damage and withdrawal
    F T Crews
    Bowles Center for Alcohol Studies, CB 7178, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    J Biomed Sci 8:134-42. 2001
    ..This study suggests that nutritional components and total caloric intake do not effect behavior during ethanol withdrawal and that a nutritionally complete diet may increase ethanol-induced brain damage...
  9. ncbi request reprint Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factor
    F T Crews
    Center for Alcohol Studies, University of North Carolina, Chapel Hill 27599 7178, USA
    Alcohol Clin Exp Res 23:1834-42. 1999
    ..Because chronic ethanol is known to cause supersensitivity to NMDA excitotoxicity in cortical neurons, this study sought to determine the effect of ethanol treatment on biogenic amine neurons...
  10. ncbi request reprint Summary report of a symposium: genes and gene delivery for diseases of alcoholism
    F T Crews
    Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 25:1778-800. 2001
    ..Three main pathologies associated with alcoholism--addiction, liver disease, and birth defects--were discussed. This summary of the meeting is grouped into sections on the brain, liver, and fetus...
  11. ncbi request reprint Effects of nicotine on ethanol dependence and brain damage
    S Penland
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7178, USA
    Alcohol 24:45-54. 2001
    ..Although results of other studies seem to indicate that nicotine increases alcohol consumption, our findings indicate that nicotine does not markedly change the development of alcohol dependence or alcohol-induced cortical damage...
  12. ncbi request reprint Binge ethanol exposure in adult rats causes necrotic cell death
    J A Obernier
    Bowles Center for Alcohol Studies, Department of Pharmacology, University of North Carolina at Chapel Hill, 27599 7178, USA
    Alcohol Clin Exp Res 26:547-57. 2002
    ..The goal of this research is to characterize the time course of binge ethanol-induced neurodegeneration and to identify apoptotic or necrotic characteristics of this neurodegeneration...
  13. ncbi request reprint Regional specificity of ethanol and NMDA action in brain revealed with FOS-like immunohistochemistry and differential routes of drug administration
    D J Knapp
    Bowles Center for Alcohol Studies, and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol Clin Exp Res 25:1662-72. 2001
    ....
  14. ncbi request reprint Neural stem cells and alcohol
    F T Crews
    University of North Carolina and Chapel Hill, NC 27599, USA
    Alcohol Clin Exp Res 27:324-35. 2003
    ..Dr. W. Michael Zawada described studies directed at dopamine neuron cell transplants into mammalian central nervous system. These studies clearly establish that ethanol has significant effects on stem cells...
  15. ncbi request reprint Brain 5-HT1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity
    D J Knapp
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Brain Res 782:1-10. 1998
    ....
  16. ncbi request reprint Inferior collicular seizure generalization produces site-selective cortical induction of cyclooxygenase 2 (COX-2)
    T J McCown
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599, USA
    Brain Res 767:370-4. 1997
    ..Thus, initial seizure generalization into the forebrain induces COX-2 expression in a highly specific area of the cerebral cortex...