Research Topics
| DAVID P CREWSSummaryAffiliation: University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Epigenetic transgenerational inheritance of altered stress responsesDavid Crews
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 109:9143-8. 2012....- Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian developmentCraig A Smith
The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
BMC Dev Biol 8:72. 2008..Evidence is presented that this gene is an ancient component of the vertebrate ovary-determining pathway... 
Brain organization in a reptile lacking sex chromosomes: effects of gonadectomy and exogenous testosteroneD Crews
Institute of Reproductive Biology, Department of Zoology, University of Texas at Austin 78712, USA
Horm Behav 30:474-86. 1996..This is the first demonstration in a vertebrate that factors other than steroid hormones can modify the organization and functional activity of sexually differentiated brain areas...- Sexually dimorphic regulation of estrogen receptor alpha mRNA in the ventromedial hypothalamus of adult whiptail lizards is testosterone dependentDavid Crews
Section of Integrative Biology, University of Texas at Austin, Institute for Neuroscience, Austin, TX 78712, USA
Brain Res 1004:136-41. 2004.... - Postnatal environment affects behavior of adult transgenic miceDavid Crews
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Exp Biol Med (Maywood) 229:935-9. 2004..These data suggest that the postnatal environment such as litter composition may influence the development of sociosexual behaviors in ERKO mice... - Historical contributions of research on reptiles to behavioral neuroendocrinologyDavid Crews
Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
Horm Behav 48:384-94. 2005..4) Hormone manipulations as a powerful tool to test hypotheses about the evolution of behavior in free-living animals... - Evolution of neuroendocrine mechanisms that regulate sexual behaviorDavid Crews
Ashbel Smith Professor of Zoology and Psychology, Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
Trends Endocrinol Metab 16:354-61. 2005.... - Epigenetics and its implications for behavioral neuroendocrinologyDavid Crews
Section of Integrative Biology and Center of Behavioral Neuroendocrinology, University of Texas at Austin, Austin, TX 78712, USA
Front Neuroendocrinol 29:344-57. 2008..This work raises the question of how events in generations past can have consequences at both the mechanistic, behavioral, and ultimately evolutionary levels... - Epigenetics, evolution, endocrine disruption, health, and diseaseDavid Crews
Section of Integrative Biology, 2400 Speedway, University of Texas, Austin, Texas 78712, USA
Endocrinology 147:S4-10. 2006..We suggest a perspective for exploring and ultimately coming to understand diseases that may have environmental or endocrine origins... - From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behaviorDavid Crews
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Brain Res 1126:109-21. 2006.... - The development of phenotypic plasticity: where biology and psychology meetDavid Crews
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
Dev Psychobiol 43:1-10. 2003 - Developmental effects on intersexual and intrasexual variation in growth and reproduction in a lizard with temperature-dependent sex determinationD Crews
Department of Zoology, University of Texas at Austin 78712, USA
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119:229-41. 1998..Thus, the leopard gecko is an excellent model to elucidate the developmental interactions among the environment and the endocrine and nervous systems that control growth and reproduction... - Effects of age and sociosexual experience on the morphology and metabolic capacity of brain nuclei in the leopard gecko (Eublepharis macularius), a lizard with temperature-dependent sex determinationD Crews
Institute of Reproductive Biology and Department of Zoology, University of Texas at Austin, 78712, USA
Brain Res 758:169-79. 1997..These data suggest that the volume and metabolic capacity of specific brain regions change as animals age and gain sociosexual experience, but the nature and degree of change depend upon prenatal events... - Role of steroidogenic factor 1 and aromatase in temperature-dependent sex determination in the red-eared slider turtleD Crews
Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
J Exp Zool 290:597-606. 2001..The inhibition of estrogen results in upregulation of SF-1 and male hatchlings. Thus, SF-1 may lie at the center of one molecular crossroad in male versus female differentiation of the red-eared slider... - Epigenetic modifications of brain and behavior: theory and practiceDavid Crews
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 59:393-8. 2011..Lastly, it seems intuitive that germline- and context-dependent epigenetic modifications interact, resulting in the individual variation observed in behaviors, but until now this hypothesis has never been tested experimentally... - The evolutionary antecedents to loveD Crews
Institute of Reproductive Biology, University of Texas at Austin 78712, USA
Psychoneuroendocrinology 23:751-64. 1998.... - Synergistic responses of steroidal estrogens in vitro (yeast) and in vivo (turtles)S F Arnold
Department of Environmental Health Sciences, Tulane School of Public Health, New Orleans, Louisiana 70112, USA
Biochem Biophys Res Commun 235:336-42. 1997..Our results suggest that the synergy of some combinations of estrogens, synthetic or steroidal, may play a role in the estrogen-dependent process of sexual development in certain species... - Endocrine disruptors: present issues, future directionsD Crews
Institute of Reproductive Biology, University of Texas, Austin 78712, USA
Q Rev Biol 75:243-60. 2000..Rather, adaptive alterations in the genes that encode steroid receptors may occur with chronic exposure to EDCs, allowing the sex hormone receptor to discriminate natural steroids from EDCs... - Epigenetics, brain, behavior, and the environmentDavid Crews
Ashbel Smith Professor of Zoology and Psychology, Section of Integrative Biology, University of Texas at Austin, USA
Hormones (Athens) 9:41-50. 2010.... - Sex determination: where environment and genetics meetDavid Crews
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Evol Dev 5:50-5. 2003..That is, sex is merely a means of categorizing individuals or gonads, whereas sexuality serves as a descriptor of concordant traits each of which is typically sexually dimorphic in its expression... - Developmental sculpting of social phenotype and plasticityJon T Sakata
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Neurosci Biobehav Rev 28:95-112. 2004..We argue that the leopard gecko is an important model of how the process of sex determination can affect sexual differentiation and of selection forces underlying the evolution of sex ratios... - Species differences in the regulation of tyrosine hydroxylase in Cnemidophorus whiptail lizardsSarah C Woolley
Section of Integrative Biology, Patterson 141, 2400 Speedway, University of Texas at Austin, Austin, Texas 78712, USA
J Neurobiol 60:360-8. 2004.... - Preoptic neuronal nitric oxide synthase induction by testosterone is consistent with a role in gating male copulatory behaviorNicholas S R Sanderson
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Eur J Neurosci 27:183-90. 2008..Results are consistent with transcriptional up-regulation of nNOS by testosterone and a central role for the enzyme in mediating hormonal gating of copulatory behavior... - Evolutionary insights into the regulation of courtship behavior in male amphibians and reptilesSarah C Woolley
Section for Integrative Biology, Division of Biological Sciences, Patterson Laboratories, University of Texas at Austin, Austin, TX 78712, USA
Physiol Behav 83:347-60. 2004.... - Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparensBrian George Dias
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 50:401-9. 2006.... - Gonadal expression of Sf1 and aromatase during sex determination in the red-eared slider turtle (Trachemys scripta), a reptile with temperature-dependent sex determinationMary Ramsey
Department of Integrative Biology, University of Texas, Austin, TX, USA
Differentiation 75:978-91. 2007..Our data do not lend support to a role for Sf1 in the regulation of aromatase expression during slider turtle sex determination, but do support a critical role for estrogen in ovarian development... - Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtlesMary Ramsey
Section of Integrative Biology, University of Texas, 2400 Speedway, Austin, TX 78712, United States
Semin Cell Dev Biol 20:283-92. 2009..Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development... - Effect of incubation temperature and androgens on dopaminergic activity in the leopard gecko, Eublepharis maculariusBrian George Dias
Institute for Neuroscience, University of Texas at Austin, Austin, Texas, USA
Dev Neurobiol 67:630-6. 2007..These data indicate that both the embryonic environment as well as the circulating hormonal milieu can modulate neurochemistry, which might in turn be a basis for individual variation in behavior... - Behavioral correlates of differences in neural metabolic capacityJon T Sakata
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Brain Res Brain Res Rev 48:1-15. 2005..We propose that knowledge of neurometabolic differences can yield valuable predictions about behavioral phenotype in other systems... - Expression of Sox9, Mis, and Dmrt1 in the gonad of a species with temperature-dependent sex determinationChristina Shoemaker
Department of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA
Dev Dyn 236:1055-63. 2007..Furthermore, we extend previous findings that Dmrt1 expression at early stages of sex determination has a dimorphic pattern consistent with a possible upstream role in determining the fate of the bipotential gonad... - Differential effects of testosterone and progesterone on the activation and retention of courtship behavior in sexual and parthenogenetic whiptail lizardsJon T Sakata
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 43:523-30. 2003..In summary, though both T and P can elicit identical sexual behaviors in both whiptail species, T has a greater and more lasting effect on courtship behavior and possibly on the neural circuits underlying courtship behavior... - Adrenal-kidney-gonad complex measurements may not predict gonad-specific changes in gene expression patterns during temperature-dependent sex determination in the red-eared slider turtle (Trachemys scripta elegans)Mary Ramsey
Department of Integrative Biology, University of Texas, Austin, Texas 78712, USA
J Exp Zool A Ecol Genet Physiol 307:463-70. 2007..Inclusion of the AK compartment masked important changes in gonadal gene expression. In addition, AK and gonad expression patterns are not additive, and gonadal gene expression cannot be predicted from intact AKG measurements... - Regulation of pseudosexual behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparensBrian George Dias
Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
Endocrinology 149:4622-31. 2008..This study illuminates how male- and female-typical sexual behaviors share common neural circuits, and that 5-HT regulates these naturally complementary, and mutually exclusive, behaviors... - The use of norms of reaction to analyze genotypic and environmental influences on behavior in mice and ratsTrevon Fuller
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Neurosci Biobehav Rev 29:445-56. 2005..We describe the main features of NoRs, the history of their use in this context, and discuss several applications in behavioral neuroscience. In addition, we give a test for determining whether distinct strains have different NoRs... - Repeated interactions with females elevate metabolic capacity in the limbic system of male ratsJon T Sakata
Institute for Neuroscience, Patterson Hall, University of Texas at Austin, Austin, TX 78712, USA
Brain Res 936:27-37. 2002..We speculate that these changes in brain metabolic capacity could be related to immediate early gene expression during copulation and could underlie the long-term behavioral changes accompanying heterosexual social experience... - Heterosexual housing increases the retention of courtship behavior following castration and elevates metabolic capacity in limbic brain nuclei in male whiptail lizards, Cnemidophorus inornatusJon T Sakata
Institute for Neuroscience, University of Texas at Austin, Texas 78712, USA
Horm Behav 42:263-73. 2002..Altogether, this demonstrates that elevations in metabolic capacity correlate with experience-dependent increases in robustness to castration... - Embryonic origin of mate choice in a lizard with temperature-dependent sex determinationOliver Putz
Section for Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Dev Psychobiol 48:29-38. 2006..Thus, sexual selection results from a combination of the female's as well as the male's life history. Female attractiveness and male choice therefore are complementary... - Hormonal state influences aspects of female mate choice in the Túngara Frog (Physalaemus pustulosus)Kathleen S Lynch
Institute for Neuroscience, University of Texas, 108 East Dean Keeton, Seay Psychology Building, Austin, 78712, USA
Horm Behav 49:450-7. 2006..S., Ryan, M.J., Wilczynski, W., 2005. Plasticity in female mate choice associated with changing reproductive states. Anim. Behav. 69, 689-699), suggesting that changes in hormone levels can influence the female's mate choice behavior... - The nitric oxide synthase inhibitor L-NAME suppresses androgen-induced male-like pseudocopulatory behavior in whiptail lizardsNicholas S R Sanderson
Institute for Neuroscience, University of Texas at Austin, 78712, USA
Brain Res 1052:236-9. 2005..The deficit was principally in mounting, suggesting that sexual motivational systems were affected, rather than consummatory mechanisms... 
Genetic network underlying temperature-dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonadsChristina M Shoemaker-Daly
Molecular, Cell and Developmental Biology, University of Texas at Austin, Austin, Texas, USA
Dev Dyn 239:1061-75. 2010..Finally, mosaic misexpression of a fusion Sox9 construct demonstrates the ability to functionally manipulate the gonad at the molecular level...- Steroidogenic enzyme gene expression in the brain of the parthenogenetic whiptail lizard, Cnemidophorus uniparensBrian George Dias
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Brain Res 1253:129-38. 2009..This study also supports the idea that non-gonadal sources of steroid hormones locally produced in behaviorally relevant brain loci are central to the mediation of behavioral output... - Response of candidate sex-determining genes to changes in temperature reveals their involvement in the molecular network underlying temperature-dependent sex determinationChristina M Shoemaker
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA
Mol Endocrinol 21:2750-63. 2007..By examining the role of these genes in TSD, we can begin to elucidate elements of conservation and divergence between sex-determining mechanisms... - Constraints on temperature-dependent sex determination in the leopard gecko (Eublepharis macularius): response to Kratochvil et alVictoria Huang
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
Naturwissenschaften 95:1137-42. 2008..These results suggest that maternal influences on sex determination are secondary relative to incubation temperature effects... - Learning effects on sperm competition and reproductive fitnessR Nicolle Matthews
University of Texas at Austin, TX 78712, USA
Psychol Sci 18:758-62. 2007..These findings demonstrate that Pavlovian conditioning contributes to reproductive fitness and suggest that individual past experience can bias genetic transmission and the evolutionary changes that result from sexual competition... - Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout miceSarah C Woolley
Section of Integrative Biology, University of Texas at Austin, TX, USA
Behav Brain Res 167:197-204. 2006.... - Changes in androgen receptor mRNA expression in the forebrain and oviduct during the reproductive cycle of female leopard geckos, Eublepharis maculariusTurk Rhen
Section of Integrative Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA
Gen Comp Endocrinol 132:133-41. 2003..Although the function of AR in the female leopard gecko is not yet clear, our results are in accord with growing evidence that androgens regulate numerous aspects of female physiology and behavior in vertebrates... - Neural substrates for sexual and thermoregulatory behavior in the male leopard gecko, Eublepharis maculariusNora Edwards
Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, United States
Brain Res 1029:77-83. 2004..Together, these findings identify the POAH as an important neural locus regulating sexual behavior but not thermoregulation and suggest that the SCN acts as a pacemaker controlling daily behavioral temperature regulation in this species... - Transgenerational epigenetic imprints on mate preferenceDavid Crews
Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 104:5942-6. 2007..Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution...
Research Grants
- Epigenetic Influences on Brain and BehaviorDavid Crews; Fiscal Year: 2004..Specific Aim III. To establish if the different behavioral profiles exhibited in such animals in adulthood are reflected in different patterns of activity in a network of interconnected limbic nuclei. ..
- EVOLUTION OF BRAIN/BEHAVIOR CONTROLLING MECHANISMSDavid Crews; Fiscal Year: 2003....
- TRAINING PROGRAM IN NEUROBIOLOGY AND BEHAVIORDavid Crews; Fiscal Year: 2003..All of the laboratories comply with NIH requirements. ..
- ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITYDavid Crews; Fiscal Year: 2002..The final category of experiments is particularly important as it will discern whether the incubation temperature effects are direct or indirect. ..
- EVOLUTION OF BRAIN-BEHAVIOR CONTROLLING MECHANISMSDavid Crews; Fiscal Year: 2009..abstract_text> ..